0001104659-23-060793.txt : 20230515 0001104659-23-060793.hdr.sgml : 20230515 20230515161635 ACCESSION NUMBER: 0001104659-23-060793 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20230331 FILED AS OF DATE: 20230515 DATE AS OF CHANGE: 20230515 EFFECTIVENESS DATE: 20230515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: VR Adviser, LLC CENTRAL INDEX KEY: 0001615982 IRS NUMBER: 464814731 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-20281 FILM NUMBER: 23922637 BUSINESS ADDRESS: STREET 1: 7 BRYANT PARK STREET 2: 23RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10018 BUSINESS PHONE: 650-475-3734 MAIL ADDRESS: STREET 1: 7 BRYANT PARK STREET 2: 23RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10018 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false false false 0001615982 XXXXXXXX 03-31-2023 03-31-2023 false VR Adviser, LLC

7 BRYANT PARK 23RD FLOOR NEW YORK NY 10018

13F HOLDINGS REPORT 028-20281 000169288 801-79382 Y Note: VR Adviser, LLC is filing this Form 13F on behalf of itself and the general partner entities of the investment funds for which it serves as the investment adviser, VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC and Venrock Opportunities Management, LLC. The reporting manager's holdings of DBV Technologies S A ("DBV") equity securities as of March 31, 2023 consisted of ordinary shares, which are not considered "Section 13(f) securities" and are, therefore, not reportable on Form 13F, in contrast to American depositary shares, which are reportable on Form 13F. This Form 13F does not reflect the disposition of any securities of DBV by the reporting manager. Sherman G. Souther 650-561-9580 /s/ Sherman G. Souther Palo Alto CA 05-15-2023 0 25 512168605 INFORMATION TABLE 2 infotable.xml ACLARIS THERAPEUTICS INC COM 00461U105 8419700 1040754 SH SOLE 1040754 0 0 AEROVATE THERAPEUTICS INC COM 008064107 16820308 833927 SH SOLE 833927 0 0 AFFIMED N V COM N01045108 1065143 1428571 SH SOLE 1428571 0 0 AMBRX BIOPHARMA INC SPONSORED ADS 02290A102 29423307 3298577 SH SOLE 3298577 0 0 ANNEXON INC COM 03589W102 12397193 3220050 SH SOLE 3220050 0 0 AVALO THERAPEUTICS INC COM NEW 05338F207 1750000 1000000 SH SOLE 1000000 0 0 CABALETTA BIO INC COM 12674W109 16318786 1973251 SH SOLE 1973251 0 0 CELCUITY INC COM 15102K100 21580207 2105386 SH SOLE 2105386 0 0 COGENT BIOSCIENCES INC COM 19240Q201 52708902 4884977 SH SOLE 4884977 0 0 DICE THERAPEUTICS INC COM 23345J104 23464350 819000 SH SOLE 819000 0 0 ENLIVEN THERAPEUTICS INC COM 29337E102 48489710 2214142 SH SOLE 2214142 0 0 FULCRUM THERAPEUTICS INC COM 359616109 3725218 1307094 SH SOLE 1307094 0 0 GH RESEARCH PLC ORDINARY SHARES G3855L106 28101829 3517125 SH SOLE 3517125 0 0 KALVISTA PHARMACEUTICALS INC COM 483497103 22925003 2916667 SH SOLE 2916667 0 0 LYRA THERAPEUTICS INC COM 55234L105 1857582 924170 SH SOLE 924170 0 0 MERUS N V COM N5749R100 22562338 1226214 SH SOLE 1226214 0 0 MILESTONE PHARMACEUTICALS IN COM 59935V107 8702719 2208812 SH SOLE 2208812 0 0 PLIANT THERAPEUTICS INC COM 729139105 38038000 1430000 SH SOLE 1430000 0 0 RALLYBIO CORP COM 75120L100 1533318 268532 SH SOLE 268532 0 0 SAVARA INC COM 805111101 12385485 6351531 SH SOLE 6351531 0 0 TERNS PHARMACEUTICALS INC COM 880881107 42855140 3619522 SH SOLE 3619522 0 0 THESEUS PHARMACEUTICALS INC COM 88369M101 6837600 770000 SH SOLE 770000 0 0 TREVI THERAPEUTICS INC COM 89532M101 5642541 3050022 SH SOLE 3050022 0 0 VECTIVBIO HLDG AG ORD SHS H9060V101 15879660 1866000 SH SOLE 1866000 0 0 VIRIDIAN THERAPEUTICS INC COM 92790C104 68684566 2699865 SH SOLE 2699865 0 0