The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 4,371 524,683 SH   DFND 2 524,683 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 7,508 556,142 SH   DFND 2 556,142 0 0
AGNICO EAGLE MINES LTD COM 008474108 646 16,232 SH   DFND 2 16,232 0 0
AGNICO EAGLE MINES LTD COM 008474108 1,108 27,843 SH   DFND 1 27,843 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 207,225 1,065,532 SH   DFND 2 340,192 0 725,340
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 17,718 91,105 SH   DFND 1 91,105 0 0
ALIGN TECHNOLOGY INC COM 016255101 4,945 28,428 SH   DFND 2 28,428 0 0
ALLSTATE CORP COM 020002101 267 2,907 SH   DFND 1 2,907 0 0
ALLSTATE CORP COM 020002101 147 1,602 SH   DFND 2 1,602 0 0
ALPHABET INC CAP STK CL C 02079K107 523,312 450,041 SH   DFND 2 268,055 0 181,986
ALPHABET INC CAP STK CL C 02079K107 25,498 21,928 SH   DFND 1 21,928 0 0
ALPHABET INC CAP STK CL A 02079K305 1,010 869 SH   DFND 2 0 0 869
AMARIN CORP PLC SPONS ADR NEW 023111206 2,845 711,329 SH   DFND 2 711,329 0 0
AMAZON INC COM 023135106 508,347 260,728 SH   DFND 2 137,532 0 123,196
AMAZON INC COM 023135106 30,033 15,404 SH   DFND 1 15,404 0 0
AMDOCS LTD SHS G02602103 615 11,193 SH   DFND 2 11,193 0 0
AMDOCS LTD SHS G02602103 1,095 19,921 SH   DFND 1 19,921 0 0
AMERICAN TOWER CORP NEW COM 03027X100 19,165 88,013 SH   DFND 1 88,013 0 0
AMERICAN TOWER CORP NEW COM 03027X100 398,958 1,832,183 SH   DFND 2 1,086,078 0 746,105
ANNALY CAPITAL MANAGEMENT IN COM 035710409 543 107,136 SH   DFND 2 107,136 0 0
ANNALY CAPITAL MANAGEMENT IN COM 035710409 973 191,925 SH   DFND 1 191,925 0 0
ANTHEM INC COM 036752103 536 2,363 SH   DFND 1 2,363 0 0
ANTHEM INC COM 036752103 27,773 122,328 SH   DFND 2 122,328 0 0
ARCO PLATFORM LTD COM CL A G04553106 105 2,483 SH   DFND 2 2,483 0 0
ARCO PLATFORM LTD COM CL A G04553106 73 1,729 SH   DFND 1 1,729 0 0
ATLANTICA YIELD PLC SHS G0751N103 1,745 78,259 SH   DFND 1 78,259 0 0
ATLANTICA YIELD PLC SHS G0751N103 1,056 47,345 SH   DFND 2 47,345 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 104 1,459 SH   DFND 2 1,459 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 74 1,037 SH   DFND 1 1,037 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 6,861 270,000 SH   DFND 2 270,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 10,609 311,751 SH   DFND 2 311,751 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 13,845 163,851 SH   DFND 2 163,851 0 0
CARA THERAPEUTICS INC COM 140755109 9,293 703,460 SH   DFND 2 703,460 0 0
CENTENE CORP DEL COM 15135B101 28,900 486,458 SH   DFND 2 486,458 0 0
COCA COLA CO COM 191216100 16,368 369,888 SH   DFND 1 369,888 0 0
COCA COLA CO COM 191216100 313,278 7,079,732 SH   DFND 2 4,291,368 0 2,788,364
COHERUS BIOSCIENCES INC COM 19249H103 14,735 908,464 SH   DFND 2 908,464 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 181 1,254 SH   DFND 2 1,254 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 274 1,899 SH   DFND 1 1,899 0 0
CVS HEALTH CORP COM 126650100 30,615 516,015 SH   DFND 2 516,015 0 0
DEX INC COM 252131107 19,536 72,553 SH   DFND 2 72,553 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 3,517 996,412 SH   DFND 2 996,412 0 0
ECOLAB INC COM 278865100 421,839 2,707,047 SH   DFND 2 1,597,708 0 1,109,339
