6-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 6-K

Report of Foreign Private Issuer

Pursuant to Rule 13a-16 or 15d-16 of

the Securities Exchange Act of 1934

August 8, 2024

Commission File Number: 001-36622

PROQR THERAPEUTICS N.V.

Zernikedreef 9

2333 CK Leiden

The Netherlands

Tel: +31 88 166 7000

(Address, Including ZIP Code, and Telephone Number,

Including Area Code, of Registrant’s Principal Executive Offices)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F  ⌧  Form 40-F  ◻

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):  ◻

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):  ◻

Furnished as Exhibit 99.1 to this Report on Form 6-K are the unaudited financial statements of ProQR Therapeutics N.V. (the “Company”) for the three and six-month periods ended June 30, 2024, and furnished as Exhibit 99.2 to this Report on Form 6-K is a press release of ProQR Therapeutics N.V. dated August 8, 2024, announcing the Company’s results for the three and six-month periods ended June 30, 2024. 

On August 8, 2024, the Company issued a press release titled, “ProQR Announces Second Quarter 2024 Operating and Financial Results,” announcing the Company’s results for the three and six-month periods ended June 30, 2024 and providing a business update. A copy of this press release is attached hereto as Exhibit 99.2 and is incorporated herein by reference.

INDEX TO EXHIBITS

Number	Description
99.1	Unaudited financial statements of ProQR Therapeutics N.V. for the three and six-month periods ended June 30, 2024.
99.2	Press Release of ProQR Therapeutics N.V. dated August 8, 2024, announcing the Company’s results for the three and six-month periods ended August 8, 2024.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

	PROQR THERAPEUTICS N.V.
Date: August 8, 2024	By:	/s/ Jurriaan Dekkers
		Jurriaan Dekkers
		Chief Financial Officer

EX-99.1

Exhibit 99.1

PROQR THERAPEUTICS N.V.
Index to Unaudited Condensed Consolidated Financial Statements

	PAGE
Unaudited Condensed Consolidated Statement of Financial Position at June 30, 2024 and December 31, 2023	1
Unaudited Condensed Consolidated Statement of Profit or Loss and Other Comprehensive Income for the Three and Six Month Periods ended June 30, 2024 and 2023	2
Unaudited Condensed Consolidated Statement of Changes in Equity for the Six Month Periods Ended June 30, 2024 and 2023	3
Unaudited Condensed Consolidated Statement of Cash Flows for the Three and Six Month Periods ended June 30, 2024 and 2023	4
Notes to Unaudited Condensed Consolidated Financial Statements	5

PAGE 1

Unaudited Condensed Consolidated Financial Statements

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Financial Position

		June 30,	December 31,
		2024	2023
		€1,000	€1,000
Assets
Current assets
Cash and cash equivalents	5	78,970	118,925
Financial asset - current	6	17,183	—
Prepayments and other receivables	7	5,116	1,538
Other taxes		497	523
Total current assets		101,766	120,986
Property, plant and equipment	8	16,285	16,897
Investments in financial assets	18	—	—
Total assets		118,051	137,883
Equity and liabilities
Equity
Equity attributable to owners of the Company		32,854	41,390
Total equity	13	32,854	41,390
Current liabilities
Borrowings	10	4,437	—
Lease liabilities	11	1,675	1,614
Derivative financial instruments	10	184	311
Trade payables		33	1,541
Social securities and other taxes		1,448	1,659
Deferred income	12	23,827	20,569
Other current liabilities	9	5,675	8,509
Total current liabilities		37,279	34,203
Borrowings	10	—	4,292
Lease liabilities	11	13,078	13,828
Deferred income	12	34,840	44,170
Total liabilities		85,197	96,493
Total equity and liabilities		118,051	137,883

The accompanying notes are an integral part of these unaudited interim condensed consolidated financial statements.

PAGE 2

Unaudited Condensed Consolidated Financial Statements

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Profit or Loss and OCI

(€ in thousands, except share and per share data)

		Three month period		Six month period
		ended June 30,		ended June 30,
		2024	2023	2024	2023
		€1,000	€1,000	€1,000	€1,000
Revenue	14	6,305	1,205	10,755	1,860
Other income	15	156	38	366	80
Research and development costs	16	(7,048)	(5,909)	(16,331)	(11,969)
General and administrative costs	17	(3,013)	(4,145)	(6,465)	(8,171)
Total operating costs		(10,061)	(10,054)	(22,796)	(20,140)
Operating result		(3,600)	(8,811)	(11,675)	(18,200)
Finance income and expense		513	470	1,001	(74)
Results related to associates and financial assets	18	—	—	—	—
Results related to financial liabilities measured at fair value through profit or loss	10	195	221	127	891
Results on derecognition of financial liabilities	19	—	101	—	509
Result before corporate income taxes		(2,892)	(8,019)	(10,547)	(16,874)
Income taxes	20	200	42	197	42
Result for the period		(2,692)	(7,977)	(10,350)	(16,832)
Other comprehensive income (foreign exchange differences on foreign operation)		85	7	276	(212)
Total comprehensive income		(2,607)	(7,970)	(10,074)	(17,044)
Result attributable to
Owners of the Company		(2,692)	(7,993)	(10,350)	(16,926)
Non-controlling interests		—	16	—	94
		(2,692)	(7,977)	(10,350)	(16,832)
Total comprehensive income attributable to
Owners of the Company		(2,607)	(7,986)	(10,074)	(17,138)
Non-controlling interests		—	16	—	94
		(2,607)	(7,970)	(10,074)	(17,044)
Share information
Weighted average number of shares outstanding1		81,665,565	80,939,392	81,618,038	80,913,751
Earnings per share attributable to owners of the Company (Euro per share)
Basic loss per share1		(0.03)	(0.10)	(0.13)	(0.21)
Diluted loss per share1		(0.03)	(0.10)	(0.13)	(0.21)

The accompanying notes are an integral part of these unaudited interim condensed consolidated financial statements.

1. For these periods the potential exercise of share options is not included in the diluted earnings per share as the Company was loss-making. Due to the anti-dilutive nature of the outstanding options, basic and diluted earnings per share are equal.

PAGE 3

Unaudited Condensed Consolidated Financial Statements

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Changes in Equity

	Attributable to owners of the Company
	Number of shares	Share Capital	Share Premium	Equity settled Employee Benefit Reserve	Translation Reserve	Accumulated Deficit	Total	Non- controlling interests	Total Equity
		€1,000	€1,000	€1,000	€1,000	€1,000	€1,000	€1,000	€1,000
Balance at January 1, 2023	84,246,967	3,370	412,540	29,052	1,212	(379,110)	67,064	(384)	66,680
Result for the period	—	—	—	—	—	(16,926)	(16,926)	94	(16,832)
Other comprehensive income	—	—	—	—	(212)	—	(212)	—	(212)
Recognition of share-based payments	—	—	—	1,860	—	—	1,860	—	1,860
Treasury shares transferred	(122,584)	—	—	—	—	—	—	—	—
Share options lapsed	—	—	—	(3,873)	—	3,873	—	—	—
Share options exercised	122,584	—	4	(231)	—	231	4	—	4
Balance at June 30, 2023	84,246,967	3,370	412,544	26,808	1,000	(391,932)	51,790	(290)	51,500
Balance at January 1, 2024	84,248,384	3,370	412,894	25,159	817	(400,850)	41,390	—	41,390
Result for the period	—	—	—	—	—	(10,350)	(10,350)	—	(10,350)
Other comprehensive income	—	—	—	—	276	—	276	—	276
Recognition of share-based payments	—	—	—	1,364	—	—	1,364	—	1,364
Treasury shares transferred	(326,455)	—	—	—	—	—	—	—	—
Share options lapsed	—	—	—	(359)	—	359	—	—	—
Share options exercised / RSUs vested	326,455	—	174	(288)	—	288	174	—	174
Balance at June 30, 2024	84,248,384	3,370	413,068	25,876	1,093	(410,553)	32,854	—	32,854

The accompanying notes are an integral part of these unaudited interim condensed consolidated financial statements.

PAGE 4

Unaudited Condensed Consolidated Financial Statements

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Cash Flows

		Three month period		Six month period
		ended June 30,		ended June 30,
		2024	2023	2024	2023
		€1.000	€1.000	€1.000	€1.000
Cash flows from operating activities
Net result		(2,692)	(7,977)	(10,350)	(16,832)
Adjustments for:
— Depreciation		711	594	1,402	1,143
— Share-based compensation	13	628	765	1,364	1,860
— Financial income and expenses		(513)	(470)	(1,001)	74
— Results related to associates and financial assets	18	—	—	—	—
— Results related to financial liabilities measured at fair value through profit or loss	10	(195)	(221)	(127)	(891)
— Results on derecognition of financial liabilities	19	—	(101)	—	(509)
— Income tax expenses	20	(200)	—	(197)	—
Changes in working capital		(4,614)	(3,622)	(13,838)	48,668
Cash (used in)/generated from operations		(6,875)	(11,032)	(22,747)	33,513
Corporate income tax received/(paid)		199	—	196	—
Interest received		610	685	1,542	865
Interest paid		(190)	—	(379)	—
Net cash (used in)/generated from operating activities		(6,256)	(10,347)	(21,388)	34,378
Cash flow from investing activities
Increase in financial asset - current	6	—	—	(17,000)	—
Purchases of property, plant and equipment		(267)	(294)	(999)	(430)
Sales of property, plant and equipment		—	—	—	47
Net cash used in investing activities		(267)	(294)	(17,999)	(383)
Cash flow from financing activities
Proceeds from exercise of share options	13	12	4	174	4
Repayment of lease liability	11	(294)	(647)	(875)	(906)
Net cash used in financing activities		(282)	(643)	(701)	(902)
Net (decrease)/increase in cash and cash equivalents		(6,805)	(11,284)	(40,088)	33,093
Currency effect cash and cash equivalents		62	860	133	694
Cash and cash equivalents, at beginning of the period		85,713	138,986	118,925	94,775
Cash and cash equivalents at the end of the period		78,970	128,562	78,970	128,562

The accompanying notes are an integral part of these unaudited interim condensed consolidated financial statements.

PAGE 5

Unaudited Condensed Consolidated Financial Statements

PROQR THERAPEUTICS N.V.
Notes to Unaudited Condensed Consolidated Financial Statements

1. General Information

ProQR Therapeutics N.V., or “ProQR” or the “Company”, is a biotechnology company domiciled in the Netherlands that primarily focuses on the discovery and development of novel therapeutic medicines.

Since September 18, 2014, the Company’s ordinary shares have been listed on Nasdaq. They are currently trading at Nasdaq Capital Market under ticker symbol PRQR.

The Company was incorporated in the Netherlands, on February 21, 2012 (Chamber of Commerce no. 54600790) and was reorganized from a private company with limited liability to a public company with limited liability on September 23, 2014. The Company has its statutory seat in Leiden, the Netherlands. The address of its headquarters and registered office is Zernikedreef 9, 2333 CK Leiden, the Netherlands.

