The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics COMM 00461U105 1,988 1,911,573 SH   SOLE   1,911,573 0 0
Amarin ADR 023111206 20,833 5,208,305 SH   SOLE   5,208,305 0 0
Apellis Pharmaceuticals, Inc COMM 03753U106 1,328 49,580 SH   SOLE   49,580 0 0
Ascendis Pharma A/S ADR 04351P101 124,983 1,109,874 SH   SOLE   1,109,874 0 0
Chiasma COMM 16706W102 5,950 1,630,221 SH   SOLE   1,630,221 0 0
Coherus BioSciences COMM 19249H103 31,357 1,933,221 SH   SOLE   1,933,221 0 0
Entasis Therapeutics Holdings Inc. COMM 293614103 3,119 1,180,178 SH   SOLE   1,180,178 0 0
Galera Therapeutics, Inc COMM 36338D108 29,295 3,083,712 SH   SOLE   3,083,712 0 0
Iterum Therapeutics COMM G6333L101 4,679 1,726,514 SH   SOLE   1,726,514 0 0
Karuna Therapeutics, Inc. COMM 48576A100 135,763 1,885,602 SH   SOLE   1,885,602 0 0
Kiniksa Pharmaceuticals, Ltd COMM CL A G5269C101 14,283 922,700 SH   SOLE   922,700 0 0
Merus N.V. COMM N5749R100 23,729 1,961,039 SH   SOLE   1,961,039 0 0
Natera COMM 632307104 92,583 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure, Inc COMM 65343E108 99,046 2,671,856 SH   SOLE   2,671,856 0 0
Nucana Biomed Ltd ADR 67022C106 13,215 2,266,666 SH   SOLE   2,266,666 0 0
Nucana Biomed Ltd Ordinary Shares GB00BYWYV 13,992 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COMM H5861P103 11,447 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COMM 70465T107 104 142,635 SH   SOLE   142,635 0 0
Principia Biopharma COMM 74257L108 84,157 1,417,258 SH   SOLE   1,417,258 0 0
Synlogic Inc. COMM 87166L100 989 574,972 SH   SOLE   574,972 0 0
Y-mAbs Therapeutics, Inc COMM 984241109 57,271 2,194,278 SH   SOLE   2,194,278 0 0
Abbvie Inc COMM 00287Y109 1,062 13,933 SH   SOLE   13,933 0 0
Acceleron Pharma Inc COMM 00434H108 4,158 46,266 SH   SOLE   46,266 0 0
Akero Therapeutics Inc COMM 00973Y958 888 41,900 SH Put SOLE   41,900 0 0
Akero Therapeutics Inc COMM 00973Y108 880 41,500 SH   SOLE   41,500 0 0
Alexion Pharmaceuticals Inc COMM 015351109 9,613 107,066 SH   SOLE   107,066 0 0
Align Technology Inc COMM 016255101 2,578 14,820 SH   SOLE   14,820 0 0
Alnylam Pharmaceuticals Inc COMM 02043Q907 838 7,700 SH Call SOLE   7,700 0 0
Amicus Therapeutics Inc COMM 03152W109 1,969 213,091 SH   SOLE   213,091 0 0
Applied Genetic Technologies Corp COMM 03820J100 969 295,478 SH   SOLE   295,478 0 0
Axsome Therapeutics Inc COMM 05464T104 1,498 25,468 SH   SOLE   25,468 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 456 228,136 SH   SOLE   228,136 0 0
Biogen Inc COMM 09062X103 6,003 18,975 SH   SOLE   18,975 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 7,605 89,996 SH   SOLE   89,996 0 0
Blueprint Medicines Corp COMM 09627Y109 1,265 21,639 SH   SOLE   21,639 0 0
Calithera Biosciences Inc COMM 13089P101 1,017 228,957 SH   SOLE   228,957 0 0
