Consolidated Schedule of Investments (unaudited) March 31, 2022   BlackRock Science and Technology Trust (BST) (Percentages shown are based on Net Assets)

Security	Shares		Value
Common Stocks
Automobiles(a) — 2.8%
Arrival SA		1,090,443	$	4,067,352
Tesla, Inc.(b)		33,525		36,126,540
				40,193,892
Capital Markets(b) — 0.7%
Coinbase Global, Inc., Class A(a)		18,583		3,528,169
S&P Global, Inc.		17,435		7,151,488
				10,679,657
Diversified Consumer Services — 0.3%
Think & Learn Private Ltd., (Acquired 09/30/20, Cost: $1,524,948)(c)(d)		997		4,687,314
Electronic Equipment, Instruments & Components — 1.5%
CDW Corp.(b)		54,202		9,696,196
Samsung SDI Co. Ltd.		23,749		11,558,392
				21,254,588
Entertainment — 0.4%
Roku, Inc.(a)(b)		46,767		5,858,502
Hotels, Restaurants & Leisure(a)(b) — 1.2%
Airbnb, Inc., Class A		37,782		6,489,436
Booking Holdings, Inc.		4,490		10,544,541
				17,033,977
Interactive Media & Services — 6.7%
Alphabet, Inc., Class A(a)(b)		15,340		42,665,909
Kakao Corp.		259,131		22,523,282
Snap, Inc., Class A(a)(b)		261,882		9,425,133
Z Holdings Corp.		2,013,100		8,702,816
ZoomInfo Technologies, Inc., CLass A(a)(b)		237,092		14,163,876
				97,481,016
Internet & Direct Marketing Retail — 3.3%
Amazon.com, Inc.(a)(b)		9,808		31,973,589
Cazoo Group Ltd.(a)(e)		1,298,058		3,582,640
Jasper Infotech Private Ltd., Series I, (Acquired 08/18/15, Cost: $1,998,435)(c)(d)		168,640		236,096
MercadoLibre, Inc.(a)(b)		10,235		12,174,328
				47,966,653
Internet Software & Services — 0.7%
Voltron Data Inc., Series A, (Acquired 01/18/22, Cost: $10,000,000)(c)(d)		6,201,935		9,923,096
IT Services — 18.2%
Accenture PLC, Class A(b)		52,691		17,768,986
Adyen NV(a)(f)		4,805		9,517,232
Automattic, Inc., Series E, (Acquired 02/03/21, Cost: $7,999,945)(c)(d)		94,117		6,925,129
Block, Inc.(a)(b)		111,131		15,069,364
GMO Payment Gateway Inc.		88,800		9,046,597
Klarna Holdings AB, (Acquired 08/07/19, Cost: $7,971,978)(c)(d)		26,430		39,446,151
Mastercard, Inc., Class A(b)		82,846		29,607,503
MongoDB, Inc.(a)(b)		32,327		14,339,934
Okta, Inc.(a)(b)		74,260		11,210,290
PayPal Holdings, Inc.(a)(b)		114,273		13,215,672
Salt Pay Co., Ltd., Series C, (Acquired 12/17/21, Cost: $24,999,987)(c)(d)		12,871		23,389,052
Shopify, Inc., Class A(a)(b)		9,282		6,274,261
Snowflake, Inc., Class A(a)(b)		13,836		3,170,243

Security	Shares		Value
IT Services (continued)
Thoughtworks Holding Inc.(a)(b)		469,678	$	9,773,999
TRAX Ltd., (Acquired 09/12/19, Cost: $4,000,013)(c)(d)		106,667		5,077,349
TRAX Ltd., Series D, (Acquired 02/18/21, Cost: $1,999,989)(c)(d)		38,361		1,825,984
Twilio, Inc., Class A(a)(b)		79,278		13,065,807
Visa, Inc., Class A(b)		113,783		25,233,656
Wise PLC, Class A(a)		1,418,170		9,169,299
				263,126,508
Professional Services — 0.4%
Planet Labs Inc., (Acquired 01/06/22, Cost: $10,000,000)(d)		1,000,000		5,080,000
Road & Rail — 1.1%
Ant Group Co., Ltd, Series C, (Acquired 05/18/18, Cost: $6,492,862)(c)(d)		1,703,548		6,337,198
Lyft, Inc., Class A(a)(b)		229,117		8,798,093
				15,135,291
Semiconductors & Semiconductor Equipment — 17.9%
Advanced Micro Devices, Inc.(a)(b)		124,266		13,587,244
Alphawave IP Group PLC(a)		1,539,553		3,578,718
Analog Devices, Inc.(b)		46,593		7,696,232
ASML Holding NV		35,031		23,408,466
Credo Technology Group Holding Ltd., (Acquired 01/27/22, Cost: $5,404,499)(d)		1,071,061		15,782,111
Globalfoundries Inc.(a)(b)		169,368		10,571,950
Lam Research Corp.(b)		40,619		21,837,181
Marvell Technology Inc.(b)		611,368		43,841,199
Micron Technology, Inc.(b)		92,793		7,227,647
Monolithic Power Systems, Inc.(b)		29,170		14,167,286
NVIDIA Corp.(b)		67,912		18,530,468
Qualcomm, Inc.(b)		42,749		6,532,902
Renesas Electronics Corp.(a)		1,000,900		11,597,395
Soitec SA(a)		71,545		13,420,721
STMicroelectronics NV		265,143		11,524,167
Taiwan Semiconductor Manufacturing Co. Ltd., ADR(b)		138,104		14,398,723
Wolfspeed, Inc.(a)(b)		187,495		21,348,181
				259,050,591
Software — 21.1%
Adobe, Inc.(a)(b)		31,718		14,451,355
ANSYS, Inc.(a)(b)		35,199		11,180,962
AppLovin Corp., Class A(a)(b)		200,487		11,040,819
Atlassian Corp. PLC, Class A(a)(b)		41,325		12,142,525
Avalara, Inc.(a)(b)		80,082		7,968,960
AvidXchange Holdings, Inc.(a)		248,268		1,998,558
AvidXchange, Inc., (Acquired 07/29/20, Cost: $2,022,088)(d)		165,028		1,324,416
Cadence Design Systems, Inc.(a)(b)		100,929		16,598,783
Crowdstrike Holdings, Inc., Class A(a)(b)		51,352		11,661,012
CS Disco, Inc.(a)(b)		215,329		7,314,726
Databricks, Inc., (Acquired 07/24/20, Cost: $960,476)(c)(d)		19,999		3,542,223
DataRobot, Inc., (Acquired 03/01/21, Cost: $583,275)(c)(d)		38,789		1,054,673
Elastic NV(a)(b)		67,504		6,004,481
Gitlab, Inc., Class A(a)(b)		156,500		8,521,425
Grammarly, Inc., (Acquired 11/17/21, Cost: $18,749,975)(c)(d)		715,323		18,884,527