ProQR Therapeutics N.V. is the ultimate parent company of the following entities:

● ProQR Therapeutics Holding B.V. (100%);

● ProQR Therapeutics I B.V. (100%);

● ProQR Therapeutics II B.V. (100%);

● ProQR Therapeutics III B.V. (100%);

● ProQR Therapeutics IV B.V. (100%);

● ProQR Therapeutics V B.V. (100%);

● ProQR Therapeutics VI B.V. (100%);

● ProQR Therapeutics VII B.V. (100%);

● ProQR Therapeutics VIII B.V. (100%);

● ProQR Therapeutics IX B.V. (100%);

● ProQR Therapeutics I Inc. (100%)

ProQR Therapeutics N.V. is also statutory director of Stichting Bewaarneming Aandelen ProQR (“ESOP Foundation”) and has full control over this entity.

As used in these condensed consolidated financial statements, unless the context indicates otherwise, all references to “ProQR” or the “Company” refer to ProQR Therapeutics N.V. including its subsidiaries and the ESOP Foundation.

PAGE 6

Unaudited Condensed Consolidated Financial Statements

2. Significant Accounting Policies

These interim condensed consolidated financial statements for the three and six month periods ended June 30, 2024 have been prepared in accordance with IAS 34 Interim Financial Statements. They should be read in conjunction with the Company’s annual financial statements for the year ended December 31, 2023. These interim condensed consolidated financial statements do not include all information required for a complete set of financial statements prepared in accordance with IFRS Standards. However, selected explanatory notes are included to explain events and transactions that are significant to an understanding of the changes in the Company’s financial position and performance since the last annual financial statements. In the opinion of management, all events and transactions that are significant to an understanding of the changes in financial position and performance of the Company since the end of the last annual reporting period are disclosed in these interim condensed consolidated financial statements. The accounting policies adopted in the preparation of the interim condensed consolidated financial statements are consistent with those applied in the preparation of the Company’s annual financial statements for the year ended December 31, 2023.

During the six month period ended June 30, 2024, the Company invested in financial assets in the form of deposits with an original maturity of longer than three months but shorter than twelve months as described in Note 6. Financial assets are measured at amortised cost as they give rise on specified dates to cash flows that are solely payments of principal and interest on the principal amount outstanding.

The Company’s financial results have varied substantially, and are expected to continue to vary, from period to period. The Company believes that its ordinary activities are not linked to any particular seasonal factors.

The management of ProQR has, upon preparing and finalizing these interim condensed consolidated financial statements, assessed the Company’s ability to fund its operations for a period of at least one year after the date of signing these interim condensed consolidated financial statements. Management expects the Company to continue as a going concern based on its existing funding, taking into account the Company’s current cash position and the projected cash flows based on the activities under execution on the basis of ProQR’s business plan and budget. Based on our current operating plan, we believe that the existing cash and cash equivalents will be sufficient to fund our anticipated level of operations at least into mid-2026. Thus, we continue to adopt the going concern basis of accounting in preparing the interim condensed consolidated financial statements.

The carrying amount of all financial assets and financial liabilities is a reasonable approximation of the fair value and therefore, information about the fair values of each class has not been disclosed.

The Company operates in one reportable segment, which comprises the discovery and development of innovative, RNA based therapeutics.

3. Adoption of New and Revised International Financial Reporting Standards

New Standards and Interpretations, which became effective as of January 1, 2024, did not have a material impact on our condensed consolidated financial statements.

PAGE 7

Unaudited Condensed Consolidated Financial Statements

4. Critical Accounting Estimates and Judgments

In the application of the Company’s accounting policies, management is required to make judgments, estimates and assumptions about the carrying amounts of assets and liabilities that are not readily apparent from other sources. The estimates and associated assumptions are based on historical experience and other factors that are considered to be relevant. Actual results may differ from these estimates.

The estimates and underlying assumptions are reviewed on an ongoing basis. Revisions to accounting estimates are recognized in the period in which the estimate is revised if the revision affects only that period or in the period of the revision and future periods if the revision affects both current and future periods.

The significant judgements made by management in applying the Company’s accounting policies, except for the significant judgements related to revenue recognition from milestone payments as further described below and in Note 14, and the key sources of estimation uncertainty were the same as those described in the Company’s annual financial statements for the year ended December 31, 2023.

Revenue recognition for the Eli Lilly collaboration and license agreement

a. Identification of the performance obligation

Note 14 describes the Company’s original research and collaboration agreement with Eli Lilly and Company, and the amended and restated research and collaboration agreement (collectively, the “Collaboration agreement”). Under the Collaboration agreement, ProQR provides Eli Lilly with a license (with a right to sub-license) to exploit compounds resulting from the collaboration. A significant amount of judgement is required to determine whether the license is distinct from the other promises in the contract. The license was concluded not to be distinct from the other promises in the contract based on the following considerations:

● the license has no stand-alone value to Eli Lilly without the Company being involved in the research and development collaboration, and;

● there are significant interdependencies between the license and the research and development services to be provided by the Company.

ProQR’s services are evaluated as predominant at inception of the contract and contractually only ProQR can perform these services as they are specific to the skills of the Company. The resulting compounds from the collaboration do not represent a series of distinct promises because they were not predetermined at the inception of the contract and can be terminated or replaced at the discretion of Lilly subject to the terms and conditions of the Collaboration agreement.

b. Determining the timing of satisfaction of performance obligations

Under the Collaboration agreement, the Company recognizes revenue over time, using an input method that estimates the satisfaction of the performance obligation as the percentage of labor hours incurred compared to the total estimated labor hours required to complete the promised services. As our estimate of the total labor hours required is dependent on the evolution of the research and development activities, it may be subject to change. If the progression and/or outcome of certain research and development activities would be different from the assumptions that were made during the preparation of these financial statements, this could lead to material adjustments to the total estimated labor hours, which might result in a reallocation of revenue between current and future periods. Our total deferred revenue balance amounts to € 58,667,000 of which € 58,181,000 is related to this Eli Lilly performance obligation at June 30, 2024. As at December 31, 2023 the entire deferred revenue balance of € 64,739,000 related to the Eli Lilly performance obligation.

PAGE 8

Unaudited Condensed Consolidated Financial Statements

c. Determining the transaction price

The Company applied judgement to determine whether the equity investments made by Eli Lilly in ProQR are part of the transaction price for the Collaboration agreement. The Company concluded that the differences between the prices that Eli Lilly paid for the shares and the ProQR stock closing prices on the days of entering into the equity investment agreements arose because of the Company’s existing obligations to deliver research and development services to Eli Lilly under the terms of the Collaboration agreement. Therefore, the above differences between the closing share prices on the agreement effective dates and the equity investment prices paid by Eli Lilly are considered to be part of the transaction price of the contract and are initially allocated to deferred revenue.

The contract also includes variable consideration, but no variable consideration was included in the initial transaction price at the inception, as it is not highly probable that a significant reversal in the amount of cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is subsequently resolved. The Company includes such variable consideration in the transaction price when the uncertainty associated with the variable consideration is resolved.

As further described in Note 14, during 2024, the Company reached milestones under the agreement, which were added to the transaction price and recognized partially as revenue during 2024 with the remainder recorded in future periods based on progress towards satisfaction of performance obligation.

The Collaboration agreement includes sales-based royalties, including commercial milestone payments based on the level of sales. Related revenue is recognized as the subsequent underlying sales occur at a point in time.

Research and development expenditures

Research expenditures are reflected in the income statement. Development expenses are currently also reflected in the income statement because the criteria for capitalization are not met. At each balance sheet date, the Company estimates the level of service performed by the vendors and the associated costs incurred for the services performed.

Although we do not expect the estimates to be materially different from amounts actually incurred, the understanding of the status and timing of services performed relative to the actual status and timing of services performed may vary and could result in reporting amounts that are too high or too low in any particular period.

5. Cash and Cash Equivalents

At June 30, 2024, the Company’s cash and cash equivalents were € 78,970,000 compared to € 118,925,000 at December 31, 2023. The cash balances are held at banks with investment grade credit ratings. Short-term credit ratings must be rated A-1/P-1/F1 at a minimum by at least one of the Nationally Recognized Statistical Rating Organizations (“NRSROs”) specifically Moody’s, Standard & Poor’s or Fitch. The cash at banks is at full disposal of the Company. Included in cash and cash equivalents are deposits fixed for at most 3-month periods at a time.

PAGE 9

Unaudited Condensed Consolidated Financial Statements

6. Financial Asset – Current

This current financial asset relates to a term deposit with an initial maturity longer than 3 months but less than 12 months and does not qualify as a cash equivalent. The deposit is held at a bank with an investment grade credit rating. Short-term credit ratings must be rated A-1/P-1/F1 at a minimum by at least one of the NRSROs specifically Moody’s, Standard & Poor’s or Fitch.

	June 30,	December 31,
	2024	2023
	€1,000	€1,000
Term deposit and interest accrued	17,183	—
	17,183	—

7. Prepayments and Other Receivables

	June 30,	December 31,
	2024	2023
	€1,000	€1,000
Prepayments	1,067	793
Other Receivables	4,049	745
	5,116	1,538

At June 30, 2024 and December 31, 2023 prepayments consisted principally of payments made by the Company for services not yet provided by vendors. At June 30, 2024 and December 31, 2023 other receivables consisted principally of amounts receivable from research collaboration partners and deposits.

8. Property, Plant and Equipment

At June 30, 2024 and December 31, 2023, property plant and equipment consisted of buildings and leasehold improvements, laboratory equipment and other assets. Buildings and leasehold improvements include a right-of-use asset relating to the lease of our Leiden office and laboratory space, with a carrying amount of € 13,741,000 at June 30, 2024 (December 31, 2023: € 14,524,000).

9. Other Current Liabilities

At June 30, 2024, other current liabilities amount to € 5,675,000 (December 31, 2023: € 8,509,000). At June 30, 2024 and December 31, 2023, other current liabilities consisted principally of accruals for services provided by vendors not yet billed, payroll related accruals and other miscellaneous liabilities.

PAGE 10

Unaudited Condensed Consolidated Financial Statements

10. Borrowings

	June 30,	December 31,
	2024	2023
	€1.000	€1.000
Innovation credit	2,899	2,899
Accrued interest on innovation credit	1,538	1,393
Total borrowings	4,437	4,292
Current portion	(4,437)	—
	—	4,292

On December 10, 2018 ProQR was awarded an Innovation credit for the sepofarsen program. Amounts were drawn under this facility from 2018 through 2022. The credit of € 3,907,000 was used to conduct the Phase 2/3 clinical study and efforts to obtain regulatory and ethical market approval (New Drug Applications (“NDA”)/ Marketing Authorization Applications (“MAA”)) of sepofarsen for LCA10. In 2023, ProQR made a partial repayment of the principal, amounting to € 1,008,000. The remaining amount payable of € 2,899,000 and accrued interest is recognized under current borrowings at June 30, 2024 and non-current borrowings at December 31, 2023.

In December 2023, ProQR received a conditional waiver of the balance of the Innovation credit including accrued interest. Consequently, the repayment of the total loan of € 4,437,000, including interest, will be waived if conditions are met, which will be reviewed annually.

In September 2022, ProQR extinguished its debt with Pontifax and Kreos by repaying all outstanding principal amounts. Pontifax’ and Kreos’ warrants remain in place until their five-year economic life expires in 2025 and 2026. These warrants are accounted for as embedded derivatives and were recognized separately from the host contract as derivative financial liabilities at fair value through profit or loss.

