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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
SAGE THERAPEUTICS, INC. COM 78667J108 90,247 547,916 SH   DFND 1,2,3 547,916 0 0
JOUNCE THERAPEUTICS, INC. COM 481116101 130,437 10,230,349 SH   DFND 1,2,3 10,230,349 0 0
MYOKARDIA, INC. COM 62857M105 121,463 2,885,104 SH   DFND 1,2,3 2,885,104 0 0
BLUEPRINT MEDICINES CORPORATION COM 09627Y109 185,038 2,453,753 SH   DFND 1,2,3 2,453,753 0 0
ALLENA PHARMACEUTICALS, INC. COM 018119107 28,077 2,790,964 SH   DFND 1,2,3 2,790,964 0 0