The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 6,368 107,500 SH   DFND 2 0 0 107,500
ACADIA HEALTHCARE PANY IN COM 00404A109 3,123 50,000 SH   DFND 2 0 0 50,000
ACADIA PHARMACEUTICALS INC COM 004225108 727 20,390 SH   DFND 2 0 0 20,390
ACCELERON PHARMA INC COM 00434H108 800 16,400 SH   DFND 2 0 0 16,400
ACORDA THERAPEUTICS INC COM 00484M106 428 10,000 SH   DFND 2 0 0 10,000
ADVANCED SEMICONDUCTOR ENGR SPONSORED ADR 00756M404 84 14,800 SH   DFND 1 14,800 0 0
ADVANCED SEMICONDUCTOR ENGR SPONSORED ADR 00756M404 130 23,000 SH   DFND 2 0 0 23,000
AERIE PHARMACEUTICALS INC COM 00771V108 4,675 192,006 SH   DFND 2 0 0 192,006
AIR METHODS CORP COM PAR $.06 009128307 10,639 253,736 SH   DFND 2 0 0 253,736
ALEXION PHARMACEUTICALS INC COM 015351109 7,861 41,211 SH   DFND 2 0 0 41,211
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 10,856 133,580 SH   DFND 2 0 0 133,580
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 873 10,740 SH   DFND 1 10,740 0 0
ALLERGAN PLC SHS G0177J108 42,701 136,642 SH   DFND 2 0 0 136,642
ALLIANCE DATA SYSTEMS CORP COM 018581108 134,571 486,570 SH   DFND 2 222,760 0 263,810
ALLIANCE DATA SYSTEMS CORP COM 018581108 13,198 47,720 SH   DFND 1 47,720 0 0
ALPHABET INC CAP STK CL C ADDED 02079K107 289,627 381,651 SH   DFND 2 169,640 0 212,011
ALPHABET INC CAP STK CL C ADDED 02079K107 27,376 36,074 SH   DFND 1 36,074 0 0
ALPHABET INC CAP STK CL A ADDED 02079K305 46,464 59,721 SH   DFND 2 32,460 0 27,261
ALPHABET INC CAP STK CL A ADDED 02079K305 6,559 8,430 SH   DFND 1 8,430 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 236,842 3,821,885 SH   DFND 2 1,768,020 0 2,053,865
AMERICAN INTL GROUP INC COM NEW 026874784 24,638 397,580 SH   DFND 1 397,580 0 0
AMERISOURCEBERGEN CORP COM 03073E105 289 2,790 SH   DFND 1 2,790 0 0
AMERISOURCEBERGEN CORP COM 03073E105 8,536 82,310 SH   DFND 2 0 0 82,310
AMGEN INC COM 031162100 38,462 236,938 SH   DFND 2 0 0 236,938
APPLIED GENETIC TECHNOL CORP COM 03820J100 1,428 70,000 SH   DFND 2 0 0 70,000
AUTOZONE INC COM 053332102 391 527 SH   DFND 1 527 0 0
AUTOZONE INC COM 053332102 415 560 SH   DFND 2 0 0 560
BAIDU INC SPON ADR REP A 056752108 9,962 52,700 SH   DFND 2 0 0 52,700
BAIDU INC SPON ADR REP A 056752108 821 4,345 SH   DFND 1 4,345 0 0
BIOGEN INC COM 09062X103 28,719 93,747 SH   DFND 2 0 0 93,747
BIOMARIN PHARMACEUTICAL INC COM 09061G101 13,365 127,575 SH   DFND 2 0 0 127,575
BLUEBIRD BIO INC COM 09609G100 321 5,000 SH   DFND 2 0 0 5,000
CARA THERAPEUTICS INC COM 140755109 4,417 262,000 SH   DFND 2 0 0 262,000
CELGENE CORP COM 151020104 44,412 370,838 SH   DFND 2 0 0 370,838
CEMPRA INC COM 15130J109 24,497 786,930 SH   DFND 2 0 0 786,930
CENTENE CORP DEL COM 15135B101 23,757 361,000 SH   DFND 2 0 0 361,000