11. Lease Liabilities

At June 30, 2024 and December 31, 2023, lease liabilities primarily consisted of the Company’s lease of office and laboratory facilities at Zernikedreef in Leiden, the Netherlands.

The Company leases office and laboratory facilities of 4,818 square meters at Zernikedreef in Leiden, the Netherlands, where our headquarters and our laboratories are located. The current lease agreement for these facilities terminates on June 30, 2031. The lease agreement contains no significant dismantling requirements.

The initial 10-year lease agreement for the Leiden office and laboratory facilities was accounted for as of commencement date July 1, 2020. This 10-year period was extended by 1 year to an 11-year period in December 2020. The lease contract may be extended for subsequent 5-year periods. As the Company is not reasonably certain to exercise these extension options, these are not included in the lease term.

The carrying amount of the right-of-use asset is disclosed in Note 8.

PAGE 11

Unaudited Condensed Consolidated Financial Statements

12. Deferred Income

​
The following table summarizes details of deferred income at June 30, 2024 and December 31, 2023. The nature of the deferred income is described in Note 14 and 15.
​

	June 30,	December 31,
	2024	2023
	€1,000	€1,000
Payments from Eli Lilly	23,341	20,569
Payments from Rett Syndrome Research Trust	486	—
Current deferred income	23,827	20,569
Payments from Eli Lilly	34,840	44,170
Non-current deferred income	34,840	44,170
Total deferred income	58,667	64,739

13. Shareholders’ Equity

The authorized share capital of the Company amounting to € 13,600,000 consists of 170,000,000 ordinary shares and 170,000,000 preference shares with a par value of € 0.04 per share. At June 30, 2024, 84,247,306 ordinary shares were issued. 81,680,195 ordinary shares were fully paid and 2,567,111 ordinary shares were held by the Company as treasury shares (December 31, 2023: 2,893,792).

Translation reserve

The translation reserve comprises all foreign currency differences arising from the translation of the financial statements of foreign operations.

Share options

The Company operates an equity-settled share-based compensation plan, which was introduced in 2013. Options and Restricted Stock Units (“RSUs”) may be granted to employees, members of the Supervisory Board, members of the Management Board and consultants. The compensation expenses included in operating costs for this plan in the six month period ended June 30, 2024 were € 1,364,000 (six month period ended June 30, 2023: € 1,860,000), of which € 1,089,000 was recorded in general and administrative costs (six month period ended June 30, 2023: € 1,644,000) and € 275,000 was recorded in research and development costs (six month period ended June 30, 2023: € 216,000).

14. Revenue

Eli Lilly

In September 2021, the Company entered into a global licensing and research collaboration with Eli Lilly and Company (‘Lilly’) focused on the discovery, development, and commercialization of potential new medicines for genetic disorders in the liver and nervous system. ProQR and Lilly will use ProQR’s proprietary Axiomer® RNA editing platform to progress new drug targets toward clinical development and commercialization.

PAGE 12

Unaudited Condensed Consolidated Financial Statements

Under the terms of the agreement, ProQR received an upfront payment and equity consideration, and is eligible to receive milestone payments and royalties on the net sales of any resulting products. In September 2021, the Company issued 3,989,976 shares to Lilly, resulting in net proceeds of $30,000,000 (€ 25,270,000). This amount included a price premium of $2,429,000 (€ 2,047,000), which was determined to be part of the transaction price and as such was initially recognized as deferred revenue. An up-front payment of $20,000,000 (€ 16,849,000) was received in October 2021.

With regard to its original collaboration with Lilly, the Company concluded as follows:

● There is one performance obligation under IFRS 15, for the transfer of a license combined with the performance of research and development activities. The Company concluded that the license is not capable of being distinct and is not distinct in the context of the contract. ProQR’s services are evaluated as predominant at inception of the contract and the compounds resulting from the collaboration do not represent a series of distinct promises because they were not predetermined at the inception of the contract and can be terminated or replaced at the discretion of Lilly subject to the terms and conditions of the Collaboration agreement.

● The transaction price of this agreement includes fixed components, consisting of an up-front fee and an equity component. The agreement also contains variable parts, which are included in the transaction price to the extent that it is highly probably that a significant reversal in the amount of cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is subsequently resolved. Milestone payments will only be included to the extent that it is highly probable that a significant reversal in the amount of cumulative revenue recognized will not occur when the uncertainty associated with the milestones is subsequently resolved. Sales-based milestones and sales-based royalties will be included as the underlying sales occur.

● The Company recognizes revenue over time, using an input method that estimates the satisfaction of the performance obligation as the percentage of labor hours incurred compared to the total estimated labor hours required to complete the promised services.

In December 2022, the Company and Lilly amended their research and collaboration agreement described above, which expanded the collaboration. Under the amended and restated research and collaboration agreement, Lilly will gain access to additional targets in the central nervous system and peripheral nervous system with ProQR’s Axiomer platform.

Pursuant to the amended and restated agreement, the Company issued 9,381,586 shares to Lilly in December 2022, resulting in gross proceeds of $ 15,000,000 (€ 14,122,000). These shares were issued at a discount of $ 480,000 (€ 451,000), which is accounted for as a reduction of the transaction price. In February 2023, ProQR also received an upfront payment of $ 60,000,000 (€ 56,412,000), which was recognized under Deferred Income. Lilly has the ability to exercise an option to further expand the partnership for a consideration of $ 50,000,000.

With regard to the amended and restated research and collaboration agreement with Lilly, the Company concluded as follows:

● There is one performance obligation under IFRS 15, for the transfer of a license combined with the performance of research and development activities. The Company concluded that the license is not capable of being distinct and is not distinct in the context of the contract. ProQR’s services are evaluated as predominant at inception of the contract and the compounds resulting from the collaboration do not represent a series of distinct promises because they were not predetermined at the inception of the contract and can be terminated or replaced at the discretion of Lilly subject to the terms and conditions of

PAGE 13

Unaudited Condensed Consolidated Financial Statements

the Collaboration agreement.

● The transaction price of this agreement includes fixed components, consisting of an up-front fee and an equity component (discount), and variable components. The variable components are not yet fully included in the transaction price. Milestone payments will only be included to the extent that it is highly probable that a significant reversal in the amount of cumulative revenue recognized will not occur when the uncertainty associated with the milestones is subsequently resolved. As further described in the note, the Company reached certain milestones. Sales-based milestones and sales-based royalties will be included as the underlying sales occur.

● The Company recognizes revenue over time, using an input method that estimates the satisfaction of the performance obligation as the percentage of labor hours incurred compared to the total estimated labor hours required to complete the promised services.

During the six month period ended June 30, 2024, the Company reached milestones amounting to $ 4,500,000 (€ 4,196,000) under the agreement, which were added to the transaction price and recognized partially as revenue during the six month period ended June 30, 2024. As at June 30, 2024, $ 3,500,000 (€ 3,275,000) is recognized in other receivables.

15. Other Income

	Six month period
	ended June 30,
	2024	2023
	€1.000	€1.000
Grant income	366	76
Other income	—	4
	366	80

In January, 2024, the Company entered into an agreement with the Rett Syndrome Research Trust (“RSRT”) that focuses on the design and development of editing oligonucleotides (“EONs”) using the Company’s Axiomer technology platform targeting the transcription factor Methyl CpG binding protein 2 (“MECP2”) and correcting mutations of interest. Under the agreement, RSRT awarded the Company up to € 1,015,000 as a research grant for the initial phase of the project.

Grants are recognized in other income in the same period in which the related R&D costs are recognized.

16. Research and Development Costs

Research and development costs amount to €16,331,000 for the six month period ended June 30, 2024 (six month period ended June 30, 2023: € 11,969,000) and are comprised of allocated employee costs including share-based payments, the costs of materials and laboratory consumables, outsourced activities, license and intellectual property costs and other allocated costs. Research and development costs increased compared to the same period in the prior year, mainly due to the Company’s increased outsourced research and development activities in the first half of 2024 and increased full time employee equivalents (“FTE”).

PAGE 14

Unaudited Condensed Consolidated Financial Statements

17. General and Administrative Costs

General and administrative costs amount to € 6,465,000 for the six month period ended June 30, 2024 (six month period ended June 30, 2023: € 8,171,000).

18. Investments in Financial Assets

Investment in financial assets consist of the Company’s investment in Phoenicis Therapeutics Inc. (“Phoenicis”) and Yarrow Biotechnology Inc (“Yarrow”).

ProQR holds a 3.9% interest in Phoenicis. At June 30, 2024, the investment amounts to € nil (December 31, 2023: € nil) after ProQR recognized a fair value loss in the third quarter of 2023 in other comprehensive income.

ProQR holds a 5.1% interest in Yarrow. In October 2023, ProQR initially recognized its investment in the Yarrow financial asset at € nil. As at June 30, 2024, the fair value of the Yarrow financial asset amounted to € nil (December 31, 2023: € nil).

19. Results Related to Derecognition of Financial Liabilities

	Six month period
	ended June 30,
	2024	2023
	€1.000	€1.000
Gain on waiver of Amylon convertible loans	—	509
	—	509

Convertible loans

Convertible loans were issued to Amylon Therapeutics B.V. (“Amylon”), an 80% subsidiary of the Company, and were interest-bearing at an average rate of 8% per annum. They were convertible into a variable number of ordinary shares within 36 months at the option of the holder or the Company in case financing criteria were met. Any unconverted loans became payable on demand after 24 – 36 months in equal quarterly terms.

In 2023 and 2022, Amylon entered into waiver agreements with its lenders. Such lenders’ loan agreements with Amylon are severed and any claims to repayment of any outstanding debt and accumulated interest are renounced. The amount of convertible loans and accumulated interest that was waived under these agreements in the six month period ended June 30, 2024 is € nil (six month period ended June 30, 2023: € 509,000).

In the third quarter of 2023, Amylon was legally dissolved.

PAGE 15

Unaudited Condensed Consolidated Financial Statements

20. Income Taxes

The current income tax liability amounts to € nil at June 30, 2024 (December 31, 2023: € nil). No significant temporary differences exist between accounting and tax results. Realization of deferred tax assets is dependent on future earnings, if any, the timing and amount of which are uncertain. Accordingly, the Company has not yet recognized any deferred tax asset related to operating losses.

Tax losses may be carried forward indefinitely. However, the offset of losses will be limited in a given year against the first € 1 million of taxable profit. For taxable profit in excess of this amount, losses may only be offset up to 50% of this excess.

21. Events After Balance Sheet Date

None.

EX-99.2

Exhibit 99.2

ProQR Announces Second Quarter 2024 Operating and Financial Results

● AX-0810 program targeting NTCP for cholestatic diseases and AX-1412 program targeting B4GALT1 for cardiovascular diseases advancing to the clinic in late 2024/early 2025 with translational data and trial design details to be announced in H2 2024

● $4.5 million in milestones achieved in H1 related to progress in the Lilly partnership

● €96.2 million cash position as of end of Q2 providing runway into mid-2026, plus additional potential milestones from Lilly partnership

LEIDEN, Netherlands & CAMBRIDGE, Mass., August 8, 2024 – ProQR Therapeutics NV. (Nasdaq: PRQR) (ProQR), a company dedicated to changing lives through transformative RNA therapies based on its proprietary Axiomer^™ RNA editing technology platform, today reported its financial and operating results for the second quarter ended June 30, 2024, and provided a business update.

