The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 5,593 524,683 SH   DFND 2 524,683 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 17,139 1,456,142 SH   DFND 2 1,456,142 0 0
AGNICO EAGLE MINES LTD COM 008474108 459 5,767 SH   DFND 2 5,767 0 0
AGNICO EAGLE MINES LTD COM 008474108 843 10,585 SH   DFND 1 10,585 0 0
ALIGN TECHNOLOGY INC COM 016255101 9,306 28,428 SH   DFND 2 28,428 0 0
ALLEGION PLC ORD SHS G0176J109 3,127 31,615 SH   DFND 2 0 0 31,615
ALLSTATE CORP COM 020002101 434 4,615 SH   DFND 2 4,615 0 0
ALLSTATE CORP COM 020002101 1,297 13,778 SH   DFND 1 13,778 0 0
ALPHABET INC CAP STK CL C 02079K107 632,416 430,332 SH   DFND 2 254,067 0 176,265
ALPHABET INC CAP STK CL C 02079K107 36,840 25,068 SH   DFND 1 25,068 0 0
ALPHABET INC CAP STK CL A 02079K305 1,274 869 SH   DFND 2 0 0 869
AMARIN CORP PLC SPONS ADR NEW 023111206 3,837 911,329 SH   DFND 2 911,329 0 0
AMAZON INC COM 023135106 47,961 15,232 SH   DFND 1 15,232 0 0
AMAZON INC COM 023135106 689,159 218,869 SH   DFND 2 113,038 0 105,831
AMDOCS LTD SHS G02602103 1,144 19,921 SH   DFND 1 19,921 0 0
AMDOCS LTD SHS G02602103 643 11,193 SH   DFND 2 11,193 0 0
AMERICAN TOWER CORP NEW COM 03027X100 424,988 1,758,111 SH   DFND 2 1,032,273 0 725,838
AMERICAN TOWER CORP NEW COM 03027X100 25,250 104,456 SH   DFND 1 104,456 0 0
ANTHEM INC COM 036752103 32,499 121,000 SH   DFND 2 121,000 0 0
ARCO PLATFORM LTD COM CL A G04553106 139 3,402 SH   DFND 2 3,402 0 0
ARCO PLATFORM LTD COM CL A G04553106 91 2,228 SH   DFND 1 2,228 0 0
ATLANTICA SUSTAINABLE INFR P SHS G0751N103 2,239 78,259 SH   DFND 1 78,259 0 0
ATLANTICA SUSTAINABLE INFR P SHS G0751N103 1,111 38,837 SH   DFND 2 38,837 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 100 1,037 SH   DFND 1 1,037 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 140 1,459 SH   DFND 2 1,459 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 20,416 400,000 SH   DFND 2 400,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 16,366 251,751 SH   DFND 2 251,751 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 12,466 163,851 SH   DFND 2 163,851 0 0
CARA THERAPEUTICS INC COM 140755109 8,952 703,460 SH   DFND 2 703,460 0 0
CENTENE CORP DEL COM 15135B101 24,193 414,756 SH   DFND 2 414,756 0 0
CHURCH & DWIGHT INC COM 171340102 372 3,974 SH   DFND 1 3,974 0 0
CHURCH & DWIGHT INC COM 171340102 205 2,189 SH   DFND 2 2,189 0 0
COCA COLA CO COM 191216100 21,013 425,621 SH   DFND 1 425,621 0 0
COCA COLA CO COM 191216100 335,380 6,793,190 SH   DFND 2 4,085,242 0 2,707,948
COGNEX CORP COM 192422103 3,184 48,912 SH   DFND 2 0 0 48,912
COHERUS BIOSCIENCES INC COM 19249H103 19,412 1,058,464 SH   DFND 2 1,058,464 0 0
COOPER COS INC COM NEW 216648402 4,611 13,679 SH   DFND 2 0 0 13,679
CVS HEALTH CORP COM 126650100 30,135 516,015 SH   DFND 2 516,015 0 0
DEX INC COM 252131107 25,558 62,000 SH   DFND 2 62,000 0 0
DOLLAR GEN CORP NEW COM 256677105 1,608 7,669 SH   DFND 1 7,669 0 0
DOLLAR GEN CORP NEW COM 256677105 883 4,214 SH   DFND 2 4,214 0 0
DROPBOX INC CL A 26210C104 4,149 215,425 SH   DFND 2 0 0 215,425
ECOLAB INC COM 278865100 401,363 2,008,420 SH   DFND 2 1,191,752 0 816,668
ECOLAB INC COM 278865100 23,835 119,268 SH   DFND 1 119,268 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 27,243 341,311 SH   DFND 2 287,241 0 54,070
