The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AGIOS PHARMACEUTICALS INC | Common | 00847X104 | 22,591 | 292,937 | SH | DFND | 5 | 0 | 292,937 | 0 | |
| AGIOS PHARMACEUTICALS INC | Common | 00847X104 | 31,469 | 408,051 | SH | DFND | 3 | 0 | 408,051 | 0 | |
| AGIOS PHARMACEUTICALS INC | Common | 00847X104 | 40,365 | 523,404 | SH | DFND | 2 | 0 | 523,404 | 0 | |
| AGIOS PHARMACEUTICALS INC | Common | 00847X104 | 7,177 | 93,067 | SH | DFND | 0 | 93,067 | 0 | ||
| ALKERMES PLC | SHS | G01767105 | 24,496 | 577,184 | SH | DFND | 5 | 0 | 577,184 | 0 | |
| ALKERMES PLC | SHS | G01767105 | 34,863 | 821,459 | SH | DFND | 3 | 0 | 821,459 | 0 | |
| ALKERMES PLC | SHS | G01767105 | 45,767 | 1,078,403 | SH | DFND | 2 | 0 | 1,078,403 | 0 | |
| ALKERMES PLC | SHS | G01767105 | 7,751 | 182,630 | SH | DFND | 0 | 182,630 | 0 | ||
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 125,932 | 4,106,044 | SH | DFND | 4 | 0 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 175,608 | 5,725,730 | SH | DFND | 1 | 0 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 30,490 | 994,145 | SH | DFND | 207,641 | 107,654 | 10,510,624 | ||
| BIOGEN INC | Common | 09062X103 | 21,692 | 61,397 | SH | DFND | 5 | 0 | 61,397 | 0 | |
| BIOGEN INC | Common | 09062X103 | 33,744 | 95,508 | SH | DFND | 3 | 0 | 95,508 | 0 | |
| BIOGEN INC | Common | 09062X103 | 41,057 | 116,207 | SH | DFND | 2 | 0 | 116,207 | 0 | |
| BIOGEN INC | Common | 09062X103 | 7,579 | 21,452 | SH | DFND | 0 | 21,452 | 0 | ||
| EVOFEM BIOSCIENCES INC | Common | 30048L104 | 6,774 | 1,672,611 | SH | DFND | 4 | 0 | 1,672,611 | 0 | |
| EVOFEM BIOSCIENCES INC | Common | 30048L104 | 29,658 | 7,323,079 | SH | DFND | 1 | 0 | 5,031,901 | 2,291,178 | |
| EVOFEM BIOSCIENCES INC | Common | 30048L104 | 2,420 | 597,507 | SH | DFND | 0 | 597,507 | 0 | ||
| NIGHTSTAR THERAPEUTICS PLC | ADR | 65413A101 | 13,935 | 682,109 | SH | DFND | 0 | 0 | 682,109 | ||
| NUCANA PLC | SPON ADR | 67022C106 | 14,254 | 572,000 | SH | DFND | 0 | 0 | 572,000 | ||
| PROTHENA CORP PLC | SHS | G72800108 | 34,654 | 2,649,408 | SH | DFND | 4 | 0 | 2,649,408 | 0 | |
| PROTHENA CORP PLC | SHS | G72800108 | 103,970 | 7,948,790 | SH | DFND | 1 | 0 | 7,948,790 | 0 | |
| PROTHENA CORP PLC | SHS | G72800108 | 17,350 | 1,326,416 | SH | DFND | 0 | 741,342 | 585,074 | ||
| THERAVANCE BIOPHARMA INC | Common | G8807B106 | 338,423 | 10,358,839 | SH | DFND | 1 | 0 | 10,358,839 | 0 | |
| THERAVANCE BIOPHARMA INC | Common | G8807B106 | 43,648 | 1,336,040 | SH | DFND | 0 | 419,041 | 916,999 | ||