1

Consolidated Schedule of Investments (unaudited) (continued) March 31, 2022   BlackRock Science and Technology Trust (BST) (Percentages shown are based on Net Assets)

Security	Shares		Value
Software (continued)
Intuit, Inc.(b)		31,439	$	15,117,129
Microsoft Corp.(b)		237,600		73,254,456
Patreon, Inc., (Acquired 08/19/21, Cost: $3,352,226)(c)(d)		59,524		2,839,890
salesforce.com, Inc.(a)(b)		65,222		13,847,935
ServiceNow, Inc.(a)(b)		31,148		17,346,010
SiteMinder Ltd.(a)		2,145,680		7,301,016
Snorkel AI, Inc., (Acquired 06/30/21, Cost: $997,636)(c)(d)		66,422		907,989
Snyk Ltd., (Acquired 09/02/21, Cost: $5,192,307)(c)(d) .		361,972		4,560,847
Unity Software, Inc.(a)(b)		117,216		11,628,999
Xero Ltd.(a)		130,197		9,867,326
Zscaler, Inc.(a)(b)		60,440		14,582,963
				304,944,005
Technology Hardware, Storage & Peripherals — 5.6%
Apple, Inc.(b)		462,554		80,766,554
Total Common Stocks — 81.9% (Cost: $584,602,858)				1,183,181,644
	Par (000)
Convertible Notes
Software — 0.6%
Warhol, Inc.(Acquired: 12/14/21, Cost: $8,000,000), 0.00%(c)(d)	$	80		8,040,000
Total Convertible Notes — 0.6% (Cost: $8,000,000)				8,040,000
	Shares
Preferred Securities
Preferred Stocks — 17.9%(c)(d)
Chemicals — 0.6%
Solugen, Inc., (Acquired 09/02/21, Cost: $9,999,977) .		269,284		8,320,876
Diversified Consumer Services — 0.3%
Think & Learn Private Ltd., Series F, (Acquired 09/30/20, Cost: $3,052,975)		1,054		4,955,295
Diversified Financial Services — 0.7%
Trumid Holdings LLC, Class L, (Acquired 09/15/21, Cost: $9,999,695)(g)		11,420		9,703,346
Entertainment — 0.4%
Discord, Inc., Series I, (Acquired 09/13/21, Cost: $7,000,088)		12,713		5,361,199
Food & Staples Retailing — 1.1%
Grubmarket, Inc., Series E, (Acquired 10/18/21, Cost: $6,999,994)		709,724		16,089,443
Food Products — 0.8%
Farmer’s Business Network, Inc. (Acquired 09/15/21, Cost: $6,999,963)		112,616		6,339,155
Series F, (Acquired 07/31/20, Cost: $2,999,886)		90,750		5,108,317
				11,447,472

Security	Shares		Value
Interactive Media & Services — 1.0%
ByteDance Ltd., Series E-1, (Acquired 11/11/20, Cost: $9,999,959)		91,262	$	14,702,999
IT Services — 1.5%
Deep Instinct Ltd., Series D-2, (Acquired 03/19/21, Cost: $2,999,391)		493,493		2,852,389
Trumid Holdings LLC(g)
Class J-A, (Acquired 07/24/20, Cost: $2,499,716)		5,038		4,280,688
Class J-B, (Acquired 07/24/20, Cost: $1,499,830)		5,038		4,280,688
Voltron Data, Inc., (Acquired 07/14/21, Cost: $5,000,000)		9,090,909		10,909,091
				22,322,856
Road & Rail — 0.3%
FlixMobility GmbH, Series F, (Acquired 07/26/19, Cost: $5,482,937)		275		4,133,115
Semiconductors & Semiconductor Equipment — 3.4%
Psiquantum Corp., Series C, (Acquired 09/09/19, Cost: $3,200,234)		690,003		14,179,562
PsiQuantum Corp., Series C, (Acquired 05/21/21, Cost: $5,000,025)		190,650		4,913,050
Rivos, Series A, (Acquired 12/03/21, Cost: $12,003,705)		1,500,000		11,805,000
SambaNova Systems, Inc., Series C, (Acquired 02/20/20, Cost: $9,972,125)		187,300		18,879,840
				49,777,452
Software — 7.8%
Bolt Financial Inc., Series E, (Acquired 01/18/22, Cost: $29,999,955)		598,682		29,999,955
Databricks, Inc.
Series F, (Acquired 10/22/19, Cost: $3,999,999)		93,135		16,496,071
Series G, (Acquired 02/01/21, Cost: $4,500,001)		25,371		4,493,712
DataRobot, Inc., Series F, (Acquired 10/27/20, Cost: $2,999,996)		228,276		6,209,107
Grammarly, Inc., Series 3, (Acquired 11/17/21, Cost: $6,249,992)		238,441		6,294,842
MNTN Digital, Inc., (Acquired 11/05/21, Cost: $24,999,980)		1,088,598		21,336,521
Patreon, Inc., Series D, (Acquired 07/14/21, Cost: $6,666,632)		119,047		5,679,732
Prosimo, Inc., Series B, (Acquired 11/04/21, Cost: $4,999,998)		2,515,811		4,905,832
Snorkel AI, Inc., Series C, (Acquired 06/30/21, Cost: $4,999,985)		332,896		4,550,688
Snyk Ltd., Series B, (Acquired 09/02/21, Cost: $4,807,688)		335,159		4,223,003
Unqork, Inc.
Series B, (Acquired 09/19/19, Cost: $3,198,416)		281,080		6,737,488
Series C, (Acquired 09/18/20, Cost: $1,303,260)		47,600		1,140,972
				112,067,923
				258,881,976
Total Preferred Securities — 17.9% (Cost: $203,436,402)				258,881,976