CEPHEID COM 15670R107 4,289 117,400 SH   DFND 2 0 0 117,400
CERNER CORP COM 156782104 554 9,200 SH   DFND 1 9,200 0 0
CERNER CORP COM 156782104 560 9,300 SH   DFND 2 0 0 9,300
CHIMERIX INC COM 16934W106 1,181 132,000 SH   DFND 2 0 0 132,000
CIGNA CORPORATION COM 125509109 19,133 130,750 SH   DFND 2 0 0 130,750
CITIGROUP INC COM NEW 172967424 219,215 4,236,040 SH   DFND 2 1,936,690 0 2,299,350
CITIGROUP INC COM NEW 172967424 21,994 425,010 SH   DFND 1 425,010 0 0
COHERUS BIOSCIENCES INC COM 19249H103 3,352 146,000 SH   DFND 2 0 0 146,000
COMCAST CORP NEW CL A 20030N101 480 8,500 SH   DFND 2 0 0 8,500
COMCAST CORP NEW CL A 20030N101 530 9,390 SH   DFND 1 9,390 0 0
COOPER COS INC COM NEW 216648402 8,012 59,700 SH   DFND 2 0 0 59,700
CREDICORP LTD COM G2519Y108 47 485 SH   DFND 2 0 0 485
CREDICORP LTD COM G2519Y108 40 415 SH   DFND 1 415 0 0
CVS HEALTH CORP COM 126650100 273,108 2,793,370 SH   DFND 2 1,268,200 0 1,525,170
CVS HEALTH CORP COM 126650100 28,658 293,120 SH   DFND 1 293,120 0 0
DANAHER CORP DEL COM 235851102 443 4,770 SH   DFND 1 4,770 0 0
DANAHER CORP DEL COM 235851102 372 4,000 SH   DFND 2 0 0 4,000
DAVITA HEALTHCARE PARTNERS I COM 23918K108 6,671 95,691 SH   DFND 2 0 0 95,691
DEX INC COM 252131107 4,089 49,925 SH   DFND 2 0 0 49,925
DISCOVER FINL SVCS COM 254709108 456 8,500 SH   DFND 2 0 0 8,500
DISCOVER FINL SVCS COM 254709108 408 7,610 SH   DFND 1 7,610 0 0
DOLLAR GEN CORP NEW COM 256677105 1,042 14,500 SH   DFND 1 14,500 0 0
DOLLAR GEN CORP NEW COM 256677105 1,028 14,300 SH   DFND 2 0 0 14,300
DUKE ENERGY CORP NEW COM NEW 26441C204 792 11,100 SH   DFND 1 11,100 0 0
DUKE ENERGY CORP NEW COM NEW 26441C204 778 10,900 SH   DFND 2 0 0 10,900
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 4,454 184,362 SH   DFND 2 0 0 184,362
EAGLE PHARMACEUTICALS INC COM 269796108 19,410 218,907 SH   DFND 2 0 0 218,907
ECOLAB INC COM 278865100 305,031 2,666,821 SH   DFND 2 1,231,240 0 1,435,581
ECOLAB INC COM 278865100 31,707 277,210 SH   DFND 1 277,210 0 0
EDISON INTL COM 281020107 799 13,500 SH   DFND 1 13,500 0 0
EDISON INTL COM 281020107 793 13,400 SH   DFND 2 0 0 13,400
ENBRIDGE INC COM 29250N105 796 17,300 SH   DFND 1 17,300 0 0
ENBRIDGE INC COM 29250N105 736 16,000 SH   DFND 2 0 0 16,000
ENDO INTL PLC SHS G30401106 1,071 17,500 SH   DFND 2 0 0 17,500
ESPERION THERAPEUTICS INC NE COM 29664W105 423 19,000 SH   DFND 2 0 0 19,000
EXACT SCIENCES CORP COM 30063P105 2,308 250,000 SH   DFND 2 0 0 250,000
EXAMWORKS GROUP INC COM 30066A105 1,995 75,000 SH   DFND 2 0 0 75,000
EXPRESS SCRIPTS HLDG CO COM 30219G108 577 6,600 SH   DFND 1 6,600 0 0
EXPRESS SCRIPTS HLDG CO COM 30219G108 17,622 201,601 SH   DFND 2 0 0 201,601