ELECTRONIC ARTS INC COM 285512109 3,701 28,381 SH   DFND 2 0 0 28,381
EXACT SCIENCES CORP COM 30063P105 38,931 381,864 SH   DFND 2 339,630 0 42,234
FIDELITY NATL INFORMATION SV COM 31620M106 405 2,749 SH   DFND 1 2,749 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 235 1,599 SH   DFND 2 1,599 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 292,220 2,679,445 SH   DFND 2 1,684,718 0 994,727
FIRST REP BK SAN FRANCISCO C COM 33616C100 16,274 149,224 SH   DFND 1 149,224 0 0
FISERV INC COM 337738108 1,561 15,148 SH   DFND 1 15,148 0 0
FISERV INC COM 337738108 858 8,323 SH   DFND 2 8,323 0 0
GLAUKOS CORP COM 377322102 12,242 247,212 SH   DFND 2 247,212 0 0
GLOBAL PMTS INC COM 37940X102 4,750 26,749 SH   DFND 2 0 0 26,749
GLOBANT S A COM L44385109 287 1,600 SH   DFND 2 1,600 0 0
GLOBANT S A COM L44385109 161 900 SH   DFND 1 900 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 9,100 93,473 SH   DFND 2 93,473 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 153,745 3,077,354 SH   DFND 2 1,547,787 0 1,529,567
HDFC BANK LTD SPONSORED ADS 40415F101 14,096 282,150 SH   DFND 1 282,150 0 0
HERON THERAPEUTICS INC COM 427746102 13,369 902,069 SH   DFND 2 902,069 0 0
HOME DEPOT INC COM 437076102 700,456 2,522,256 SH   DFND 2 1,476,555 0 1,045,701
HOME DEPOT INC COM 437076102 43,068 155,084 SH   DFND 1 155,084 0 0
HUMANA INC COM 444859102 36,198 87,459 SH   DFND 2 87,459 0 0
ICICI BANK LIMITED ADR 45104G104 48,831 4,967,577 SH   DFND 2 1,676,609 0 3,290,968
ICICI BANK LIMITED ADR 45104G104 3,675 373,898 SH   DFND 1 373,898 0 0
IHS MARKIT LTD SHS G47567105 53,593 682,622 SH   DFND 2 636,180 0 46,442
ILLUMINA INC COM 452327109 17,920 57,978 SH   DFND 2 57,978 0 0
INFOSYS LTD SPONSORED ADR 456788108 3,206 232,178 SH   DFND 2 232,178 0 0
INSMED INC COM PAR $.01 457669307 14,242 443,110 SH   DFND 2 443,110 0 0
INSULET CORP COM 45784P101 17,249 72,908 SH   DFND 2 72,908 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 806 8,052 SH   DFND 2 8,052 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,629 16,286 SH   DFND 1 16,286 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 29,756 41,937 SH   DFND 2 41,937 0 0
JOHNSON & JOHNSON COM 478160104 229 1,535 SH   DFND 2 1,535 0 0
JOHNSON & JOHNSON COM 478160104 394 2,647 SH   DFND 1 2,647 0 0
KEURIG DR PEPPER INC COM 49271V100 1,449 52,505 SH   DFND 1 52,505 0 0
KEURIG DR PEPPER INC COM 49271V100 793 28,729 SH   DFND 2 28,729 0 0
KRYSTAL BIOTECH INC COM 501147102 7,999 185,809 SH   DFND 2 185,809 0 0
LHC GROUP INC COM 50187A107 23,521 110,657 SH   DFND 2 110,657 0 0
MCCORMICK & CO INC COM NON VTG 579780206 2,875 14,813 SH   DFND 2 0 0 14,813
MERCADOLIBRE INC COM 58733R102 2,650 2,448 SH   DFND 2 239 0 2,209
MERCADOLIBRE INC COM 58733R102 150 139 SH   DFND 1 139 0 0
MERCK & CO. INC COM 58933Y105 15,489 186,728 SH   DFND 2 186,728 0 0
MICROSOFT CORP COM 594918104 721,388 3,429,791 SH   DFND 2 2,142,628 0 1,287,163
MICROSOFT CORP COM 594918104 37,870 180,049 SH   DFND 1 180,049 0 0
MONDELEZ INTL INC CL A 609207105 47,107 819,964 SH   DFND 2 819,964 0 0
MONDELEZ INTL INC CL A 609207105 1,129 19,656 SH   DFND 1 19,656 0 0
MSCI INC COM 55354G100 2,402 6,732 SH   DFND 2 0 0 6,732
