10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

(Mark One)

⌧ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended March 31, 2022

OR

◻ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission file number: 001-37526

Zynerba Pharmaceuticals, Inc.

(Exact name of registrant as specified in its charter)

Delaware (State or other jurisdiction of incorporation or organization)	26-0389433 (I.R.S. Employer Identification Number)
80 W. Lancaster Avenue, Suite 300 Devon, PA (Address of principal executive offices)	19333 (Zip Code)

(484) 581-7505
(Registrant’s telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class:	Trading Symbol	Name of each exchange on which registered:
Common Stock, $0.001 par value per share	ZYNE	The Nasdaq Global Market

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. ⌧Yes ◻ No

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). ⌧Yes ◻ No

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer ◻	Accelerated filer ◻
	Smaller reporting company ⌧
Non-accelerated filer ⌧	Emerging growth company ◻

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ◻ No ⌧

As of May 11, 2022, the registrant had 43,595,959 shares of common stock, $0.001 par value per share, outstanding.

TABLE OF CONTENTS

PART I—FINANCIAL INFORMATION		5
Item 1.	Consolidated Financial Statements (Unaudited)	5
	Consolidated Balance Sheets as of March 31, 2022 and December 31, 2021 (Unaudited)	5
	Consolidated Statements of Operations for the Three Months Ended March 31, 2022 and 2021 (Unaudited)	6
	Consolidated Statements of Stockholders’ Equity for the Three Months Ended March 31, 2022 and 2021 (Unaudited)	7
	Consolidated Statements of Cash Flows for the Three Months Ended March 31, 2022 and 2021 (Unaudited)	8
	Notes to Unaudited Consolidated Financial Statements	9
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	17
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	25
Item 4.	Controls and Procedures	25
PART II—OTHER INFORMATION		26
Item 1.	Legal Proceedings	26
Item 1A.	Risk Factors	26
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	26
Item 3.	Defaults Upon Senior Securities	26
Item 4.	Mine Safety Disclosures	26
Item 5.	Other Information	26
Item 6.	Exhibits	27
	Signatures	28

2

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

Statements made in this Quarterly Report on Form 10-Q, or this Quarterly Report, that are not statements of historical or current facts, such as those under the heading “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements discuss our current expectations and projections relating to our financial condition, results of operations, plans, objectives, future performance and business. These statements may be preceded by, followed by or include the words “aim,” “anticipate,” “believe,” “estimate,” “expect,” “forecast,” “intend,” “outlook,” “plan,” “potential,” “project,” “projection,” “seek,” “may,” “could,” “would,” “will,” “should,” “can,” “can have,” “likely,” the negatives thereof and other words and terms of similar meaning.

Forward-looking statements are inherently subject to risks, uncertainties and assumptions; they are not guarantees of performance. You should not place undue reliance on these statements. We have based these forward-looking statements on our current expectations and projections about future events. Although we believe that our assumptions made in connection with the forward-looking statements are reasonable, we cannot assure you that the assumptions and expectations will prove to be correct.

You should understand that the following important factors could affect our future results and could cause those results or other outcomes to differ materially from those expressed or implied in our forward-looking statements:

● our expectations, projections and estimates regarding expenses, future revenue, capital requirements, incentive and other tax credit eligibility, collectability and timing and availability of and the need for additional financing;

● the results, cost and timing of our preclinical studies and clinical trials, including any delays to such clinical trials relating to enrollment or site initiation, as well as the number of required trials for regulatory approval and the criteria for success in such trials;

● our dependence on third parties in the conduct of our preclinical studies and clinical trials;

● legal and regulatory developments in the United States and foreign countries, including any actions or advice that may affect the design, initiation, timing, continuation, progress or outcome of clinical trials or result in the need for additional clinical trials;

● that the results of our preclinical studies and earlier clinical trials of our product candidates may not be predictive of future results and we may not have favorable results in our ongoing or planned clinical trials;

● the difficulties and expenses associated with obtaining and maintaining regulatory approval of our product candidates, and the indication and labeling under any such approval;

● our plans and ability to develop and commercialize our product candidates;

● the successful development of our commercialization capabilities, including sales and marketing capabilities, whether alone or with potential future collaborators;

● the size and growth of the potential markets for our product candidates, the rate and degree of market acceptance of our product candidates and our ability to serve those markets;

● the coverage and reimbursement status for our product candidates from third-party payors;

● the success of competing therapies and products that are or become available;

● our ability to limit our exposure under product liability lawsuits, shareholder class action lawsuits or other litigation;

● our ability to obtain and maintain intellectual property protection for our product candidates;

● legislative changes and recently proposed changes regarding the healthcare system, including changes and proposed changes to the Patient Protection and Affordable Care Act;

● our ability to obtain and maintain third-party manufacturing for our product candidates on commercially reasonable terms;

● delays, interruptions or failures in the manufacture and supply of our product candidates;

● the performance of third parties upon which we depend, including third-party contract research organizations, or CROs, contract manufacturing organizations, or CMOs, contractor laboratories and independent contractors;

● our ability to recruit or retain key scientific, commercial or management personnel or to retain our executive officers;

● our ability to maintain proper functionality and security of our internal computer and information systems and prevent or avoid cyberattacks, malicious intrusion, breakdown, destruction, loss of data privacy or other significant disruption;

3

● the extent to which health epidemics and other outbreaks of communicable diseases, including the ongoing COVID-19 pandemic, could disrupt our operations or materially and adversely affect our business and financial conditions;

● the extent to which inflation, global instability, including political instability, such as a deterioration in the relationship between the U.S. and China or the conflict between Russia and Ukraine, including any additional resulting sanctions, export controls or other restrictive actions that may be imposed by the U.S. and/or other countries against governmental or other entities in, for example, Russia, may disrupt our business operations and/or our financial condition; and

● the other risks, uncertainties and factors discussed in our Annual Report on Form 10-K for the fiscal year ended December 31, 2021, or our 2021 Annual Report, under the caption “Item 1A. Risk Factors”.

In light of these risks and uncertainties, expected results or other anticipated events or circumstances discussed in this Quarterly Report (including the exhibits hereto) might not occur. We undertake no obligation, and specifically decline any obligation, to publicly update or revise any forward-looking statements, even if experience or future developments make it clear that projected results expressed or implied in such statements will not be realized, except as may be required by law.

4

PART I – FINANCIAL INFORMATION

Item 1. Consolidated Financial Statements (Unaudited)

ZYNERBA PHARMACEUTICALS, INC.
CONSOLIDATED BALANCE SHEETS

(UNAUDITED)

	March 31,		December 31,
	2022		2021
Assets
Current assets:
Cash and cash equivalents	$	69,697,865	$	67,808,000
Incentive and tax receivables		1,602,831		9,580,468
Prepaid expenses and other current assets		1,930,380		2,831,392
Total current assets		73,231,076		80,219,860
Property and equipment, net		376,745		385,833
Incentive and tax receivables		264,206		—
Right-of-use assets		509,002		565,814
Total assets	$	74,381,029	$	81,171,507
Liabilities and Stockholders' Equity
Current liabilities:
Accounts payable	$	1,603,834	$	1,798,813
Accrued expenses		7,103,959		7,896,598
Lease liabilities		210,512		209,068
Total current liabilities		8,918,305		9,904,479
Lease liabilities, long-term		295,754		353,694
Total liabilities		9,214,059		10,258,173
Stockholders' equity:
Preferred stock, $0.001 par value; 10,000,000 shares authorized; no shares issued or outstanding		—		—
Common stock, $0.001 par value; 200,000,000 shares authorized; 43,324,097 shares issued and outstanding at March 31, 2022 and 41,217,537 shares issued and outstanding at December 31, 2021		43,324		41,218
Additional paid-in capital		313,095,744		310,353,595
Accumulated deficit		(247,972,098)		(239,481,479)
Total stockholders' equity		65,166,970		70,913,334
Total liabilities and stockholders' equity	$	74,381,029	$	81,171,507

See accompanying notes to unaudited consolidated financial statements.

5

ZYNERBA PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS

(UNAUDITED)

	Three months ended March 31,
	2022		2021
Operating expenses:
Research and development	$	5,146,605	$	4,609,010
General and administrative		3,757,310		3,275,797
Total operating expenses		8,903,915		7,884,807
Loss from operations		(8,903,915)		(7,884,807)
Other income (expense):
Interest income		96,044		5,633
Foreign exchange gain (loss)		317,252		(82,454)
Total other income (expense)		413,296		(76,821)
Net loss	$	(8,490,619)	$	(7,961,628)
Net loss per share basic and diluted	$	(0.21)	$	(0.20)
Basic and diluted weighted average shares outstanding		40,304,484		40,065,715

See accompanying notes to unaudited consolidated financial statements.

6

ZYNERBA PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

(UNAUDITED)

	Three months ended March 31, 2022
								Total
	Common stock			Additional		Accumulated		stockholders'
	Shares	Amount		paid-in capital		deficit		equity
Balance at December 31, 2021	41,217,537	$	41,218	$	310,353,595	$	(239,481,479)	$	70,913,334
Issuance of common stock, net of issuance costs	857,060		857		1,582,916		—		1,583,773
Issuance of restricted stock	1,249,500		1,249		(1,249)		—		—
Stock-based compensation expense	—		—		1,160,482		—		1,160,482
Net loss	—		—		—		(8,490,619)		(8,490,619)
Balance at March 31, 2022	43,324,097	$	43,324	$	313,095,744	$	(247,972,098)	$	65,166,970

	Three months ended March 31, 2021
								Total
	Common stock			Additional		Accumulated		stockholders'
	Shares	Amount		paid-in capital		deficit		equity
Balance at December 31, 2020	29,975,264	$	29,975	$	262,286,008	$	(202,172,455)	$	60,143,528
Issuance of common stock, net of issuance costs	10,244,326		10,245		42,210,099		—		42,220,344
Issuance of restricted stock	1,018,822		1,019		(1,019)		—		—
Exercise of stock options	13,125		13		47,893		—		47,906
Stock-based compensation expense	—		—		1,264,837		—		1,264,837
Net loss	—		—		—		(7,961,628)		(7,961,628)
Balance at March 31, 2021	41,251,537	$	41,252	$	305,807,818	$	(210,134,083)	$	95,714,987

See accompanying notes to unaudited consolidated financial statements.

7

ZYNERBA PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

(UNAUDITED)

	Three months ended March 31,
	2022		2021
Cash flows from operating activities:
Net loss	$	(8,490,619)	$	(7,961,628)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation		60,695		61,455
Stock-based compensation		1,160,482		1,264,837
Changes in operating assets and liabilities:
Incentive and tax receivables		7,713,431		(306,038)
Prepaid expenses and other assets		805,897		105,854
Right-of-use assets and liabilities		316		(3,957)
Accounts payable		(256,931)		(859,523)
Accrued expenses		(792,639)		(593,967)
Net cash provided by (used in) operating activities		200,632		(8,292,967)
Cash flows from investing activities:
Purchases of property and equipment		(51,607)		—
Net cash used in investing activities		(51,607)		—
Cash flows from financing activities:
Proceeds from the issuance of common stock		1,789,524		43,193,660
Payment of financing fees and expenses		(48,684)		(975,592)
Proceeds from the exercise of stock options		—		47,906
Net cash provided by financing activities		1,740,840		42,265,974
Net increase in cash and cash equivalents		1,889,865		33,973,007
Cash and cash equivalents at beginning of period		67,808,000		59,157,187
Cash and cash equivalents at end of period	$	69,697,865	$	93,130,194
Supplemental disclosures of cash flow information:
Financing costs included in accounts payable and accrued expenses at end of period	$	104,452	$	15,000
Property and equipment acquired but unpaid at end of period	$	—	$	11,055

See accompanying notes to unaudited consolidated financial statements

8

ZYNERBA PHARMACEUTICALS, INC.

NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS

(1) Nature of Business and Liquidity

Zynerba Pharmaceuticals, Inc., together with its subsidiary, Zynerba Pharmaceuticals Pty Ltd (collectively, “Zynerba,” the “Company,” or “we”), is a clinical stage specialty pharmaceutical company focused on the development of pharmaceutically-produced transdermal cannabinoid therapies for rare and near-rare neuropsychiatric disorders, including Fragile X syndrome, autism spectrum disorder and 22q11.2 deletion syndrome.

The Company has incurred losses and negative cash flows from operations since inception and has an accumulated deficit of $248.0 million as of March 31, 2022. The Company anticipates incurring additional losses until such time, if ever, that it can generate significant revenue from its product candidates currently in development. The Company's primary source of liquidity has been the issuance of equity securities.

On May 11, 2021, the Company entered into a Controlled Equity Offering^SM Sales Agreement (the “2021 Sales Agreement”) with Cantor Fitzgerald & Co., Canaccord Genuity, LLC, H.C. Wainwright & Co. LLC and Ladenburg Thalmann & Co. Inc., as sales agents (collectively, the “2021 Sales Agents”), pursuant to which the Company may sell, from time to time, up to $75.0 million of its common stock. In the first quarter of 2022, the Company sold and issued 857,060 shares of common stock under the 2021 Sales Agreement in the open market at a weighted average selling price of $2.09 per share, resulting in gross proceeds of $1.8 million. Net proceeds after deducting commissions and offering expenses were $1.6 million. From April 1, 2022 through May 11, 2022, the Company sold and issued 297,362 shares of its common stock in the open market at a weighted average selling price of $2.17 per share, for gross and net proceeds, after deducting commissions and offering expenses, of $0.6 million.

In August 2019, the Company entered into a Controlled Equity Offering^SM Sales Agreement (the “2019 Sales Agreement”) with Cantor Fitzgerald & Co., Canaccord Genuity, LLC, H.C. Wainwright & Co. LLC and Ladenburg Thalmann & Co. Inc., as sales agents (collectively, the “2019 Sales Agents”), pursuant to which the Company sold $75.0 million of its common stock. In the first quarter of 2021, the Company sold and issued 10,244,326 shares of common stock under the 2019 Sales Agreement in the open market at a weighted average selling price of $4.22 per share, resulting in gross proceeds of $43.2 million. Net proceeds after deducting commissions and offering expenses were $42.2 million. As of February 9, 2021, the Company had utilized the entire $75.0 million under the 2019 Sales Agreement.

Management believes that the Company’s cash and cash equivalents as of March 31, 2022 are sufficient to fund operations and capital requirements into the second half of 2023. Substantial additional financings will be needed by the Company to fund its operations, and to complete clinical development of and to commercially develop its product candidates. The Company’s ability to raise sufficient additional financing depends on many factors beyond its control, including the current and ongoing volatility in the capital markets as a result of, among other factors, the COVID-19 pandemic and geopolitical tensions or the outbreak of hostilities or war. There is no assurance that such financing will be available when needed or on acceptable terms.

The Company is subject to those risks associated with any clinical stage pharmaceutical company that has substantial expenditures for research and development. There can be no assurance that the Company's research and development projects will be successful, that products developed will obtain necessary regulatory approval, or that any approved product will be commercially viable. In addition, the Company operates in an environment of rapid technological change and is largely dependent on the services of its employees and consultants.