C O N S O L I D A T E D  S C H E D U L E  O F   I N V E S T M E N T S 2

Consolidated Schedule of Investments (unaudited) (continued) March 31, 2022   BlackRock Science and Technology Trust (BST) (Percentages shown are based on Net Assets)

Security	Shares		Value
Warrants
IT Services — 0.0%
TRAX Ltd. (Expires 09/15/2023), (Acquired 09/12/19, Cost: $0)(c)(d)		17,065	$	94,199
Total Warrants — 0.0% (Cost: $ — )				94,199
Total Long-Term Investments — 100.4% (Cost: $796,039,260)				1,450,197,819
Short-Term Securities
Money Market Funds — 0.8%
BlackRock Liquidity Funds, T-Fund, Institutional Class, 0.21%(h)(i)		10,449,533		10,449,533
SL Liquidity Series, LLC, Money Market Series, 0.43%(h)(i)(j)		976,538		976,245
Total Short-Term Securities — 0.8% (Cost: $11,425,582)				11,425,778
Total Investments Before Options Written — 101.2% (Cost: $807,464,842)				1,461,623,597
Options Written — (1.2)% (Premiums Received: $(11,756,963))				(16,674,962	)
Total Investments, Net of Options Written — 100.0% (Cost: $795,707,879)				1,444,948,635
Liabilities in Excess of Other Assets — 0.0%				(41,998	)
Net Assets — 100.0%			$	1,444,906,637

(a) Non-income producing security.

(b) All or a portion of the security has been pledged and/or segregated as collateral in connection with outstanding exchange-traded options written.

(c) Security is valued using significant unobservable inputs and is classified as Level 3 in the fair value hierarchy.

(d) Restricted security as to resale, excluding 144A securities. The Trust held restricted securities with a current value of $418,840,220, representing 29.0% of its net assets as of period end, and an original cost of $325,687,041.

(e) All or a portion of this security is on loan.

(f) Security exempt from registration pursuant to Rule 144A under the Securities Act of 1933, as amended. These securities may be resold in transactions exempt from registration to qualified institutional investors.

(g) All or a portion of the security is held by a wholly-owned subsidiary.

(h) Affiliate of the Trust.

(i) Annualized 7-day yield as of period end.

(j) All or a portion of this security was purchased with the cash collateral from loaned securities.

For Trust compliance purposes, the Trust’s industry classifications refer to one or more of the industry sub-classifications used by one or more widely recognized market indexes or rating group indexes, and/or as defined by the investment adviser. These definitions may not apply for purposes of this report, which may combine such industry sub-classifications for reporting ease.

Affiliates

Investments in issuers considered to be affiliate(s) of the Trust during the period ended March 31, 2022 for purposes of Section 2(a)(3) of the Investment Company Act of 1940, as amended, were as follows:

Affiliated Issuer	Value at 12/31/21		Purchases at Cost			Proceeds from Sales			Net Realized Gain (Loss)			Change in Unrealized Appreciation (Depreciation)		Value at 03/31/22		Shares Held at 03/31/22		Income			Capital Gain Distributions from Underlying Funds
BlackRock Liquidity Funds, T-Fund, Institutional Class	$	42,574,872	$	—		$	(32,125,339	)(a)	$	—		$	—	$	10,449,533		10,449,533	$	1,796		$	—
SL Liquidity Series, LLC, Money Market Series		840,396		136,447	(a)		—			(794	)		196		976,245		976,538		11,783	(b)		—
									$	(794	)	$	196	$	11,425,778			$	13,579		$	—

(a) Represents net amount purchased (sold).

(b) All or a portion represents securities lending income earned from the reinvestment of cash collateral from loaned securities, net of fees and collateral investment expenses, and other payments to and from borrowers of securities.

Derivative Financial Instruments Outstanding as of Period End

Exchange-Traded Options Written

Description	Number of Contracts		Expiration Date		Exercise Price		Notional Amount (000)		Value
Call
Accenture PLC, Class A		89		04/01/22	USD	335.00	USD	3,001	$	(32,485	)
Adobe, Inc.		18		04/01/22	USD	470.00	USD	820		(666	)
Apple, Inc.		23		04/01/22	USD	180.00	USD	402		(127	)

3

Consolidated Schedule of Investments (unaudited) (continued) March 31, 2022   BlackRock Science and Technology Trust (BST)

Exchange-Traded Options Written (continued)

