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Note 2 - Significant Accounting Policies - Share-based Compensation Expense (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share-based compensation expense $ 4,464 $ 12,581 $ 3,358
Research and Development Expense [Member]      
Share-based compensation expense 2,020 3,558 1,635
General and Administrative Expense [Member]      
Share-based compensation expense 2,162 7,537 1,723
Cost of Sales [Member]      
Share-based compensation expense $ 282 $ 1,486 $ 0