(2) Summary of Significant Accounting Policies

a. Basis of Presentation

The accompanying unaudited interim consolidated financial statements of the Company have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. The interim unaudited consolidated financial statements have been prepared on the same basis as the consolidated financial statements as of and for the year ended December 31, 2021 included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 (the “2021 Annual

9

ZYNERBA PHARMACEUTICALS, INC.

NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

Report”), filed with the Securities and Exchange Commission (the “SEC”). In the opinion of management, the accompanying consolidated financial statements of the Company include all normal and recurring adjustments (which consist primarily of accruals, estimates and assumptions that impact the consolidated financial statements) considered necessary to present fairly the Company's financial position as of March 31, 2022, its results of operations and cash flows for the three months ended March 31, 2022 and 2021. Operating results for any interim period are not necessarily indicative of results for any future interim period or for the entire year. The accompanying unaudited interim consolidated financial statements should be read in conjunction with the consolidated financial statements and related notes included in the 2021 Annual Report.

b. Use of Estimates

The preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the financial statements and reported amounts of expenses during the reporting period. Actual results could differ from such estimates.

c. Incentive and Tax Receivables

The Company’s subsidiary, Zynerba Pharmaceuticals Pty Ltd (the “Subsidiary”), is incorporated in Australia. The Subsidiary is eligible to participate in an Australian research and development tax incentive program. As part of this program, the Subsidiary is eligible to receive a cash refund from the Australian Taxation Office (“ATO”) for a percentage of the research and development costs expended by the Subsidiary in Australia. The cash refund is available to eligible companies with an annual aggregate revenue of less than $20.0 million (Australian) during the reimbursable period. The Company estimates the amount of cash refund it expects to receive related to the Australian research and development tax incentive program and records the incentives when it is probable (1) the Company will comply with relevant conditions of the program and (2) the incentive will be received. The Company evaluates its eligibility under tax incentive programs as of each balance sheet date based on the most current and relevant data available. If the Company is deemed to be ineligible or unable to receive the Australian research and development tax credit, or the Australian government significantly reduces or eliminates the tax credit, the actual cash refund the Company receives may materially differ from its estimates.

In December 2018, the Company submitted an Advance Overseas Finding (“AOF”) application to a division of the Australian Government’s Department of Industry, Innovation and Science (“AusIndustry”), for a portion of the Company’s research and development activities incurred outside of Australia, which was approved by AusIndustry in July 2019. During the year ended December 31, 2019, the Company recorded $8.3 million as an incentive and tax receivable and recorded a corresponding credit to research and development expense for amounts expected to be received through the AOF for the period January 1, 2018 through December 31, 2019. In June 2020, the ATO informed the Company that it may not qualify for the AOF program based on their interpretation of certain eligibility requirements and, during the three months ended June 30, 2020, the Company determined it was no longer probable that the AOF claim would be received and the Company recorded a full reserve against the AOF receivable.

During the three months ended March 31, 2022, the Company concluded its conversations with the ATO on these matters and made the decision to no longer pursue the AOF claim, resulting in the write off of both the AOF receivable and the corresponding reserve during the period. During the three months ended March 31, 2022, the Company received a payment of $8.0 million from the ATO for the non-AOF research and development incentive for the years ended December 31, 2018, 2019 and 2020.

The Subsidiary incurs Goods and Services Tax (“GST”) on services provided by Australian vendors. As an Australian entity, the Subsidiary is entitled to a refund of the GST paid. The Company’s estimate of the amount of cash refund it expects to receive related to GST incurred is included in “Incentive and tax receivables” in the accompanying consolidated balance sheets. As of March 31, 2022, incentive and tax receivables included $0.3 million for refundable GST on expenses incurred with Australian vendors during the three months ended March 31, 2022.

10

ZYNERBA PHARMACEUTICALS, INC.

NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

Current incentive and tax receivables consisted of the following as of March 31, 2022 and December 31, 2021:

	March 31,		December 31,
	2022		2021
Research and development incentive (non-AOF) for the period 1/1/18 - 12/31/18	$	—	$	3,144,152
Research and development incentive (non-AOF) for the period 1/1/19 - 12/31/19		—		2,914,931
Research and development incentive (non-AOF) for the period 1/1/20 - 12/31/20		—		1,993,038
Research and development incentive (non-AOF) for the period 1/1/21 - 12/31/21		1,270,293		1,226,688
Research and development incentive (AOF) for the period 1/1/18 - 12/31/19		—		8,566,843
Goods and services tax		332,538		301,659
Total incentive and tax receivables before reserve for AOF		1,602,831		18,147,311
Reserve for research and development incentive (AOF) for the period 1/1/18 - 12/31/19		—		(8,566,843)
Total incentive and tax receivables - current assets	$	1,602,831	$	9,580,468

As of March 31, 2022, the Company’s estimate of the amount of cash refund it expects to receive for 2021 eligible spending as part of this incentive program was $1.3 million and was recorded as a current asset. The Company’s estimate of the amount of cash refund it expects to receive for 2022 eligible spending through March 31, 2022 was $0.3 million and was recorded as a non-current asset.

d. Research and Development

Research and development costs are expensed as incurred and are primarily comprised of external research and development expenses incurred under arrangements with third parties, such as contract research organizations, contract manufacturing organizations, consultants and employee-related expenses including salaries and benefits. At the end of each reporting period, the Company compares the payments made to each service provider to the estimated progress towards completion of the related project. Factors that the Company considers in preparing these estimates include the number of patients enrolled in studies, milestones achieved and other criteria related to the efforts of its vendors. These estimates will be subject to change as additional information becomes available. Depending on the timing of payments to vendors and estimated services provided, the Company will record net prepaid or accrued expenses related to these costs. Research and development expenses are recorded net of expected refunds of eligible research and development costs paid pursuant to the Australian research and development tax incentive program and GST incurred on services provided by Australian vendors.

The following table summarizes research and development expenses for the three months ended March 31, 2022 and 2021:

	Three months ended March 31,
	2022		2021
Research and development expenses - before R&D incentive	$	5,404,208	$	4,949,514
Research and development incentive		(257,603)		(340,504)
Total research and development expenses	$	5,146,605	$	4,609,010

e. Net Loss Per Share

Basic net loss per share is determined using the weighted average number of shares of common stock outstanding during each period. Diluted net income per share includes the effect, if any, from the potential exercise or conversion of securities, such as restricted stock and stock options, which would result in the issuance of incremental shares of common stock. Basic and dilutive computations of net loss per share are the same in periods in which a net loss exists as the dilutive effects of restricted stock and stock options would be anti-dilutive.

11

ZYNERBA PHARMACEUTICALS, INC.

NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

The following potentially dilutive securities outstanding as of March 31, 2022 and 2021 have been excluded from the computation of diluted weighted average shares outstanding, as their effects on net loss per share for the periods presented would be anti-dilutive:

	March 31,
	2022	2021
Stock options	6,063,038	5,225,538
Unvested restricted stock	2,234,322	1,185,822
	8,297,360	6,411,360

f. Recent Accounting Pronouncements

The Company does not expect any recently issued accounting pronouncements to have a significant impact on its future results of operations, financial position or cash flow.

(3) Fair Value Measurements

The Company measures certain assets and liabilities at fair value in accordance with Accounting Standards

Codification (“ASC 820”), Fair Value Measurements and Disclosures. ASC 820 defines fair value as the price that would be received to sell an asset or paid to transfer a liability (the exit price) in an orderly transaction between market participants at the measurement date. The guidance in ASC 820 outlines a valuation framework and creates a fair value hierarchy that serves to increase the consistency and comparability of fair value measurements and the related disclosures. In determining fair value, the Company maximizes the use of quoted prices and observable inputs. Observable inputs are inputs that market participants would use in pricing the asset or liability based on market data obtained from independent sources. The fair value hierarchy is broken down into three levels based on the source of inputs as follows:

Level 1 — Valuations based on unadjusted quoted prices in active markets for identical assets or liabilities.

Level 2 — Valuations based on observable inputs and quoted prices in active markets for similar assets and liabilities.

Level 3 — Valuations based on unobservable inputs and models that are supported by little or no market activity.

In accordance with the fair value hierarchy described above, the following table sets forth the Company's financial assets measured at fair value on a recurring basis as of March 31, 2022 and December 31, 2021:

			Fair Value Measurement
	Carrying amount		as of March 31, 2022
	as of March 31, 2022		Level 1		Level 2		Level 3
Cash equivalents (money market accounts)	$	60,763,307	$	60,763,307	$	—	$	—
	$	60,763,307	$	60,763,307	$	—	$	—

			Fair Value Measurement
	Carrying amount		as of December 31, 2021
	as of December 31, 2021		Level 1		Level 2		Level 3
Cash equivalents (money market accounts)	$	67,709,279	$	67,709,279	$	—	$	—
	$	67,709,279	$	67,709,279	$	—	$	—

12

ZYNERBA PHARMACEUTICALS, INC.

NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

(4) Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consisted of the following as of March 31, 2022 and December 31, 2021:

	March 31,		December 31,
	2022		2021
Prepaid development expenses	$	520,644	$	543,897
Prepaid insurance		1,126,238		1,952,867
Deferred financing costs		42,500		137,615
Other current assets		240,998		197,013
Total prepaid expenses and other current assets	$	1,930,380	$	2,831,392

(5) Property and Equipment

Property and equipment consisted of the following as of March 31, 2022 and December 31, 2021:

	Estimated
	useful life	March 31,		December 31,
	(in years)	2022		2021
Equipment	2-5	$	740,543	$	740,543
Computer equipment	3-5		30,319		30,319
Furniture and fixtures	3-5		311,356		311,356
Leasehold improvements	various		68,881		68,881
Construction in process			130,949		79,342
Total cost			1,282,048		1,230,441
Less accumulated depreciation			(905,303)		(844,608)
Property and equipment, net		$	376,745	$	385,833

Depreciation expense was $60,695 and $61,455 for the three months ended March 31, 2022 and 2021 respectively.

(6) Accrued Expenses

Accrued expenses consisted of the following as of March 31, 2022 and December 31, 2021:

	March 31,		December 31,
	2022		2021
Accrued compensation	$	913,923	$	2,412,291
Accrued research and development		5,286,347		5,125,010
Other		903,689		359,297
Total accrued expenses	$	7,103,959	$	7,896,598

(7) Common Stock

On May 11, 2021, the Company entered into the 2021 Sales Agreement with the 2021 Sales Agents, pursuant to which the Company may sell, from time to time, up to $75.0 million of its common stock. In the first quarter of 2022, the Company sold and issued 857,060 shares of common stock under the 2021 Sales Agreement in the open market at a weighted average selling price of $2.09 per share, resulting in gross proceeds of $1.8 million. Net proceeds after deducting commissions and offering expenses were $1.6 million. From April 1, 2022 through May 11, 2022, the Company sold and issued 297,362 shares of its common stock in the open market at a weighted average selling price of $2.17 per share, for gross and net proceeds, after deducting commissions and offering expenses, of $0.6 million.

In August 2019, the Company entered into the 2019 Sales Agreement with the 2019 Sales Agents pursuant to which the Company sold $75.0 million of its common stock. In the first quarter of 2021, the Company sold and issued 10,244,326 shares of common stock under the 2019 Sales Agreement in the open market at a weighted average selling price of $4.22

13

ZYNERBA PHARMACEUTICALS, INC.

NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

per share, resulting in gross proceeds of $43.2 million. Net proceeds after deducting commissions and offering expenses were $42.2 million. As of February 9, 2021, the Company had utilized the entire $75.0 million under the 2019 Sales Agreement.

(8) Stock-Based Compensation

The Company maintains the Amended and Restated 2014 Omnibus Incentive Compensation Plan, as amended (the “2014 Plan”), which allows for the granting of incentive stock options, nonqualified stock options, stock appreciation rights, stock awards, stock units, performance units and other stock-based awards to employees, officers, non-employee directors, consultants, and advisors. In addition, the 2014 Plan provides selected executive employees with the opportunity to receive bonus awards that are considered qualified performance-based compensation. The 2014 Plan is subject to automatic annual increases in the number of shares authorized for issuance under the 2014 Plan on the first trading day of January each year equal to the lesser of 1.5 million shares or 10% of the number of shares of common stock outstanding on the last trading day of December of the preceding year. As of January 1, 2022, the number of shares of common stock that may be issued under the 2014 Plan was automatically increased by 1.5 million shares, increasing the total number of shares of common stock available for issuance under the 2014 Plan to 10,804,869 shares. As of March 31, 2022, 1,779,008 shares were available for future issuance under the 2014 Plan.

Options issued under the 2014 Plan have a contractual life of 10 years and may be exercisable in cash or as otherwise determined by the board of directors. The Company has granted options to employees and non-employee directors. Stock options granted to employees primarily vest 25% upon the first anniversary of the grant date and the balance of unvested options vests in quarterly installments over the remaining three years. Stock options granted annually to non-employee directors vest on the earlier of the one-year anniversary of the grant date, or the date of the Company’s next annual stockholders’ meeting that occurs after the grant date. The Company’s non-employee director compensation policy enables directors to receive stock options in lieu of quarterly cash payments. Any option granted to the directors in lieu of cash compensation vests in full on the grant date. The Company records forfeitures as they occur.

Stock-based compensation expense for performance-based grants are recorded when management estimates that the vesting of these shares is probable based on the status of the Company’s research and development programs and other relevant factors, which were established by the Company’s board of directors. The Company’s board of directors determines if the performance conditions have been met.

During the three months ended March 31, 2021, the Company granted 506,911 time-based restricted stock awards to employees with two-year cliff vesting of which 469,911 restricted stock awards remained outstanding as of March 31, 2022. In addition, during the three months ended March 31, 2021, the Company granted 506,911 performance-based restricted stock awards to employees of which 469,911 restricted stock awards remained outstanding as of March 31, 2022. The performance-based conditions for these performance-based grants were deemed probable of achievement and, as of March 31, 2022, the Company has recorded $1.5 million in stock-based compensation expense related to these grants. As of March 31, 2022, there was $0.2 million of unrecognized stock-based compensation expense related to these performance-based awards, which will be expensed over the estimated service period related to each performance condition.

During the three months ended March 31, 2022, the Company granted 693,000 time-based restricted stock awards to employees and consultants. In addition, during the three months ended March 31, 2022, the Company granted 556,500 performance-based restricted stock awards to employees. As of March 31, 2022, none of the performance-based metrics were deemed probable of achievement.

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ZYNERBA PHARMACEUTICALS, INC.

NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

For the three months ended March 31, 2022 and 2021, the Company recorded stock-based compensation expense related to its stock option grants and restricted stock awards, as follows:

	Stock Option Grants				Restricted stock awards				Total
	2022		2021		2022		2021		2022			2021
Research and development	$	261,402	$	432,930	$	268,094	$	186,461	$	529,496	$	619,391
General and administrative		317,424		512,436		313,562		133,010		630,986		645,446
	$	578,826	$	945,366	$	581,656	$	319,471	$	1,160,482	$	1,264,837

The following table summarizes the Company’s stock option activity for the three months ended March 31, 2022:

		Weighted-		Weighted-
		Average		Average	Aggregate
	Number	Exercise		Contractual	Intrinsic
	of Shares	Price		Life (in Years)	Value
Outstanding as of December 31, 2021	5,224,913	$	8.74
Granted	903,750		2.47
Forfeited	(65,625)		12.82
Outstanding as of March 31, 2022	6,063,038		7.76	6.55	$	—
Exercisable as of March 31, 2022	3,998,496		9.98	5.30	$	—
Vested and expected to vest as of March 31, 2022	6,063,038	$	7.76

The weighted-average grant date fair values of options granted during the three months ended March 31, 2022 and 2021 were $1.99 and $2.79, respectively.

The fair values of stock options granted were calculated using the Black-Scholes option pricing model with the following weighted-average assumptions:

	Three months ended March 31,
	2022	2021
Weighted-average risk-free interest rate	1.63%	0.36%
Expected term of options (in years)	6.25	6.25
Expected stock price volatility	101.37%	95.60%
Expected dividend yield	0%	0%

As of March 31, 2022, there was $4.9 million of unrecognized stock-based compensation expense related to stock options, which is expected to be recognized over a weighted-average period of 2.78 years. During the three months ended March 31, 2021, the Company received $47,906 in cash from the exercise of employee stock options.

The following table summarizes the Company’s restricted stock award activity under the 2014 Plan for the three months ended March 31, 2022:

		Weighted
		Average		Aggregate
		Grant Date		Intrinsic
	Shares	Fair Value		Value
Unvested as of December 31, 2021	989,822	$	3.62
Granted	1,249,500		2.42
Vested	(5,000)		4.91
Unvested as of March 31, 2022	2,234,322	$	2.95	$	4,580,360
Expected to vest as of March 31, 2022	1,672,822	$	3.12	$	3,429,285

As of March 31, 2022, excluding performance-based restricted stock awards that have not been deemed probable, there was $2.4 million of unrecognized stock-based compensation expense related to unvested restricted stock awards, which is expected to be recognized over a weighted-average period of 0.78 years.

15

ZYNERBA PHARMACEUTICALS, INC.

NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

(9) Operating Lease Obligations

The Company adopted Accounting Standards Update No. 2016-02, Leases (Topic 842), Accounting Standards Codification 842 prospectively using the modified-retrospective method and elected the package of transition practical expedients that does not require reassessment of: (1) whether any existing or expired contracts are or contain leases, (2) lease classification and (3) initial direct costs. In addition, the Company has elected other available practical expedients to not separate lease and nonlease components, which consist principally of common area maintenance charges, and to exclude leases with an initial term of 12 months or less.

The Company leases its headquarters where it occupies 10,877 square feet of office space. On March 1, 2021, the Company extended its lease for three additional years until May 31, 2024. The Company’s lease contains variable lease costs that do not depend on a rate or index and consist primarily of common area maintenance, taxes, and insurance charges. As the implicit rate was not readily determinable for the Company’s lease, the Company used an estimated incremental borrowing rate, or discount rate, to determine the initial present value of the lease payments. The discount rate for the lease was calculated using a synthetic credit rating model.

As of March 1, 2021, the effective date of the lease modification, the Company remeasured the lease liability for the remaining portion of the lease and adjusted the lease liability to $755,085 and right-of-use assets to $752,391, which was recorded net of a deferred rent liability of $2,694. As of March 31, 2022, the Company’s right-of-use asset, net of amortization, was $509,002.

Other operating lease information as of March 31, 2022:

Weighted-average remaining lease term - operating leases	2.2	years
Weighted-average discount rate - operating leases	2.76	%

The following is a maturity analysis of the annual undiscounted cash flows of the operating lease liabilities as of March 31, 2022:

	March 31,
Year ending:	2022
December 31, 2022	$	180,315
December 31, 2023		240,421
December 31, 2024		100,175
Total minimum lease payments		520,911
Less: imputed lease interest		(14,645)
Total lease liabilities	$	506,266

Lease expense for the three months ended March 31, 2022 was comprised of the following:

	Three months ended March 31,
		2022		2021
Operating lease expense	$	60,421	$	62,946
Variable lease expense		17,602		16,841
Total lease expense	$	78,023	$	79,787

Total cash payments related to leases were $77,707 and $83,744 for the three months ended March 31, 2022 and 2021, respectively.

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Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations

You should read the following discussion and analysis of our financial condition and results of operations together with our unaudited interim consolidated financial statements and related notes appearing elsewhere in this Quarterly Report and the audited consolidated financial statements and notes thereto for the year ended December 31, 2021 and the related Management’s Discussion and Analysis of Financial Condition and Results of Operations, both of which are contained in our 2021 Annual Report. The following discussion contains forward-looking statements that involve risks, uncertainties and assumptions. Our actual results and the timing of certain events could differ materially from those anticipated in these forward-looking statements as a result of many factors. We discuss factors that we believe could cause or contribute to these differences below and elsewhere in this Quarterly Report, including those set forth under “Cautionary Note Regarding Forward-looking Statements” and “Risk Factors” in this Quarterly Report and our 2021 Annual Report.

Overview

Company Overview

We are the leader in pharmaceutically-produced transdermal cannabinoid therapies for rare and near-rare neuropsychiatric disorders. We are committed to improving the lives of patients and their families living with severe, chronic health conditions including Fragile X syndrome, or FXS, autism spectrum disorder, or ASD, and 22q11.2 deletion syndrome, or 22q.

Cannabinoids are a class of compounds derived from Cannabis plants. The two primary cannabinoids contained in Cannabis are cannabidiol and tetrahydrocannabinol, or THC. Clinical and preclinical data suggest that cannabidiol may have positive effects on treating behavioral symptoms of FXS, ASD and 22q.

We are currently developing Zygel, the first and only pharmaceutically-produced cannabidiol formulated as a permeation-enhanced gel for transdermal delivery and manufactured without the presence of THC, which is patent protected through 2030. Five additional patents expiring in 2038 are directed to methods of use relating to Zygel, including methods of treating FXS and ASD.

In preclinical animal studies, Zygel’s permeation enhancer increased delivery of cannabidiol through the layers of the skin and into the circulatory system. These preclinical studies suggest increased bioavailability, consistent plasma levels and the avoidance of first-pass liver metabolism of cannabidiol when delivered transdermally. In addition, an in vitro study published in Cannabis and Cannabinoid Research in April 2016 demonstrated that cannabidiol is degraded to THC (the major psychoactive cannabinoid in Cannabis) in an acidic environment such as the stomach. As a result, we believe such degradation may lead to increased psychoactive effects if cannabidiol is delivered orally. These effects may be avoided with the transdermal delivery of Zygel, which maintains cannabidiol in a neutral pH.

Zygel is being developed as a clear gel and is targeting treatment of behavioral symptoms of FXS, ASD and 22q. We have received orphan drug designations from the United States Food and Drug Administration, or FDA, for cannabidiol, the active ingredient in Zygel, for the treatment of FXS and 22q. During the first quarter of 2022, we received orphan drug designation from the European Commission for cannabidiol, the active ingredient in Zygel, for the treatment of FXS. In May 2019, we received Fast Track designation from the FDA for treatment of behavioral symptoms associated with FXS. The FDA’s Fast Track program is designed to facilitate the development of drugs intended to treat serious conditions and fill unmet medical needs and can lead to expedited review by the FDA in order to get new important drugs to the patient earlier.

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Clinical Development Programs

Our clinical programs for Zygel include ongoing and planned clinical trials evaluating Zygel in the treatment of behavioral symptoms of FXS, ASD and 22q.

* FDA Orphan Drug and Fast Track designations; EU Orphan Drug designation

** FDA Orphan Drug designation

As of May 9, 2022, the Zygel safety database across all clinical studies conducted by us includes data from 916 volunteers and patients. Across these clinical studies, Zygel has been well-tolerated with a safety profile that has been consistent across our Phase 2 and Phase 3 clinical trials.

FXS

CONNECT-FX Trial

In June 2020, we announced results of our CONNECT-FX clinical trial, a multi-national randomized, double-blind, placebo-controlled, 14-week study designed to assess the efficacy and safety of Zygel in children and adolescents ages three through 17 years who have full mutation of the FMR1 gene. While Zygel did not achieve statistical significance versus placebo in the primary endpoint of improvement in the Social Avoidance subscale of the Aberrant Behavior Checklist – Community FXS, or ABC-C_FXS, a pre-planned ad hoc analysis of the most severely impacted patients in the trial, as defined by patients having at least 90% methylation (“highly methylated”) of the impacted FMR1 gene, demonstrated that those patients receiving Zygel achieved statistical significance in the primary endpoint of improvement at 12 weeks of treatment in the Social Avoidance subscale of the ABC-C_FXS compared to placebo. We performed a subsequent analysis of the CONNECT-FX population within those patients having 100% or complete methylation of the impacted FMR1 gene, which demonstrated that these patients having complete methylation and receiving Zygel similarly achieved statistical significance in the primary endpoint of improvement at 12 weeks of treatment in the Social Avoidance subscale of the ABC-C_FXS compared to placebo.

RECONNECT Trial

In September 2021, we announced that we had initiated our RECONNECT (A Randomized, Double-Blind, Placebo-Controlled, Multiple-Center, Efficacy and Safety Study of ZYN002 Administered as a Transdermal Gel to Children and Adolescents with Fragile X Syndrome) trial, a pivotal, multi-national, confirmatory Phase 3 trial of Zygel in patients with FXS. The trial is designed to confirm the positive results observed in a population of responders in our CONNECT-FX trial.

RECONNECT is an 18-week trial that is expected to enroll approximately 200 children and adolescents, aged three through 17 years, at approximately 25 clinical sites in the United States, Australia, the United Kingdom and Ireland. Approximately 160 of the patients enrolled will have complete (100%) methylation of their FMR1 gene and

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approximately 40 patients will have partial methylation of their FMR1 gene. Patients will be randomized 1:1 to either Zygel or placebo. Randomization will be stratified by gender, methylation status and weight.

The primary endpoint for the trial will be the change from baseline to the end of the treatment period in the ABC-C_FXS Social Avoidance subscale in patients who have complete methylation of their FMR1 gene. The ABC-C_FXS Social Avoidance subscale is the same primary endpoint used in the CONNECT-FX trial.

Key secondary efficacy endpoints include: (i) the change from baseline to the end of the treatment period in the ABC-C_FXS Irritability subscale in patients who have complete methylation of their FMR1 gene; (ii) the percent of patients with any improvement on the Caregiver Global Impression of Change, or CaGI-C, at the end of the treatment period for Social Interactions among patients with complete methylation of the FMR1 gene; (iii) the percent of patients rated as improved on the Clinical Global Impression- Improvement, or CGI-I, scale among patients with complete methylation (100%) of the FMR1 gene; and (iv) the change from baseline to the end of the treatment period in the ABC-C_FXS Social Avoidance subscale among all randomized patients (complete and partial methylation of the FMR1 gene).

Top-line results for the RECONNECT trial are expected in the second half of 2023. All patients who complete dosing in the RECONNECT trial will be eligible to enroll in our ongoing open-label extension trial.

ASD

Phase 2 BRIGHT Trial

In May 2020, we reported positive top-line results of our Phase 2 BRIGHT clinical trial, a 14-week, open-label clinical trial designed to assess the safety, tolerability and efficacy of Zygel for the treatment of pediatric and adolescent patients with ASD. Patients treated with Zygel demonstrated statistically significant improvement at week 14 compared to baseline for each Aberrant Behavior Checklist – Community, or ABC-C, subscale (Irritability, Inappropriate Speech, Stereotypy, Social Withdrawal and Hyperactivity). The results of the other efficacy assessments were consistent with the results demonstrated in the ABC-C. In September 2021, we reported additional safety and efficacy data from our BRIGHT trial for the 18 patients that continued from week 14 through a longer term, 38-week treatment period, which we refer to as Period 2. In the 18 patients who completed treatment through the 38-week treatment period, statistically significant improvements compared to baseline were sustained in all efficacy measures.

Phase 3 Program

We plan to advance our clinical program in ASD with two Phase 3 trials, the first of which is expected to start in the second half of 2022. We are finalizing the Phase 3 trial protocol and will submit an Investigational New Drug application to the FDA prior to commencing the pivotal program. In 2021, we received guidance from the FDA that included an agreement on utilizing the irritability subscale of the ABC-C as the primary endpoint to support an indication for the treatment of irritability in ASD. This is the same endpoint that was utilized in the BRIGHT trial and the same primary endpoint utilized in the pivotal trials for the two existing FDA approved treatments for ASD.

22q

Phase 2 INSPIRE Trial

In May 2019, we initiated our open-label Phase 2 INSPIRE clinical trial, a 14-week, open-label clinical trial designed to assess the safety, tolerability and efficacy of Zygel for treatment of behavioral symptoms of 22q. Recruitment into the INSPIRE trial had been delayed due to the impact of COVID-19 and resulting significant travel restrictions in Australia and, in the fourth quarter of 2021, we added an additional U.S. clinical trial site to the INSPIRE trial to assist in the completion of enrollment. In February 2022, we announced that we have completed enrollment of the INSPIRE trial, consisting of 20 patients (ages four through 15), and we expect to have top-line data by mid-year 2022. We plan to move forward with 22q as an orphan designated indication, subject to results from the INSPIRE trial and subsequent discussion with the FDA on the regulatory path forward.

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Impact of COVID-19

We continue to closely monitor the status of the COVID-19 pandemic, including its potential impact on our clinical development plans, patient recruitment and overall clinical trial timelines going forward. In response to the impact of COVID-19, for our current clinical development programs, we implemented multiple measures consistent with the FDA’s guidance on the conduct of clinical trials of medical products during the COVID-19 pandemic, including remote site monitoring and patient visits using telemedicine where needed and appropriate, direct-to-patient drug shipments and local study-related clinical laboratory collection.

Operations

We have never been profitable and have incurred net losses since inception. Our net losses were $8.5 million and $8.0 million for the three months ended March 31, 2022 and 2021, respectively. As of March 31, 2022, our accumulated deficit was $248.0 million. We expect to incur losses for the foreseeable future, and we expect these losses to increase as we continue our development of, and seek regulatory approvals for, our product candidates. Because of the numerous risks and uncertainties associated with product development, we are unable to predict the timing or amount of increased expenses or when, or if, we will be able to achieve or maintain profitability.

Financial Operations Overview

The following discussion sets forth certain components of our consolidated statements of operations as well as factors that impact those items.

Research and Development Expenses 

Our research and development expenses relating to our product candidates consisted of the following:

● expenses associated with preclinical development and clinical trials;

● personnel-related expenses, such as salaries, benefits, travel and other related expenses, including stock-based compensation;

● payments to third-party CROs, CMOs, contractor laboratories and independent contractors; and

● depreciation, maintenance and other facility-related expenses.