FACEBOOK INC CL A 30303M102 280,672 2,681,755 SH   DFND 2 1,239,780 0 1,441,975
FACEBOOK INC CL A 30303M102 28,771 274,895 SH   DFND 1 274,895 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 830 13,700 SH   DFND 2 0 0 13,700
FIDELITY NATL INFORMATION SV COM 31620M106 879 14,500 SH   DFND 1 14,500 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 495 7,500 SH   DFND 1 7,500 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 456 6,900 SH   DFND 2 0 0 6,900
FLEX PHARMA INC COM 33938A105 1,868 150,000 SH   DFND 2 0 0 150,000
GILEAD SCIENCES INC COM 375558103 333,934 3,300,072 SH   DFND 2 1,260,980 0 2,039,092
GILEAD SCIENCES INC COM 375558103 28,406 280,720 SH   DFND 1 280,720 0 0
HCA HOLDINGS INC COM 40412C101 10,961 162,075 SH   DFND 2 0 0 162,075
HDFC BANK LTD ADR REPS 3 SHS 40415F101 138,578 2,249,650 SH   DFND 2 2,176,800 0 72,850
HDFC BANK LTD ADR REPS 3 SHS 40415F101 5,218 84,700 SH   DFND 1 84,700 0 0
HOME DEPOT INC COM 437076102 39,264 296,890 SH   DFND 1 296,890 0 0
HOME DEPOT INC COM 437076102 381,865 2,887,450 SH   DFND 2 1,314,680 0 1,572,770
HORIZON PHARMA PLC SHS G4617B105 14,335 661,500 SH   DFND 2 0 0 661,500
HUMANA INC COM 444859102 1,321 7,400 SH   DFND 2 0 0 7,400
ICICI BK LTD ADR 45104G104 21,298 2,720,090 SH   DFND 2 0 0 2,720,090
ICICI BK LTD ADR 45104G104 1,644 209,950 SH   DFND 1 209,950 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 319 40,680 SH   DFND 2 0 0 40,680
INGREDION INC COM 457187102 546 5,700 SH   DFND 1 5,700 0 0
INGREDION INC COM 457187102 594 6,200 SH   DFND 2 0 0 6,200
INNOCOLL AG SPONSORED ADR 45780Q103 2,450 295,184 SH   DFND 2 0 0 295,184
INSULET CORP COM 45784P101 5,596 148,000 SH   DFND 2 0 0 148,000
INTERCEPT PHARMACEUTICALS IN COM 45845P108 568 3,800 SH   DFND 2 0 0 3,800
INTRA CELLULAR THERAPIES INC COM 46116X101 6,670 124,000 SH   DFND 2 0 0 124,000
IONIS PHARMACEUTICALS INC COM ADDED 462222100 4,710 76,060 SH   DFND 2 0 0 76,060
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 13,309 94,689 SH   DFND 2 0 0 94,689
JOHNSON & JOHNSON COM 478160104 28,298 275,486 SH   DFND 2 0 0 275,486
JOHNSON & JOHNSON COM 478160104 746 7,265 SH   DFND 1 7,265 0 0
JPMORGAN CHASE & CO COM 46625H100 726 11,000 SH   DFND 1 11,000 0 0
JPMORGAN CHASE & CO COM 46625H100 759 11,500 SH   DFND 2 0 0 11,500
K2M GROUP HLDGS INC COM 48273J107 1,997 101,151 SH   DFND 2 0 0 101,151
KEMPHARM INC COM 488445107 3,277 165,000 SH   DFND 2 0 0 165,000
KERYX BIOPHARMACEUTICALS INC COM 492515101 2,127 421,110 SH   DFND 2 0 0 421,110
KITE PHARMA INC COM 49803L109 2,896 47,000 SH   DFND 2 0 0 47,000
KROGER CO COM 501044101 247 5,900 SH   DFND 1 5,900 0 0
KROGER CO COM 501044101 213 5,100 SH   DFND 2 0 0 5,100
L BRANDS INC COM 501797104 314,355 3,280,685 SH   DFND 2 1,498,560 0 1,782,125