“In the second quarter, we took important steps toward advancing our first editing oligonucleotide programs to clinical stage, with AX-0810 targeting NTCP for cholestatic diseases and AX-1412 targeting B4GALT1 for cardiovascular diseases on track to enter the clinic in late 2024/early 2025,” said Daniel A. de Boer, Founder and CEO of ProQR. “We were excited to share data at ASGCT in May, demonstrating in vivo proof of target engagement with meaningful changes in disease-relevant biomarkers in non-human primates for our NTCP program. As we progress our CTA/IND-enabling studies, we plan to announce translational data and more about our clinical plans for AX-0810 in the second half of the year, as well as preclinical proof of concept and translational data for AX-1412.”

de Boer continued, “Beyond our own pipeline programs, we are pleased with the progress we are making in our partnership with Lilly and highlight the achievement of multiple milestones in the first half of the year. With the benefits of a productive partnership, a differentiated pipeline strategy rooted in human genetics, our leading IP portfolio, and a strong cash balance with runway into mid-2026, we look forward to continued execution as we advance our science and pipeline programs.”

Recent Progress and Anticipated Upcoming Events

● In June, ProQR presented at the RNA Editing Summit in Boston, highlighting its Axiomer technology platform and AX-0810, the Company’s program targeting NTCP for cholestatic diseases.

● In May at the American Society of Cell and Gene Therapy (ASGCT) Annual Meeting, ProQR presented preclinical proof of concept in vitro and in vivo data for AX-0810 for Cholestatic

Diseases targeting NTCP (poster P-705). ProQR scientists showed for the first time in the ADAR RNA editing field in vivo proof of target engagement (RNA editing) with meaningful changes in biomarkers in NHPs using Axiomer RNA Editing Oligonucleotides. At ASGCT, ProQR and partner Eli Lilly presented preclinical data related to Axiomer in poster P-726 titled “Complex Metabolism and Prolonged PK/PD of a GalNAc-Conjugated Editing Oligonucleotide (EON) in Mice”.

● Anticipated Upcoming Events:

● AX-0810 targeting NTCP for cholestatic diseases: clinical development candidate translational data to be reported, and design for the clinical trial to be shared in H2 2024 with program to advance to the clinic in late 2024/early 2025.

● AX-1412 targeting B4GALT1 for cardiovascular diseases: preclinical proof of concept data and translational data to be reported in H2 2024 with program to advance to the clinic in late 2024/early 2025.

● Potential additional new pipeline target announcements in 2024.

● Continue to execute on partnership with Eli Lilly and Company (Lilly), with potential additional data updates to come in 2024, along with potential additional milestone income from existing partnership, and potential option to exercise for expansion of deal to 15 targets, which would result in a $50 million opt-in payment to ProQR.

● ProQR may selectively form new partnerships, which could include multi-target discovery alliances, or product alliances on specific programs.

Financial Highlights

At June 30, 2024, ProQR held cash and cash equivalents and short term financial assets of €96.2 million, compared to €118.9 million cash and cash equivalents at December 31, 2023. Net cash used in operating activities during the three-month period ended June 30, 2024 was €6.3 million, compared to €10.3 million used for the same period last year. During the first half of 2024, the Company achieved certain milestones in the collaboration agreement with Eli Lilly amounting to $4.5 million (€4.2 million). Milestone income achieved in Q2 was received in July.

Research and development (R&D) costs were €7.1 million for the quarter ended June 30, 2024 compared to €5.9 million for the same period last year.

General and administrative costs were €3.0 million for the quarter ended June 30, 2024 compared to €4.1 million for the same period last year.

Net loss for the three-month period ended June 30, 2024 was €2.7 million, or €0.03 per diluted share, compared to €8.0 million, or €0.10 per diluted share, for the same period last year. For further financial information for the period ended June 30, 2024, please refer to the Q2 financial report filing.

About Axiomer™

ProQR is pioneering a next-generation RNA base editing technology called Axiomer^™, which could potentially yield a new class of medicines for diverse types of diseases. Axiomer^™ “Editing Oligonucleotides”, or EONs, mediate single nucleotide changes to RNA in a highly specific and targeted way using molecular machinery that is present in human cells called ADAR (Adenosine Deaminase Acting on RNA). Axiomer^™ EONs are designed to recruit and direct endogenously expressed ADARs to change an Adenosine (A) to an Inosine (I) in the RNA – an Inosine is translated as a Guanosine (G) – correcting an RNA with a disease-causing mutation back to a normal (wild type) RNA, modulating protein expression, or altering a protein so that it will have a new function that helps prevent or treat disease.

About Biliary Atresia (BA) and Primary Sclerosing Cholangitis (PSC)

Cholestatic disorders refer to a group of diseases presenting excessive and toxic buildup of bile acids in the liver due to bile ducts dysfunction. This leads to liver damage and a range of debilitating symptoms. Without treatment, liver damage can progress through various stages, ultimately leading to liver failure and elevated risk of liver malignancy, affecting life expectancy. Cholestatic diseases remain leading causes of liver transplantation. There are no approved therapies for primary sclerosing cholangitis (PSC) for adults and biliary atresia (BA) for pediatrics It is estimated that 80,000 and 20,000 individuals have PSC and BA, respectively, in North America and in Europe.

About AX-0810 targeting NTCP

The majority of the bile acids present in the liver cells originate from the enterohepatic reuptake cycle. The key transporter responsible for hepatic uptake of bile acids from portal circulation is the sodium (Na+)-taurocholate cotransporting polypeptide (NTCP, SLC10A1 gene) expressed in the liver. AX-0810 is designed to introduce a loss of function variant in SLC10A1 RNA that has been found in human genetics to prevent re-uptake of bile acids in liver via NTCP. Based on its mechanism of action, AX-0810 has the potential to become a disease modifying treatment for PSC and BA primarily among other cholestatic diseases.

About Cardiovascular Diseases

Cardiovascular diseases (CVDs) are a group of health conditions that affect the heart and blood vessels, such as atherosclerosis which can lead to severe problems like heart attacks, heart failure, and stroke. CVDs represent the leading cause of disability and death in the world. Approximately 18 million people die every year from CVDs representing one third of all the global deaths. Despite available lipid lowering therapies and hypertension medications, the risk of CVDs is still projected to increase rapidly over the coming years.

About AX-1412 targeting B4GALT1

Gene–based analysis of rare beta-1,4-galactosyltransferase 1 (B4GALT1) missense variant (p.Asn352Ser) is known to lead to B4GALT1 protein loss of function and showed an association with decreased coronary artery disease. These beneficial effects are mediated by hypo-galactosylation of the apolipoprotein B100 and fibrinogen, known – independent – drivers of increased risk of CVDs. AX-1412 introduces a protective variant into B4GALT1 RNA to address the remaining residual risk of developing cardiovascular diseases. ProQR intends to advance AX-1412 targeting B4GALT1 to early clinical proof of concept stage, then would seek to partner this program.

About ProQR

ProQR Therapeutics is dedicated to changing lives through the creation of transformative RNA therapies. ProQR is pioneering a next-generation RNA technology called Axiomer^™, which uses a cell’s own editing machinery called ADAR to make specific single nucleotide edits in RNA to reverse a mutation or modulate protein expression and could potentially yield a new class of medicines for both rare and prevalent diseases with unmet need. Based on our unique proprietary RNA repair platform technologies we are growing our pipeline with patients and loved ones in mind.

Learn more about ProQR at www.proqr.com.

Forward Looking Statements

This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as “continue,” "anticipate," "believe," "could," "estimate," "expect," "goal," "intend," "look forward to", "may," "plan," "potential," "predict," "project," "should," "will," "would" and similar expressions. Such forward-looking statements include, but are not limited to, statements regarding our business, technology, strategy, preclinical model data, our initial pipeline targets and the upcoming strategic priorities and milestones related thereto, our Axiomer^™ platform, including the continued development and advancement of our Axiomer platform, the therapeutic potential of our Axiomer RNA editing oligonucleotides and our ability to expand preclinical in vivo and in vitro data, the timing, progress and results of our preclinical studies and other development activities, including the release of data related thereto, our patent estate, including our anticipated strength and our continued investment in it, as well as the timing of our clinical development, the potential of our technologies and product candidates, the collaboration with Lilly and the intended and potential benefits thereof, including the receipt of milestone and royalty payments from commercial product sales, if any, from the products covered by the collaboration, our ability to selectively form new partnerships and enter into future collaborations, and our financial position and cash-runway. Forward-looking statements are based on management's beliefs and assumptions and on information available to management only as of the date of this press release. Our actual results could differ materially from those expressed or implied by these forward-looking statements for many reasons, including, without limitation, the risks, uncertainties and other factors in our filings

made with the Securities and Exchange Commission, including certain sections of our annual report filed on Form 20-F. These risks and uncertainties include, among others, the cost, timing and results of preclinical studies and clinical trials and other development activities by us and our collaborative partners whose operations and activities may be slowed or halted shortage and pressure on supply and logistics on the global market; the likelihood of our preclinical and clinical programs being initiated and executed on timelines provided and reliance on our contract research organizations and predictability of timely enrollment of subjects and patients to advance our clinical trials and maintain their own operations; our reliance on contract manufacturers to supply materials for research and development and the risk of supply interruption from a contract manufacturer; the potential for future data to alter initial and preliminary results of early-stage clinical trials; the unpredictability of the duration and results of the regulatory review of applications or clearances that are necessary to initiate and continue to advance and progress our clinical programs; the ability to secure, maintain and realize the intended benefits of collaborations with partners, including the collaboration with Lilly; the possible impairment of, inability to obtain, and costs to obtain intellectual property rights; possible safety or efficacy concerns that could emerge as new data are generated in research and development; general business, operational, financial and accounting risks, and risks related to litigation and disputes with third parties; and risks related to macroeconomic conditions and market volatility resulting from global economic developments, geopolitical instability and conflicts. Given these risks, uncertainties, and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.

ProQR Therapeutics N.V.