Description	Number of Contracts		Expiration Date		Exercise Price		Notional Amount (000)		Value
Call (continued)
Block, Inc.		102		04/01/22	USD	140.00	USD	1,383	$	(8,874	)
Coinbase Global, Inc., Class A		39		04/01/22	USD	195.00	USD	740		(4,388	)
MercadoLibre, Inc.		8		04/01/22	USD	1,260.00	USD	952		(4,640	)
NVIDIA Corp.		117		04/01/22	USD	280.00	USD	3,192		(9,828	)
ServiceNow, Inc.		27		04/01/22	USD	625.00	USD	1,504		(1,080	)
Twilio, Inc., Class A		90		04/01/22	USD	180.00	USD	1,483		(1,170	)
Zscaler, Inc.		32		04/01/22	USD	260.00	USD	772		(368	)
Airbnb, Inc., Class A		41		04/08/22	USD	170.00	USD	704		(23,780	)
Alphabet Inc., Class A		20		04/08/22	USD	2,800.00	USD	5,563		(70,000	)
Apple, Inc.		282		04/08/22	USD	170.00	USD	4,924		(160,035	)
Block, Inc.		103		04/08/22	USD	120.00	USD	1,397		(174,842	)
Booking Holdings, Inc.		6		04/08/22	USD	2,410.00	USD	1,409		(14,580	)
Crowdstrike Holdings, Inc., Class A		27		04/08/22	USD	205.00	USD	613		(64,057	)
Marvell Technology Inc.		388		04/08/22	USD	77.51	USD	2,782		(10,011	)
Mastercard, Inc., Class A		39		04/08/22	USD	370.00	USD	1,394		(6,689	)
MercadoLibre, Inc.		12		04/08/22	USD	1,210.00	USD	1,427		(37,080	)
MongoDB, Inc.		12		04/08/22	USD	420.00	USD	532		(37,620	)
Okta, Inc.		109		04/08/22	USD	195.00	USD	1,645		(2,834	)
PayPal Holdings, Inc.		88		04/08/22	USD	115.00	USD	1,018		(29,040	)
Roku, Inc.		41		04/08/22	USD	155.00	USD	514		(759	)
Snap, Inc., Class A		154		04/08/22	USD	42.00	USD	554		(2,079	)
Snowflake, Inc., Class A		25		04/08/22	USD	285.00	USD	573		(500	)
Taiwan Semiconductor Manufacturing Co. Ltd., ADR		295		04/08/22	USD	118.00	USD	3,076		(1,475	)
Tesla, Inc.		45		04/08/22	USD	890.00	USD	4,849		(851,962	)
Unity Software, Inc.		187		04/08/22	USD	115.00	USD	1,855		(6,078	)
Visa, Inc., Class A		45		04/08/22	USD	225.00	USD	998		(9,540	)
Zscaler, Inc.		31		04/08/22	USD	275.00	USD	748		(1,488	)
Zscaler, Inc.		31		04/08/22	USD	260.00	USD	748		(5,255	)
Accenture PLC, Class A		26		04/14/22	USD	325.00	USD	877		(39,390	)
Airbnb, Inc., Class A		50		04/14/22	USD	165.00	USD	859		(51,250	)
Alphabet Inc., Class A		18		04/14/22	USD	2,960.00	USD	5,006		(10,440	)
Amazon.com, Inc.		7		04/14/22	USD	3,130.00	USD	2,282		(112,297	)
Analog Devices, Inc.		82		04/14/22	USD	175.00	USD	1,354		(8,200	)
ANSYS, Inc.		61		04/14/22	USD	340.00	USD	1,938		(16,013	)
Apple, Inc.		426		04/14/22	USD	170.00	USD	7,438		(273,705	)
Applovin Corp., Class A		191		04/14/22	USD	75.00	USD	1,052		(5,730	)
Atlassian Corp., PLC Class A		97		04/14/22	USD	270.00	USD	2,850		(290,515	)
Avalara, Inc.		190		04/14/22	USD	115.00	USD	1,891		(9,975	)
Block, Inc.		78		04/14/22	USD	115.00	USD	1,058		(172,185	)
Cadence Design Systems, Inc.		250		04/14/22	USD	154.00	USD	4,112		(297,720	)
CDW Corp.		168		04/14/22	USD	191.00	USD	3,005		(10,833	)
CS Disco, Inc.		270		04/14/22	USD	40.00	USD	917		(97,200	)
Elastic NV		43		04/14/22	USD	105.00	USD	382		(1,720	)
Elastic NV		105		04/14/22	USD	85.00	USD	934		(66,675	)
Gitlab, Inc., Class A		586		04/14/22	USD	70.00	USD	3,191		(27,835	)
Globalfoundries Inc.		275		04/14/22	USD	65.00	USD	1,717		(58,437	)
Lam Research Corp.		64		04/14/22	USD	590.00	USD	3,441		(13,248	)
Lyft, Inc., Class A		215		04/14/22	USD	40.00	USD	826		(17,308	)
Marvell Technology Inc.		436		04/14/22	USD	85.00	USD	3,127		(3,924	)
Mastercard, Inc., Class A		41		04/14/22	USD	355.00	USD	1,465		(38,130	)
Microsoft Corp.		170		04/14/22	USD	330.00	USD	5,241		(10,625	)
MongoDB, Inc.		16		04/14/22	USD	480.00	USD	710		(9,920	)
Monolithic Power Systems, Inc.		101		04/14/22	USD	510.00	USD	4,905		(70,700	)
NVIDIA Corp.		56		04/14/22	USD	265.00	USD	1,528		(83,300	)
Okta, Inc.		44		04/14/22	USD	200.00	USD	664		(594	)
Roku, Inc.		38		04/14/22	USD	160.00	USD	476		(1,387	)
salesforce.com, Inc.		80		04/14/22	USD	240.00	USD	1,699		(1,320	)
ServiceNow, Inc.		30		04/14/22	USD	600.00	USD	1,671		(13,050	)
Shopify, Inc., Class A		14		04/14/22	USD	800.00	USD	946		(7,910	)
Snap, Inc., Class A		210		04/14/22	USD	39.00	USD	756		(15,120	)
Tesla, Inc.		17		04/14/22	USD	1,100.00	USD	1,832		(63,410	)
Thoughtworks Holding Inc.		478		04/14/22	USD	30.00	USD	995		(14,340	)

C O N S O L I D A T E D  S C H E D U L E  O F   I N V E S T M E N T S 4

Consolidated Schedule of Investments (unaudited) (continued) March 31, 2022   BlackRock Science and Technology Trust (BST)

Exchange-Traded Options Written (continued)

