Income Taxes (Tables)

12 Months Ended

Dec. 31, 2020

Summary of Loss Before Income Tax Provision by Region

The following table summarizes the Company’s loss before income tax provision by region for the years ended December 31, 2020 and 2019 (in thousands):

	Years Ended December 31,
	2020			2019
United States	$	(36,250	)	$	(28,800	)
Foreign		(1,054	)		(133	)
Total loss before income provision	$	(37,304	)	$	(28,933	)

Reconciliation of Effective Tax Rate and Federal Statutory Rate

A reconciliation of the Company’s effective tax rate and federal statutory rate is summarized as follows (in thousands):

	Years Ended December 31,
	2020			2019
Federal income taxes	$	(7,834	)	$	(6,076	)
State income taxes		(2,605	)		(2,020	)
Permanent differences		161			(57	)
Research and development credits		(1,129	)		(939	)
Stock options		524			304
Other		2			(132	)
Change in valuation allowance		10,881			8,920
	$	—		$	—

Significant Components of Company's Net Deferred Tax Assets

Significant components of the Company’s net deferred tax assets are summarized as follows (in thousands):

	December 31,
	2020			2019
Deferred tax assets:
Net operating losses		27,867			19,440
Research and development credits		3,913			2,784
Lease liability		489			657
Depreciation and amortization		242			183
Other accruals and prepaid expenses		1,688			428
Total gross deferred tax assets		34,199			23,492
Less: Valuation allowance		(33,757	)		(22,876	)
Deferred tax assets, net		442			616
Deferred tax liabilities:
Right-of-use asset		(442	)		(616	)
Total gross deferred tax liabilities		(442	)		(616	)
Net deferred tax assets	$	—		$	—

Summary of Changes to Company's Unrecognized Tax Benefits

The following table summarizes the changes to the Company’s unrecognized tax benefits (in thousands):

Balance at December 31, 2018	$	479
Increases related to prior year positions		183
Balance at December 31, 2019		662
Increases related to current year positions		212
Balance at December 31, 2020	$	874