UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No. )

Filed by the Registrant  ☒

Filed by a Party other than the Registrant  ☐

Check the appropriate box:

☐ Preliminary Proxy Statement

☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

☐ Definitive Proxy Statement

☒ Definitive Additional Materials

☐ Soliciting Material under § 240.14a-12

Metacrine, Inc.

(Name of Registrant as Specified in its Charter)

(Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check all boxes that apply):

☒ No fee required.

☐ Fee paid previously with preliminary materials.

☐ Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

	Metacrine, Inc. Important Notice Regarding the Availability of Proxy Materials
P.O. BOX 8016, CARY, NC 27512-9903	2022 Annual Meeting of Stockholders to be held on May 18, 2022
	For stockholders of record as of March 29, 2022
	This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. This is not a ballot. You cannot use this notice to vote your shares. We encourage you to access and review all of the important information contained in the proxy materials before voting.
	To view the proxy materials, and to obtain directions to attend the meeting, go to: www.proxydocs.com/MTCR
	To vote your proxy while visiting this site, you will need the 12 digit control number in the box below.
	Under United States Securities and Exchange Commission rules, proxy materials do not have to be delivered in paper. Proxy materials can be distributed by making them available on the internet.

	For a convenient way to view proxy materials and VOTE go to
	www.proxydocs.com/MTCR
	Have the 12 digit control number located in the shaded box above available
	when you access the website and follow the instructions.
	If you want to receive a paper or e-mail copy of the proxy material, you must request one. There is no charge to you for requesting a copy. In order to receive a paper package in time for this year’s meeting, you must make this request on or before May 06, 2022.
	To order paper materials, use one of the following methods.

  INTERNET www.investorelections.com/MTCR   TELEPHONE (866) 648-8133   * E-MAIL paper@investorelections.com  

  When requesting via the Internet or telephone you will need the 12 digit control number located in the shaded box above.   * If requesting material by e-mail, please send a blank e-mail with the 12 digit control number (located above) in the subject line. No other requests, instructions OR other inquiries should be included with your e-mail requesting material.

Metacrine, Inc.
Meeting Materials: Notice of Meeting and Proxy Statement & Annual Report on Form 10-K
Meeting Type:   Annual Meeting of Stockholders
Date:	Wednesday, May 18, 2022
Time:	8:00 AM, Pacific Time
Place:	Annual Meeting to be held via live webcast - please visit
	www.proxydocs.com/MTCR for more details.
You must register to attend the Annual Meeting online and/or participate at www.proxydocs.com/MTCR
	SEE REVERSE FOR FULL AGENDA

Metacrine, Inc.

2022 Annual Meeting of Stockholders

THE BOARD OF DIRECTORS RECOMMENDS A VOTE:

FOR ON PROPOSALS 1 AND 2

PROPOSAL

1. Election of Class II Directors

1.01 Richard Heyman, Ph.D.

1.02 Ronald Evans, Ph.D.

2. To ratify the selection of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2022