Investor contact:Sarah KielyProQR Therapeutics N.V.T: +1 617 599 6228skiely@proqr.comor

Peter KelleherLifeSci AdvisorsT: +1 617 430 7579pkelleher@lifesciadvisors.com

Media contact:
Robert Stanislaro

FTI Consulting

T: +1 212 850 5657
robert.stanislaro@fticonsulting.com

Financial Tables

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Financial Position

	June 30,	December 31,
	2024	2023
	€1,000	€1,000
Assets
Current assets
Cash and cash equivalents	78,970	118,925
Financial asset - current	17,183	—
Prepayments and other receivables	5,116	1,538
Other taxes	497	523
Total current assets	101,766	120,986
Property, plant and equipment	16,285	16,897
Investments in financial assets	—	—
Total assets	118,051	137,883
Equity and liabilities
Equity
Equity attributable to owners of the Company	32,854	41,390
Total equity	32,854	41,390
Current liabilities
Borrowings	4,437	—
Lease liabilities	1,675	1,614
Derivative financial instruments	184	311
Trade payables	33	1,541
Social securities and other taxes	1,448	1,659
Deferred income	23,827	20,569
Other current liabilities	5,675	8,509
Total current liabilities	37,279	34,203
Borrowings	—	4,292
Lease liabilities	13,078	13,828
Deferred income	34,840	44,170
Total liabilities	85,197	96,493
Total equity and liabilities	118,051	137,883

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Profit or Loss and OCI

(€ in thousands, except share and per share data)

	Three month period		Six month period
	ended June 30,		ended June 30,
	2024	2023	2024	2023
	€1,000	€1,000	€1,000	€1,000
Revenue	6,305	1,205	10,755	1,860
Other income	156	38	366	80
Research and development costs	(7,048)	(5,909)	(16,331)	(11,969)
General and administrative costs	(3,013)	(4,145)	(6,465)	(8,171)
Total operating costs	(10,061)	(10,054)	(22,796)	(20,140)
Operating result	(3,600)	(8,811)	(11,675)	(18,200)
Finance income and expense	513	470	1,001	(74)
Results related to associates and financial assets	—	—	—	—
Results related to financial liabilities measured at fair value through profit or loss	195	221	127	891
Results on derecognition of financial liabilities	—	101	—	509
Result before corporate income taxes	(2,892)	(8,019)	(10,547)	(16,874)
Income taxes	200	42	197	42
Result for the period	(2,692)	(7,977)	(10,350)	(16,832)
Other comprehensive income (foreign exchange differences on foreign operation)	85	7	276	(212)
Total comprehensive income	(2,607)	(7,970)	(10,074)	(17,044)
Result attributable to
Owners of the Company	(2,692)	(7,993)	(10,350)	(16,926)
Non-controlling interests	—	16	—	94
	(2,692)	(7,977)	(10,350)	(16,832)
Total comprehensive income attributable to
Owners of the Company	(2,607)	(7,986)	(10,074)	(17,138)
Non-controlling interests	—	16	—	94
	(2,607)	(7,970)	(10,074)	(17,044)
Share information
Weighted average number of shares outstanding1	81,665,565	80,939,392	81,618,038	80,913,751
Earnings per share attributable to owners of the Company (Euro per share)
Basic loss per share1	(0.03)	(0.10)	(0.13)	(0.21)
Diluted loss per share1	(0.03)	(0.10)	(0.13)	(0.21)

1. For these periods the potential exercise of share options is not included in the diluted earnings per share as the Company was loss-making. Due to the anti-dilutive nature of the outstanding options, basic and diluted earnings per share are equal.

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Changes in Equity

	Attributable to owners of the Company
	Number of shares	Share Capital	Share Premium	Equity settled Employee Benefit Reserve	Translation Reserve	Accumulated Deficit	Total	Non- controlling interests	Total Equity
		€1,000	€1,000	€1,000	€1,000	€1,000	€1,000	€1,000	€1,000
Balance at January 1, 2023	84,246,967	3,370	412,540	29,052	1,212	(379,110)	67,064	(384)	66,680
Result for the period	—	—	—	—	—	(16,926)	(16,926)	94	(16,832)
Other comprehensive income	—	—	—	—	(212)	—	(212)	—	(212)
Recognition of share-based payments	—	—	—	1,860	—	—	1,860	—	1,860
Treasury shares transferred	(122,584)	—	—	—	—	—	—	—	—
Share options lapsed	—	—	—	(3,873)	—	3,873	—	—	—
Share options exercised	122,584	—	4	(231)	—	231	4	—	4
Balance at June 30, 2023	84,246,967	3,370	412,544	26,808	1,000	(391,932)	51,790	(290)	51,500
Balance at January 1, 2024	84,248,384	3,370	412,894	25,159	817	(400,850)	41,390	—	41,390
Result for the period	—	—	—	—	—	(10,350)	(10,350)	—	(10,350)
Other comprehensive income	—	—	—	—	276	—	276	—	276
Recognition of share-based payments	—	—	—	1,364	—	—	1,364	—	1,364
Treasury shares transferred	(326,455)	—	—	—	—	—	—	—	—
Share options lapsed	—	—	—	(359)	—	359	—	—	—
Share options exercised / RSUs vested	326,455	—	174	(288)	—	288	174	—	174
Balance at June 30, 2024	84,248,384	3,370	413,068	25,876	1,093	(410,553)	32,854	—	32,854

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Cash Flows

	Three month period		Six month period
	ended June 30,		ended June 30,
	2024	2023	2024	2023
	€1,000	€1,000	€1,000	€1,000
Cash flows from operating activities
Net result	(2,692)	(7,977)	(10,350)	(16,832)
Adjustments for:
— Depreciation	711	594	1,402	1,143
— Share-based compensation	628	765	1,364	1,860
— Financial income and expenses	(513)	(470)	(1,001)	74
— Results related to associates and financial assets	—	—	—	—
— Results related to financial liabilities measured at fair value through profit or loss	(195)	(221)	(127)	(891)
— Results on derecognition of financial liabilities	—	(101)	—	(509)
— Income tax expenses	(200)	—	(197)	—
Changes in working capital	(4,614)	(3,622)	(13,838)	48,668
Cash (used in)/generated from operations	(6,875)	(11,032)	(22,747)	33,513
Corporate income tax received/(paid)	199	—	196	—
Interest received	610	685	1,542	865
Interest paid	(190)	—	(379)	—
Net cash (used in)/generated from operating activities	(6,256)	(10,347)	(21,388)	34,378
Cash flow from investing activities
Increase in financial asset - current	—	—	(17,000)	—
Purchases of property, plant and equipment	(267)	(294)	(999)	(430)
Sales of property, plant and equipment	—	—	—	47
Net cash used in investing activities	(267)	(294)	(17,999)	(383)
Cash flow from financing activities
Proceeds from exercise of share options	12	4	174	4
Repayment of lease liability	(294)	(647)	(875)	(906)
Net cash used in financing activities	(282)	(643)	(701)	(902)
Net (decrease)/increase in cash and cash equivalents	(6,805)	(11,284)	(40,088)	33,093
Currency effect cash and cash equivalents	62	860	133	694
Cash and cash equivalents, at beginning of the period	85,713	138,986	118,925	94,775
Cash and cash equivalents at the end of the period	78,970	128,562	78,970	128,562

XML

Document and Entity Information	6 Months Ended
	Jun. 30, 2024
Document and Entity Information [Abstract]
Entity Registrant Name	ProQR Therapeutics N.V.
Entity Central Index Key	0001612940
Document Type	6-K
Document Period End Date	Jun. 30, 2024
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2024
Document Fiscal Period Focus	Q2

XML

Condensed Consolidated Statement of Financial Position - EUR (€) € in Thousands	Jun. 30, 2024	Dec. 31, 2023
Current assets
Cash and cash equivalents	€ 78,970	€ 118,925
Financial asset - current	17,183
Prepayments and other receivables	5,116	1,538
Other taxes	497	523
Total current assets	101,766	120,986
Property, plant and equipment	16,285	16,897
Total assets	118,051	137,883
Equity
Equity attributable to owners of the Company	32,854	41,390
Total equity	32,854	41,390
Current liabilities
Borrowings	4,437
Lease liabilities	1,675	1,614
Derivative financial instruments	184	311
Trade payables	33	1,541
Social securities and other taxes	1,448	1,659
Deferred income	23,827	20,569
Other current liabilities	5,675	8,509
Total current liabilities	37,279	34,203
Borrowings		4,292
Lease liabilities	13,078	13,828
Deferred income	34,840	44,170
Total liabilities	85,197	96,493
Total equity and liabilities	€ 118,051	€ 137,883

XML

Condensed Consolidated Statement of Profit or Loss and OCI - EUR (€) € in Thousands		3 Months Ended		6 Months Ended
		Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Consolidated Statement of Profit or Loss and Comprehensive Income
Revenue		€ 6,305	€ 1,205	€ 10,755	€ 1,860
Other income		156	38	366	80
Research and development costs		(7,048)	(5,909)	(16,331)	(11,969)
General and administrative costs		(3,013)	(4,145)	(6,465)	(8,171)
Total operating costs		(10,061)	(10,054)	(22,796)	(20,140)
Operating result		(3,600)	(8,811)	(11,675)	(18,200)
Finance income and expense		513	470	1,001	(74)
Results related to financial liabilities measured at fair value through profit or loss		195	221	127	891
Result on derecognition of financial liabilities			101		509
Result before corporate income taxes		(2,892)	(8,019)	(10,547)	(16,874)
Income taxes		200	42	197	42
Result for the period		(2,692)	(7,977)	(10,350)	(16,832)
Other comprehensive income (foreign exchange differences on foreign operation)		85	7	276	(212)
Total comprehensive income		(2,607)	(7,970)	(10,074)	(17,044)
Result attributable to
Owners of the Company		(2,692)	(7,993)	(10,350)	(16,926)
Non-controlling interests			16		94
Result for the period		(2,692)	(7,977)	(10,350)	(16,832)
Total comprehensive income attributable to
Owners of the Company		(2,607)	(7,986)	(10,074)	(17,138)
Non-controlling interests			16		94
Total comprehensive income		€ (2,607)	€ (7,970)	€ (10,074)	€ (17,044)
Share information
Weighted average number of shares outstanding, basic	[1]	81,665,565	80,939,392	81,618,038	80,913,751
Weighted average number of shares outstanding, diluted		81,665,565	80,939,392	81,618,038	80,913,751
Earnings per share attributable to owners of the Company (Euro per share)
Basic loss per share	[1]	€ (0.03)	€ (0.10)	€ (0.13)	€ (0.21)
Diluted loss per share	[1]	€ (0.03)	€ (0.10)	€ (0.13)	€ (0.21)

[1] For these periods the potential exercise of share options is not included in the diluted earnings per share as the Company was loss-making. Due to the anti-dilutive nature of the outstanding options, basic and diluted earnings per share are equal

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Condensed Consolidated Statement of Changes in Equity - EUR (€) € in Thousands	Share capital	Share Premium	Equity Settled Employee Benefit Reserve	Translation Reserve	Accumulated Deficit	Total	Non-controlling Interests	Total
Balance at beginning of period at Dec. 31, 2022	€ 3,370	€ 412,540	€ 29,052	€ 1,212	€ (379,110)	€ 67,064	€ (384)	€ 66,680
Balance at beginning of period (in shares) at Dec. 31, 2022	84,246,967
Result for the period					(16,926)	(16,926)	94	(16,832)
Other comprehensive income				(212)		(212)		(212)
Recognition of share-based payments			1,860			1,860		1,860
Treasury shares transferred (in shares)	(122,584)
Shares options lapsed			(3,873)		3,873
Share options exercised / RSUs vested		4	(231)		231	4		4
Share options exercised / RSUs vested (in shares)	122,584
Balance at end of period at Jun. 30, 2023	€ 3,370	412,544	26,808	1,000	(391,932)	51,790	€ (290)	51,500
Balance at end of period (in shares) at Jun. 30, 2023	84,246,967
Balance at beginning of period at Dec. 31, 2023	€ 3,370	412,894	25,159	817	(400,850)	41,390		41,390
Balance at beginning of period (in shares) at Dec. 31, 2023	84,248,384
Result for the period					(10,350)	(10,350)		(10,350)
Other comprehensive income				276		276		276
Recognition of share-based payments			1,364			1,364		1,364
Treasury shares transferred (in shares)	(326,455)
Shares options lapsed			(359)		359
Share options exercised / RSUs vested		174	(288)		288	174		174
Share options exercised / RSUs vested (in shares)	326,455
Balance at end of period at Jun. 30, 2024	€ 3,370	€ 413,068	€ 25,876	€ 1,093	€ (410,553)	€ 32,854		€ 32,854
Balance at end of period (in shares) at Jun. 30, 2024	84,248,384