Description	Number of Contracts		Expiration Date		Exercise Price		Notional Amount (000)		Value
Call (continued)
Thoughtworks Holding Inc.		269		04/14/22	USD	25.00	USD	560	$	(8,070	)
Twilio, Inc., Class A		67		04/14/22	USD	195.00	USD	1,104		(4,322	)
Visa, Inc., Class A		70		04/14/22	USD	210.00	USD	1,552		(91,700	)
Wolfspeed, Inc.		93		04/14/22	USD	120.00	USD	1,059		(28,598	)
Wolfspeed, Inc.		93		04/14/22	USD	115.00	USD	1,059		(39,990	)
ZoomInfo Technologies, Inc., Class A		304		04/14/22	USD	60.00	USD	1,816		(72,200	)
Advanced Micro Devices, Inc.		203		04/22/22	USD	126.00	USD	2,220		(17,560	)
Alphabet Inc., Class A		13		04/22/22	USD	2,750.00	USD	3,616		(115,050	)
Amazon.com, Inc.		15		04/22/22	USD	3,060.00	USD	4,890		(346,237	)
Analog Devices, Inc.		75		04/22/22	USD	170.00	USD	1,239		(21,188	)
Apple, Inc.		324		04/22/22	USD	170.00	USD	5,657		(264,870	)
Apple, Inc.		23		04/22/22	USD	180.00	USD	402		(4,899	)
Atlassian PLC, Class A		17		04/22/22	USD	285.00	USD	500		(36,295	)
Block, Inc.		104		04/22/22	USD	140.00	USD	1,410		(70,200	)
Crowdstrike Holdings, Inc., Class A		74		04/22/22	USD	205.00	USD	1,680		(193,510	)
Intuit, Inc.		16		04/22/22	USD	500.00	USD	769		(12,080	)
Lyft, Inc., Class A		88		04/22/22	USD	44.00	USD	338		(2,596	)
Marvell Technology Inc.		208		04/22/22	USD	70.00	USD	1,492		(84,760	)
Mastercard, Inc., Class A		48		04/22/22	USD	370.00	USD	1,715		(22,560	)
MercadoLibre, Inc.		8		04/22/22	USD	1,080.00	USD	952		(108,600	)
Micron Technology, Inc.		170		04/22/22	USD	80.00	USD	1,324		(39,610	)
Microsoft Corp.		102		04/22/22	USD	300.00	USD	3,145		(138,210	)
PayPal Holdings, Inc.		196		04/22/22	USD	110.00	USD	2,267		(164,640	)
Tesla, Inc.		25		04/22/22	USD	935.00	USD	2,694		(392,562	)
Tesla, Inc.		18		04/22/22	USD	1,075.00	USD	1,940		(110,115	)
Unity Software, Inc.		53		04/22/22	USD	101.00	USD	526		(27,825	)
Visa, Inc., Class A		169		04/22/22	USD	220.00	USD	3,748		(118,722	)
Zscaler, Inc.		55		04/22/22	USD	220.00	USD	1,327		(145,475	)
Accenture PLC, Class A		82		04/29/22	USD	345.00	USD	2,765		(44,280	)
Adobe, Inc.		100		04/29/22	USD	460.00	USD	4,556		(144,500	)
Airbnb, Inc., Class A		50		04/29/22	USD	180.00	USD	859		(27,125	)
Analog Devices, Inc.		2		04/29/22	USD	160.00	USD	33		(1,830	)
Block, Inc.		29		04/29/22	USD	120.00	USD	393		(57,637	)
Booking Holdings, Inc.		10		04/29/22	USD	2,300.00	USD	2,348		(114,400	)
Coinbase Global, Inc., Class A		20		04/29/22	USD	205.00	USD	380		(15,800	)
Lam Research Corp.		68		04/29/22	USD	530.00	USD	3,656		(214,370	)
Lyft, Inc., Class A		194		04/29/22	USD	40.00	USD	745		(29,003	)
Marvell Technology Inc.		467		04/29/22	USD	73.00	USD	3,349		(133,562	)
MercadoLibre, Inc.		10		04/29/22	USD	1,000.00	USD	1,189		(206,900	)
MongoDB, Inc.		30		04/29/22	USD	450.00	USD	1,331		(75,600	)
NVIDIA Corp.		81		04/29/22	USD	250.00	USD	2,210		(241,987	)
Okta, Inc.		44		04/29/22	USD	175.00	USD	664		(8,426	)
Qualcomm, Inc.		162		04/29/22	USD	170.00	USD	2,476		(32,562	)
Roku, Inc.		41		04/29/22	USD	150.00	USD	514		(9,410	)
salesforce.com, Inc.		60		04/29/22	USD	220.00	USD	1,274		(26,550	)
Shopify, Inc., Class A		14		04/29/22	USD	680.00	USD	946		(75,320	)
Snap, Inc., Class A		313		04/29/22	USD	34.00	USD	1,126		(141,632	)
Snowflake, Inc., Class A		26		04/29/22	USD	195.00	USD	596		(102,830	)
Taiwan Semiconductor Manufacturing Co. Ltd., ADR		143		04/29/22	USD	110.00	USD	1,491		(25,669	)
Twilio, Inc., Class A		140		04/29/22	USD	185.00	USD	2,307		(57,050	)
Unity Software, Inc.		92		04/29/22	USD	110.00	USD	913		(28,244	)
Zscaler, Inc.		46		04/29/22	USD	250.00	USD	1,110		(45,885	)
Advanced Micro Devices, Inc.		143		05/06/22	USD	124.00	USD	1,564		(37,609	)
Amazon.com, Inc.		4		05/06/22	USD	3,380.00	USD	1,304		(35,770	)
Analog Devices, Inc.		73		05/06/22	USD	175.00	USD	1,206		(17,338	)
Crowdstrike Holdings, Inc., Class A		91		05/06/22	USD	225.00	USD	2,066		(142,642	)
Intuit, Inc.		101		05/06/22	USD	490.00	USD	4,856		(165,135	)
Lam Research Corp.		43		05/06/22	USD	600.00	USD	2,312		(36,120	)
Lyft, Inc., Class A		187		05/06/22	USD	43.00	USD	718		(19,542	)
Mastercard, Inc., Class A		146		05/06/22	USD	385.00	USD	5,218		(59,495	)
Microsoft Corp.		186		05/06/22	USD	320.00	USD	5,735		(113,460	)
Okta, Inc.		38		05/06/22	USD	160.00	USD	574		(24,130	)

