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Note 11 - Selected Quarterly Financial Data (Unaudited)
 12 Months Ended
Dec. 31, 2017
Notes to Financial Statements  
Quarterly Financial Information [Text Block]
11.
Selected Quarterly Financial Data (Unaudited)
 
Selected Quarterly Financial Data (Unaudited) for the year ended
December 31, 2017
and
2016
is presented below (in thousands except per share data):
 
2017   First Quarter   Second Quarter   Third Quarter   Fourth Quarter
Loss from operations    
(10,271
 )    
(9,688
 )    
(6,593
 )    
(7,507
 )
Net Loss    
(10,563
 )    
(9,133
 )    
(6,205
 )    
(7,249
 )
Net loss per share—basic and diluted    
(0.32
 )    
(0.26
 )    
(0.18
 )    
(0.20
 )
 
2016   First Quarter   Second Quarter   Third Quarter   Fourth Quarter
Loss from operations    
(10,248
 )    
(13,615
 )    
(12,459
 )    
(16,441
 )
Net Loss    
(10,257
 )    
(13,622
 )    
(12,484
 )    
(16,398
 )
Net loss per share—basic and diluted    
(0.32
 )    
(0.42
 )    
(0.38
 )    
(0.50
 )