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Consolidated Statement of Cash Flows - EUR (€) € in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Cash flows from operating activities
Net result	€ (2,692)	€ (7,977)	€ (10,350)	€ (16,832)
Adjustments for:
Depreciation	711	594	1,402	1,143
Share-based compensation	628	765	1,364	1,860
Financial income and expenses	(513)	(470)	(1,001)	74
Results related to financial liabilities measured at fair value through profit or loss	(195)	(221)	(127)	(891)
Results on derecognition of financial liabilities		(101)		(509)
Income tax expenses	(200)		(197)
Changes in working capital	(4,614)	(3,622)	(13,838)	48,668
Cash (used in)/generated from operations	(6,875)	(11,032)	(22,747)	33,513
Corporate income tax received/(paid)	199		196
Interest received	610	685	1,542	865
Interest paid	(190)		(379)
Net cash (used in)/generated from operating activities	(6,256)	(10,347)	(21,388)	34,378
Cash flow from investing activities
Increase in financial asset - current			(17,000)
Purchases of property, plant and equipment	(267)	(294)	(999)	(430)
Sales of property, plant and equipment				47
Net cash used in investing activities	(267)	(294)	(17,999)	(383)
Cash flow from financing activities
Proceeds from exercise of share options	12	4	174	4
Repayment of lease liability	(294)	(647)	(875)	(906)
Net cash used in financing activities	(282)	(643)	(701)	(902)
Net (decrease)/increase in cash and cash equivalents	(6,805)	(11,284)	(40,088)	33,093
Currency effect cash and cash equivalents	62	860	133	694
Cash and cash equivalents, at beginning of the period	85,713	138,986	118,925	94,775
Cash and cash equivalents at the end of the period	€ 78,970	€ 128,562	€ 78,970	€ 128,562

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General Information

6 Months Ended

Jun. 30, 2024

General Information

General Information

1. General Information

ProQR Therapeutics N.V., or “ProQR” or the “Company”, is a biotechnology company domiciled in the Netherlands that primarily focuses on the discovery and development of novel therapeutic medicines.

Since September 18, 2014, the Company’s ordinary shares have been listed on Nasdaq. They are currently trading at Nasdaq Capital Market under ticker symbol PRQR.

The Company was incorporated in the Netherlands, on February 21, 2012 (Chamber of Commerce no. 54600790) and was reorganized from a private company with limited liability to a public company with limited liability on September 23, 2014. The Company has its statutory seat in Leiden, the Netherlands. The address of its headquarters and registered office is Zernikedreef 9, 2333 CK Leiden, the Netherlands.

ProQR Therapeutics N.V. is the ultimate parent company of the following entities:

● ProQR Therapeutics Holding B.V. (100%);

● ProQR Therapeutics I B.V. (100%);

● ProQR Therapeutics II B.V. (100%);

● ProQR Therapeutics III B.V. (100%);

● ProQR Therapeutics IV B.V. (100%);

● ProQR Therapeutics V B.V. (100%);

● ProQR Therapeutics VI B.V. (100%);

● ProQR Therapeutics VII B.V. (100%);

● ProQR Therapeutics VIII B.V. (100%);

● ProQR Therapeutics IX B.V. (100%);

● ProQR Therapeutics I Inc. (100%)

ProQR Therapeutics N.V. is also statutory director of Stichting Bewaarneming Aandelen ProQR (“ESOP Foundation”) and has full control over this entity.

As used in these condensed consolidated financial statements, unless the context indicates otherwise, all references to “ProQR” or the “Company” refer to ProQR Therapeutics N.V. including its subsidiaries and the ESOP Foundation.

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Significant Accounting Policies

6 Months Ended

Jun. 30, 2024

Significant Accounting Policies

Significant Accounting Policies

2. Significant Accounting Policies

These interim condensed consolidated financial statements for the three and six month periods ended June 30, 2024 have been prepared in accordance with IAS 34 Interim Financial Statements. They should be read in conjunction with the Company’s annual financial statements for the year ended December 31, 2023. These interim condensed consolidated financial statements do not include all information required for a complete set of financial statements prepared in accordance with IFRS Standards. However, selected explanatory notes are included to explain events and transactions that are significant to an understanding of the changes in the Company’s financial position and performance since the last annual financial statements. In the opinion of management, all events and transactions that are significant to an understanding of the changes in financial position and performance of the Company since the end of the last annual reporting period are disclosed in these interim condensed consolidated financial statements. The accounting policies adopted in the preparation of the interim condensed consolidated financial statements are consistent with those applied in the preparation of the Company’s annual financial statements for the year ended December 31, 2023.

During the six month period ended June 30, 2024, the Company invested in financial assets in the form of deposits with an original maturity of longer than three months but shorter than twelve months as described in Note 6. Financial assets are measured at amortised cost as they give rise on specified dates to cash flows that are solely payments of principal and interest on the principal amount outstanding.

The Company’s financial results have varied substantially, and are expected to continue to vary, from period to period. The Company believes that its ordinary activities are not linked to any particular seasonal factors.

The management of ProQR has, upon preparing and finalizing these interim condensed consolidated financial statements, assessed the Company’s ability to fund its operations for a period of at least one year after the date of signing these interim condensed consolidated financial statements. Management expects the Company to continue as a going concern based on its existing funding, taking into account the Company’s current cash position and the projected cash flows based on the activities under execution on the basis of ProQR’s business plan and budget. Based on our current operating plan, we believe that the existing cash and cash equivalents will be sufficient to fund our anticipated level of operations at least into mid-2026. Thus, we continue to adopt the going concern basis of accounting in preparing the interim condensed consolidated financial statements.

The carrying amount of all financial assets and financial liabilities is a reasonable approximation of the fair value and therefore, information about the fair values of each class has not been disclosed.

The Company operates in one reportable segment, which comprises the discovery and development of innovative, RNA based therapeutics.

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Adoption of New and Revised International Financial Reporting Standards

6 Months Ended

Jun. 30, 2024

Adoption of New and Revised International Financial Reporting Standards

Adoption of New and Revised International Financial Reporting Standards

3. Adoption of New and Revised International Financial Reporting Standards

New Standards and Interpretations, which became effective as of January 1, 2024, did not have a material impact on our condensed consolidated financial statements.

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Critical Accounting Estimates and Judgments

6 Months Ended

Jun. 30, 2024

Critical Accounting Estimates and Judgments

Critical Accounting Estimates and Judgments

4. Critical Accounting Estimates and Judgments

In the application of the Company’s accounting policies, management is required to make judgments, estimates and assumptions about the carrying amounts of assets and liabilities that are not readily apparent from other sources. The estimates and associated assumptions are based on historical experience and other factors that are considered to be relevant. Actual results may differ from these estimates.

The estimates and underlying assumptions are reviewed on an ongoing basis. Revisions to accounting estimates are recognized in the period in which the estimate is revised if the revision affects only that period or in the period of the revision and future periods if the revision affects both current and future periods.

The significant judgements made by management in applying the Company’s accounting policies, except for the significant judgements related to revenue recognition from milestone payments as further described below and in Note 14, and the key sources of estimation uncertainty were the same as those described in the Company’s annual financial statements for the year ended December 31, 2023.

Revenue recognition for the Eli Lilly collaboration and license agreement

a. Identification of the performance obligation

Note 14 describes the Company’s original research and collaboration agreement with Eli Lilly and Company, and the amended and restated research and collaboration agreement (collectively, the “Collaboration agreement”). Under the Collaboration agreement, ProQR provides Eli Lilly with a license (with a right to sub-license) to exploit compounds resulting from the collaboration. A significant amount of judgement is required to determine whether the license is distinct from the other promises in the contract. The license was concluded not to be distinct from the other promises in the contract based on the following considerations:

● the license has no stand-alone value to Eli Lilly without the Company being involved in the research and development collaboration, and;

● there are significant interdependencies between the license and the research and development services to be provided by the Company.

ProQR’s services are evaluated as predominant at inception of the contract and contractually only ProQR can perform these services as they are specific to the skills of the Company. The resulting compounds from the collaboration do not represent a series of distinct promises because they were not predetermined at the inception of the contract and can be terminated or replaced at the discretion of Lilly subject to the terms and conditions of the Collaboration agreement.

b. Determining the timing of satisfaction of performance obligations

Under the Collaboration agreement, the Company recognizes revenue over time, using an input method that estimates the satisfaction of the performance obligation as the percentage of labor hours incurred compared to the total estimated labor hours required to complete the promised services. As our estimate of the total labor hours required is dependent on the evolution of the research and development activities, it may be subject to change. If the progression and/or outcome of certain research and development activities would be different from the assumptions that were made during the preparation of these financial statements, this could lead to material adjustments to the total estimated labor hours, which might result in a reallocation of revenue between current and future periods. Our total deferred revenue balance amounts to € 58,667,000 of which € 58,181,000 is related to this Eli Lilly performance obligation at June 30, 2024. As at December 31, 2023 the entire deferred revenue balance of € 64,739,000 related to the Eli Lilly performance obligation.

c. Determining the transaction price

The Company applied judgement to determine whether the equity investments made by Eli Lilly in ProQR are part of the transaction price for the Collaboration agreement. The Company concluded that the differences between the prices that Eli Lilly paid for the shares and the ProQR stock closing prices on the days of entering into the equity investment agreements arose because of the Company’s existing obligations to deliver research and development services to Eli Lilly under the terms of the Collaboration agreement. Therefore, the above differences between the closing share prices on the agreement effective dates and the equity investment prices paid by Eli Lilly are considered to be part of the transaction price of the contract and are initially allocated to deferred revenue.

The contract also includes variable consideration, but no variable consideration was included in the initial transaction price at the inception, as it is not highly probable that a significant reversal in the amount of cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is subsequently resolved. The Company includes such variable consideration in the transaction price when the uncertainty associated with the variable consideration is resolved.

As further described in Note 14, during 2024, the Company reached milestones under the agreement, which were added to the transaction price and recognized partially as revenue during 2024 with the remainder recorded in future periods based on progress towards satisfaction of performance obligation.

The Collaboration agreement includes sales-based royalties, including commercial milestone payments based on the level of sales. Related revenue is recognized as the subsequent underlying sales occur at a point in time.

Research and development expenditures

Research expenditures are reflected in the income statement. Development expenses are currently also reflected in the income statement because the criteria for capitalization are not met. At each balance sheet date, the Company estimates the level of service performed by the vendors and the associated costs incurred for the services performed.

Although we do not expect the estimates to be materially different from amounts actually incurred, the understanding of the status and timing of services performed relative to the actual status and timing of services performed may vary and could result in reporting amounts that are too high or too low in any particular period.

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Cash and Cash Equivalents

6 Months Ended

Jun. 30, 2024

Cash and Cash Equivalents.

Cash and Cash Equivalents

5. Cash and Cash Equivalents

At June 30, 2024, the Company’s cash and cash equivalents were € 78,970,000 compared to € 118,925,000 at December 31, 2023. The cash balances are held at banks with investment grade credit ratings. Short-term credit ratings must be rated A-1/P-1/F1 at a minimum by at least one of the Nationally Recognized Statistical Rating Organizations (“NRSROs”) specifically Moody’s, Standard & Poor’s or Fitch. The cash at banks is at full disposal of the Company. Included in cash and cash equivalents are deposits fixed for at most 3-month periods at a time.