5

Consolidated Schedule of Investments (unaudited) (continued) March 31, 2022   BlackRock Science and Technology Trust (BST)

Exchange-Traded Options Written (continued)

Description	Number of Contracts		Expiration Date		Exercise Price		Notional Amount (000)		Value
Call (continued)
Snap, Inc., Class A		150		05/06/22	USD	39.00	USD	540	$	(37,875	)
Taiwan Semiconductor Manufacturing Co. Ltd., ADR		252		05/06/22	USD	115.00	USD	2,627		(26,082	)
Tesla, Inc.		45		05/06/22	USD	1,100.00	USD	4,849		(328,500	)
Zscaler, Inc.		31		05/06/22	USD	265.00	USD	748		(20,770	)
Marvell Technology Inc.		722		05/13/22	USD	77.00	USD	5,177		(184,471	)
Shopify, Inc., Class A		6		05/13/22	USD	775.00	USD	406		(18,390	)
Advanced Micro Devices, Inc.		119		05/20/22	USD	125.00	USD	1,301		(39,865	)
Alphabet Inc., Class A		6		05/20/22	USD	2,820.00	USD	1,669		(61,710	)
Amazon.com, Inc.		10		05/20/22	USD	3,200.00	USD	3,260		(194,125	)
ANSYS, Inc.		70		05/20/22	USD	340.00	USD	2,224		(57,050	)
Apple, Inc.		78		05/20/22	USD	170.00	USD	1,362		(77,220	)
Applovin Corp., Class A		560		05/20/22	USD	55.00	USD	3,084		(344,400	)
Atlassian Corp., PLC Class A		40		05/20/22	USD	330.00	USD	1,175		(48,200	)
Avalara, Inc.		110		05/20/22	USD	90.00	USD	1,095		(156,200	)
Cadence Design Systems, Inc.		130		05/20/22	USD	160.00	USD	2,138		(151,450	)
CDW Corp.		35		05/20/22	USD	190.00	USD	626		(12,338	)
Coinbase Global, Inc., Class A		10		05/20/22	USD	200.00	USD	190		(14,850	)
CS Disco, Inc.		537		05/20/22	USD	35.00	USD	1,824		(204,060	)
Elastic NV		105		05/20/22	USD	90.00	USD	934		(71,400	)
Globalfoundries Inc.		360		05/20/22	USD	85.00	USD	2,247		(45,000	)
Lam Research Corp.		28		05/20/22	USD	565.00	USD	1,505		(59,570	)
Lyft, Inc., Class A		175		05/20/22	USD	42.50	USD	672		(26,950	)
Marvell Technology Inc.		517		05/20/22	USD	80.00	USD	3,707		(96,679	)
Mastercard, Inc., Class A		36		05/20/22	USD	345.00	USD	1,287		(86,490	)
Micron Technology, Inc.		180		05/20/22	USD	87.50	USD	1,402		(32,850	)
Microsoft Corp.		135		05/20/22	USD	315.00	USD	4,162		(129,262	)
MongoDB, Inc.		63		05/20/22	USD	400.00	USD	2,795		(398,790	)
Monolithic Power Systems, Inc.		44		05/20/22	USD	500.00	USD	2,137		(125,840	)
Okta, Inc.		43		05/20/22	USD	170.00	USD	649		(20,640	)
PayPal Holdings, Inc.		144		05/20/22	USD	130.00	USD	1,665		(43,200	)
Roku, Inc.		55		05/20/22	USD	135.00	USD	689		(58,850	)
S&P Global, Inc.		66		05/20/22	USD	420.00	USD	2,707		(72,270	)
salesforce.com, Inc.		104		05/20/22	USD	230.00	USD	2,208		(38,220	)
ServiceNow, Inc.		59		05/20/22	USD	580.00	USD	3,286		(165,790	)
Snap, Inc., Class A		155		05/20/22	USD	42.00	USD	558		(30,225	)
Tesla, Inc.		17		05/20/22	USD	1,025.00	USD	1,832		(205,232	)
Thoughtworks Holding Inc.		746		05/20/22	USD	22.50	USD	1,552		(91,385	)
Unity Software, Inc.		107		05/20/22	USD	95.00	USD	1,062		(135,087	)
Wolfspeed, Inc.		94		05/20/22	USD	125.00	USD	1,070		(52,640	)
ZoomInfo Technologies, Inc.		404		05/20/22	USD	70.00	USD	2,413		(62,620	)
Marvell Technology Inc.		320		06/17/22	USD	80.00	USD	2,295		(100,480	)
									$	(12,809,019	)