We expense all research and development costs as incurred. Clinical development expenses for our product candidates are a significant component of our current research and development expenses. Generally, expenses associated with clinical trials will increase as our clinical trials progress. Product candidates in later stage clinical development generally have higher research and development expenses than those in earlier stages of development, primarily due to increased size and duration of the clinical trials. We track and record information regarding external research and development expenses for each grant, study or trial that we conduct. We use third-party CROs, CMOs, contractor laboratories and independent contractors in preclinical studies and clinical trials. We recognize the expenses associated with third parties performing these services for us in our preclinical studies and clinical trials based on the percentage of each study completed at the end of each reporting period.

Our Australian subsidiary, Zynerba Pharmaceuticals Pty Ltd, or the Subsidiary, is incorporated in Australia and is eligible to participate in an Australian research and development tax incentive program. As part of this program, the Subsidiary is eligible to receive a cash refund from the Australian Taxation Office, or the ATO, for a percentage of the research and development costs expended by the Subsidiary in Australia. The cash refund is available to eligible companies with an annual aggregate revenue of less than $20.0 million (Australian dollars) during the reimbursable period. We estimate the amount of cash refund we expect to receive related to the Australian research and development tax incentive program and record the incentives when it is probable (1) we will comply with relevant conditions of the program and (2) the incentive will be received. We evaluate the Subsidiary’s eligibility under tax incentive programs as of each balance sheet date based on the most current and relevant data available. If the Subsidiary is deemed to be ineligible or unable to receive the Australian research and development tax credit, or the Australian government

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significantly reduces or eliminates the tax credit, the actual cash refund we receive may materially differ from our estimates.

The following table summarizes research and development expenses for the three months ended March 31, 2022 and 2021:

	Three months ended March 31,
	2022		2021
Research and development expenses - before R&D incentive	$	5,404,208	$	4,949,514
Research and development incentive		(257,603)		(340,504)
Total research and development expenses	$	5,146,605	$	4,609,010

We expect research and development expenses to increase for the year ending December 31, 2022 as compared to 2021, as we continue to conduct our RECONNECT and INSPIRE clinical trials for FXS and 22q, respectively, and initiate our Phase 3 clinical program for ASD in the second half of 2022. These expenditures are subject to numerous uncertainties regarding timing and cost to completion. Completion of our preclinical development and clinical trials may take several years or more and the length of time generally varies according to the type, complexity, novelty and intended use of a product candidate. The cost of clinical trials may vary significantly over the life of a project as a result of differences arising during clinical development, including, among others:

● the number of sites included in the clinical trials;

● the length of time required to enroll suitable patients;

● the size of patient populations participating in the clinical trials;

● the duration of patient follow-ups;

● the development stage of the product candidates; and

● the efficacy and safety profile of the product candidates.

Due to the early stages of our research and development, we are unable to determine the duration or completion costs of our development of our product candidates. As a result of the difficulties of forecasting research and development costs of our product candidates as well as the other uncertainties discussed above, we are unable to determine when and to what extent we will generate revenue from the commercialization and sale of an approved product candidate.

General and Administrative Expenses 

General and administrative expenses consist primarily of salaries, benefits and other related costs, including stock-based compensation, for personnel serving in our executive, finance, legal, human resource, investor relations and commercial functions. Our general and administrative expenses also include facility and related costs not included in research and development expenses, professional fees for legal services, including patent-related expenses, litigation settlement expenses, consulting, tax and accounting services, insurance, market research and general corporate expenses. We expect that our general and administrative expenses will increase for the next several years as we increase our headcount with the continued development and potential commercialization of our product candidates.

Interest Income

Interest income primarily consists of interest earned on balances maintained in our money market bank account. 

Foreign Exchange Gain (Loss)

Foreign exchange gain (loss) relates to the effect of exchange rates on transactions incurred by the Subsidiary.

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Critical Accounting Estimates

Our management’s discussion and analysis of our financial condition and results of operations is based on our consolidated financial statements, which have been prepared in accordance with U.S. generally accepted accounting principles, or GAAP. The preparation of these financial statements requires us to make estimates and judgments that affect the reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reported period. In accordance with GAAP, we base our estimates on historical experience, known trends and events and various other factors that we believe to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying amounts of assets and liabilities that are not readily apparent from other sources. Actual results may differ from these estimates under different assumptions or conditions.

We define our critical accounting policies as those that require us to make subjective estimates and judgments about matters that are uncertain and are likely to have a material impact on our financial condition and results of operations as well as the specific manner in which we apply those principles. Critical accounting estimates and the accounting policies critical to the process of making significant judgments and estimates in the preparation of our consolidated financial statements are discussed in our 2021 Annual Report under Part II, Item 7, “Critical Accounting Policies and Use of Estimates.” During the three months ended March 31, 2022, there have been no material changes to the critical accounting estimates or critical accounting policies discussed in our 2021 Annual Report.

Results of Operations

Comparison of the Three Months Ended March 31, 2022 and 2021

Research and Development Expenses

Research and development expenses increased by $0.5 million, or 12%, to $5.1 million for the three months ended March 31, 2022 from $4.6 million for the three months ended March 31, 2021. The increase was primarily related to increases in manufacturing costs associated with our Zygel program and a reduction in the non-AOF Australian research and development incentive.

General and Administrative Expenses

General and administrative expenses increased by $0.5 million, or 15%, to $3.8 million for the three months ended March 31, 2022 from $3.3 million for the three months ended March 31, 2021. The increase was primarily related to higher employee-related costs, including recruiting fees and increased directors’ and officers’ liability insurance costs.

Other Income (Expense)

During the three months ended March 31, 2022 and 2021, we recognized $0.1 million and $5,633, respectively, in interest income. The increase in interest income was primarily related to interest income received from the ATO for the payment of prior year’s non-AOF research and development incentives. During the three months ended March 31, 2022 and 2021, we recognized a foreign currency gain of $0.3 million and a foreign currency loss of $0.1 million, respectively. Foreign currency gains and losses are due primarily to the remeasurement of the Subsidiary’s assets and liabilities, which are denominated in the local currency to the Subsidiary’s functional currency, which is the U.S. dollar.

Liquidity and Capital Resources

Since our inception in 2007, we have devoted most of our cash resources to research and development and general and administrative activities. We have financed our operations primarily with the proceeds from the issuance and sale of equity securities (most notably our initial public offering, our follow-on public offerings and sales under our “at-the-market” offerings) and convertible promissory notes, state and federal grants and research services.

To date, we have not generated any revenue from the sale of products, and we do not anticipate generating any revenue from the sales of products for the foreseeable future. We have incurred losses and generated negative cash flows from operations since inception. As of March 31, 2022, our principal sources of liquidity were our cash and cash equivalents of $69.7 million. Our working capital was $64.3 million as of March 31, 2022.

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Management believes that cash and cash equivalents as of March 31, 2022 are sufficient to fund operations and capital requirements into the second half of 2023. The economic effects of the COVID-19 pandemic remain fluid and management will continue to closely monitor the situation to ensure our cash and cash equivalents will help us manage the impact of the COVID-19 pandemic on our business and related liquidity needs. Substantial additional financings will be needed to fund our operations and to complete clinical development of and to commercially develop our product candidates. There is no assurance that such financing will be available when needed or on acceptable terms. Our ability to access the capital markets or otherwise raise such capital may be adversely impacted by global economic conditions and the disruptions to, and volatility in, financial markets in the United States and worldwide resulting from, among other factors, the ongoing COVID-19 pandemic and geopolitical tensions or the outbreak of hostilities or war.

Equity Financings

On May 11, 2021, we entered into a Controlled Equity Offering^SM Sales Agreement, or the 2021 Sales Agreement, with Cantor Fitzgerald & Co., Canaccord Genuity, LLC, H.C. Wainwright & Co. LLC and Ladenburg Thalmann & Co. Inc., as sales agents, pursuant to which we may sell, from time to time, up to $75.0 million of our common stock. In the first quarter of 2022, we sold and issued 857,060 shares of common stock under the 2021 Sales Agreement in the open market at a weighted average selling price of $2.09 per share, resulting in gross proceeds of $1.8 million. Net proceeds after deducting commissions and offering expenses were $1.6 million. From April 1, 2022 through May 11, 2022, we sold and issued 297,362 shares of its common stock in the open market at a weighted average selling price of $2.17 per share, for gross and net proceeds, after deducting commissions and offering expenses, of $0.6.

Debt

We had no debt outstanding as of March 31, 2022 or December 31, 2021.

Future Capital Requirements

During the three months ended March 31, 2022, net cash provided by operating activities was $0.2 million, and our accumulated deficit as of March 31, 2022 was $248.0 million. Our expectations regarding future cash requirements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures or investments that we may make in the future. To the extent that we enter into any of those types of transactions, we may need to raise substantial additional capital.

We expect to continue to incur substantial additional operating losses for at least the next several years as we continue to develop our product candidates and seek marketing approval and, subject to obtaining such approval, the eventual commercialization of our product candidates. If we obtain marketing approval for any of our product candidates, we will incur significant sales, marketing and manufacturing expenses. In addition, we expect to incur additional expenses to add operational, financial and information systems and personnel, including personnel to support our planned product commercialization efforts. We also expect to continue to incur significant costs to comply with corporate governance, internal controls and similar requirements associated with operating as a public reporting company.

Our future use of operating cash and capital requirements will depend on many forward-looking factors, including the following:

● the initiation, progress, timing, costs and results of preclinical studies and clinical trials for our product candidates;

● the clinical development plans we establish for these product candidates;

● the number and characteristics of product candidates that we may develop or in-license;

● the terms of any collaboration agreements we may choose to execute;

● the outcome, timing and cost of meeting regulatory requirements established by the FDA, the European Medicines Agency or other comparable foreign regulatory authorities;

23

● the cost of filing, prosecuting, defending and enforcing our patent claims and other intellectual property rights;

● the cost of defending intellectual property disputes, including patent infringement actions brought by third parties against us;

● costs and timing of the implementation of commercial scale manufacturing activities;

● the cost of establishing, or outsourcing, sales, marketing and distribution capabilities for any product candidates for which we may receive regulatory approval in regions where we choose to independently commercialize our products;

● the extent to which health epidemics and other outbreaks of communicable diseases, including the ongoing COVID-19 pandemic, could disrupt our operations or materially and adversely affect our business and financial conditions; and

● the timing and outcome of the ATO’s review regarding our eligibility to receive tax credits related to the research and development tax incentive program.

To the extent that our capital resources are insufficient to meet our future operating and capital requirements, we will need to finance our cash needs through public or private equity offerings, debt financings, collaboration and licensing arrangements or other financing alternatives. We have no committed external sources of funds. Additional equity or debt financing or collaboration and licensing arrangements may not be available on acceptable terms, if at all.

If we raise additional funds by issuing equity securities, including through the 2021 Sales Agreement, our stockholders will experience dilution.

Cash Flows

The following table summarizes our cash flows from operating, investing and financing activities for the three months ended March 31, 2022 and 2021.

	Three Months Ended March 31,
	2022		2021
Statement of Cash Flows Data:
Total net cash provided by (used in):
Operating activities	$	200,632	$	(8,292,967)
Investing activities		(51,607)		—
Financing activities		1,740,840		42,265,974
Net increase in cash and cash equivalents	$	1,889,865	$	33,973,007

Operating Activities

For the three months ended March 31, 2022, cash provided by operating activities was $0.2 million compared to $8.3 million of cash used in operating activities for the three months ended March 31, 2021. The change from the comparable 2021 period was primarily due to the Company receiving payment of $8.0 million from the ATO for the non-AOF research and development incentive for the years ended December 31, 2018, 2019 and 2020. Our cash flows used in operations may differ substantially from our net loss due to non-cash charges and changes in balance sheet accounts.

Excluding the $8.0 million of cash received from the ATO in 2022, we expect cash used in operating activities to increase for the year ending December 31, 2022 as compared to 2021, as we continue to conduct our RECONNECT and INSPIRE clinical trials for FXS and 22q, respectively, and initiate our Phase 3 clinical program in ASD in the second half of 2022.

Investing Activities

For the three months ended March 31, 2022, cash used in investing activities represented the cost of expenditures made for manufacturing equipment.

24

Financing Activities

Cash provided by financing activities for the three months ended March 31, 2022 consisted of $1.7 million in net proceeds from sales of our shares of common stock under the 2021 Sales Agreement. Cash provided by financing activities for the three months ended March 31, 2021 consisted of $42.2 million in net proceeds from sales of our shares of common stock under the 2019 Sales Agreement.

Off-Balance Sheet Arrangements

We do not have any off-balance sheet arrangements or relationships with unconsolidated entities or financial partnerships, such as entities often referred to as structured finance or special purpose entities.

Recently Adopted Accounting Pronouncements

For descriptions of recently issued accounting pronouncements, see “Note 2 –Recent Accounting Pronouncements” of our Notes to Unaudited Consolidated Financial Statements included above in Part I of this Quarterly Report.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

We are exposed to various market risks, which may result in potential losses arising from adverse changes in market rates, such as interest rates and foreign exchange rates. We do not enter into derivatives or other financial instruments for trading or speculative purposes nor do we engage in any hedging activities. As of March 31, 2022, we had cash and cash equivalents of $69.7 million, consisting primarily of cash and money market account balances. Because of the short-term maturities of our cash and cash equivalents, we do not believe that an immediate 10% increase in interest rates would have any significant impact on the realized value of our investments. Accordingly, we do not believe we are exposed to material market risk with respect to our cash and cash equivalents.

We have engaged third parties to manufacture our product candidates in Australia, Canada and the United Kingdom and to conduct clinical trials for our product candidates in the United States, Australia and New Zealand. Manufacturing and research costs related to these operations are paid for in a combination of U.S. dollars and local currencies, limiting our foreign currency exchange rate risk, however, our financial statements are reported in U.S. dollars and changes in foreign currency exchange rates could significantly affect our financial condition, results of operations, or cash flows. If we conduct clinical trials and seek to manufacture a more significant portion of our product candidates outside of the United States in the future, we could incur significant foreign currency exchange rate risk.

Item 4. Controls and Procedures.

Evaluation of Disclosure Controls and Procedures

Our management, with the participation of our Chief Executive Officer and Chief Financial Officer, evaluated the effectiveness of our disclosure controls and procedures as of March 31, 2022. The term “disclosure controls and procedures,” as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended, or the Exchange Act, means controls and other procedures of a company that are designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the rules and forms, promulgated by the Securities and Exchange Commission. Management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving their objectives and management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures. Based on the evaluation of the effectiveness of the design and operation of our disclosure controls and procedures as of March 31, 2022, our Chief Executive Officer and Chief Financial Officer concluded that, as of such date, our disclosure controls and procedures were effective at the reasonable assurance level.

Changes in Internal Control Over Financial Reporting

There were no changes in our internal control over financial reporting during the three months ended March 31, 2022 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

25

PART II—OTHER INFORMATION

Item 1. Legal Proceedings.

We may become engaged in legal actions arising in the ordinary course of our business (such as, for example, proceedings relating to employment matters or the initiation or defense of proceedings relating to intellectual property rights) from time to time and, while there can be no assurance, we believe that the ultimate outcome of these legal actions will not have a material adverse effect on our business, results of operations, financial condition or cash flows.