ECOLAB INC COM 278865100 21,369 137,127 SH   DFND 1 137,127 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 18,060 95,747 SH   DFND 2 95,747 0 0
EXACT SCIENCES CORP COM 30063P105 19,409 334,630 SH   DFND 2 334,630 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 334 2,749 SH   DFND 1 2,749 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 195 1,599 SH   DFND 2 1,599 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 229,550 2,789,862 SH   DFND 2 1,763,836 0 1,026,026
FIRST REP BK SAN FRANCISCO C COM 33616C100 10,854 131,911 SH   DFND 1 131,911 0 0
FISERV INC COM 337738108 345 3,629 SH   DFND 1 3,629 0 0
FISERV INC COM 337738108 200 2,110 SH   DFND 2 2,110 0 0
FRANCO NEVADA CORP COM 351858105 194 1,954 SH   DFND 1 1,954 0 0
FRANCO NEVADA CORP COM 351858105 338 3,399 SH   DFND 2 3,399 0 0
GLAUKOS CORP COM 377322102 3,000 97,212 SH   DFND 2 97,212 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 8,185 93,473 SH   DFND 2 93,473 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 122,911 3,195,806 SH   DFND 2 1,452,088 0 1,743,718
HDFC BANK LTD SPONSORED ADS 40415F101 9,437 245,362 SH   DFND 1 245,362 0 0
HERON THERAPEUTICS INC COM 427746102 8,242 702,069 SH   DFND 2 702,069 0 0
HOME DEPOT INC COM 437076102 491,187 2,630,750 SH   DFND 2 1,555,017 0 1,075,733
HOME DEPOT INC COM 437076102 25,411 136,097 SH   DFND 1 136,097 0 0
HUMANA INC COM 444859102 20,411 65,000 SH   DFND 2 65,000 0 0
ICICI BANK LIMITED ADR 45104G104 40,837 4,804,398 SH   DFND 2 1,513,430 0 3,290,968
ICICI BANK LIMITED ADR 45104G104 3,507 412,594 SH   DFND 1 412,594 0 0
ILLUMINA INC COM 452327109 15,835 57,978 SH   DFND 2 57,978 0 0
IMMUNOMEDICS INC COM 452907108 5,931 440,000 SH   DFND 2 440,000 0 0
INSMED INC COM PAR $.01 457669307 7,103 443,110 SH   DFND 2 443,110 0 0
INSULET CORP COM 45784P101 12,079 72,908 SH   DFND 2 72,908 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,653 20,465 SH   DFND 1 20,465 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 941 11,656 SH   DFND 2 11,656 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 20,768 41,937 SH   DFND 2 41,937 0 0
JOHNSON & JOHNSON COM 478160104 201 1,535 SH   DFND 2 1,535 0 0
JOHNSON & JOHNSON COM 478160104 347 2,647 SH   DFND 1 2,647 0 0
KRYSTAL BIOTECH INC COM 501147102 5,872 135,809 SH   DFND 2 135,809 0 0
LHC GROUP INC COM 50187A107 13,411 95,657 SH   DFND 2 95,657 0 0
MERCADOLIBRE INC COM 58733R102 116 238 SH   DFND 1 238 0 0
MERCADOLIBRE INC COM 58733R102 183 375 SH   DFND 2 375 0 0
MERCK & CO. INC COM 58933Y105 17,444 226,728 SH   DFND 2 226,728 0 0
MICROSOFT CORP COM 594918104 570,830 3,619,489 SH   DFND 2 2,288,517 0 1,330,972
MICROSOFT CORP COM 594918104 25,499 161,682 SH   DFND 1 161,682 0 0
MONDELEZ INTL INC CL A 609207105 32,379 646,536 SH   DFND 2 646,536 0 0
MONDELEZ INTL INC CL A 609207105 258 5,148 SH   DFND 1 5,148 0 0
MSCI INC COM 55354G100 197,089 682,064 SH   DFND 2 367,696 0 314,368
MSCI INC COM 55354G100 11,732 40,600 SH   DFND 1 40,600 0 0
MYOKARDIA INC COM 62857M105 5,483 116,950 SH   DFND 2 116,950 0 0
NEW ORIENTAL ED & TECH GRP I SPON ADR 647581107 1,120 10,343 SH   DFND 1 10,343 0 0
NEW ORIENTAL ED & TECH GRP I SPON ADR 647581107 12,086 111,663 SH   DFND 2 36,777 0 74,886
