CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
CONSOLIDATED STATEMENTS OF OPERATIONS
Revenue	$ 27,148	$ 6,149	$ 3,958
Operating expenses
Research and development	(127,726)	(111,090)	(91,568)
General and administrative	(63,387)	(57,305)	(45,795)
Total operating expenses	(191,113)	(168,395)	(137,363)
Operating loss	(163,965)	(162,246)	(133,405)
Interest income	1,542	1,095	2,313
Other (expense) income, net	(536)	3,852	1,162
Loss before income tax expense	(162,959)	(157,299)	(129,930)
Income tax expense	(2,497)	(791)	(162)
Net loss attributable to ordinary shareholders	$ (165,456)	$ (158,090)	$ (130,092)
Net loss per ordinary share
Basic (in dollars per share)	$ (0.17)	$ (0.17)	$ (0.15)
Diluted (in dollars per share)	$ (0.17)	$ (0.17)	$ (0.15)
Weighted average shares outstanding:
Basic (in shares)	967,242,403	934,833,017	854,783,763
Diluted (in shares)	967,242,403	934,833,017	854,783,763