Item 1A. Risk Factors.

You should carefully consider the risk factors described in our 2021 Annual Report under the caption “Item 1A. “Risk Factors.” There have been no material changes in our risk factors included in our 2021 Annual Report. The risks described in our 2021 Annual Report are not the only risks facing our company. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially adversely affect our business, financial condition or future results.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.

Recent Sales of Unregistered Securities

None.

Purchase of Equity Securities

We did not purchase any of our registered equity securities during the period covered by this Quarterly Report.

Item 3. Defaults Upon Senior Securities.

None.

Item 4. Mine Safety Disclosures.

Not applicable.

Item 5. Other Information.

Not applicable.

26

Item 6. Exhibits.

The following exhibits are being filed herewith:

EXHIBIT INDEX

Exhibit No.	Exhibit
31.1	Certification of Chief Executive Officer pursuant to Rules 13a-14(a) or 15d-14(a) of the Securities Exchange Act of 1934, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (filed herewith).
31.2	Certification of Chief Financial Officer pursuant to Rules 13a-14(a) or 15d-14(a) of the Securities Exchange Act of 1934, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (filed herewith).
32.1	Certification of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (furnished herewith).
32.2	Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (furnished herewith).
101 INS	Inline XBRL Document (filed herewith).
101 SCH	Inline XBRL Taxonomy Extension Schema (filed herewith).
101 CAL	Inline XBRL Taxonomy Extension Schema Calculation Linkbase (filed herewith).
101 DEF	Inline XBRL Taxonomy Extension Schema Definition Linkbase (filed herewith).
101 LAB	Inline XBRL Taxonomy Extension Schema Label Linkbase (filed herewith).
101 PRE	Inline XBRL Taxonomy Extension Schema Presentation Linkbase (filed herewith).
104	Cover Page Interactive Data File (formatted as Inline XBRL and contained in exhibit 101)

27

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	ZYNERBA PHARMACEUTICALS, INC.
Date: May 16, 2022	By:	/s/ ARMANDO ANIDO
		Armando Anido
		Chief Executive Officer
		(Principal Executive Officer)
Date: May 16, 2022	By:	/s/ JAMES E. FICKENSCHER
		James E. Fickenscher
		Chief Financial Officer
		(Principal Financial and Accounting Officer)

28

EX-31.1

Exhibit 31.1

CERTIFICATION

I, Armando Anido, certify that:

1. I have reviewed this quarterly report on Form 10-Q of Zynerba Pharmaceuticals, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

By: /s/ Armando Anido

Name: Armando Anido

Title: Chairman and Chief Executive Officer

Dated: May 16, 2022

EX-31.2

Exhibit 31.2

CERTIFICATION

I, James E. Fickenscher, certify that:

1. I have reviewed this quarterly report on Form 10-Q of Zynerba Pharmaceuticals, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

By: /s/ James E. Fickenscher

Name: James E. Fickenscher

Title: Chief Financial Officer

Dated: May 16, 2022

EX-32.1

Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the quarterly report of Zynerba Pharmaceuticals, Inc. (the “Company”) on Form 10-Q for the fiscal quarter ended March 31, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Armando Anido, Chairman and Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

/s/ Armando Anido

Armando Anido

Chairman and Chief Executive Officer

Dated: May 16, 2022

EX-32.2

Exhibit 32.2

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the quarterly report of Zynerba Pharmaceuticals, Inc. (the “Company”) on Form 10-Q for the fiscal quarter ended March 31, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, James E. Fickenscher, Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

/s/ James E. Fickenscher

James E. Fickenscher

Chief Financial Officer

Dated: May 16, 2022

XML

Document and Entity Information - shares	3 Months Ended
	Mar. 31, 2022	May 11, 2022
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Transition Report	false
Document Period End Date	Mar. 31, 2022
Entity File Number	001-37526
Entity Registrant Name	Zynerba Pharmaceuticals, Inc.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	26-0389433
Entity Address, Address Line One	80 W. Lancaster Avenue
Entity Address, Address Line Two	Suite 300
Entity Address, City or Town	Devon
Entity Address, State or Province	PA
Entity Address, Postal Zip Code	19333
City Area Code	484
Local Phone Number	581-7505
Title of 12(b) Security	Common Stock, $0.001 par value per share
Trading Symbol	ZYNE
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		43,595,959
Entity Central Index Key	0001621443
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q1
Amendment Flag	false

XML

CONSOLIDATED BALANCE SHEETS - USD ($)	Mar. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 69,697,865	$ 67,808,000
Incentive and tax receivables	1,602,831	9,580,468
Prepaid expenses and other current assets	1,930,380	2,831,392
Total current assets	73,231,076	80,219,860
Property and equipment, net	376,745	385,833
Incentive and tax receivables	264,206
Right-of-use assets	509,002	565,814
Total assets	74,381,029	81,171,507
Current liabilities:
Accounts payable	1,603,834	1,798,813
Accrued expenses	7,103,959	7,896,598
Lease liabilities	210,512	209,068
Total current liabilities	8,918,305	9,904,479
Lease liabilities, long-term	295,754	353,694
Total liabilities	9,214,059	10,258,173
Stockholders' equity:
Preferred stock, $0.001 par value; 10,000,000 shares authorized; no shares issued or outstanding
Common stock, $0.001 par value; 200,000,000 shares authorized; 43,324,097 shares issued and outstanding at March 31, 2022 and 41,217,537 shares issued and outstanding at December 31, 2021	43,324	41,218
Additional paid-in capital	313,095,744	310,353,595
Accumulated deficit	(247,972,098)	(239,481,479)
Total stockholders' equity	65,166,970	70,913,334
Total liabilities and stockholders' equity	$ 74,381,029	$ 81,171,507

XML

CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Mar. 31, 2022	Dec. 31, 2021
CONSOLIDATED BALANCE SHEETS
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value	$ 0.001	$ 0.001
Common stock, shares authorized	200,000,000	200,000,000
Common stock, shares issued	43,324,097	41,217,537
Common stock, shares outstanding	43,324,097	41,217,537

XML

CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Operating expenses:
Research and development	$ 5,146,605	$ 4,609,010
General and administrative	3,757,310	3,275,797
Total operating expenses	8,903,915	7,884,807
Loss from operations	(8,903,915)	(7,884,807)
Other income (expense):
Interest income	96,044	5,633
Foreign exchange gain (loss)	317,252	(82,454)
Total other income (expense)	413,296	(76,821)
Net loss	$ (8,490,619)	$ (7,961,628)
Net loss per share basic	$ (0.21)	$ (0.20)
Net loss per share diluted	$ (0.21)	$ (0.20)
Basic weighted average shares outstanding	40,304,484	40,065,715
Diluted weighted average shares outstanding	40,304,484	40,065,715

XML

CONSOLIDATED STATEMENTS OF STOCKHOLDERS EQUITY - USD ($)	Common stock	Additional paid-capital	Accumulated deficit	Total
Balance at Dec. 31, 2020	$ 29,975	$ 262,286,008	$ (202,172,455)	$ 60,143,528
Balance (in shares) at Dec. 31, 2020	29,975,264
Increase (Decrease) in Stockholders' Equity (Deficit)
Issuance of common stock, net of issuance costs	$ 10,245	42,210,099		42,220,344
Issuance of common stock, net of issuance costs (in shares)	10,244,326
Issuance of restricted stock	$ 1,019	(1,019)
Issuance of restricted stock (in shares)	1,018,822
Exercise of stock options	$ 13	47,893		47,906
Exercise of stock options (in shares)	13,125
Stock-based compensation expense		1,264,837		1,264,837
Net loss			(7,961,628)	(7,961,628)
Balance at Mar. 31, 2021	$ 41,252	305,807,818	(210,134,083)	95,714,987
Balance (in shares) at Mar. 31, 2021	41,251,537
Balance at Dec. 31, 2021	$ 41,218	310,353,595	(239,481,479)	70,913,334
Balance (in shares) at Dec. 31, 2021	41,217,537
Increase (Decrease) in Stockholders' Equity (Deficit)
Issuance of common stock, net of issuance costs	$ 857	1,582,916		1,583,773
Issuance of common stock, net of issuance costs (in shares)	857,060
Issuance of restricted stock	$ 1,249	(1,249)
Issuance of restricted stock (in shares)	1,249,500
Stock-based compensation expense		1,160,482		1,160,482
Net loss			(8,490,619)	(8,490,619)
Balance at Mar. 31, 2022	$ 43,324	$ 313,095,744	$ (247,972,098)	$ 65,166,970
Balance (in shares) at Mar. 31, 2022	43,324,097

XML

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Cash flows from operating activities:
Net loss	$ (8,490,619)	$ (7,961,628)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation	60,695	61,455
Stock-based compensation	1,160,482	1,264,837
Changes in operating assets and liabilities:
Incentive and tax receivables	7,713,431	(306,038)
Prepaid expenses and other assets	805,897	105,854
Right-of-use assets and liabilities	316	(3,957)
Accounts payable	(256,931)	(859,523)
Accrued expenses	(792,639)	(593,967)
Net cash provided by (used in) operating activities	200,632	(8,292,967)
Cash flows from investing activities:
Purchases of property and equipment	(51,607)
Net cash used in investing activities	(51,607)
Cash flows from financing activities:
Proceeds from the issuance of common stock	1,789,524	43,193,660
Payment of financing fees and expenses	(48,684)	(975,592)
Proceeds from the exercise of stock options		47,906
Net cash provided by financing activities	1,740,840	42,265,974
Net increase in cash and cash equivalents	1,889,865	33,973,007
Cash and cash equivalents at beginning of period	67,808,000	59,157,187
Cash and cash equivalents at end of period	69,697,865	93,130,194
Supplemental disclosures of cash flow information:
Financing costs included in accounts payable and accrued expenses at end of period	$ 104,452	15,000
Property and equipment acquired but unpaid at end of period		$ 11,055

XML

Nature of Business and Liquidity

3 Months Ended

Mar. 31, 2022

Nature of Business and Liquidity

Nature of Business and Liquidity

(1) Nature of Business and Liquidity

Zynerba Pharmaceuticals, Inc., together with its subsidiary, Zynerba Pharmaceuticals Pty Ltd (collectively, “Zynerba,” the “Company,” or “we”), is a clinical stage specialty pharmaceutical company focused on the development of pharmaceutically-produced transdermal cannabinoid therapies for rare and near-rare neuropsychiatric disorders, including Fragile X syndrome, autism spectrum disorder and 22q11.2 deletion syndrome.

The Company has incurred losses and negative cash flows from operations since inception and has an accumulated deficit of $248.0 million as of March 31, 2022. The Company anticipates incurring additional losses until such time, if ever, that it can generate significant revenue from its product candidates currently in development. The Company's primary source of liquidity has been the issuance of equity securities.

On May 11, 2021, the Company entered into a Controlled Equity Offering^SM Sales Agreement (the “2021 Sales Agreement”) with Cantor Fitzgerald & Co., Canaccord Genuity, LLC, H.C. Wainwright & Co. LLC and Ladenburg Thalmann & Co. Inc., as sales agents (collectively, the “2021 Sales Agents”), pursuant to which the Company may sell, from time to time, up to $75.0 million of its common stock. In the first quarter of 2022, the Company sold and issued 857,060 shares of common stock under the 2021 Sales Agreement in the open market at a weighted average selling price of $2.09 per share, resulting in gross proceeds of $1.8 million. Net proceeds after deducting commissions and offering expenses were $1.6 million. From April 1, 2022 through May 11, 2022, the Company sold and issued 297,362 shares of its common stock in the open market at a weighted average selling price of $2.17 per share, for gross and net proceeds, after deducting commissions and offering expenses, of $0.6 million.

In August 2019, the Company entered into a Controlled Equity Offering^SM Sales Agreement (the “2019 Sales Agreement”) with Cantor Fitzgerald & Co., Canaccord Genuity, LLC, H.C. Wainwright & Co. LLC and Ladenburg Thalmann & Co. Inc., as sales agents (collectively, the “2019 Sales Agents”), pursuant to which the Company sold $75.0 million of its common stock. In the first quarter of 2021, the Company sold and issued 10,244,326 shares of common stock under the 2019 Sales Agreement in the open market at a weighted average selling price of $4.22 per share, resulting in gross proceeds of $43.2 million. Net proceeds after deducting commissions and offering expenses were $42.2 million. As of February 9, 2021, the Company had utilized the entire $75.0 million under the 2019 Sales Agreement.

Management believes that the Company’s cash and cash equivalents as of March 31, 2022 are sufficient to fund operations and capital requirements into the second half of 2023. Substantial additional financings will be needed by the Company to fund its operations, and to complete clinical development of and to commercially develop its product candidates. The Company’s ability to raise sufficient additional financing depends on many factors beyond its control, including the current and ongoing volatility in the capital markets as a result of, among other factors, the COVID-19 pandemic and geopolitical tensions or the outbreak of hostilities or war. There is no assurance that such financing will be available when needed or on acceptable terms.

The Company is subject to those risks associated with any clinical stage pharmaceutical company that has substantial expenditures for research and development. There can be no assurance that the Company's research and development projects will be successful, that products developed will obtain necessary regulatory approval, or that any approved product will be commercially viable. In addition, the Company operates in an environment of rapid technological change and is largely dependent on the services of its employees and consultants.

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Summary of Significant Accounting Policies

3 Months Ended

Mar. 31, 2022

Summary of Significant Accounting Policies

Summary of Significant Accounting Policies

(2) Summary of Significant Accounting Policies

a. Basis of Presentation

The accompanying unaudited interim consolidated financial statements of the Company have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. The interim unaudited consolidated financial statements have been prepared on the same basis as the consolidated financial statements as of and for the year ended December 31, 2021 included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 (the “2021 Annual

Report”), filed with the Securities and Exchange Commission (the “SEC”). In the opinion of management, the accompanying consolidated financial statements of the Company include all normal and recurring adjustments (which consist primarily of accruals, estimates and assumptions that impact the consolidated financial statements) considered necessary to present fairly the Company's financial position as of March 31, 2022, its results of operations and cash flows for the three months ended March 31, 2022 and 2021. Operating results for any interim period are not necessarily indicative of results for any future interim period or for the entire year. The accompanying unaudited interim consolidated financial statements should be read in conjunction with the consolidated financial statements and related notes included in the 2021 Annual Report.

b. Use of Estimates

The preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the financial statements and reported amounts of expenses during the reporting period. Actual results could differ from such estimates.

c. Incentive and Tax Receivables

The Company’s subsidiary, Zynerba Pharmaceuticals Pty Ltd (the “Subsidiary”), is incorporated in Australia. The Subsidiary is eligible to participate in an Australian research and development tax incentive program. As part of this program, the Subsidiary is eligible to receive a cash refund from the Australian Taxation Office (“ATO”) for a percentage of the research and development costs expended by the Subsidiary in Australia. The cash refund is available to eligible companies with an annual aggregate revenue of less than $20.0 million (Australian) during the reimbursable period. The Company estimates the amount of cash refund it expects to receive related to the Australian research and development tax incentive program and records the incentives when it is probable (1) the Company will comply with relevant conditions of the program and (2) the incentive will be received. The Company evaluates its eligibility under tax incentive programs as of each balance sheet date based on the most current and relevant data available. If the Company is deemed to be ineligible or unable to receive the Australian research and development tax credit, or the Australian government significantly reduces or eliminates the tax credit, the actual cash refund the Company receives may materially differ from its estimates.

