The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AGIOS PHARMACEUTICALS INC | Common | 00847X104 | 7,554 | 89,685 | SH | DFND | 5 | 0 | 89,685 | 0 | |
| AGIOS PHARMACEUTICALS INC | Common | 00847X104 | 8,181 | 97,129 | SH | DFND | 3 | 0 | 97,129 | 0 | |
| AGIOS PHARMACEUTICALS INC | Common | 00847X104 | 15,293 | 181,561 | SH | DFND | 2 | 0 | 181,561 | 0 | |
| AGIOS PHARMACEUTICALS INC | Common | 00847X104 | 1,821 | 21,625 | SH | DFND | 0 | 21,625 | 0 | ||
| ALKERMES PLC | SHS | G01767105 | 35,954 | 873,510 | SH | DFND | 5 | 0 | 873,510 | 0 | |
| ALKERMES PLC | SHS | G01767105 | 60,169 | 1,461,840 | SH | DFND | 3 | 0 | 1,222,207 | 0 | |
| ALKERMES PLC | SHS | G01767105 | 75,005 | 1,822,275 | SH | DFND | 2 | 0 | 1,822,275 | 0 | |
| ALKERMES PLC | SHS | G01767105 | 23,024 | 559,385 | SH | DFND | 0 | 319,752 | 239,633 | ||
| ALTRIA GROUP INC | Common | 02209S103 | 6,701 | 118,000 | SH | DFND | 5 | 0 | 118,000 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 31,745 | 1,184,954 | SH | DFND | 1 | 0 | 1,184,954 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 10,898 | 406,789 | SH | DFND | 0 | 107,654 | 299,135 | ||
| BIOGEN INC | Common | 09062X103 | 15,780 | 54,369 | SH | DFND | 5 | 0 | 54,369 | 0 | |
| BIOGEN INC | Common | 09062X103 | 26,793 | 92,313 | SH | DFND | 3 | 0 | 92,313 | 0 | |
| BIOGEN INC | Common | 09062X103 | 32,551 | 112,151 | SH | DFND | 2 | 0 | 112,151 | 0 | |
| BIOGEN INC | Common | 09062X103 | 6,017 | 20,731 | SH | DFND | 0 | 20,731 | 0 | ||
| EVOFEM BIOSCIENCES INC | Common | 30048L104 | 4,533 | 1,672,611 | SH | DFND | 4 | 0 | 1,672,611 | 0 | |
| EVOFEM BIOSCIENCES INC | Common | 30048L104 | 19,846 | 7,323,079 | SH | DFND | 1 | 0 | 5,121,351 | 2,201,728 | |
| EVOFEM BIOSCIENCES INC | Common | 30048L104 | 1,619 | 597,507 | SH | DFND | 0 | 597,507 | 0 | ||
| NIGHTSTAR THERAPEUTICS PLC | ADR | 65413A101 | 5,024 | 314,000 | SH | DFND | 0 | 0 | 314,000 | ||
| NUCANA PLC | SPON ADR | 67022C106 | 7,980 | 420,000 | SH | DFND | 0 | 0 | 420,000 | ||
| PROTHENA CORP PLC | SHS | G72800108 | 38,628 | 2,649,408 | SH | DFND | 4 | 0 | 2,649,408 | 0 | |
| PROTHENA CORP PLC | SHS | G72800108 | 115,893 | 7,948,790 | SH | DFND | 1 | 0 | 7,948,790 | 0 | |
| PROTHENA CORP PLC | SHS | G72800108 | 19,339 | 1,326,416 | SH | DFND | 0 | 741,342 | 585,074 | ||
| THERAVANCE BIOPHARMA INC | Common | G8807B106 | 225,980 | 9,963,839 | SH | DFND | 1 | 0 | 9,963,839 | 0 | |
| THERAVANCE BIOPHARMA INC | Common | G8807B106 | 28,351 | 1,250,040 | SH | DFND | 0 | 419,041 | 830,999 | ||