Exhibit 107

Calculation of Filing Fee Tables

Form S-3

(Form Type)

Spyre Therapeutics, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered and Carry Forward Securities

Security Type

Security Class Title

Fee Calculation or Carry Forward Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Carry Forward Form Type

Carry Forward File Number

Carry Forward Initial effective date

Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward

Newly Registered Securities

Fees to Be Paid

Equity

Common stock, $0.0001 par value per share(1)

Rule 457(c)

46,330,799(2)

$28.40(3)

$1,315,794,691.60(3)

0.00014760

$194,211.30

Carry Forward Securities

Carry Forward Securities

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

Total Offering Amounts

$1,315,794,691.60

$194,211.30

Total Fees Previously Paid

N/A

Total Fee Offsets

N/A

Net Fee Due

$194,211.30

__________________

(1)Pursuant to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), this registration statement also covers such an indeterminate amount of shares of common stock as may become issuable to prevent dilution resulting from stock splits, stock dividends and similar events.

(2)The amount registered consists of up to (i) 31,137,912 shares of Common Stock, (ii) 13,841,800 shares of Common Stock issuable upon the conversion of 346,045 shares of Series A Preferred Stock, (iii) 666,680 shares of Common Stock issuable upon the conversion of 16,667 shares of Series B Preferred Stock, and (iv) 684,407 shares of Common Stock issuable upon exercise of warrants to purchase Common Stock.

(3)Estimated solely for the purpose of calculating the registration fee, based on the average of the high and low prices of the shares of Common Stock on The Nasdaq Global Select Market on September 16, 2024 (such date being within five business days of the date that this registration statement was first filed with the Securities and Exchange Commission, in accordance with Rule 457(c) under the Securities Act).