In December 2018, the Company submitted an Advance Overseas Finding (“AOF”) application to a division of the Australian Government’s Department of Industry, Innovation and Science (“AusIndustry”), for a portion of the Company’s research and development activities incurred outside of Australia, which was approved by AusIndustry in July 2019. During the year ended December 31, 2019, the Company recorded $8.3 million as an incentive and tax receivable and recorded a corresponding credit to research and development expense for amounts expected to be received through the AOF for the period January 1, 2018 through December 31, 2019. In June 2020, the ATO informed the Company that it may not qualify for the AOF program based on their interpretation of certain eligibility requirements and, during the three months ended June 30, 2020, the Company determined it was no longer probable that the AOF claim would be received and the Company recorded a full reserve against the AOF receivable.

During the three months ended March 31, 2022, the Company concluded its conversations with the ATO on these matters and made the decision to no longer pursue the AOF claim, resulting in the write off of both the AOF receivable and the corresponding reserve during the period. During the three months ended March 31, 2022, the Company received a payment of $8.0 million from the ATO for the non-AOF research and development incentive for the years ended December 31, 2018, 2019 and 2020.

The Subsidiary incurs Goods and Services Tax (“GST”) on services provided by Australian vendors. As an Australian entity, the Subsidiary is entitled to a refund of the GST paid. The Company’s estimate of the amount of cash refund it expects to receive related to GST incurred is included in “Incentive and tax receivables” in the accompanying consolidated balance sheets. As of March 31, 2022, incentive and tax receivables included $0.3 million for refundable GST on expenses incurred with Australian vendors during the three months ended March 31, 2022.

Current incentive and tax receivables consisted of the following as of March 31, 2022 and December 31, 2021:

	March 31,		December 31,
	2022		2021
Research and development incentive (non-AOF) for the period 1/1/18 - 12/31/18	$	—	$	3,144,152
Research and development incentive (non-AOF) for the period 1/1/19 - 12/31/19		—		2,914,931
Research and development incentive (non-AOF) for the period 1/1/20 - 12/31/20		—		1,993,038
Research and development incentive (non-AOF) for the period 1/1/21 - 12/31/21		1,270,293		1,226,688
Research and development incentive (AOF) for the period 1/1/18 - 12/31/19		—		8,566,843
Goods and services tax		332,538		301,659
Total incentive and tax receivables before reserve for AOF		1,602,831		18,147,311
Reserve for research and development incentive (AOF) for the period 1/1/18 - 12/31/19		—		(8,566,843)
Total incentive and tax receivables - current assets	$	1,602,831	$	9,580,468

As of March 31, 2022, the Company’s estimate of the amount of cash refund it expects to receive for 2021 eligible spending as part of this incentive program was $1.3 million and was recorded as a current asset. The Company’s estimate of the amount of cash refund it expects to receive for 2022 eligible spending through March 31, 2022 was $0.3 million and was recorded as a non-current asset.

d. Research and Development

Research and development costs are expensed as incurred and are primarily comprised of external research and development expenses incurred under arrangements with third parties, such as contract research organizations, contract manufacturing organizations, consultants and employee-related expenses including salaries and benefits. At the end of each reporting period, the Company compares the payments made to each service provider to the estimated progress towards completion of the related project. Factors that the Company considers in preparing these estimates include the number of patients enrolled in studies, milestones achieved and other criteria related to the efforts of its vendors. These estimates will be subject to change as additional information becomes available. Depending on the timing of payments to vendors and estimated services provided, the Company will record net prepaid or accrued expenses related to these costs. Research and development expenses are recorded net of expected refunds of eligible research and development costs paid pursuant to the Australian research and development tax incentive program and GST incurred on services provided by Australian vendors.

The following table summarizes research and development expenses for the three months ended March 31, 2022 and 2021:

	Three months ended March 31,
	2022		2021
Research and development expenses - before R&D incentive	$	5,404,208	$	4,949,514
Research and development incentive		(257,603)		(340,504)
Total research and development expenses	$	5,146,605	$	4,609,010

e. Net Loss Per Share

Basic net loss per share is determined using the weighted average number of shares of common stock outstanding during each period. Diluted net income per share includes the effect, if any, from the potential exercise or conversion of securities, such as restricted stock and stock options, which would result in the issuance of incremental shares of common stock. Basic and dilutive computations of net loss per share are the same in periods in which a net loss exists as the dilutive effects of restricted stock and stock options would be anti-dilutive.

The following potentially dilutive securities outstanding as of March 31, 2022 and 2021 have been excluded from the computation of diluted weighted average shares outstanding, as their effects on net loss per share for the periods presented would be anti-dilutive:

	March 31,
	2022	2021
Stock options	6,063,038	5,225,538
Unvested restricted stock	2,234,322	1,185,822
	8,297,360	6,411,360

f. Recent Accounting Pronouncements

The Company does not expect any recently issued accounting pronouncements to have a significant impact on its future results of operations, financial position or cash flow.

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Fair Value Measurements

3 Months Ended

Mar. 31, 2022

Fair Value Measurements

Fair Value Measurements

(3) Fair Value Measurements

The Company measures certain assets and liabilities at fair value in accordance with Accounting Standards

Codification (“ASC 820”), Fair Value Measurements and Disclosures. ASC 820 defines fair value as the price that would be received to sell an asset or paid to transfer a liability (the exit price) in an orderly transaction between market participants at the measurement date. The guidance in ASC 820 outlines a valuation framework and creates a fair value hierarchy that serves to increase the consistency and comparability of fair value measurements and the related disclosures. In determining fair value, the Company maximizes the use of quoted prices and observable inputs. Observable inputs are inputs that market participants would use in pricing the asset or liability based on market data obtained from independent sources. The fair value hierarchy is broken down into three levels based on the source of inputs as follows:

Level 1 — Valuations based on unadjusted quoted prices in active markets for identical assets or liabilities.

Level 2 — Valuations based on observable inputs and quoted prices in active markets for similar assets and liabilities.

Level 3 — Valuations based on unobservable inputs and models that are supported by little or no market activity.

In accordance with the fair value hierarchy described above, the following table sets forth the Company's financial assets measured at fair value on a recurring basis as of March 31, 2022 and December 31, 2021:

			Fair Value Measurement
	Carrying amount		as of March 31, 2022
	as of March 31, 2022		Level 1		Level 2		Level 3
Cash equivalents (money market accounts)	$	60,763,307	$	60,763,307	$	—	$	—
	$	60,763,307	$	60,763,307	$	—	$	—

			Fair Value Measurement
	Carrying amount		as of December 31, 2021
	as of December 31, 2021		Level 1		Level 2		Level 3
Cash equivalents (money market accounts)	$	67,709,279	$	67,709,279	$	—	$	—
	$	67,709,279	$	67,709,279	$	—	$	—

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Prepaid Expenses and Other Current Assets

3 Months Ended

Mar. 31, 2022

Prepaid Expenses and Other Current Assets

Prepaid Expenses and Other Current Assets

(4) Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consisted of the following as of March 31, 2022 and December 31, 2021:

	March 31,		December 31,
	2022		2021
Prepaid development expenses	$	520,644	$	543,897
Prepaid insurance		1,126,238		1,952,867
Deferred financing costs		42,500		137,615
Other current assets		240,998		197,013
Total prepaid expenses and other current assets	$	1,930,380	$	2,831,392

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Property and Equipment

3 Months Ended

Mar. 31, 2022

Property and Equipment

Property and Equipment

(5) Property and Equipment

Property and equipment consisted of the following as of March 31, 2022 and December 31, 2021:

	Estimated
	useful life	March 31,		December 31,
	(in years)	2022		2021
Equipment	2-5	$	740,543	$	740,543
Computer equipment	3-5		30,319		30,319
Furniture and fixtures	3-5		311,356		311,356
Leasehold improvements	various		68,881		68,881
Construction in process			130,949		79,342
Total cost			1,282,048		1,230,441
Less accumulated depreciation			(905,303)		(844,608)
Property and equipment, net		$	376,745	$	385,833

Depreciation expense was $60,695 and $61,455 for the three months ended March 31, 2022 and 2021 respectively.

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Accrued Expenses

3 Months Ended

Mar. 31, 2022

Accrued Expenses

Accrued Expenses

(6) Accrued Expenses

Accrued expenses consisted of the following as of March 31, 2022 and December 31, 2021:

	March 31,		December 31,
	2022		2021
Accrued compensation	$	913,923	$	2,412,291
Accrued research and development		5,286,347		5,125,010
Other		903,689		359,297
Total accrued expenses	$	7,103,959	$	7,896,598

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Common Stock

3 Months Ended

Mar. 31, 2022

Common Stock

Common Stock

(7) Common Stock

On May 11, 2021, the Company entered into the 2021 Sales Agreement with the 2021 Sales Agents, pursuant to which the Company may sell, from time to time, up to $75.0 million of its common stock. In the first quarter of 2022, the Company sold and issued 857,060 shares of common stock under the 2021 Sales Agreement in the open market at a weighted average selling price of $2.09 per share, resulting in gross proceeds of $1.8 million. Net proceeds after deducting commissions and offering expenses were $1.6 million. From April 1, 2022 through May 11, 2022, the Company sold and issued 297,362 shares of its common stock in the open market at a weighted average selling price of $2.17 per share, for gross and net proceeds, after deducting commissions and offering expenses, of $0.6 million.

In August 2019, the Company entered into the 2019 Sales Agreement with the 2019 Sales Agents pursuant to which the Company sold $75.0 million of its common stock. In the first quarter of 2021, the Company sold and issued 10,244,326 shares of common stock under the 2019 Sales Agreement in the open market at a weighted average selling price of $4.22

per share, resulting in gross proceeds of $43.2 million. Net proceeds after deducting commissions and offering expenses were $42.2 million. As of February 9, 2021, the Company had utilized the entire $75.0 million under the 2019 Sales Agreement.

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Stock-Based Compensation

3 Months Ended

Mar. 31, 2022

Stock-Based Compensation

Stock-Based Compensation

(8) Stock-Based Compensation

The Company maintains the Amended and Restated 2014 Omnibus Incentive Compensation Plan, as amended (the “2014 Plan”), which allows for the granting of incentive stock options, nonqualified stock options, stock appreciation rights, stock awards, stock units, performance units and other stock-based awards to employees, officers, non-employee directors, consultants, and advisors. In addition, the 2014 Plan provides selected executive employees with the opportunity to receive bonus awards that are considered qualified performance-based compensation. The 2014 Plan is subject to automatic annual increases in the number of shares authorized for issuance under the 2014 Plan on the first trading day of January each year equal to the lesser of 1.5 million shares or 10% of the number of shares of common stock outstanding on the last trading day of December of the preceding year. As of January 1, 2022, the number of shares of common stock that may be issued under the 2014 Plan was automatically increased by 1.5 million shares, increasing the total number of shares of common stock available for issuance under the 2014 Plan to 10,804,869 shares. As of March 31, 2022, 1,779,008 shares were available for future issuance under the 2014 Plan.

Options issued under the 2014 Plan have a contractual life of 10 years and may be exercisable in cash or as otherwise determined by the board of directors. The Company has granted options to employees and non-employee directors. Stock options granted to employees primarily vest 25% upon the first anniversary of the grant date and the balance of unvested options vests in quarterly installments over the remaining three years. Stock options granted annually to non-employee directors vest on the earlier of the one-year anniversary of the grant date, or the date of the Company’s next annual stockholders’ meeting that occurs after the grant date. The Company’s non-employee director compensation policy enables directors to receive stock options in lieu of quarterly cash payments. Any option granted to the directors in lieu of cash compensation vests in full on the grant date. The Company records forfeitures as they occur.

Stock-based compensation expense for performance-based grants are recorded when management estimates that the vesting of these shares is probable based on the status of the Company’s research and development programs and other relevant factors, which were established by the Company’s board of directors. The Company’s board of directors determines if the performance conditions have been met.

During the three months ended March 31, 2021, the Company granted 506,911 time-based restricted stock awards to employees with two-year cliff vesting of which 469,911 restricted stock awards remained outstanding as of March 31, 2022. In addition, during the three months ended March 31, 2021, the Company granted 506,911 performance-based restricted stock awards to employees of which 469,911 restricted stock awards remained outstanding as of March 31, 2022. The performance-based conditions for these performance-based grants were deemed probable of achievement and, as of March 31, 2022, the Company has recorded $1.5 million in stock-based compensation expense related to these grants. As of March 31, 2022, there was $0.2 million of unrecognized stock-based compensation expense related to these performance-based awards, which will be expensed over the estimated service period related to each performance condition.

During the three months ended March 31, 2022, the Company granted 693,000 time-based restricted stock awards to employees and consultants. In addition, during the three months ended March 31, 2022, the Company granted 556,500 performance-based restricted stock awards to employees. As of March 31, 2022, none of the performance-based metrics were deemed probable of achievement.

For the three months ended March 31, 2022 and 2021, the Company recorded stock-based compensation expense related to its stock option grants and restricted stock awards, as follows:

	Stock Option Grants				Restricted stock awards				Total
	2022		2021		2022		2021		2022			2021
Research and development	$	261,402	$	432,930	$	268,094	$	186,461	$	529,496	$	619,391
General and administrative		317,424		512,436		313,562		133,010		630,986		645,446
	$	578,826	$	945,366	$	581,656	$	319,471	$	1,160,482	$	1,264,837

The following table summarizes the Company’s stock option activity for the three months ended March 31, 2022:

		Weighted-		Weighted-
		Average		Average	Aggregate
	Number	Exercise		Contractual	Intrinsic
	of Shares	Price		Life (in Years)	Value
Outstanding as of December 31, 2021	5,224,913	$	8.74
Granted	903,750		2.47
Forfeited	(65,625)		12.82
Outstanding as of March 31, 2022	6,063,038		7.76	6.55	$	—
Exercisable as of March 31, 2022	3,998,496		9.98	5.30	$	—
Vested and expected to vest as of March 31, 2022	6,063,038	$	7.76

The weighted-average grant date fair values of options granted during the three months ended March 31, 2022 and 2021 were $1.99 and $2.79, respectively.

The fair values of stock options granted were calculated using the Black-Scholes option pricing model with the following weighted-average assumptions:

	Three months ended March 31,
	2022	2021
Weighted-average risk-free interest rate	1.63%	0.36%
Expected term of options (in years)	6.25	6.25
Expected stock price volatility	101.37%	95.60%
Expected dividend yield	0%	0%

As of March 31, 2022, there was $4.9 million of unrecognized stock-based compensation expense related to stock options, which is expected to be recognized over a weighted-average period of 2.78 years. During the three months ended March 31, 2021, the Company received $47,906 in cash from the exercise of employee stock options.