L BRANDS INC COM 501797104 32,040 334,380 SH   DFND 1 334,380 0 0
LDR HLDG CORP COM 50185U105 4,191 166,917 SH   DFND 2 0 0 166,917
LILLY ELI & CO COM 532457108 303 3,600 SH   DFND 1 3,600 0 0
LILLY ELI & CO COM 532457108 295 3,500 SH   DFND 2 0 0 3,500
MASTERCARD INC CL A 57636Q104 2,726 28,000 SH   DFND 2 0 0 28,000
MCKESSON CORP COM 58155Q103 225,612 1,143,902 SH   DFND 2 525,570 0 618,332
MCKESSON CORP COM 58155Q103 24,536 124,405 SH   DFND 1 124,405 0 0
MEDIVATION INC COM 58501N101 4,460 92,262 SH   DFND 2 0 0 92,262
MEDNAX INC COM 58502B106 645 9,000 SH   DFND 2 0 0 9,000
MEDNAX INC COM 58502B106 573 8,000 SH   DFND 1 8,000 0 0
MEDTRONIC PLC SHS G5960L103 631 8,200 SH   DFND 1 8,200 0 0
MEDTRONIC PLC SHS G5960L103 738 9,600 SH   DFND 2 0 0 9,600
MERCK & CO INC NEW COM 58933Y105 10,796 204,397 SH   DFND 2 0 0 204,397
MIMEDX GROUP INC COM 602496101 1,874 200,000 SH   DFND 2 0 0 200,000
MONDELEZ INTL INC CL A 609207105 578 12,900 SH   DFND 2 0 0 12,900
MONDELEZ INTL INC CL A 609207105 610 13,600 SH   DFND 1 13,600 0 0
NEWLINK GENETICS CORP COM 651511107 482 13,235 SH   DFND 2 0 0 13,235
NEXTERA ENERGY INC COM 65339F101 457 4,400 SH   DFND 2 0 0 4,400
NEXTERA ENERGY INC COM 65339F101 468 4,500 SH   DFND 1 4,500 0 0
NIKE INC CL B 654106103 8,469 135,500 SH   DFND 2 0 0 135,500
NIKE INC CL B 654106103 2,286 36,580 SH   DFND 1 36,580 0 0
NOVADAQ TECHNOLOGIES INC COM 66987G102 3,822 300,000 SH   DFND 2 0 0 300,000
NUVASIVE INC COM 670704105 2,065 38,160 SH   DFND 2 0 0 38,160
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 837 70,460 SH   DFND 2 0 0 70,460
PFIZER INC COM 717081103 37,087 1,148,915 SH   DFND 2 0 0 1,148,915
PG&E CORP COM 69331C108 606 11,400 SH   DFND 2 0 0 11,400
PG&E CORP COM 69331C108 628 11,810 SH   DFND 1 11,810 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 2,650 51,513 SH   DFND 2 0 0 51,513
PTC THERAPEUTICS INC COM 69366J200 2,064 63,700 SH   DFND 2 0 0 63,700
RADIUS HEALTH INC COM NEW 750469207 1,128 18,330 SH   DFND 2 0 0 18,330
REGENERON PHARMACEUTICALS COM 75886F107 1,591 2,930 SH   DFND 2 0 0 2,930
REGULUS THERAPEUTICS INC COM 75915K101 1,395 160,000 SH   DFND 2 0 0 160,000
RELYPSA INC COM 759531106 8,304 293,000 SH   DFND 2 0 0 293,000
REYNOLDS AMERICAN INC COM 761713106 199,682 4,326,800 SH   DFND 2 2,286,700 0 2,040,100
REYNOLDS AMERICAN INC COM 761713106 20,684 448,200 SH   DFND 1 448,200 0 0
SENSATA TECHNOLOGIES HLDG NV SHS N7902X106 118,368 2,569,860 SH   DFND 2 1,218,700 0 1,351,160
SENSATA TECHNOLOGIES HLDG NV SHS N7902X106 11,503 249,750 SH   DFND 1 249,750 0 0
SERVICE CORP INTL COM 817565104 755 29,000 SH   DFND 1 29,000 0 0
SERVICE CORP INTL COM 817565104 734 28,200 SH   DFND 2 0 0 28,200
