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Note 6 - Common Stock Options (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Share-based Compensation, Stock Options, Activity [Table Text Block]
 
 
Options
 
Exercise Price
 
Weighted-Average
Exercise Price
Options outstanding at December 31, 2015
 
 
4,786,577
 
 
$0.53
-
$21.99
 
 
$
8.56
 
Granted
 
 
1,059,990
 
 
7.71
-
19.10
 
 
 
11.72
 
Exercised
 
 
(204,159
)
 
0.74
-
19.09
 
 
 
5.56
 
Forfeitures
 
 
(453,750
)
 
0.52
-
16.91
 
 
 
12.79
 
Options outstanding at December 31, 2016
 
 
5,188,658
 
 
$0.52
-
$21.99
 
 
$
8.49
 
Granted
 
 
1,251,000
 
 
4.15
-
12.62
 
 
 
4.85
 
Exercised
 
 
(406,667
)
 
0.93
-
14.71
 
 
 
2.28
 
Forfeitures
 
 
(729,367
)
 
0.94
-
21.99
 
 
 
11.90
 
Options outstanding at December 31, 2017
 
 
5,303,624
 
 
$2.50
-
$21.99
 
 
$
7.69
 
Granted
 
 
1,153,500
 
 
2.50
-
5.93
 
 
 
4.32
 
Exercised
 
 
(160,500
)
 
 
2.50
 
 
 
 
2.50
 
Forfeitures
 
 
(761,185
)
 
2.50
-
19.09
 
 
 
6.12
 
Options outstanding at December 31, 2018
 
 
5,535,439
 
 
$2.50
-
$21.99
 
 
$
7.30