The following table summarizes the Company’s restricted stock award activity under the 2014 Plan for the three months ended March 31, 2022:

		Weighted
		Average		Aggregate
		Grant Date		Intrinsic
	Shares	Fair Value		Value
Unvested as of December 31, 2021	989,822	$	3.62
Granted	1,249,500		2.42
Vested	(5,000)		4.91
Unvested as of March 31, 2022	2,234,322	$	2.95	$	4,580,360
Expected to vest as of March 31, 2022	1,672,822	$	3.12	$	3,429,285

As of March 31, 2022, excluding performance-based restricted stock awards that have not been deemed probable, there was $2.4 million of unrecognized stock-based compensation expense related to unvested restricted stock awards, which is expected to be recognized over a weighted-average period of 0.78 years.

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Operating Lease Obligations

3 Months Ended

Mar. 31, 2022

Operating Lease Obligations

Operating Lease Obligations

(9) Operating Lease Obligations

The Company adopted Accounting Standards Update No. 2016-02, Leases (Topic 842), Accounting Standards Codification 842 prospectively using the modified-retrospective method and elected the package of transition practical expedients that does not require reassessment of: (1) whether any existing or expired contracts are or contain leases, (2) lease classification and (3) initial direct costs. In addition, the Company has elected other available practical expedients to not separate lease and nonlease components, which consist principally of common area maintenance charges, and to exclude leases with an initial term of 12 months or less.

The Company leases its headquarters where it occupies 10,877 square feet of office space. On March 1, 2021, the Company extended its lease for three additional years until May 31, 2024. The Company’s lease contains variable lease costs that do not depend on a rate or index and consist primarily of common area maintenance, taxes, and insurance charges. As the implicit rate was not readily determinable for the Company’s lease, the Company used an estimated incremental borrowing rate, or discount rate, to determine the initial present value of the lease payments. The discount rate for the lease was calculated using a synthetic credit rating model.

As of March 1, 2021, the effective date of the lease modification, the Company remeasured the lease liability for the remaining portion of the lease and adjusted the lease liability to $755,085 and right-of-use assets to $752,391, which was recorded net of a deferred rent liability of $2,694. As of March 31, 2022, the Company’s right-of-use asset, net of amortization, was $509,002.

Other operating lease information as of March 31, 2022:

Weighted-average remaining lease term - operating leases	2.2	years
Weighted-average discount rate - operating leases	2.76	%

The following is a maturity analysis of the annual undiscounted cash flows of the operating lease liabilities as of March 31, 2022:

	March 31,
Year ending:	2022
December 31, 2022	$	180,315
December 31, 2023		240,421
December 31, 2024		100,175
Total minimum lease payments		520,911
Less: imputed lease interest		(14,645)
Total lease liabilities	$	506,266

Lease expense for the three months ended March 31, 2022 was comprised of the following:

	Three months ended March 31,
		2022		2021
Operating lease expense	$	60,421	$	62,946
Variable lease expense		17,602		16,841
Total lease expense	$	78,023	$	79,787

Total cash payments related to leases were $77,707 and $83,744 for the three months ended March 31, 2022 and 2021, respectively.

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Summary of Significant Accounting Policies (Policies)

3 Months Ended

Mar. 31, 2022

Summary of Significant Accounting Policies

Basis of Presentation

a. Basis of Presentation

The accompanying unaudited interim consolidated financial statements of the Company have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. The interim unaudited consolidated financial statements have been prepared on the same basis as the consolidated financial statements as of and for the year ended December 31, 2021 included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 (the “2021 Annual

Report”), filed with the Securities and Exchange Commission (the “SEC”). In the opinion of management, the accompanying consolidated financial statements of the Company include all normal and recurring adjustments (which consist primarily of accruals, estimates and assumptions that impact the consolidated financial statements) considered necessary to present fairly the Company's financial position as of March 31, 2022, its results of operations and cash flows for the three months ended March 31, 2022 and 2021. Operating results for any interim period are not necessarily indicative of results for any future interim period or for the entire year. The accompanying unaudited interim consolidated financial statements should be read in conjunction with the consolidated financial statements and related notes included in the 2021 Annual Report.

Use of Estimates

b. Use of Estimates

The preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the financial statements and reported amounts of expenses during the reporting period. Actual results could differ from such estimates.

Incentive and Tax Receivables

c. Incentive and Tax Receivables

The Company’s subsidiary, Zynerba Pharmaceuticals Pty Ltd (the “Subsidiary”), is incorporated in Australia. The Subsidiary is eligible to participate in an Australian research and development tax incentive program. As part of this program, the Subsidiary is eligible to receive a cash refund from the Australian Taxation Office (“ATO”) for a percentage of the research and development costs expended by the Subsidiary in Australia. The cash refund is available to eligible companies with an annual aggregate revenue of less than $20.0 million (Australian) during the reimbursable period. The Company estimates the amount of cash refund it expects to receive related to the Australian research and development tax incentive program and records the incentives when it is probable (1) the Company will comply with relevant conditions of the program and (2) the incentive will be received. The Company evaluates its eligibility under tax incentive programs as of each balance sheet date based on the most current and relevant data available. If the Company is deemed to be ineligible or unable to receive the Australian research and development tax credit, or the Australian government significantly reduces or eliminates the tax credit, the actual cash refund the Company receives may materially differ from its estimates.

In December 2018, the Company submitted an Advance Overseas Finding (“AOF”) application to a division of the Australian Government’s Department of Industry, Innovation and Science (“AusIndustry”), for a portion of the Company’s research and development activities incurred outside of Australia, which was approved by AusIndustry in July 2019. During the year ended December 31, 2019, the Company recorded $8.3 million as an incentive and tax receivable and recorded a corresponding credit to research and development expense for amounts expected to be received through the AOF for the period January 1, 2018 through December 31, 2019. In June 2020, the ATO informed the Company that it may not qualify for the AOF program based on their interpretation of certain eligibility requirements and, during the three months ended June 30, 2020, the Company determined it was no longer probable that the AOF claim would be received and the Company recorded a full reserve against the AOF receivable.

During the three months ended March 31, 2022, the Company concluded its conversations with the ATO on these matters and made the decision to no longer pursue the AOF claim, resulting in the write off of both the AOF receivable and the corresponding reserve during the period. During the three months ended March 31, 2022, the Company received a payment of $8.0 million from the ATO for the non-AOF research and development incentive for the years ended December 31, 2018, 2019 and 2020.

The Subsidiary incurs Goods and Services Tax (“GST”) on services provided by Australian vendors. As an Australian entity, the Subsidiary is entitled to a refund of the GST paid. The Company’s estimate of the amount of cash refund it expects to receive related to GST incurred is included in “Incentive and tax receivables” in the accompanying consolidated balance sheets. As of March 31, 2022, incentive and tax receivables included $0.3 million for refundable GST on expenses incurred with Australian vendors during the three months ended March 31, 2022.

Current incentive and tax receivables consisted of the following as of March 31, 2022 and December 31, 2021:

	March 31,		December 31,
	2022		2021
Research and development incentive (non-AOF) for the period 1/1/18 - 12/31/18	$	—	$	3,144,152
Research and development incentive (non-AOF) for the period 1/1/19 - 12/31/19		—		2,914,931
Research and development incentive (non-AOF) for the period 1/1/20 - 12/31/20		—		1,993,038
Research and development incentive (non-AOF) for the period 1/1/21 - 12/31/21		1,270,293		1,226,688
Research and development incentive (AOF) for the period 1/1/18 - 12/31/19		—		8,566,843
Goods and services tax		332,538		301,659
Total incentive and tax receivables before reserve for AOF		1,602,831		18,147,311
Reserve for research and development incentive (AOF) for the period 1/1/18 - 12/31/19		—		(8,566,843)
Total incentive and tax receivables - current assets	$	1,602,831	$	9,580,468

As of March 31, 2022, the Company’s estimate of the amount of cash refund it expects to receive for 2021 eligible spending as part of this incentive program was $1.3 million and was recorded as a current asset. The Company’s estimate of the amount of cash refund it expects to receive for 2022 eligible spending through March 31, 2022 was $0.3 million and was recorded as a non-current asset.

Research and Development

d. Research and Development

Research and development costs are expensed as incurred and are primarily comprised of external research and development expenses incurred under arrangements with third parties, such as contract research organizations, contract manufacturing organizations, consultants and employee-related expenses including salaries and benefits. At the end of each reporting period, the Company compares the payments made to each service provider to the estimated progress towards completion of the related project. Factors that the Company considers in preparing these estimates include the number of patients enrolled in studies, milestones achieved and other criteria related to the efforts of its vendors. These estimates will be subject to change as additional information becomes available. Depending on the timing of payments to vendors and estimated services provided, the Company will record net prepaid or accrued expenses related to these costs. Research and development expenses are recorded net of expected refunds of eligible research and development costs paid pursuant to the Australian research and development tax incentive program and GST incurred on services provided by Australian vendors.

The following table summarizes research and development expenses for the three months ended March 31, 2022 and 2021:

	Three months ended March 31,
	2022		2021
Research and development expenses - before R&D incentive	$	5,404,208	$	4,949,514
Research and development incentive		(257,603)		(340,504)
Total research and development expenses	$	5,146,605	$	4,609,010

Net Loss Per Share

e. Net Loss Per Share

Basic net loss per share is determined using the weighted average number of shares of common stock outstanding during each period. Diluted net income per share includes the effect, if any, from the potential exercise or conversion of securities, such as restricted stock and stock options, which would result in the issuance of incremental shares of common stock. Basic and dilutive computations of net loss per share are the same in periods in which a net loss exists as the dilutive effects of restricted stock and stock options would be anti-dilutive.

The following potentially dilutive securities outstanding as of March 31, 2022 and 2021 have been excluded from the computation of diluted weighted average shares outstanding, as their effects on net loss per share for the periods presented would be anti-dilutive:

	March 31,
	2022	2021
Stock options	6,063,038	5,225,538
Unvested restricted stock	2,234,322	1,185,822
	8,297,360	6,411,360

Recent Accounting Pronouncements

f. Recent Accounting Pronouncements

The Company does not expect any recently issued accounting pronouncements to have a significant impact on its future results of operations, financial position or cash flow.

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Summary of Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2022

Summary of Significant Accounting Policies

Schedule of incentive and tax receivables

	March 31,		December 31,
	2022		2021
Research and development incentive (non-AOF) for the period 1/1/18 - 12/31/18	$	—	$	3,144,152
Research and development incentive (non-AOF) for the period 1/1/19 - 12/31/19		—		2,914,931
Research and development incentive (non-AOF) for the period 1/1/20 - 12/31/20		—		1,993,038
Research and development incentive (non-AOF) for the period 1/1/21 - 12/31/21		1,270,293		1,226,688
Research and development incentive (AOF) for the period 1/1/18 - 12/31/19		—		8,566,843
Goods and services tax		332,538		301,659
Total incentive and tax receivables before reserve for AOF		1,602,831		18,147,311
Reserve for research and development incentive (AOF) for the period 1/1/18 - 12/31/19		—		(8,566,843)
Total incentive and tax receivables - current assets	$	1,602,831	$	9,580,468

Schedule of research and development expenses

	Three months ended March 31,
	2022		2021
Research and development expenses - before R&D incentive	$	5,404,208	$	4,949,514
Research and development incentive		(257,603)		(340,504)
Total research and development expenses	$	5,146,605	$	4,609,010

Summary of potentially dilutive securities excluded from the computation of diluted weighted average shares outstanding

	March 31,
	2022	2021
Stock options	6,063,038	5,225,538
Unvested restricted stock	2,234,322	1,185,822
	8,297,360	6,411,360

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Fair Value Measurements (Tables)

3 Months Ended

Mar. 31, 2022

Fair Value Measurements

Summary of financial assets measured at fair value on a recurring basis

			Fair Value Measurement
	Carrying amount		as of March 31, 2022
	as of March 31, 2022		Level 1		Level 2		Level 3
Cash equivalents (money market accounts)	$	60,763,307	$	60,763,307	$	—	$	—
	$	60,763,307	$	60,763,307	$	—	$	—

			Fair Value Measurement
	Carrying amount		as of December 31, 2021
	as of December 31, 2021		Level 1		Level 2		Level 3
Cash equivalents (money market accounts)	$	67,709,279	$	67,709,279	$	—	$	—
	$	67,709,279	$	67,709,279	$	—	$	—

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Prepaid Expenses and Other Current Assets (Tables)

3 Months Ended

Mar. 31, 2022

Prepaid Expenses and Other Current Assets

Schedule of prepaid expenses and other current assets

	March 31,		December 31,
	2022		2021
Prepaid development expenses	$	520,644	$	543,897
Prepaid insurance		1,126,238		1,952,867
Deferred financing costs		42,500		137,615
Other current assets		240,998		197,013
Total prepaid expenses and other current assets	$	1,930,380	$	2,831,392

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Property and Equipment (Tables)

3 Months Ended

Mar. 31, 2022

Property and Equipment

Schedule of property and equipment

	Estimated
	useful life	March 31,		December 31,
	(in years)	2022		2021
Equipment	2-5	$	740,543	$	740,543
Computer equipment	3-5		30,319		30,319
Furniture and fixtures	3-5		311,356		311,356
Leasehold improvements	various		68,881		68,881
Construction in process			130,949		79,342
Total cost			1,282,048		1,230,441
Less accumulated depreciation			(905,303)		(844,608)
Property and equipment, net		$	376,745	$	385,833

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Accrued Expenses (Tables)

3 Months Ended

Mar. 31, 2022

Accrued Expenses

Schedule of accrued expenses

	March 31,		December 31,
	2022		2021
Accrued compensation	$	913,923	$	2,412,291
Accrued research and development		5,286,347		5,125,010
Other		903,689		359,297
Total accrued expenses	$	7,103,959	$	7,896,598

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Stock-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2022

Stock-Based Compensation

Schedule of stock-based compensation expense

	Stock Option Grants				Restricted stock awards				Total
	2022		2021		2022		2021		2022			2021
Research and development	$	261,402	$	432,930	$	268,094	$	186,461	$	529,496	$	619,391
General and administrative		317,424		512,436		313,562		133,010		630,986		645,446
	$	578,826	$	945,366	$	581,656	$	319,471	$	1,160,482	$	1,264,837

Summary of stock option activity

		Weighted-		Weighted-
		Average		Average	Aggregate
	Number	Exercise		Contractual	Intrinsic
	of Shares	Price		Life (in Years)	Value
Outstanding as of December 31, 2021	5,224,913	$	8.74
Granted	903,750		2.47
Forfeited	(65,625)		12.82
Outstanding as of March 31, 2022	6,063,038		7.76	6.55	$	—
Exercisable as of March 31, 2022	3,998,496		9.98	5.30	$	—
Vested and expected to vest as of March 31, 2022	6,063,038	$	7.76

Schedule of weighted-average assumptions used to calculate fair values of stock options

	Three months ended March 31,
	2022	2021
Weighted-average risk-free interest rate	1.63%	0.36%
Expected term of options (in years)	6.25	6.25
Expected stock price volatility	101.37%	95.60%
Expected dividend yield	0%	0%

