UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
_______________

FORM F-X

APPOINTMENT OF AGENT FOR SERVICE OF
PROCESS AND UNDERTAKING
_______________

A.	Name of issuer or person filing (“Filer”): Trillium Therapeutics Inc.
B.	(1)	This is (check one):
	[X]	An original filing for the Filer.
	[_]	An amended filing for the Filer.
	(2)	Check the following box if you are filing the Form F-X in paper in accordance with Regulation S- T Rule 101(b)(9) [_]
C.	Identify the filing in conjunction with which this Form is being filed:

Name of registrant:	Trillium Therapeutics Inc.
Form type:	Form 40-F
File number (if known):	1-36596
Filed by:	Trillium Therapeutics Inc.
Date filed (if filed concurrently, so indicate):	March 24, 2015 (filed concurrently)

D.	The Filer is incorporated or organized under the laws of Ontario, Canada and has its principal place of business at 96 Skyway Avenue, Toronto, Ontario, Canada M9W 4Y9; telephone (416) 595-0627.
E.	Filer designates and appoints Puglisi & Associates (“Agent”), located at 850 Library Avenue, Suite 204, Newark, Delaware 19711; telephone (302) 738-6680 as the agent of the Filer upon whom may be served any process, pleadings, subpoenas, or other papers in:

(a)

any investigation or administrative proceeding conducted by the Commission; and

(b)

any civil suit or action brought against the Filer or to which the Filer has been joined as defendant or respondent, in any appropriate court in any place subject to the jurisdiction of any state or of the United States, or of any of its territories or possessions or of the District of Columbia, where the investigation, proceeding or cause of action arises out of or relates to or concerns the securities in relation to which the obligation to file an annual report on Form 40-F arises, or any purchases or sales of such securities. The Filer stipulates and agrees that any such civil suit or action or administrative proceeding may be commenced by the service of process upon, and that the service of an administrative subpoena shall be effected by service upon such agent for service of process, and that service as aforesaid shall be taken and held in all courts and administrative tribunals to be valid and binding as if personal service thereof had been made.

F.	The Filer stipulates and agrees to appoint a successor agent for service of process and file an amended Form F-X if the Filer discharges the Agent or the Agent is unwilling or unable to accept service on behalf of the Filer at any time until six years have elapsed from the date the issuer of the securities to which the Form 40-F relates has ceased reporting under the Exchange Act.
	The Filer further undertakes to advise the Commission promptly of any change to the Agent’s name or address during the applicable period by amendment of this Form, referencing the file number of the relevant form in conjunction with which the amendment is being filed.

G. The Filer undertakes to make available, in person or by telephone, representatives to respond to inquiries made by the Commission staff, and to furnish promptly, when requested to do so by the Commission staff, information relating to the Form 40-F; the securities to which the Form 40-F relates; and the transactions in such securities.

SIGNATURES

The Filer certifies that it has duly caused this power of attorney, consent, stipulation and agreement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Toronto, Ontario, Country of Canada, this 24^th day of March, 2015.

TRILLIUM THERAPEUTICS INC.

By: /s/ Niclas Stiernholm                                        
       Name: Niclas Stiernholm 
       Title: President and Chief Executive Officer

This statement has been signed by the following person in the capacity indicated on March 24, 2015.

PUGLISI & ASSOCIATES
as Agent for Service of Process for Trillium Therapeutics Inc.

By: /s/ Donald J. Puglisi                                          
       Name: Donald J. Puglisi 
       Title: Managing Director