EXHIBIT 32.2

Certification of Chief Financial Officer Pursuant to 18 U.S.C. Section 1350

(as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002)

In connection with the Annual Report on Form 10-K for the year ended December 31, 2020 (the “Report”), I, Mary Usategui, Chief Accounting Officer of Professional Holding Corp. (the “Company”) hereby certify that:

1.    The Report fully complies with the requirements of Section 13(a) or 15(d), as applicable, of the Securities Exchange Act of 1934; and

2.    The information contained in the Periodic Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated: March 26, 2021	/s/ Mary Usategui
	Name: Mary Usategui
	Title: Chief Accounting Officer

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