The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALKERMES PLC SHS G01767105 117,423 2,025,931 SH   DFND 2 0 2,025,931 0
ALKERMES PLC SHS G01767105 95,312 1,644,439 SH   DFND 3 0 1,644,439 0
ALKERMES PLC SHS G01767105 56,413 973,307 SH   DFND 5 0 973,307 0
ALKERMES PLC SHS G01767105 36,326 626,751 SH   DFND   0 365,816 260,935
BIOGEN INC Common 09062X103 30,709 112,151 SH   DFND 2 0 112,151 0
BIOGEN INC Common 09062X103 25,277 92,313 SH   DFND 3 0 92,313 0
BIOGEN INC Common 09062X103 14,887 54,369 SH   DFND 5 0 54,369 0
BIOGEN INC Common 09062X103 5,677 20,731 SH   DFND   0 20,731 0
EVOFEM BIOSCIENCES INC Common 30048L104 35,693 5,620,952 SH   DFND 1 0 5,620,952 0
EVOFEM BIOSCIENCES INC Common 30048L104 10,621 1,672,611 SH   DFND 4 0 1,672,611 0
EVOFEM BIOSCIENCES INC Common 30048L104 1,092 171,975 SH   DFND   0 171,975 0
PROTHENA CORP PLC SHS G72800108 282,806 7,703,790 SH   DFND 1 0 7,703,790 0
PROTHENA CORP PLC SHS G72800108 92,781 2,527,408 SH   DFND 4 0 2,527,408 0
PROTHENA CORP PLC SHS G72800108 48,693 1,326,416 SH   DFND   0 741,342 585,074
THERAVANCE BIOPHARMA INC Common G8807B106 233,984 9,648,839 SH   DFND 1 0 9,648,839 0
THERAVANCE BIOPHARMA INC Common G8807B106 30,313 1,250,040 SH   DFND   0 419,041 830,999