OTC Options Written

Description	Counterparty	Number of Contracts		Expiration Date		Exercise Price		Notional Amount (000)		Value
Call
Kakao Corp.	Morgan Stanley & Co. International PLC		41,600		04/01/22	USD	90,467.67	USD	4,430,400	$	(549,634	)
Renesas Electronics Corp.	JPMorgan Chase Bank N.A.		380,900		04/01/22	JPY	1,386.47	JPY	545,449		(107,682	)
Kakao Corp.	JPMorgan Chase Bank N.A.		55,500		04/06/22	USD	93,169.44	USD	5,910,750		(610,748	)
Wolfspeed, Inc.	Citibank N.A.		9,300		04/06/22	USD	105.90	USD	1,059		(82,320	)
Adyen NV	Credit Suisse International		1,800		04/07/22	EUR	1,816.42	EUR	3,256		(93,436	)
Alphawave IP Group PLC.	Goldman Sachs International		84,200		04/07/22	GBP	1.74	GBP	148		(10,667	)
Soitec SA	Goldman Sachs International		1,900		04/07/22	EUR	139.69	EUR	325		(62,825	)
Samsung SDI Co. Ltd.	JPMorgan Chase Bank N.A.		8,900		04/20/22	USD	581,319.65	USD	5,304,400		(230,232	)
Soitec SA	UBS AG		7,700		04/20/22	EUR	169.02	EUR	1,317		(61,087	)
Gmo Payment Gateway Inc.	Goldman Sachs International		8,100		04/21/22	JPY	12,268.72	JPY	101,898		(50,091	)
Wolfspeed, Inc.	Barclays Bank PLC		26,000		04/21/22	USD	108.34	USD	2,960		(229,972	)
Xero Ltd.	UBS AG		48,800		04/21/22	AUD	105.16	AUD	5,014		(112,619	)

C O N S O L I D A T E D  S C H E D U L E  O F   I N V E S T M E N T S 6

Consolidated Schedule of Investments (unaudited) (continued) March 31, 2022   BlackRock Science and Technology Trust (BST)

OTC Options Written (continued)

Description	Counterparty	Number of Contracts		Expiration Date		Exercise Price			Notional Amount (000)			Value
Call (continued)
Alphawave IP Group PLC	UBS AG		60,000		04/26/22		GBP	1.57		GBP	106	$	(20,901	)
Asml Holding NV	Goldman Sachs International		10,900		04/27/22		EUR	572.96		EUR	6,649		(536,725	)
Gmo Payment Gateway Inc.	UBS AG		8,800		04/27/22		JPY	10,943.86		JPY	110,704		(120,468	)
Renesas Electronics Corp.	BNP Paribas S.A.		119,500		04/27/22		JPY	1,372.25		JPY	171,124		(85,422	)
Soitec SA	Morgan Stanley & Co. International PLC		4,500		04/27/22		EUR	136.31		EUR	770		(167,990	)
Stmicroelectronics NV	Goldman Sachs International		26,200		04/27/22		EUR	36.22		EUR	1,037		(110,859	)
Yahoo Japan Corp.	JPMorgan Chase Bank N.A.		246,000		04/27/22		JPY	524.38		JPY	131,954		(54,065	)
Yahoo Japan Corp.	JPMorgan Chase Bank N.A.		509,000		05/02/22		JPY	536.42		JPY	273,028		(69,127	)
Stmicroelectronics NV	Goldman Sachs International		40,400		05/04/22		EUR	40.51		EUR	1,599		(55,438	)
Asml Holding NV	Goldman Sachs International		6,700		05/05/22		EUR	658.80		EUR	4,087		(51,162	)
Soitec SA	Morgan Stanley & Co. International PLC		1,700		05/05/22		EUR	182.43		EUR	291		(7,483	)
Wolfspeed, Inc.	BNP Paribas S.A.		7,000		05/05/22		USD	105.84		USD	797		(91,530	)
Gmo Payment Gateway Inc.	JPMorgan Chase Bank N.A.		16,400		05/06/22		JPY	12,453.00		JPY	206,312		(118,107	)
Soitec SA	Morgan Stanley & Co. International PLC		9,000		05/13/22		EUR	185.82		EUR	1,540		(39,939	)
Stmicroelectronics NV	Credit Suisse International		32,900		05/13/22		EUR	44.03		EUR	1,303		(17,829	)
Soitec SA	Morgan Stanley & Co. International PLC		2,100		05/18/22		EUR	183.39		EUR	359		(12,163	)
Thoughtworks Holding Inc.	Bank of America N.A.		26,800		06/03/22		USD	22.36		USD	558		(44,412	)
ZoomInfo Technologies, Inc.	JPMorgan Chase Bank N.A.		18,100		06/10/22		USD	65.62		USD	1,081		(61,010	)
												$	(3,865,943	)

Fair Value Hierarchy as of Period End

Various inputs are used in determining the fair value of financial instruments. These inputs to valuation techniques are categorized into a fair value hierarchy consisting of three broad levels for financial reporting purposes as follows:

• Level 1 – Unadjusted price quotations in active markets/exchanges for identical assets or liabilities that the Trust has the ability to access;

• Level 2 – Other observable inputs (including, but not limited to, quoted prices for similar assets or liabilities in markets that are active, quoted prices for identical or similar assets or liabilities in markets that are not active, inputs other than quoted prices that are observable for the assets or liabilities (such as interest rates, yield curves, volatilities, prepayment speeds, loss severities, credit risks and default rates) or other market–corroborated inputs); and

• Level 3 – Unobservable inputs based on the best information available in the circumstances, to the extent observable inputs are not available (including the BlackRock Global Valuation Methodologies Committee’s (the “Global Valuation Committee’s”) assumptions used in determining the fair value of financial instruments).

The hierarchy gives the highest priority to unadjusted quoted prices in active markets for identical assets or liabilities (Level 1 measurements) and the lowest priority to unobservable inputs (Level 3 measurements). Accordingly, the degree of judgment exercised in determining fair value is greatest for instruments categorized in Level 3. The inputs used to measure fair value may fall into different levels of the fair value hierarchy. In such cases, for disclosure purposes, the fair value hierarchy classification is determined based on the lowest level input that is significant to the fair value measurement in its entirety. Investments classified within Level 3 have significant unobservable inputs used by the Global Valuation Committee in determining the price for Fair Valued Investments. Level 3 investments include equity or debt issued by privately held companies or funds. There may not be a secondary market, and/or there are a limited number of investors. The categorization of a value determined for financial instruments is based on the pricing transparency of the financial instruments and is not necessarily an indication of the risks associated with investing in those securities. For information about the Trust’s policy regarding valuation of financial instruments, refer to its most recent financial statements.