MYOKARDIA INC COM 62857M105 15,944 116,950 SH   DFND 2 116,950 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 25,323 169,384 SH   DFND 2 51,909 0 117,475
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 2,067 13,829 SH   DFND 1 13,829 0 0
NEWMONT CORP COM 651639106 871 13,725 SH   DFND 2 13,725 0 0
NEWMONT CORP COM 651639106 1,625 25,607 SH   DFND 1 25,607 0 0
NEXTERA ENERGY INC COM 65339F101 22,074 79,528 SH   DFND 1 79,528 0 0
NEXTERA ENERGY INC COM 65339F101 410,578 1,479,242 SH   DFND 2 825,284 0 653,958
NOVOCURE LTD ORD SHS G6674U108 26,913 241,784 SH   DFND 2 241,784 0 0
PROCTER AND GAMBLE CO COM 742718109 475,241 3,419,245 SH   DFND 2 2,007,484 0 1,411,761
PROCTER AND GAMBLE CO COM 742718109 29,726 213,873 SH   DFND 1 213,873 0 0
PTC INC COM 69370C100 2,674 32,323 SH   DFND 2 0 0 32,323
QUIDEL CORP COM 74838J101 32,907 150,000 SH   DFND 2 150,000 0 0
RESMED INC COM 761152107 3,300 19,247 SH   DFND 2 0 0 19,247
S&P GLOBAL INC COM 78409V104 232,872 645,791 SH   DFND 2 337,754 0 308,037
S&P GLOBAL INC COM 78409V104 16,467 45,665 SH   DFND 1 45,665 0 0
SAREPTA THERAPEUTICS INC COM 803607100 20,409 145,329 SH   DFND 2 145,329 0 0
SEA LTD SPONSORD ADS 81141R100 118,442 768,903 SH   DFND 2 239,912 0 528,991
SEA LTD SPONSORD ADS 81141R100 9,214 59,816 SH   DFND 1 59,816 0 0
SERVICE CORP INTL COM 817565104 38,779 919,366 SH   DFND 2 818,961 0 100,405
SERVICE CORP INTL COM 817565104 857 20,315 SH   DFND 1 20,315 0 0
SMITH A O CORP COM 831865209 4,021 76,158 SH   DFND 2 0 0 76,158
SYNOPSYS INC COM 871607107 4,176 19,518 SH   DFND 2 0 0 19,518
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 26,453 326,297 SH   DFND 1 326,297 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 39,191 483,417 SH   DFND 2 385,147 0 98,270
TAL EDUCATION GROUP SPONSORED ADS 874080104 18,855 247,965 SH   DFND 2 80,392 0 167,573
TAL EDUCATION GROUP SPONSORED ADS 874080104 1,550 20,387 SH   DFND 1 20,387 0 0
TELEFLEX INCORPORATED COM 879369106 19,744 58,000 SH   DFND 2 58,000 0 0
THERAPEUTICSMD INC COM 88338N107 9,780 6,189,834 SH   DFND 2 6,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 811,217 1,837,327 SH   DFND 2 1,155,852 0 681,475
THERMO FISHER SCIENTIFIC INC COM 883556102 44,729 101,306 SH   DFND 1 101,306 0 0
TYLER TECHNOLOGIES INC COM 902252105 2,017 5,786 SH   DFND 2 0 0 5,786
VERTEX PHARMACEUTICALS INC COM 92532F100 18,656 68,557 SH   DFND 2 68,557 0 0
VISA INC COM CL A 92826C839 978,708 4,894,272 SH   DFND 2 2,912,570 0 1,981,702
VISA INC COM CL A 92826C839 59,063 295,357 SH   DFND 1 295,357 0 0
VOCERA MUNICATIONS INC COM 92857F107 7,417 255,058 SH   DFND 2 255,058 0 0
WATERS CORP COM 941848103 3,630 18,549 SH   DFND 2 0 0 18,549
WEYERHAEUSER CO MTN BE COM NEW 962166104 30,996 1,086,829 SH   DFND 2 1,086,829 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 1,064 21,676 SH   DFND 2 21,676 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 1,697 34,575 SH   DFND 1 34,575 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 335 1,606 SH   DFND 2 1,606 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 623 2,985 SH   DFND 1 2,985 0 0
XP INC CL A G98239109 172 4,123 SH   DFND 2 4,123 0 0
XP INC CL A G98239109 100 2,406 SH   DFND 1 2,406 0 0
XYLEM INC COM 98419M100 3,741 44,476 SH   DFND 2 0 0 44,476