Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Summary of Loss Before Income Tax Provision by Region

The following table summarizes the Company’s loss before income tax provision by region for the years ended December 31, 2021 and 2020 (in thousands):

	Years Ended December 31,
	2021			2020
United States	$	(62,118	)	$	(36,250	)
Foreign		(89	)		(1,054	)
Total loss before income provision	$	(62,207	)	$	(37,304	)

Reconciliation of Effective Tax Rate and Federal Statutory Rate

A reconciliation of the Company’s effective tax rate and federal statutory rate is summarized as follows (in thousands):

	Years Ended December 31,
	2021			2020
Federal income taxes	$	(13,063	)	$	(7,834	)
State income taxes		(4,344	)		(2,605	)
Permanent differences		(17	)		161
Research and development credits		(1,484	)		(1,129	)
Stock options		1,326			524
Other		63			2
Change in valuation allowance		17,519			10,881
	$	—		$	—

Significant Components of Company's Net Deferred Tax Assets

Significant components of the Company’s net deferred tax assets are summarized as follows (in thousands):

	December 31,
	2021			2020
Deferred tax assets:
Net operating losses	$	43,605		$	27,867
Research and development credits		5,397			3,913
Lease liability		282			489
Depreciation and amortization		284			242
Other accruals and prepaid expenses		1,962			1,688
Total gross deferred tax assets		51,530			34,199
Less: Valuation allowance		(51,278	)		(33,757	)
Deferred tax assets, net		252			442
Deferred tax liabilities:
Right-of-use asset		(252	)		(442	)
Total gross deferred tax liabilities		(252	)		(442	)
Net deferred tax assets	$	—		$	—

Summary of Changes to Company's Unrecognized Tax Benefits

The following table summarizes the changes to the Company’s unrecognized tax benefits (in thousands):

Balance at December 31, 2019	$	662
Increases related to prior year positions		212
Balance at December 31, 2020		874
Increases related to current year positions		279
Balance at December 31, 2021	$	1,153