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Financial Asset - Current

6 Months Ended

Jun. 30, 2024

Financial Asset - Current

Financial Asset - Current

6. Financial Asset – Current

This current financial asset relates to a term deposit with an initial maturity longer than 3 months but less than 12 months and does not qualify as a cash equivalent. The deposit is held at a bank with an investment grade credit rating. Short-term credit ratings must be rated A-1/P-1/F1 at a minimum by at least one of the NRSROs specifically Moody’s, Standard & Poor’s or Fitch.

	June 30,	December 31,
	2024	2023
	€1,000	€1,000
Term deposit and interest accrued	17,183	—
	17,183	—

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Prepayments and Other Receivables

6 Months Ended

Jun. 30, 2024

Prepayments and Other Receivables.

Prepayments and Other Receivables

7. Prepayments and Other Receivables

	June 30,	December 31,
	2024	2023
	€1,000	€1,000
Prepayments	1,067	793
Other Receivables	4,049	745
	5,116	1,538

At June 30, 2024 and December 31, 2023 prepayments consisted principally of payments made by the Company for services not yet provided by vendors. At June 30, 2024 and December 31, 2023 other receivables consisted principally of amounts receivable from research collaboration partners and deposits.

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Property, Plant and Equipment

6 Months Ended

Jun. 30, 2024

Property, Plant and Equipment

Property, Plant and Equipment

8. Property, Plant and Equipment

At June 30, 2024 and December 31, 2023, property plant and equipment consisted of buildings and leasehold improvements, laboratory equipment and other assets. Buildings and leasehold improvements include a right-of-use asset relating to the lease of our Leiden office and laboratory space, with a carrying amount of € 13,741,000 at June 30, 2024 (December 31, 2023: € 14,524,000).

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Other Current Liabilities

6 Months Ended

Jun. 30, 2024

Other Current Liabilities.

Other Current Liabilities

9. Other Current Liabilities

At June 30, 2024, other current liabilities amount to € 5,675,000 (December 31, 2023: € 8,509,000). At June 30, 2024 and December 31, 2023, other current liabilities consisted principally of accruals for services provided by vendors not yet billed, payroll related accruals and other miscellaneous liabilities.

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Borrowings

6 Months Ended

Jun. 30, 2024

Borrowings

Borrowings

10. Borrowings

	June 30,	December 31,
	2024	2023
	€1.000	€1.000
Innovation credit	2,899	2,899
Accrued interest on innovation credit	1,538	1,393
Total borrowings	4,437	4,292
Current portion	(4,437)	—
	—	4,292

On December 10, 2018 ProQR was awarded an Innovation credit for the sepofarsen program. Amounts were drawn under this facility from 2018 through 2022. The credit of € 3,907,000 was used to conduct the Phase 2/3 clinical study and efforts to obtain regulatory and ethical market approval (New Drug Applications (“NDA”)/ Marketing Authorization Applications (“MAA”)) of sepofarsen for LCA10. In 2023, ProQR made a partial repayment of the principal, amounting to € 1,008,000. The remaining amount payable of € 2,899,000 and accrued interest is recognized under current borrowings at June 30, 2024 and non-current borrowings at December 31, 2023.

In December 2023, ProQR received a conditional waiver of the balance of the Innovation credit including accrued interest. Consequently, the repayment of the total loan of € 4,437,000, including interest, will be waived if conditions are met, which will be reviewed annually.

In September 2022, ProQR extinguished its debt with Pontifax and Kreos by repaying all outstanding principal amounts. Pontifax’ and Kreos’ warrants remain in place until their five-year economic life expires in 2025 and 2026. These warrants are accounted for as embedded derivatives and were recognized separately from the host contract as derivative financial liabilities at fair value through profit or loss.

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Lease Liabilities

6 Months Ended

Jun. 30, 2024

Lease Liabilities

Lease Liabilities

11. Lease Liabilities

At June 30, 2024 and December 31, 2023, lease liabilities primarily consisted of the Company’s lease of office and laboratory facilities at Zernikedreef in Leiden, the Netherlands.

The Company leases office and laboratory facilities of 4,818 square meters at Zernikedreef in Leiden, the Netherlands, where our headquarters and our laboratories are located. The current lease agreement for these facilities terminates on June 30, 2031. The lease agreement contains no significant dismantling requirements.

The initial 10-year lease agreement for the Leiden office and laboratory facilities was accounted for as of commencement date July 1, 2020. This 10-year period was extended by 1 year to an 11-year period in December 2020. The lease contract may be extended for subsequent 5-year periods. As the Company is not reasonably certain to exercise these extension options, these are not included in the lease term.

The carrying amount of the right-of-use asset is disclosed in Note 8.

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Deferred Income

6 Months Ended

Jun. 30, 2024

Deferred Income

Deferred Income

12. Deferred Income

​
The following table summarizes details of deferred income at June 30, 2024 and December 31, 2023. The nature of the deferred income is described in Note 14 and 15.
​

	June 30,	December 31,
	2024	2023
	€1,000	€1,000
Payments from Eli Lilly	23,341	20,569
Payments from Rett Syndrome Research Trust	486	—
Current deferred income	23,827	20,569
Payments from Eli Lilly	34,840	44,170
Non-current deferred income	34,840	44,170
Total deferred income	58,667	64,739

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Shareholders Equity

6 Months Ended

Jun. 30, 2024

Shareholders Equity

Shareholders Equity

13. Shareholders’ Equity

The authorized share capital of the Company amounting to € 13,600,000 consists of 170,000,000 ordinary shares and 170,000,000 preference shares with a par value of € 0.04 per share. At June 30, 2024, 84,247,306 ordinary shares were issued. 81,680,195 ordinary shares were fully paid and 2,567,111 ordinary shares were held by the Company as treasury shares (December 31, 2023: 2,893,792).

Translation reserve

The translation reserve comprises all foreign currency differences arising from the translation of the financial statements of foreign operations.

Share options

The Company operates an equity-settled share-based compensation plan, which was introduced in 2013. Options and Restricted Stock Units (“RSUs”) may be granted to employees, members of the Supervisory Board, members of the Management Board and consultants. The compensation expenses included in operating costs for this plan in the six month period ended June 30, 2024 were € 1,364,000 (six month period ended June 30, 2023: € 1,860,000), of which € 1,089,000 was recorded in general and administrative costs (six month period ended June 30, 2023: € 1,644,000) and € 275,000 was recorded in research and development costs (six month period ended June 30, 2023: € 216,000).

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Revenue

6 Months Ended

Jun. 30, 2024

Revenue.

Revenue

14. Revenue

Eli Lilly

In September 2021, the Company entered into a global licensing and research collaboration with Eli Lilly and Company (‘Lilly’) focused on the discovery, development, and commercialization of potential new medicines for genetic disorders in the liver and nervous system. ProQR and Lilly will use ProQR’s proprietary Axiomer® RNA editing platform to progress new drug targets toward clinical development and commercialization.

Under the terms of the agreement, ProQR received an upfront payment and equity consideration, and is eligible to receive milestone payments and royalties on the net sales of any resulting products. In September 2021, the Company issued 3,989,976 shares to Lilly, resulting in net proceeds of $30,000,000 (€ 25,270,000). This amount included a price premium of $2,429,000 (€ 2,047,000), which was determined to be part of the transaction price and as such was initially recognized as deferred revenue. An up-front payment of $20,000,000 (€ 16,849,000) was received in October 2021.

With regard to its original collaboration with Lilly, the Company concluded as follows:

● There is one performance obligation under IFRS 15, for the transfer of a license combined with the performance of research and development activities. The Company concluded that the license is not capable of being distinct and is not distinct in the context of the contract. ProQR’s services are evaluated as predominant at inception of the contract and the compounds resulting from the collaboration do not represent a series of distinct promises because they were not predetermined at the inception of the contract and can be terminated or replaced at the discretion of Lilly subject to the terms and conditions of the Collaboration agreement.

● The transaction price of this agreement includes fixed components, consisting of an up-front fee and an equity component. The agreement also contains variable parts, which are included in the transaction price to the extent that it is highly probably that a significant reversal in the amount of cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is subsequently resolved. Milestone payments will only be included to the extent that it is highly probable that a significant reversal in the amount of cumulative revenue recognized will not occur when the uncertainty associated with the milestones is subsequently resolved. Sales-based milestones and sales-based royalties will be included as the underlying sales occur.

● The Company recognizes revenue over time, using an input method that estimates the satisfaction of the performance obligation as the percentage of labor hours incurred compared to the total estimated labor hours required to complete the promised services.

In December 2022, the Company and Lilly amended their research and collaboration agreement described above, which expanded the collaboration. Under the amended and restated research and collaboration agreement, Lilly will gain access to additional targets in the central nervous system and peripheral nervous system with ProQR’s Axiomer platform.

Pursuant to the amended and restated agreement, the Company issued 9,381,586 shares to Lilly in December 2022, resulting in gross proceeds of $ 15,000,000 (€ 14,122,000). These shares were issued at a discount of $ 480,000 (€ 451,000), which is accounted for as a reduction of the transaction price. In February 2023, ProQR also received an upfront payment of $ 60,000,000 (€ 56,412,000), which was recognized under Deferred Income. Lilly has the ability to exercise an option to further expand the partnership for a consideration of $ 50,000,000.

With regard to the amended and restated research and collaboration agreement with Lilly, the Company concluded as follows:

● There is one performance obligation under IFRS 15, for the transfer of a license combined with the performance of research and development activities. The Company concluded that the license is not capable of being distinct and is not distinct in the context of the contract. ProQR’s services are evaluated as predominant at inception of the contract and the compounds resulting from the collaboration do not represent a series of distinct promises because they were not predetermined at the inception of the contract and can be terminated or replaced at the discretion of Lilly subject to the terms and conditions of

the Collaboration agreement.

● The transaction price of this agreement includes fixed components, consisting of an up-front fee and an equity component (discount), and variable components. The variable components are not yet fully included in the transaction price. Milestone payments will only be included to the extent that it is highly probable that a significant reversal in the amount of cumulative revenue recognized will not occur when the uncertainty associated with the milestones is subsequently resolved. As further described in the note, the Company reached certain milestones. Sales-based milestones and sales-based royalties will be included as the underlying sales occur.

● The Company recognizes revenue over time, using an input method that estimates the satisfaction of the performance obligation as the percentage of labor hours incurred compared to the total estimated labor hours required to complete the promised services.

During the six month period ended June 30, 2024, the Company reached milestones amounting to $ 4,500,000 (€ 4,196,000) under the agreement, which were added to the transaction price and recognized partially as revenue during the six month period ended June 30, 2024. As at June 30, 2024, $ 3,500,000 (€ 3,275,000) is recognized in other receivables.

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Other Income

6 Months Ended

Jun. 30, 2024

Other Income

Other Income

15. Other Income

	Six month period
	ended June 30,
	2024	2023
	€1.000	€1.000
Grant income	366	76
Other income	—	4
	366	80

In January, 2024, the Company entered into an agreement with the Rett Syndrome Research Trust (“RSRT”) that focuses on the design and development of editing oligonucleotides (“EONs”) using the Company’s Axiomer technology platform targeting the transcription factor Methyl CpG binding protein 2 (“MECP2”) and correcting mutations of interest. Under the agreement, RSRT awarded the Company up to € 1,015,000 as a research grant for the initial phase of the project.

