Attorney-in-Fact

0001104659-22-022072.txt : 20220214 0001104659-22-022072.hdr.sgml : 20220214 20220214112344 ACCESSION NUMBER: 0001104659-22-022072 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20211231 FILED AS OF DATE: 20220214 DATE AS OF CHANGE: 20220214 EFFECTIVENESS DATE: 20220214 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Sofinnova Investments, Inc. CENTRAL INDEX KEY: 0001631134 IRS NUMBER: 000000000 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-18774 FILM NUMBER: 22627304 BUSINESS ADDRESS: STREET 1: 3000 Sand Hill Road STREET 2: BUILDING 4-SUITE 250 CITY: Menlo Park STATE: CA ZIP: 94025 BUSINESS PHONE: 650.681.8428 MAIL ADDRESS: STREET 1: 3000 Sand Hill Road STREET 2: BUILDING 4-SUITE 250 CITY: Menlo Park STATE: CA ZIP: 94025 FORMER COMPANY: FORMER CONFORMED NAME: Sofinnova Ventures Inc DATE OF NAME CHANGE: 20150120 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001631134 XXXXXXXX 12-31-2021 12-31-2021 false Sofinnova Investments, Inc.

3000 Sand Hill Road Building 4-Suite 250 Menlo Park CA 94025

13F HOLDINGS REPORT 028-18774 Y Sofinnova Investments, Inc. is filing this Form 13F on behalf of itself and the general partner entities of the investment funds for which it serves as the investment adviser, Sofinnova Management VII, L.L.C., Sofinnova Management VIII, L.L.C., Sofinnova Management IX, L.L.C., Sofinnova Management X, L.L.C., Sofinnova BioEquities GP LLC, and Sofinnova Synergy Master Fund, LP. Nathalie Auber Attorney-in-Fact 650-681-8428 /s/ Nathalie Auber Menlo Park CA 02-11-2022 0 72 1712054 INFORMATION TABLE 2 infotable.xml Aerovate Therapeutics, Inc. COMM 008064107 44315 3758686 SH SOLE 3758686 0 0 Akouos, Inc. COMM 00973J101 12878 1515074 SH SOLE 1515074 0 0 Ascendis Pharma A/S ADR 04351P101 67241 499824 SH SOLE 499824 0 0 Bolt Biotherapeutics, Inc. COMM 097702104 13497 2754437 SH SOLE 2754437 0 0 Checkmate Pharmaceuticals Inc COMM 162818108 10351 3606707 SH SOLE 3606707 0 0 Fusion Pharmaceuticals Inc COMM 36118A100 326 78066 SH SOLE 78066 0 0 Galera Therapeutics, Inc COMM 36338D108 14154 3083712 SH SOLE 3083712 0 0 Inozyme Pharma, Inc. COMM 45790W108 13833 2028308 SH SOLE 2028308 0 0 Karuna Therapeutics, Inc. COMM 48576A100 255770 1952441 SH SOLE 1952441 0 0 Natera Inc COMM 632307104 289561 3100560 SH SOLE 3100560 0 0 Nextcure, Inc COMM 65343E108 16031 2671856 SH SOLE 2671856 0 0 Nucana Plc ADR 67022C106 13328 5599999 SH SOLE 5599999 0 0 Nucana Plc Ordinary Shares GB00BYWYV 5712 2400000 SH SOLE 2400000 0 0 ObsEva SA COMM H5861P103 9452 4749623 SH SOLE 4749623 0 0 PDS Biotechnology Corporation COMM 70465T107 1155 142635 SH SOLE 142635 0 0 Synlogic Inc. COMM 87166L100 1391 574972 SH SOLE 574972 0 0 Vera Therapeutics, Inc. CL A 92337R101 77883 2914776 SH SOLE 2914776 0 0 Y-mAbs Therapeutics, Inc COMM 984241109 35569 2194278 SH SOLE 2194278 0 0 Abbvie Inc COMM 00287Y109 42247 312018 SH SOLE 312018 0 0 Adicet Bio Inc COMM 007002108 5439 310988 SH SOLE 310988 0 0 Agenus Inc COMM 00847G705 6315 1961032 SH SOLE 1961032 0 0 Align Technology Inc COMM 016255101 25077 38159 SH SOLE 38159 0 0 Aligos Therapeutics Inc COMM 01626L105 1517 127791 SH SOLE 127791 0 0 Axsome Therapeutics Inc COMM 05464T104 3778 100000 SH Put SOLE 100000 0 0 BioCryst