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Stock-Based Compensation - Schedule of Estimate Fair Value of Stock Options Granted (Details)
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Equity Incentive Plans    
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]    
Expected term (in years) 6 years 10 days 6 years 3 days
Expected volatility 82.00% 85.00%
Risk-free interest 2.57% 2.72%
Dividend yield 0.00% 0.00%
2016 Employee Stock Purchase Plan    
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]    
Expected term (in years) 5 months 26 days 5 months 26 days
Expected volatility 66.00% 69.00%
Risk-free interest 2.55% 2.00%
Dividend yield 0.00% 0.00%