ChemoCentryx Inc COMM 16383L106 912 22,698 SH   SOLE   22,698 0 0
Compugen Ltd COMM M25722105 605 83,310 SH   SOLE   83,310 0 0
Fate Therapeutics Inc COMM 31189P102 232 10,457 SH   SOLE   10,457 0 0
Gilead Sciences Inc COMM 375558903 2,564 34,300 SH Call SOLE   34,300 0 0
Heron Therapeutics Inc COMM 427746102 1,577 134,337 SH   SOLE   134,337 0 0
Homology Medicines Inc COMM 438083107 994 63,975 SH   SOLE   63,975 0 0
Intra-Cellular Therapies Inc COMM 46116X101 223 14,522 SH   SOLE   14,522 0 0
Iovance Biotherapeutics Inc COMM 462260900 1,539 51,400 SH Call SOLE   51,400 0 0
Kadmon Holdings Inc COMM 48283N106 1,781 424,982 SH   SOLE   424,982 0 0
Kala Pharmaceuticals Inc COMM 483119103 2,723 309,777 SH   SOLE   309,777 0 0
Kala Pharmaceuticals Inc COMM 483119953 1,813 206,300 SH Put SOLE   206,300 0 0
Menlo Therapeutics Inc COMM 586858102 453 169,035 SH   SOLE   169,035 0 0
Merck & Co Inc COMM 58933Y105 13,625 177,080 SH   SOLE   177,080 0 0
Mersana Therapeutics Inc COMM 59045L106 450 77,148 SH   SOLE   77,148 0 0
Mirum Pharmaceuticals Inc COMM 604749101 1,635 116,765 SH   SOLE   116,765 0 0
MyoKardia Inc COMM 62857M105 2,758 58,840 SH   SOLE   58,840 0 0
Otonomy Inc COMM 68906L105 922 467,940 SH   SOLE   467,940 0 0
PTC Therapeutics Inc COMM 69366J200 4,232 94,871 SH   SOLE   94,871 0 0
PTC Therapeutics Inc COMM 69366J900 620 13,900 SH Call SOLE   13,900 0 0
Puma Biotechnology Inc COMM 74587V107 1,498 177,526 SH   SOLE   177,526 0 0
Rigel Pharmaceuticals Inc COMM 766559603 631 404,192 SH   SOLE   404,192 0 0
SAGE Therapeutics Inc COMM 78667J108 805 28,016 SH   SOLE   28,016 0 0
Sarepta Therapeutics Inc COMM 803607100 3,132 32,022 SH   SOLE   32,022 0 0
TG Therapeutics Inc COMM 88322Q108 836 84,948 SH   SOLE   84,948 0 0
United Therapeutics Corp COMM 91307C102 7,635 80,519 SH   SOLE   80,519 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 7,034 29,560 SH   SOLE   29,560 0 0
Zogenix Inc COMM 98978L204 227 9,174 SH   SOLE   9,174 0 0
Zymeworks Inc COMM 98985W102 496 13,975 SH   SOLE   13,975 0 0
Abbvie Inc COMM 00287Y109 629 8,257 SH   OTR 1 8,257 0 0
Acceleron Pharma Inc COMM 00434H108 2,477 27,564 SH   OTR 1 27,564 0 0
Akero Therapeutics Inc COMM 00973Y958 532 25,100 SH Put OTR 1 25,100 0 0
Akero Therapeutics Inc COMM 00973Y108 526 24,827 SH   OTR 1 24,827 0 0
Alexion Pharmaceuticals Inc COMM 015351109 5,698 63,455 SH   OTR 1 63,455 0 0
Align Technology Inc COMM 016255101 1,527 8,776 SH   OTR 1 8,776 0 0
Alnylam Pharmaceuticals Inc COMM 02043Q907 522 4,800 SH Call OTR 1 4,800 0 0
Amicus Therapeutics Inc COMM 03152W109 1,167 126,297 SH   OTR 1 126,297 0 0
Applied Genetic Technologies Corp COMM 03820J100 576 175,613 SH   OTR 1 175,613 0 0