Summary of restricted stock activity

		Weighted
		Average		Aggregate
		Grant Date		Intrinsic
	Shares	Fair Value		Value
Unvested as of December 31, 2021	989,822	$	3.62
Granted	1,249,500		2.42
Vested	(5,000)		4.91
Unvested as of March 31, 2022	2,234,322	$	2.95	$	4,580,360
Expected to vest as of March 31, 2022	1,672,822	$	3.12	$	3,429,285

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Operating Lease Obligations (Tables)

3 Months Ended

Mar. 31, 2022

Operating Lease Obligations

Schedule of other operating lease information

Weighted-average remaining lease term - operating leases	2.2	years
Weighted-average discount rate - operating leases	2.76	%

Schedule of operating lease liabilities maturity analysis

	March 31,
Year ending:	2022
December 31, 2022	$	180,315
December 31, 2023		240,421
December 31, 2024		100,175
Total minimum lease payments		520,911
Less: imputed lease interest		(14,645)
Total lease liabilities	$	506,266

Schedule of lease expense

	Three months ended March 31,
		2022		2021
Operating lease expense	$	60,421	$	62,946
Variable lease expense		17,602		16,841
Total lease expense	$	78,023	$	79,787

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Nature of Business and Liquidity - Common Stock and Other (Details) - USD ($)	1 Months Ended	3 Months Ended		18 Months Ended
	May 11, 2022	Mar. 31, 2022	Mar. 31, 2021	Feb. 09, 2021	Dec. 31, 2021	May 11, 2021	Aug. 31, 2019
Sales of Stock
Accumulated deficit		$ 247,972,098			$ 239,481,479
Proceeds from the issuance of common stock		$ 1,789,524	$ 43,193,660
2019 Sales Agreement.
Sales of Stock
Maximum aggregate value of common stock available for offering							$ 75,000,000.0
Shares issued			10,244,326
Weighted average selling price per share			$ 4.22
Proceeds from the issuance of common stock			$ 43,200,000	$ 75,000,000.0
Net proceeds from the issuance of common stock			$ 42,200,000
2021 Sales Agreement
Sales of Stock
Maximum aggregate value of common stock available for offering						$ 75,000,000.0
Shares issued	297,362	857,060
Weighted average selling price per share	$ 2.17	$ 2.09
Proceeds from the issuance of common stock		$ 1,800,000
Net proceeds from the issuance of common stock	$ 600,000	$ 1,600,000

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Summary of Significant Accounting Policies - Incentive and Tax Receivable (Details) - Australian Taxation Office - USD ($) $ in Millions	3 Months Ended	12 Months Ended
	Mar. 31, 2022	Dec. 31, 2019
Incentive and Tax Receivable
Aggregate revenue maximum to be eligible to receive a cash refund	$ 20.0
Research and development incentive and tax receivable		$ 8.3
Research and development incentive tax credit		$ 8.3
Research and development incentive	8.0
Incentive And Tax Receivables Current
Incentive and Tax Receivable
Estimated GST receivable	$ 0.3

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Summary of Significant Accounting Policies - Current incentive and Tax Receivable (Details) - USD ($)	Mar. 31, 2022	Dec. 31, 2021
Incentive and Tax Receivable
Total incentive and tax receivables - current assets	$ 1,602,831	$ 9,580,468
Australian Taxation Office
Incentive and Tax Receivable
Research and development incentive (non-AOF) for the period 1/1/18 - 12/31/18		3,144,152
Research and development incentive (non-AOF) for the period 1/1/19 - 12/31/19		2,914,931
Research and development incentive (non-AOF) for the period 1/1/20 - 12/31/20		1,993,038
Research and development incentive (non-AOF) for the period 1/1/21 - 12/31/21	1,270,293	1,226,688
Research and development incentive (AOF) for the period 1/1/18 - 12/31/19		8,566,843
Goods and services tax	332,538	301,659
Total incentive and tax receivables before reserve for AOF	1,602,831	18,147,311
Reserve for research and development incentive (AOF) for the period 1/1/18 - 12/31/19		(8,566,843)
Total incentive and tax receivables - current assets	1,602,831	$ 9,580,468
Australian Taxation Office | Incentive And Tax Receivables Current
Incentive and Tax Receivable
Cash refund from research and development incentive program	1,300,000
Australian Taxation Office | Incentive And Tax Receivables Noncurrent.
Incentive and Tax Receivable
Cash refund from research and development incentive program	$ 300,000

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Summary of Significant Accounting Policies - Research and Development (Details) - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Research and Development
Research and development expenses - before R&D incentive	$ 5,404,208	$ 4,949,514
Research and development incentive	(257,603)	(340,504)
Total research and development expense	$ 5,146,605	$ 4,609,010

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Summary of Significant Accounting Policies - Anti-dilutive securities (Details) - shares	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Antidilutive Securities Excluded from Computation of Earnings Per Share
Anti-dilutive securities	8,297,360	6,411,360
Stock options
Antidilutive Securities Excluded from Computation of Earnings Per Share
Anti-dilutive securities	6,063,038	5,225,538
Restricted stock
Antidilutive Securities Excluded from Computation of Earnings Per Share
Anti-dilutive securities	2,234,322	1,185,822

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Fair Value Measurements (Details) - USD ($)	Mar. 31, 2022	Dec. 31, 2021
Carrying value
Fair value on a recurring basis
Cash equivalents (money market accounts)	$ 60,763,307	$ 67,709,279
Total	60,763,307	67,709,279
Recurring | Fair Value Measurement | Level 1
Fair value on a recurring basis
Cash equivalents (money market accounts)	60,763,307	67,709,279
Total	$ 60,763,307	$ 67,709,279

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Prepaid Expenses and Other Current Assets (Details) - USD ($)	Mar. 31, 2022	Dec. 31, 2021
Prepaid Expenses and Other Current Assets
Prepaid development expenses	$ 520,644	$ 543,897
Prepaid insurance	1,126,238	1,952,867
Deferred financing costs	42,500	137,615
Other current assets	240,998	197,013
Total prepaid expenses and other current assets	$ 1,930,380	$ 2,831,392

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Property and Equipment (Details) - USD ($)	3 Months Ended		12 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Property, Plant and Equipment
Total cost	$ 1,282,048		$ 1,230,441
Less accumulated depreciation	(905,303)		(844,608)
Property and equipment, net	376,745		385,833
Depreciation expense	60,695	$ 61,455
Equipment
Property, Plant and Equipment
Total cost	$ 740,543		$ 740,543
Equipment | Minimum
Property, Plant and Equipment
Estimated useful life	2 years		2 years
Equipment | Maximum
Property, Plant and Equipment
Estimated useful life	5 years		5 years
Computer equipment
Property, Plant and Equipment
Total cost	$ 30,319		$ 30,319
Computer equipment | Minimum
Property, Plant and Equipment
Estimated useful life	3 years		3 years
Computer equipment | Maximum
Property, Plant and Equipment
Estimated useful life	5 years		5 years
Furniture and fixtures
Property, Plant and Equipment
Total cost	$ 311,356		$ 311,356
Furniture and fixtures | Minimum
Property, Plant and Equipment
Estimated useful life	3 years		3 years
Furniture and fixtures | Maximum
Property, Plant and Equipment
Estimated useful life	5 years		5 years
Leasehold improvements
Property, Plant and Equipment
Estimated useful life (in years)	various		various
Total cost	$ 68,881		$ 68,881
Construction in process
Property, Plant and Equipment
Total cost	$ 130,949		$ 79,342

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Accrued Expenses (Details) - USD ($)	Mar. 31, 2022	Dec. 31, 2021
Accrued Expenses
Accrued compensation	$ 913,923	$ 2,412,291
Accrued research and development	5,286,347	5,125,010
Other	903,689	359,297
Total accrued expenses	$ 7,103,959	$ 7,896,598

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Common Stock (Details) - USD ($)	1 Months Ended	3 Months Ended		18 Months Ended
	May 11, 2022	Mar. 31, 2022	Mar. 31, 2021	Feb. 09, 2021	May 11, 2021	Aug. 31, 2019
Sales of Stock
Proceeds from the issuance of common stock		$ 1,789,524	$ 43,193,660
2021 Sales Agreement
Sales of Stock
Maximum aggregate value of common stock available for offering					$ 75,000,000.0
Shares issued	297,362	857,060
Weighted average selling price per share	$ 2.17	$ 2.09
Proceeds from the issuance of common stock		$ 1,800,000
Net proceeds from the issuance of common stock	$ 600,000	$ 1,600,000
2019 Sales Agreement.
Sales of Stock
Maximum aggregate value of common stock available for offering						$ 75,000,000.0
Shares issued			10,244,326
Weighted average selling price per share			$ 4.22
Proceeds from the issuance of common stock			$ 43,200,000	$ 75,000,000.0
Net proceeds from the issuance of common stock			$ 42,200,000

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Stock-Based Compensation - Stock Based Compensation Narrative (Details) - 2014 Plan - USD ($)		3 Months Ended
	Jan. 01, 2022	Mar. 31, 2022	Mar. 31, 2021
Stock-Based Compensation
Annual threshold increase of authorized shares for issuance		1,500,000
Annual threshold increase of authorized shares for issuance (as a percent)		10.00%
Additional number of shares authorized for issuance	1,500,000
Shares reserved for issuance	10,804,869
Shares available for issuance		1,779,008
Share based compensation expense		$ 1,160,482	$ 1,264,837
Stock options
Stock-Based Compensation
Contractual life (in years)		10 years
Share based compensation expense		$ 578,826	$ 945,366
Stock options | Employees
Stock-Based Compensation
Vesting percentage		25.00%
Vesting period		3 years
Stock options | Board of Directors
Stock-Based Compensation
Vesting period		1 year
Time Based Restricted Stock
Stock-Based Compensation
Shares granted		693,000	506,911
Shares outstanding		469,911
Vesting period			2 years
Performance Based Restricted Awards
Stock-Based Compensation
Shares granted		556,500	506,911
Shares outstanding		469,911
Share based compensation expense		$ 1,500,000
Unrecognized stock based compensation expense		$ 200,000

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Stock-Based Compensation - Stock-Based Compensation Expense (Details) - 2014 Plan - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Stock-Based Compensation
Stock-based compensation	$ 1,160,482	$ 1,264,837
Research and development
Stock-Based Compensation
Stock-based compensation	529,496	619,391
General and administrative
Stock-Based Compensation
Stock-based compensation	630,986	645,446
Stock options
Stock-Based Compensation
Stock-based compensation	578,826	945,366
Stock options | Research and development
Stock-Based Compensation
Stock-based compensation	261,402	432,930
Stock options | General and administrative
Stock-Based Compensation
Stock-based compensation	317,424	512,436
Restricted stock
Stock-Based Compensation
Stock-based compensation	581,656	319,471
Restricted stock | Research and development
Stock-Based Compensation
Stock-based compensation	268,094	186,461
Restricted stock | General and administrative
Stock-Based Compensation
Stock-based compensation	$ 313,562	$ 133,010

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Stock-Based Compensation - Options Activity, Unrecognized Costs, Valuation (Details) - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Additional disclosures
Proceeds from the exercise of stock options		$ 47,906
2014 Plan | Stock options
Options
Balance (in shares)	5,224,913
Granted (in shares)	903,750
Forfeited (in shares)	(65,625)
Balance (in shares)	6,063,038
Options exercisable (in shares)	3,998,496
Options vested and expected to vest (in shares)	6,063,038
Weighted average exercise price per share
Balance (in dollars per shares)	$ 8.74
Granted (in dollars per shares)	2.47
Forfeited (in dollars per share)	12.82
Balance (in dollars per shares)	7.76
Options exercisable (in dollars per shares)	9.98
Options vested and expected to vest (in dollars per share)	$ 7.76
Additional disclosures
Options Outstanding Weighted Average Contractual term	6 years 6 months 18 days
Options Vested and Expected to Vest Weighted Average Contractual Life	5 years 3 months 18 days
Expected stock based compensation expense	$ 4,900,000
Recognition period for compensation costs	2 years 9 months 10 days
Proceeds from the exercise of stock options		$ 47,906
Weighted Average Grant Date Fair Value
Granted (in dollars per share)	$ 1.99	$ 2.79
Assumptions and Methodology
Weighted average risk-free interest rate (as a percent)	1.63%	0.36%
Expected term of options (in years)	6 years 3 months	6 years 3 months
Expected stock price volatility (as a percent)	101.37%	95.60%
Expected dividend yield (as a percent)	0.00%	0.00%

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Stock-Based Compensation - Restricted Stock Activity, Unrecognized Costs (Details) - 2014 Plan - Restricted stock	3 Months Ended
	Mar. 31, 2022 USD ($) $ / shares shares
Restricted stock award activity
Unvested balance (in shares) | shares	989,822
Granted (in shares) | shares	1,249,500
Vested (in shares) | shares	(5,000)
Unvested balance (in shares) | shares	2,234,322
Weighted Average Grant Date Fair Value
Unvested balance (in dollars per share) | $ / shares	$ 3.62
Granted (in dollars per share) | $ / shares	2.42
Vested (in dollars per share) | $ / shares	4.91
Unvested balance (in dollars per share) | $ / shares	$ 2.95
Aggregate intrinsic value | $	$ 4,580,360
Unvested restricted stock awards expected to vest (in shares) | shares	1,672,822
Vested and expected to vest - Weighted average grant date fair value | $ / shares	$ 3.12
Vested and expected to vest - Aggregate Intrinsic Value | $	$ 3,429,285
Unrecognized compensation expense related to unvested awards | $	$ 2,400,000
Recognition period for compensation costs	9 months 10 days

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Operating Lease Obligations - Narrative (Details)		3 Months Ended
	Mar. 01, 2021 USD ($)	Mar. 31, 2022 USD ($) ft²	Dec. 31, 2021 USD ($)
Operating Lease Obligations
Practical expedients - Package		true
Practical expedients - Single lease component		true
Area of leasable office space | ft²		10,877
Extended term of lease	3 years
Operating lease liability	$ 755,085	$ 506,266
Right-of-use assets	752,391	$ 509,002	$ 565,814
Deferred rent liability included in right-of-use assets	$ 2,694

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Operating Lease Obligations - Other Operating Lease Information (Details)	Mar. 31, 2022
Operating Lease Obligations
Weighted-average remaining lease term - operating leases	2 years 2 months 12 days
Weighted-average discount rate - operating leases	2.76%

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Operating Lease Obligations - Maturities (Details) - USD ($)	Mar. 31, 2022	Mar. 01, 2021
Maturity Analysis of Operating Lease Liabilities
December 31, 2022	$ 180,315
December 31, 2023	240,421
December 31, 2024	100,175
Total minimum lease payments	520,911
Less: imputed lease interest	(14,645)
Total lease liabilities	$ 506,266	$ 755,085

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Operating Lease Obligations - Lease Expense and Payments (Details) - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Lease expense
Operating lease expense	$ 60,421	$ 62,946
Variable lease expense	17,602	16,841
Total lease expense	78,023	79,787
Cash payments related to leases	$ 77,707	$ 83,744