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Consolidated Statements of Cash Flows - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Operating activities      
Net loss $ (37,483,000) $ (21,724,000) $ (9,927,000)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation 699,000 644,000 784,000
Share-based compensation expense 4,407,000 $ 7,020,000 $ 739,000
Gain on disposal of property and equipment (157,000)
Changes in operating assets and liabilities:      
Prepaid expenses and other current (1,579,000) $ 38,000 $ (252,000)
Accounts payable 840,000 1,068,000 103,000
Accrued expenses (52,000) $ 1,234,000 (326,000)
Deferred rent 17,000 (29,000)
Net cash used in operating activities (33,308,000) $ (11,700,000) (8,908,000)
Investing activities      
Purchase of property and equipment (2,322,000) $ (1,397,000) $ (59,000)
Expenditures on building construction (8,070,000)
Net cash used in investing activities (10,392,000) $ (1,397,000) $ (59,000)
Financing activities      
Issuance of common stock and warrants, net 75,712,000 63,784,000 $ 12,045,000
Issuance of common stock under stock option plan 1,348,000 $ 150,000
Collection of subscription receivable $ 410,000
Deferred offering costs $ (324,000)
Net cash provided by financing activities $ 77,470,000 63,200,000 $ 12,045,000
Effect of foreign exchange rate on cash and cash equivalents (48,000) (18,000) (1,000)
Net change in cash and cash equivalents 33,722,000 50,085,000 3,077,000
Cash and cash equivalents, beginning of period 57,329,000 7,244,000 4,167,000
Cash and cash equivalents, end of period $ 91,051,000 $ 57,329,000 $ 7,244,000