NEWMONT CORP COM 651639106 1,159 25,607 SH   DFND 1 25,607 0 0
NEWMONT CORP COM 651639106 621 13,725 SH   DFND 2 13,725 0 0
NEXTERA ENERGY INC COM 65339F101 288,068 1,197,189 SH   DFND 2 727,212 0 469,977
NEXTERA ENERGY INC COM 65339F101 12,543 52,127 SH   DFND 1 52,127 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 772 17,955 SH   DFND 1 17,955 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 540 12,547 SH   DFND 2 12,547 0 0
NOVOCURE LTD ORD SHS G6674U108 11,231 166,784 SH   DFND 2 166,784 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 2,384 334,366 SH   DFND 2 334,366 0 0
PROCTER & GAMBLE CO COM 742718109 392,696 3,569,964 SH   DFND 2 2,112,090 0 1,457,874
PROCTER & GAMBLE CO COM 742718109 19,308 175,524 SH   DFND 1 175,524 0 0
SAREPTA THERAPEUTICS INC COM 803607100 14,216 145,329 SH   DFND 2 145,329 0 0
SEA LTD SPONSORED ADS 81141R100 2,902 65,485 SH   DFND 1 65,485 0 0
SEA LTD SPONSORED ADS 81141R100 34,377 775,838 SH   DFND 2 246,847 0 528,991
SERVICE CORP INTL COM 817565104 31,717 810,971 SH   DFND 2 810,971 0 0
SERVICE CORP INTL COM 817565104 220 5,618 SH   DFND 1 5,618 0 0
STARBUCKS CORP COM 855244109 23,707 360,615 SH   DFND 2 360,615 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 4,834 998,677 SH   DFND 2 998,677 0 0
STORE CAP CORP COM 862121100 443 24,443 SH   DFND 2 24,443 0 0
STORE CAP CORP COM 862121100 767 42,351 SH   DFND 1 42,351 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 27,790 581,494 SH   DFND 2 375,508 0 205,986
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 12,907 270,073 SH   DFND 1 270,073 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 13,043 244,896 SH   DFND 2 77,323 0 167,573
TAL EDUCATION GROUP SPONSORED ADS 874080104 1,075 20,179 SH   DFND 1 20,179 0 0
TELEFLEX INCORPORATED COM 879369106 15,522 53,000 SH   DFND 2 53,000 0 0
THERAPEUTICSMD INC COM 88338N107 6,561 6,189,834 SH   DFND 2 6,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 25,185 88,803 SH   DFND 1 88,803 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 542,128 1,911,594 SH   DFND 2 1,208,772 0 702,822
TJX COS INC NEW COM 872540109 356 7,443 SH   DFND 2 7,443 0 0
TJX COS INC NEW COM 872540109 663 13,861 SH   DFND 1 13,861 0 0
UNITEDHEALTH GROUP INC COM 91324P102 594 2,383 SH   DFND 1 2,383 0 0
UNITEDHEALTH GROUP INC COM 91324P102 334 1,339 SH   DFND 2 1,339 0 0
US BANCORP DEL COM NEW 902973304 25,109 728,854 SH   DFND 2 728,854 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 16,313 68,557 SH   DFND 2 68,557 0 0
VICI PPTYS INC COM 925652109 990 59,469 SH   DFND 1 59,469 0 0
VICI PPTYS INC COM 925652109 578 34,725 SH   DFND 2 34,725 0 0
VISA INC COM CL A 92826C839 893,816 5,547,520 SH   DFND 2 3,298,761 0 2,248,759
VISA INC COM CL A 92826C839 45,619 283,137 SH   DFND 1 283,137 0 0
VOCERA MUNICATIONS INC COM 92857F107 5,417 255,058 SH   DFND 2 255,058 0 0
WEYERHAEUSER CO COM 962166104 18,422 1,086,829 SH   DFND 2 1,086,829 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 1,074 39,013 SH   DFND 2 39,013 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 1,697 61,644 SH   DFND 1 61,644 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 389 2,288 SH   DFND 2 2,288 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 555 3,266 SH   DFND 1 3,266 0 0