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Note 2 - Significant Accounting Policies - Stock Option Valuation Assumptions (Details) - $ / shares
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Weighted-average grant date fair value per share (in dollars per share) $ 4.92 $ 9.29
Expected volatility 0.00%  
Minimum [Member]    
Expected volatility 82.00% 83.00%
Risk-free interest rate 1.50% 0.50%
Expected life (Year) 5 years 4 months 17 days 5 years 4 months 17 days
Maximum [Member]    
Expected volatility 83.00% 91.00%
Risk-free interest rate 4.10% 1.40%
Expected life (Year) 6 years 3 months 6 years 3 months