Pharmaceuticals Inc COMM 09058V103 20920 1510473 SH SOLE 1510473 0 0 Biomarin Pharmaceutical Inc COMM 09061G101 7715 87322 SH SOLE 87322 0 0 Blueprint Medicines Corp COMM 09627Y109 26261 245182 SH SOLE 245182 0 0 Celldex Therapeutics Inc COMM 15117B202 10492 271533 SH SOLE 271533 0 0 ChemoCentryx Inc COMM 16383L106 26624 731222 SH SOLE 731222 0 0 Cyteir Therapeutics Inc COMM 23284P103 2040 179450 SH SOLE 179450 0 0 Cytokinetics Inc COMM 23282W605 21166 464366 SH SOLE 464366 0 0 Dexcom Inc COMM 252131107 17399 32404 SH SOLE 32404 0 0 Edwards Lifesciences Corp COMM 28176E108 182 1406 SH SOLE 1406 0 0 Fulcrum Therapeutics Inc COMM 359616109 10927 617670 SH SOLE 617670 0 0 Guardant Health Inc COMM 40131M109 23261 232563 SH SOLE 232563 0 0 Heron Therapeutics Inc COMM 427746102 26781 2933351 SH SOLE 2933351 0 0 Horizon Therapeutics PLC COMM G46188101 23900 221792 SH SOLE 221792 0 0 Immatics NV COMM N44445109 13798 1026623 SH SOLE 1026623 0 0 ImmunoGen Inc COMM 45253H101 12984 1749882 SH SOLE 1749882 0 0 Inflarx NV COMM N44821101 5530 1161736 SH SOLE 1161736 0 0 Inhibrx Inc COMM 45720L107 16100 368679 SH SOLE 368679 0 0 Insmed Inc COMM 457669307 12034 441773 SH SOLE 441773 0 0 Insulet Corp COMM 45784P101 284 1066 SH SOLE 1066 0 0 Intercept Pharmaceuticals Inc COMM 45845P108 2450 150400 SH Call SOLE 150400 0 0 Intra-Cellular Therapies Inc COMM 46116X101 2979 56915 SH SOLE 56915 0 0 Invesco QQQ Trust Series 1 COMM 46090E103 39785 100000 SH Put SOLE 100000 0 0 Iveric Bio Inc COMM 46583P102 13356 798789 SH SOLE 798789 0 0 Jounce Therapeutics Inc COMM 481116101 13216 1582777 SH SOLE 1582777 0 0 Karuna Therapeutics Inc COMM 48576A100 83 636 SH SOLE 636 0 0 Kura Oncology Inc COMM 50127T109 5168 369173 SH SOLE 369173 0 0 Kura Oncology Inc COMM 50127T109 2450 175000 SH Call SOLE 175000 0 0 Marinus Pharmaceuticals Inc COMM 56854Q200 2035 171338 SH SOLE 171338 0 0 Mink Therapeutics Inc COMM 603693102 1541 345499 SH SOLE 345499 0 0 Natera Inc COMM 632307104 224 2400 SH SOLE 2400 0 0 Novocure Ltd COMM G6674U108 3754 50000 SH Call SOLE 50000 0 0 PTC Therapeutics Inc COMM 69366J200 5275 132448 SH SOLE 132448 0 0 Protagonist Therapeutics Inc COMM 74366E102 10281 300600 SH Call SOLE 300600 0 0 Protagonist Therapeutics Inc COMM 74366E102 16493 482257 SH SOLE 482257 0 0 Regenxbio Inc COMM 75901B107 32964 1008081 SH SOLE 1008081 0 0 Roche Holding AG ADR 771195104 70764 1369011 SH SOLE 1369011 0 0 SPDR S&P 500 ETF Trust COMM 78462F103 47496 100000 SH Put SOLE 100000 0 0 Sarepta Therapeutics Inc COMM 803607100 10872 120732 SH SOLE 120732 0 0 Sierra Oncology Inc COMM 82640U404 4615 212281 SH SOLE 212281 0 0 Syndax Pharmaceuticals Inc COMM 87164F105 20822 951226 SH SOLE 951226 0 0 Travere Therapeutics Inc COMM 89422G107 32308 1040858 SH SOLE 1040858 0 0 Uniqure NV COMM N90064101 10267 495025 SH SOLE 495025 0 0 United Therapeutics Corp COMM 91307C102 28037 129754 SH SOLE 129754 0 0 Vir Biotechnology Inc COMM 92764N102 8374 200000 SH Put SOLE 200000 0 0 Xencor Inc COMM 98401F105 21546 537030 SH SOLE 537030 0 0 Zymeworks Inc COMM 98985W102 6437 392712 SH SOLE 392712 0 0 iRhythm Technologies Inc COMM 450056106 19876 168882 SH SOLE 168882 0 0 iShares Russell 2000 ETF COMM 464287655 33368 150000 SH Put SOLE 150000 0 0