Certain investments of the Trust were fair valued using net asset value (“NAV”) per share as no quoted market value is available and therefore have been excluded from the fair value hierarchy.

The following table summarizes the Trust’s financial instruments categorized in the fair value hierarchy. The breakdown of the Trust’s financial instruments into major categories is disclosed in the Consolidated Schedule of Investments above.

	Level 1		Level 2		Level 3		Total
Assets
Investments
Long-Term Investments
Common Stocks
Automobiles	$	40,193,892	$	—	$	—	$	40,193,892
Capital Markets		10,679,657		—		—		10,679,657
Diversified Consumer Services		—		—		4,687,314		4,687,314
Electronic Equipment, Instruments & Components		9,696,196		11,558,392		—		21,254,588

7

Consolidated Schedule of Investments (unaudited) (continued) March 31, 2022   BlackRock Science and Technology Trust (BST)

Fair Value Hierarchy as of Period End (continued)

	Level 1			Level 2			Level 3		Total
Common Stocks (continued)
Entertainment	$	5,858,502		$	—		$	—	$	5,858,502
Hotels, Restaurants & Leisure		17,033,977			—			—		17,033,977
Interactive Media & Services		66,254,918			31,226,098			—		97,481,016
Internet & Direct Marketing Retail		47,730,557			—			236,096		47,966,653
Internet Software & Services		—			—			9,923,096		9,923,096
IT Services		158,729,715			27,733,128			76,663,665		263,126,508
Professional Services		—			5,080,000			—		5,080,000
Road & Rail		8,798,093			—			6,337,198		15,135,291
Semiconductors & Semiconductor Equipment		179,739,013			79,311,578			—		259,050,591
Software		254,661,098			18,492,758			31,790,149		304,944,005
Technology Hardware, Storage & Peripherals		80,766,554			—			—		80,766,554
Convertible Notes		—			—			8,040,000		8,040,000
Preferred Securities
Preferred Stocks		—			—			258,881,976		258,881,976
Warrants		—			—			94,199		94,199
Short-Term Securities
Money Market Funds		10,449,533			—			—		10,449,533
	$	890,591,705		$	173,401,954		$	396,653,693		1,460,647,352
Investments Valued at NAV(a)										976,245
									$	1,461,623,597
Derivative Financial Instruments(b)
Liabilities
Equity Contracts	$	(12,490,455	)	$		(4,184,507)	$	—	$	(16,674,962	)

(a) Certain investments of the Trust were fair valued using NAV per share as no quoted market value is available and therefore have been excluded from the fair value hierarchy.

(b) Derivative financial instruments are options written. Options written are shown at value.

A reconciliation of Level 3 financial instruments is presented when the Trust had a significant amount of Level 3 investments at the beginning and/or end of the period in relation to net assets. The following table is a reconciliation of Level 3 investments for which significant unobservable inputs were used in determining fair value:

	Common Stocks		Convertible Notes		Preferred Stocks			Warrants			Total
Assets
Opening balance, as of December 31, 2021	$	119,431,663	$	8,000,000	$	240,189,562		$	117,749		$	367,738,974
Transfers into Level 3.		—		—		—			—			—
Transfers out of Level 3		—		—		—			—			—
Accrued discounts/premiums		—		—		—			—			—
Net realized gain (loss)		—		—		—			—			—
Net change in unrealized appreciation (depreciation)(a)		205,857		40,000		(5,903,042	)		(23,550	)		(5,680,735	)
Purchases		9,999,998		—		29,999,955			—			39,999,953
Sales		—		—		(5,404,499	)		—			(5,404,499	)
Closing balance, as of March 31, 2022	$	129,637,518	$	8,040,000	$	258,881,976		$	94,199		$	396,653,693
Net change in unrealized appreciation (depreciation) on investments still held at March 31, 2022(a)	$	205,857	$	40,000	$	(2,931,844	)	$	(23,550	)	$	(2,709,537	)

(a) Any difference between net change in unrealized appreciation (depreciation) and net change in unrealized appreciation (depreciation) on investments still held at March 31, 2022 is generally due to investments no longer held or categorized as Level 3 at period end.

The following table summarizes the valuation approaches used and unobservable inputs utilized by the BlackRock Global Valuation Methodologies Committee (the “Global Valuation Committee”) to determine the value of certain of the Trust’s Level 3 financial instruments as of period end.

	Value		Valuation Approach		Unobservable Inputs		Range of Unobservable Inputs Utilized(a)		Weighted Average of Unobservable Inputs Based on Fair Value
Assets
Common Stocks	$	129,637,518		Market		Revenue Multiple		3.50 - 30.00x		19.82x
						Volatility		38% - 75%		60%
						Time to Exit		0.5 - 4.0		2.6

C O N S O L I D A T E D  S C H E D U L E  O F   I N V E S T M E N T S 8

Consolidated Schedule of Investments (unaudited) (continued) March 31, 2022   BlackRock Science and Technology Trust (BST)

	Value		Valuation Approach	Unobservable Inputs	Range of Unobservable Inputs Utilized(a)		Weighted Average of Unobservable Inputs Based on Fair Value
Convertible Notes	$	8,040,000	Market	Discount		21%		—
				Volatility		60%		—
				Revenue Multiple		4.25x		—
Preferred Stocks		258,881,976	Market	Revenue Multiple		3.00x - 30.00x		17.40x
				Volatility		50% - 75%		62%
				Time to Exit		4.0 - 5.0		4.3
				Recent Transactions		$ 22.67		—
Warrants		94,199	Market	Volatility		38%		—
				Time to Exit		0.5		—
	$	396,653,693

^(a)  A significant change in unobservable input would have resulted in a correlated (inverse) significant change to value.

Currency Abbreviation
AUD	Australian Dollar
EUR	Euro
GBP	British Pound
JPY	Japanese Yen
USD	United States Dollar
Portfolio Abbreviation
ADR	American Depositary Receipt
S&P	Standard & Poor’s

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