Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of Income before Income Tax

For the years ended December 31, 2022, 2021, and 2020, the loss before income taxes consisted of the following:

(In thousands)	2022		2021		2020
Domestic	$	(89,440)	$	(56,165)	$	(22,748)
Foreign	91		47		31
Total loss before income taxes	$	(89,349)	$	(56,118)	$	(22,717)

Schedule of Components of Income Tax Expense

For the years ended December 31, 2022, 2021, and 2020, the components of the income tax provision were as follows:

(In thousands)	2022		2021		2020
Current:
Federal	$	—	$	—	$	(19)
State	(494)		(120)		(127)
Foreign	(42)		(2)		(4)
Total current	$	(536)	$	(122)	$	(150)
Deferred:
Federal	$	—	$	—	$	—
State	—		—		—
Foreign	—		—		—
Total deferred	$	—	$	—	$	—
Income tax provision	$	(536)	$	(122)	$	(150)

Schedule of Effective Income Tax Rate Reconciliation

The reconciliation of the statutory federal income tax rate to the Company’s effective tax rate for the years ended December 31, 2022, 2021, and 2020 were as follows:

	2022		2021		2020
Tax at federal statutory rate	21.00	%	21.00	%	21.00	%
State tax, net of federal benefit	(0.38)		(0.19)		(0.49)
Stock-based compensation	(4.02)		44.13		94.02
Officer’s compensation limitation	(1.51)		—		—
Other items	(0.60)		(0.16)		(0.59)
Research and development credits	4.36		7.04		9.74
Net operating loss expiration	—		(8.08)		(14.00)
Change in valuation allowance	(19.45)		(63.95)		(110.34)
Effective tax rate	(0.60)	%	(0.21)	%	(0.66)	%

Schedule of Deferred Tax Assets and Liabilities

As of December 31, 2022 and 2021, the significant components of the Company’s deferred tax assets and liabilities were as follows:

(In thousands)	2022		2021
Deferred tax assets:
Net operating loss carryforwards	$	80,296	$	100,836
Stock-based compensation	7,628		5,617
Operating lease liability	4,066		5,296
Accrued liabilities, reserves and other	10,216		7,259
Capitalized research and development	33,179		—
Tax Credits	24,470		17,044
Gross deferred tax assets	159,855		136,052
Valuation allowance	(157,353)		(132,162)
Total deferred tax assets	2,502		3,890
Deferred tax liabilities:
Prepaid expenses	(753)		—
Operating lease asset	(1,749)		(2,452)
Debt issuance cost	—		(75)
Depreciation and amortization	—		(1,363)
Total deferred tax liabilities	(2,502)		(3,890)
Net deferred tax assets	$	—	$	—

Summary of Valuation Allowance

The change in valuation allowance for deferred tax assets was as follows for the periods presented:

(In thousands) Year Ended December 31,	Balance at Beginning of Year		Additions Charged to Costs & Expenses		Additions Charged to Other Accounts		Deductions		Balance at End of Year
2022	$	132,162	$	24,489	$	702	$	—	$	157,353
2021	92,390		39,772		—		—		132,162
2020	63,542		28,848		—		—		92,390

Summary of Unrecognized Tax Benefits

For the years ended December 31, 2022, 2021, and 2020, the activity related to the unrecognized tax benefits were as follows:

(In thousands)	2022		2021		2020
Gross unrecognized tax benefits—beginning balance	$	15,391	$	13,338	$	12,782
Increase related to tax positions taken during prior year	1,234		697		131
Decrease related to tax positions taken during prior year	(1,253)		(148)		—
Increase related to tax positions taken during current year	1,354		1,635		608
Decrease related to expiration of unrecognized tax benefit	(153)		(131)		(183)
Gross unrecognized tax benefits—ending balance	$	16,573	$	15,391	$	13,338