900 Northbrook Drive
Suite 200
Trevose, PA 19053
(610) 254-9022
March 31, 2021
VIA EDGAR
United States Securities and Exchange Commission
100 F Street, NE
Washington, D.C. 20549
Attention: Jane Park
Re: Strongbridge Biopharma plc – Request for Acceleration
Registration Statement on Form S-3
File No. 333- 254733
Ladies and Gentlemen:
Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Strongbridge Biopharma plc (the “Registrant”) hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333- 254733) (the “Registration Statement”), so that it may become effective at 4:30 p.m. Eastern Standard Time on Thursday, April 1, 2021, or as soon thereafter as practicable.
The Registrant hereby authorizes Wendy Grasso, Esq. of Reed Smith LLP, attorney for the Registrant, to orally modify or withdraw this request for acceleration.
The Registrant requests that it be notified of such effectiveness by a telephone call to Wendy Grasso at (917) 993-3645.
STRONGBRIDGE BIOPHARMA PLC
By: _/s/ Richard Kollender____________________________
Richard Kollender
Chief Financial Officer