UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended		12 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Cash flows from operating activities
Net loss	$ (136,206)	$ (119,232)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	4,009	4,333
Amortization	629
Share-based compensation expense	14,294	15,802
Unrealized foreign exchange gains	(2,501)	(213)
Amortization on available-for-sale debt securities	2,165	4,094
Other	765	2,239
Changes in operating assets and liabilities:
Increase in receivables and other operating assets	(29,778)	(31,809)
Increase/(decrease) in payables and other current liabilities	15,200	(109)
(Decrease)/increase in deferred revenue	(12,388)	1,696	$ 46,567
Net cash used in operating activities	(143,811)	(123,199)
Cash flows from investing activities
Acquisition of property, plant and equipment	(26,081)	(4,558)
Acquisition of intangibles assets	(231)	(181)
Maturity or redemption of marketable securities	136,694	190,393
Investment in marketable securities	(42,197)	(81,363)
Net cash provided by investing activities	68,185	104,291
Cash flows from financing activities
Proceeds from issuance of common stock from offerings, net of commissions and issuance costs	11,422	2,529
Proceeds from exercise of stock options	42	707
Net cash provided by financing activities	11,464	3,236
Effect of currency exchange rate changes on cash, cash equivalents and restricted cash	(6,791)	(1,177)
Net decrease in cash, cash equivalents and restricted cash	(70,953)	(16,849)
Cash, cash equivalents and restricted cash at start of period	151,666	61,484	61,484
Cash, cash equivalents and restricted cash at end of period	$ 80,713	$ 44,635	$ 151,666