Consolidated statements of stockholders' equity - USD ($) $ in Thousands	Total	Follow-on Offering	Common Stock	Common Stock Follow-on Offering	Additional Paid-in Capital	Additional Paid-in Capital Follow-on Offering	Accumulated Other Comprehensive Gain (Loss)	Accumulated Deficit
Balance at Dec. 31, 2019	$ 224,428		$ 3		$ 282,460			$ (58,035)
Balance, Shares at Dec. 31, 2019			32,861,842
Stock-based compensation	5,768				5,768
Issuance of common stock upon exercise of stock options	2,843				2,843
Issuance of common stock upon exercise of stock options, Shares			822,916
Issuance of common stock related to employee stock purchase plan	352				352
Issuance of common stock related to employee stock purchase plan, Shares			17,391
Issuance of common stock		$ 104,930		$ 1		$ 104,929
Issuance of common stock, Shares				2,875,000
Net loss	(52,243)							(52,243)
Balance at Dec. 31, 2020	286,078		$ 4		396,352			(110,278)
Balance, Shares at Dec. 31, 2020			36,577,149
Unrealized loss on marketable securities	(168)						$ (168)
Stock-based compensation	16,450				16,450
Issuance of common stock upon exercise of stock options	$ 777				777
Issuance of common stock upon exercise of stock options, Shares	287,566		304,857
Issuance of common stock related to employee stock purchase plan	$ 509				509
Issuance of common stock related to employee stock purchase plan, Shares			20,493
Issuance of common stock		$ (64)				$ (64)
Net loss	(85,805)							(85,805)
Balance at Dec. 31, 2021	$ 217,777		$ 4		$ 414,024		$ (168)	$ (196,083)
Balance, Shares at Dec. 31, 2021			36,902,499