The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AGIOS PHARMACEUTICALS INC | Common | 00847X104 | 43,157 | 639,928 | SH | DFND | 3 | 0 | 639,928 | 0 | |
| AGIOS PHARMACEUTICALS INC | Common | 00847X104 | 61,842 | 916,999 | SH | DFND | 2 | 0 | 916,999 | 0 | |
| AGIOS PHARMACEUTICALS INC | Common | 00847X104 | 44,344 | 657,532 | SH | DFND | 0 | 657,532 | 0 | ||
| ALKERMES PLC | SHS | G01767105 | 29,245 | 801,459 | SH | DFND | 3 | 0 | 801,459 | 0 | |
| ALKERMES PLC | SHS | G01767105 | 39,351 | 1,078,403 | SH | DFND | 2 | 0 | 1,078,403 | 0 | |
| ALKERMES PLC | SHS | G01767105 | 27,726 | 759,814 | SH | DFND | 0 | 759,814 | 0 | ||
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 125,756 | 3,996,044 | SH | DFND | 4 | 0 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 204,237 | 6,489,884 | SH | DFND | 1 | 0 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 48,951 | 1,555,491 | SH | DFND | 298,879 | 0 | 11,742,540 | ||
| BIOGEN INC | Common | 09062X103 | 20,167 | 85,318 | SH | DFND | 3 | 0 | 85,318 | 0 | |
| BIOGEN INC | Common | 09062X103 | 28,481 | 120,489 | SH | DFND | 2 | 0 | 120,489 | 0 | |
| BIOGEN INC | Common | 09062X103 | 22,275 | 94,233 | SH | DFND | 0 | 94,233 | 0 | ||
| EVOFEM BIOSCIENCES INC | Common | 30048L104 | 4,944 | 1,412,611 | SH | DFND | 4 | 0 | 1,412,611 | 0 | |
| EVOFEM BIOSCIENCES INC | Common | 30048L104 | 31,985 | 9,138,504 | SH | DFND | 1 | 0 | 5,490,530 | 3,647,974 | |
| EVOFEM BIOSCIENCES INC | Common | 30048L104 | 3,474 | 992,613 | SH | DFND | 0 | 992,613 | 0 | ||
| NUCANA PLC | SPON ADR | 67022C106 | 32,861 | 1,933,000 | SH | DFND | 1 | 0 | 1,933,000 | 0 | |
| NUCANA PLC | SPON ADR | 67022C106 | 22,066 | 1,297,999 | SH | DFND | 0 | 185,000 | 1,112,999 | ||
| PROTHENA CORP PLC | SHS | G72800108 | 28,559 | 2,354,408 | SH | DFND | 4 | 0 | 2,354,408 | 0 | |
| PROTHENA CORP PLC | SHS | G72800108 | 96,419 | 7,948,790 | SH | DFND | 1 | 0 | 7,948,790 | 0 | |
| PROTHENA CORP PLC | SHS | G72800108 | 19,668 | 1,621,416 | SH | DFND | 0 | 705,000 | 916,416 | ||
| THERAVANCE BIOPHARMA INC | Common | G8807B106 | 250,526 | 11,050,980 | SH | DFND | 1 | 0 | 11,050,980 | 0 | |
| THERAVANCE BIOPHARMA INC | Common | G8807B106 | 52,798 | 2,328,999 | SH | DFND | 0 | 762,000 | 1,566,999 | ||