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We consent to the reference to our firm under the caption "Experts" in the Post-Effective Amendment No. 1 to the Registration Statement (Form S-1 No. 333-24409) on Form S-3 and related Prospectus of Alpine Immune Sciences, Inc. for the registration of 7,709,416 shares of common stock and to the incorporation by reference therein of our report dated March 18, 2021, with respect to the consolidated financial statements of Alpine Immune Sciences, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2020, filed with the Securities and Exchange Commission.