Axsome Therapeutics Inc COMM 05464T104 889 15,114 SH   OTR 1 15,114 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 273 136,250 SH   OTR 1 136,250 0 0
Biogen Inc COMM 09062X103 3,568 11,279 SH   OTR 1 11,279 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 4,521 53,501 SH   OTR 1 53,501 0 0
Blueprint Medicines Corp COMM 09627Y109 750 12,826 SH   OTR 1 12,826 0 0
Calithera Biosciences Inc COMM 13089P101 602 135,696 SH   OTR 1 135,696 0 0
ChemoCentryx Inc COMM 16383L106 541 13,455 SH   OTR 1 13,455 0 0
Compugen Ltd COMM M25722105 359 49,517 SH   OTR 1 49,517 0 0
Fate Therapeutics Inc COMM 31189P102 143 6,442 SH   OTR 1 6,442 0 0
Gilead Sciences Inc COMM 375558903 1,525 20,400 SH Call OTR 1 20,400 0 0
Heron Therapeutics Inc COMM 427746102 943 80,335 SH   OTR 1 80,335 0 0
Homology Medicines Inc COMM 438083107 589 37,915 SH   OTR 1 37,915 0 0
Intra-Cellular Therapies Inc COMM 46116X101 134 8,691 SH   OTR 1 8,691 0 0
Iovance Biotherapeutics Inc COMM 462260900 913 30,500 SH Call OTR 1 30,500 0 0
Kadmon Holdings Inc COMM 48283N106 1,059 252,855 SH   OTR 1 252,855 0 0
Kala Pharmaceuticals Inc COMM 483119103 1,618 184,119 SH   OTR 1 184,119 0 0
Kala Pharmaceuticals Inc COMM 483119953 1,082 123,100 SH Put OTR 1 123,100 0 0
Menlo Therapeutics Inc COMM 586858102 273 101,689 SH   OTR 1 101,689 0 0
Merck & Co Inc COMM 58933Y105 8,075 104,951 SH   OTR 1 104,951 0 0
Mersana Therapeutics Inc COMM 59045L106 267 45,824 SH   OTR 1 45,824 0 0
Mirum Pharmaceuticals Inc COMM 604749101 967 69,083 SH   OTR 1 69,083 0 0
MyoKardia Inc COMM 62857M105 1,638 34,949 SH   OTR 1 34,949 0 0
Otonomy Inc COMM 68906L105 559 283,853 SH   OTR 1 283,853 0 0
PTC Therapeutics Inc COMM 69366J200 2,508 56,228 SH   OTR 1 56,228 0 0
PTC Therapeutics Inc COMM 69366J900 370 8,300 SH Call OTR 1 8,300 0 0
Puma Biotechnology Inc COMM 74587V107 891 105,527 SH   OTR 1 105,527 0 0
Rigel Pharmaceuticals Inc COMM 766559603 377 241,736 SH   OTR 1 241,736 0 0
SAGE Therapeutics Inc COMM 78667J108 477 16,601 SH   OTR 1 16,601 0 0
Sarepta Therapeutics Inc COMM 803607100 1,856 18,977 SH   OTR 1 18,977 0 0
TG Therapeutics Inc COMM 88322Q108 495 50,347 SH   OTR 1 50,347 0 0
United Therapeutics Corp COMM 91307C102 4,524 47,712 SH   OTR 1 47,712 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 4,169 17,519 SH   OTR 1 17,519 0 0
Zogenix Inc COMM 98978L204 135 5,451 SH   OTR 1 5,451 0 0
Zymeworks Inc COMM 98985W102 294 8,282 SH   OTR 1 8,282 0 0
Abbvie Inc COMM 00287Y109 2,119 27,810 SH   OTR 2 27,810 0 0
Acceleron Pharma Inc COMM 00434H108 8,208 91,330 SH   OTR 2 91,330 0 0
Akero Therapeutics Inc COMM 00973Y958 1,760 83,000 SH Put OTR 2 83,000 0 0
Akero Therapeutics Inc COMM 00973Y108 1,740 82,088 SH   OTR 2 82,088 0 0
Alexion Pharmaceuticals Inc COMM 015351109 12,281 136,779 SH   OTR 2 136,779 0 0
