Purple Biotech Ltd.
4 Oppenheimer Street

Science Park

Rehovot 7670104, Israel

April 3, 2023

VIA EDGAR

United States Securities and Exchange Commission
Division of Corporation Finance
Office of Life Sciences

100 F Street N.E.

Washington, D.C. 20549

Attention: Cindy Polynice

Re: PURPLE BIOTECH LTD.
Registration Statement on Form F-3
Filed March 23, 2023 File No. 333-270769

Ladies and Gentlemen:

Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended, Purple Biotech Ltd. (the “Company”) hereby respectfully requests that the effective date of the Company’s Registration Statement on Form F-3 (File No. 333-270769) (the “Registration Statement”) be accelerated by the Securities and Exchange Commission to 4:30 p.m., Eastern Time on April 5, 2023, or as soon thereafter as practicable.

The undersigned respectfully requests that it be notified of the effectiveness of the Registration Statement by telephone call to the Company’s counsel, Haynes and Boone, LLP, by calling Jayun Koo at (212) 659-7300, and that such effectiveness also be confirmed in writing.

Very truly yours,
Purple Biotech Ltd.
By:	/s/ Isaac Israel
	Isaac Israel
	Acting Chief Executive Officer

cc:	Rick A. Werner, Esq., Haynes and Boone, LLP
	Jayun Koo, Esq., Haynes and Boone, LLP