SHIRE PLC SPONSORED ADR 82481R106 21,386 104,324 SH   DFND 2 0 0 104,324
SNAP ON INC COM 833034101 245 1,430 SH   DFND 1 1,430 0 0
SNAP ON INC COM 833034101 206 1,200 SH   DFND 2 0 0 1,200
SORRENTO THERAPEUTICS INC COM NEW 83587F202 1,942 222,981 SH   DFND 2 0 0 222,981
SPARK THERAPEUTICS INC COM 84652J103 3,562 78,620 SH   DFND 2 0 0 78,620
SPECTRANETICS CORP COM 84760C107 3,297 218,956 SH   DFND 2 0 0 218,956
SUPERNUS PHARMACEUTICALS INC COM 868459108 3,199 238,000 SH   DFND 2 0 0 238,000
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 4,998 219,700 SH   DFND 2 204,700 0 15,000
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 240 10,560 SH   DFND 1 10,560 0 0
TARGET CORP COM 87612E106 385 5,300 SH   DFND 1 5,300 0 0
TARGET CORP COM 87612E106 428 5,900 SH   DFND 2 0 0 5,900
TD AMERITRADE HLDG CORP COM 87236Y108 14,991 431,900 SH   DFND 1 431,900 0 0
TD AMERITRADE HLDG CORP COM 87236Y108 151,080 4,352,650 SH   DFND 2 2,004,800 0 2,347,850
TETRAPHASE PHARMACEUTICALS I COM 88165N105 6,274 625,510 SH   DFND 2 0 0 625,510
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 20,874 318,000 SH   DFND 2 0 0 318,000
THERMO FISHER SCIENTIFIC INC COM 883556102 312 2,200 SH   DFND 2 0 0 2,200
THERMO FISHER SCIENTIFIC INC COM 883556102 346 2,440 SH   DFND 1 2,440 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 891 16,420 SH   DFND 1 16,420 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 868 16,000 SH   DFND 2 0 0 16,000
TRANSENTERIX INC COM NEW 89366M201 1,580 637,169 SH   DFND 2 0 0 637,169
TROVAGENE INC COM NEW 897238309 1,774 328,584 SH   DFND 2 0 0 328,584
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 4,487 40,000 SH   DFND 2 0 0 40,000
UNION PAC CORP COM 907818108 152 1,940 SH   DFND 2 0 0 1,940
UNITEDHEALTH GROUP INC COM 91324P102 647 5,500 SH   DFND 1 5,500 0 0
UNITEDHEALTH GROUP INC COM 91324P102 39,369 334,658 SH   DFND 2 0 0 334,658
V F CORP COM 918204108 423 6,800 SH   DFND 2 0 0 6,800
V F CORP COM 918204108 386 6,200 SH   DFND 1 6,200 0 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 16,413 161,461 SH   DFND 2 0 0 161,461
VERIZON MUNICATIONS INC COM 92343V104 540 11,690 SH   DFND 1 11,690 0 0
VERIZON MUNICATIONS INC COM 92343V104 337 7,300 SH   DFND 2 0 0 7,300
VERTEX PHARMACEUTICALS INC COM 92532F100 2,705 21,500 SH   DFND 2 0 0 21,500
VISA INC COM CL A 92826C839 59,620 768,790 SH   DFND 1 768,790 0 0
VISA INC COM CL A 92826C839 582,440 7,510,510 SH   DFND 2 3,449,430 0 4,061,080
WELLS FARGO & CO NEW COM 949746101 265,792 4,889,478 SH   DFND 2 2,209,540 0 2,679,938
WELLS FARGO & CO NEW COM 949746101 27,737 510,240 SH   DFND 1 510,240 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 4,280 150,000 SH   DFND 2 0 0 150,000