Align Technology Inc COMM 016255101 3,984 22,904 SH   OTR 2 22,904 0 0
Alnylam Pharmaceuticals Inc COMM 02043Q907 1,589 14,600 SH Call OTR 2 14,600 0 0
Amicus Therapeutics Inc COMM 03152W109 1,720 186,142 SH   OTR 2 186,142 0 0
Applied Genetic Technologies Corp COMM 03820J100 1,940 591,524 SH   OTR 2 591,524 0 0
Axsome Therapeutics Inc COMM 05464T104 1,917 32,581 SH   OTR 2 32,581 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 903 451,304 SH   OTR 2 451,304 0 0
Biogen Inc COMM 09062X103 7,079 22,374 SH   OTR 2 22,374 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 8,158 96,549 SH   OTR 2 96,549 0 0
Blueprint Medicines Corp COMM 09627Y109 1,675 28,635 SH   OTR 2 28,635 0 0
Calithera Biosciences Inc COMM 13089P101 2,017 454,349 SH   OTR 2 454,349 0 0
ChemoCentryx Inc COMM 16383L106 1,227 30,542 SH   OTR 2 30,542 0 0
Compugen Ltd COMM M25722105 1,214 167,173 SH   OTR 2 167,173 0 0
Fate Therapeutics Inc COMM 31189P102 437 19,665 SH   OTR 2 19,665 0 0
Gilead Sciences Inc COMM 375558903 3,387 45,300 SH Call OTR 2 45,300 0 0
Heron Therapeutics Inc COMM 427746102 3,134 266,936 SH   OTR 2 266,936 0 0
Homology Medicines Inc COMM 438083107 2,001 128,773 SH   OTR 2 128,773 0 0
Intra-Cellular Therapies Inc COMM 46116X101 443 28,792 SH   OTR 2 28,792 0 0
Iovance Biotherapeutics Inc COMM 462260900 2,039 68,100 SH Call OTR 2 68,100 0 0
Kadmon Holdings Inc COMM 48283N106 3,555 848,341 SH   OTR 2 848,341 0 0
Kala Pharmaceuticals Inc COMM 483119103 5,455 620,624 SH   OTR 2 620,624 0 0
Kala Pharmaceuticals Inc COMM 483119953 3,585 407,900 SH Put OTR 2 407,900 0 0
Menlo Therapeutics Inc COMM 586858102 895 334,105 SH   OTR 2 334,105 0 0
Merck & Co Inc COMM 58933Y105 13,985 181,764 SH   OTR 2 181,764 0 0
Mersana Therapeutics Inc COMM 59045L106 595 102,028 SH   OTR 2 102,028 0 0
Mirum Pharmaceuticals Inc COMM 604749101 3,258 232,741 SH   OTR 2 232,741 0 0
MyoKardia Inc COMM 62857M105 3,813 81,329 SH   OTR 2 81,329 0 0
Otonomy Inc COMM 68906L105 1,505 763,836 SH   OTR 2 763,836 0 0
PTC Therapeutics Inc COMM 69366J200 6,295 141,118 SH   OTR 2 141,118 0 0
PTC Therapeutics Inc COMM 69366J900 1,240 27,800 SH Call OTR 2 27,800 0 0
Puma Biotechnology Inc COMM 74587V107 2,996 354,973 SH   OTR 2 354,973 0 0
Rigel Pharmaceuticals Inc COMM 766559603 1,249 800,390 SH   OTR 2 800,390 0 0
SAGE Therapeutics Inc COMM 78667J108 856 29,813 SH   OTR 2 29,813 0 0
Sarepta Therapeutics Inc COMM 803607100 4,950 50,604 SH   OTR 2 50,604 0 0
TG Therapeutics Inc COMM 88322Q108 1,378 140,010 SH   OTR 2 140,010 0 0
United Therapeutics Corp COMM 91307C102 9,988 105,328 SH   OTR 2 105,328 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 9,181 38,585 SH   OTR 2 38,585 0 0
Zogenix Inc COMM 98978L204 454 18,358 SH   OTR 2 18,358 0 0
Zymeworks Inc COMM 98985W102 984 27,732 SH   OTR 2 27,732 0 0