Grants are recognized in other income in the same period in which the related R&D costs are recognized.

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Research and Development Costs

6 Months Ended

Jun. 30, 2024

Research and Development Costs

Research and Development Costs

16. Research and Development Costs

Research and development costs amount to €16,331,000 for the six month period ended June 30, 2024 (six month period ended June 30, 2023: € 11,969,000) and are comprised of allocated employee costs including share-based payments, the costs of materials and laboratory consumables, outsourced activities, license and intellectual property costs and other allocated costs. Research and development costs increased compared to the same period in the prior year, mainly due to the Company’s increased outsourced research and development activities in the first half of 2024 and increased full time employee equivalents (“FTE”).

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General and Administrative Costs

6 Months Ended

Jun. 30, 2024

General and Administrative Costs

General and Administrative Costs

17. General and Administrative Costs

General and administrative costs amount to € 6,465,000 for the six month period ended June 30, 2024 (six month period ended June 30, 2023: € 8,171,000).

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Investment in Financial Assets

6 Months Ended

Jun. 30, 2024

Investments in Financial Assets

Investments in Financial Assets

18. Investments in Financial Assets

Investment in financial assets consist of the Company’s investment in Phoenicis Therapeutics Inc. (“Phoenicis”) and Yarrow Biotechnology Inc (“Yarrow”).

ProQR holds a 3.9% interest in Phoenicis. At June 30, 2024, the investment amounts to € nil (December 31, 2023: € nil) after ProQR recognized a fair value loss in the third quarter of 2023 in other comprehensive income.

ProQR holds a 5.1% interest in Yarrow. In October 2023, ProQR initially recognized its investment in the Yarrow financial asset at € nil. As at June 30, 2024, the fair value of the Yarrow financial asset amounted to € nil (December 31, 2023: € nil).

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Results Related to Derecognition of Financial Liabilities

6 Months Ended

Jun. 30, 2024

Results Related to Derecognition of Financial Liabilities

Results Related to Derecognition of Financial Liabilities

19. Results Related to Derecognition of Financial Liabilities

	Six month period
	ended June 30,
	2024	2023
	€1.000	€1.000
Gain on waiver of Amylon convertible loans	—	509
	—	509

Convertible loans

Convertible loans were issued to Amylon Therapeutics B.V. (“Amylon”), an 80% subsidiary of the Company, and were interest-bearing at an average rate of 8% per annum. They were convertible into a variable number of ordinary shares within 36 months at the option of the holder or the Company in case financing criteria were met. Any unconverted loans became payable on demand after 24 – 36 months in equal quarterly terms.

In 2023 and 2022, Amylon entered into waiver agreements with its lenders. Such lenders’ loan agreements with Amylon are severed and any claims to repayment of any outstanding debt and accumulated interest are renounced. The amount of convertible loans and accumulated interest that was waived under these agreements in the six month period ended June 30, 2024 is € nil (six month period ended June 30, 2023: € 509,000).

In the third quarter of 2023, Amylon was legally dissolved.

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Income Taxes

6 Months Ended

Jun. 30, 2024

Income Taxes

Income Taxes

20. Income Taxes

The current income tax liability amounts to € nil at June 30, 2024 (December 31, 2023: € nil). No significant temporary differences exist between accounting and tax results. Realization of deferred tax assets is dependent on future earnings, if any, the timing and amount of which are uncertain. Accordingly, the Company has not yet recognized any deferred tax asset related to operating losses.

Tax losses may be carried forward indefinitely. However, the offset of losses will be limited in a given year against the first € 1 million of taxable profit. For taxable profit in excess of this amount, losses may only be offset up to 50% of this excess.

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Events After Balance Sheet Date

6 Months Ended

Jun. 30, 2024

Events After Balance Sheet Date

Events After Balance Sheet Date

21. Events After Balance Sheet Date

None.

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Critical Accounting Estimates and Judgments (Policies)

6 Months Ended

Jun. 30, 2024

Critical Accounting Estimates and Judgments

Revenue recognition for the Eli Lilly collaboration and license agreement

Revenue recognition for the Eli Lilly collaboration and license agreement

a. Identification of the performance obligation

Note 14 describes the Company’s original research and collaboration agreement with Eli Lilly and Company, and the amended and restated research and collaboration agreement (collectively, the “Collaboration agreement”). Under the Collaboration agreement, ProQR provides Eli Lilly with a license (with a right to sub-license) to exploit compounds resulting from the collaboration. A significant amount of judgement is required to determine whether the license is distinct from the other promises in the contract. The license was concluded not to be distinct from the other promises in the contract based on the following considerations:

● the license has no stand-alone value to Eli Lilly without the Company being involved in the research and development collaboration, and;

● there are significant interdependencies between the license and the research and development services to be provided by the Company.

ProQR’s services are evaluated as predominant at inception of the contract and contractually only ProQR can perform these services as they are specific to the skills of the Company. The resulting compounds from the collaboration do not represent a series of distinct promises because they were not predetermined at the inception of the contract and can be terminated or replaced at the discretion of Lilly subject to the terms and conditions of the Collaboration agreement.

b. Determining the timing of satisfaction of performance obligations

Under the Collaboration agreement, the Company recognizes revenue over time, using an input method that estimates the satisfaction of the performance obligation as the percentage of labor hours incurred compared to the total estimated labor hours required to complete the promised services. As our estimate of the total labor hours required is dependent on the evolution of the research and development activities, it may be subject to change. If the progression and/or outcome of certain research and development activities would be different from the assumptions that were made during the preparation of these financial statements, this could lead to material adjustments to the total estimated labor hours, which might result in a reallocation of revenue between current and future periods. Our total deferred revenue balance amounts to € 58,667,000 of which € 58,181,000 is related to this Eli Lilly performance obligation at June 30, 2024. As at December 31, 2023 the entire deferred revenue balance of € 64,739,000 related to the Eli Lilly performance obligation.

c. Determining the transaction price

The Company applied judgement to determine whether the equity investments made by Eli Lilly in ProQR are part of the transaction price for the Collaboration agreement. The Company concluded that the differences between the prices that Eli Lilly paid for the shares and the ProQR stock closing prices on the days of entering into the equity investment agreements arose because of the Company’s existing obligations to deliver research and development services to Eli Lilly under the terms of the Collaboration agreement. Therefore, the above differences between the closing share prices on the agreement effective dates and the equity investment prices paid by Eli Lilly are considered to be part of the transaction price of the contract and are initially allocated to deferred revenue.

The contract also includes variable consideration, but no variable consideration was included in the initial transaction price at the inception, as it is not highly probable that a significant reversal in the amount of cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is subsequently resolved. The Company includes such variable consideration in the transaction price when the uncertainty associated with the variable consideration is resolved.

As further described in Note 14, during 2024, the Company reached milestones under the agreement, which were added to the transaction price and recognized partially as revenue during 2024 with the remainder recorded in future periods based on progress towards satisfaction of performance obligation.

The Collaboration agreement includes sales-based royalties, including commercial milestone payments based on the level of sales. Related revenue is recognized as the subsequent underlying sales occur at a point in time.

Research and development expenditures

Research and development expenditures

Research expenditures are reflected in the income statement. Development expenses are currently also reflected in the income statement because the criteria for capitalization are not met. At each balance sheet date, the Company estimates the level of service performed by the vendors and the associated costs incurred for the services performed.

Although we do not expect the estimates to be materially different from amounts actually incurred, the understanding of the status and timing of services performed relative to the actual status and timing of services performed may vary and could result in reporting amounts that are too high or too low in any particular period.

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Financial Asset - Current (Tables)

6 Months Ended

Jun. 30, 2024

Financial Asset - Current

Financial asset - current

	June 30,	December 31,
	2024	2023
	€1,000	€1,000
Term deposit and interest accrued	17,183	—
	17,183	—

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Prepayments and Other Receivables (Tables)

6 Months Ended

Jun. 30, 2024

Prepayments and Other Receivables.

Prepayments and Other Receivables

	June 30,	December 31,
	2024	2023
	€1,000	€1,000
Prepayments	1,067	793
Other Receivables	4,049	745
	5,116	1,538

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Borrowings (Tables)

6 Months Ended

Jun. 30, 2024

Borrowings

Schedule of borrowings

	June 30,	December 31,
	2024	2023
	€1.000	€1.000
Innovation credit	2,899	2,899
Accrued interest on innovation credit	1,538	1,393
Total borrowings	4,437	4,292
Current portion	(4,437)	—
	—	4,292

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Deferred Income (Tables)

6 Months Ended

Jun. 30, 2024

Deferred Income

Schedule of deferred income

	June 30,	December 31,
	2024	2023
	€1,000	€1,000
Payments from Eli Lilly	23,341	20,569
Payments from Rett Syndrome Research Trust	486	—
Current deferred income	23,827	20,569
Payments from Eli Lilly	34,840	44,170
Non-current deferred income	34,840	44,170
Total deferred income	58,667	64,739

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Other Income (Tables)

6 Months Ended

Jun. 30, 2024

Other Income

Schedule of other income

	Six month period
	ended June 30,
	2024	2023
	€1.000	€1.000
Grant income	366	76
Other income	—	4
	366	80

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Results Related to Derecognition of Financial Liabilities (Tables)

6 Months Ended

Jun. 30, 2024

Results Related to Derecognition of Financial Liabilities

Schedule of results related to derecognition of financial liabilities

	Six month period
	ended June 30,
	2024	2023
	€1.000	€1.000
Gain on waiver of Amylon convertible loans	—	509
	—	509

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General Information (Details)	6 Months Ended	24 Months Ended
	Jun. 30, 2024	Dec. 31, 2019
ProQR Therapeutics Holding B.V. [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary	100.00%
ProQR Therapeutics I B.V. [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary	100.00%
ProQR Therapeutics II B.V. [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary	100.00%
ProQR Therapeutics III B.V. [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary	100.00%
ProQR Therapeutics IV B.V. [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary	100.00%
ProQR Therapeutics V B.V. [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary	100.00%
ProQR Therapeutics VI B.V. [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary	100.00%
ProQR Therapeutics VII B.V. [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary	100.00%
ProQR Therapeutics VIII B.V. [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary	100.00%
ProQR Therapeutics IX B.V. [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary	100.00%
Amylon Therapeutics B.V [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary		80.00%
ProQR Therapeutics I Inc. [Member]
Disclosure of subsidiaries [line items]
Proportion of ownership interest in subsidiary	100.00%

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Significant Accounting Policies (Details)	6 Months Ended
	Jun. 30, 2024 segment
Significant Accounting Policies
Number of reportable segment	1

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Critical Accounting Estimates and Judgments (Details) € in Thousands, $ in Thousands	Jun. 30, 2024 EUR (€)	Dec. 31, 2023 EUR (€)	Sep. 30, 2021 EUR (€)	Sep. 30, 2021 USD ($)
Disclosure of disaggregation of revenue from contracts with customers [line items]
Deferred income	€ 58,667	€ 64,739
Eli Lilly
Disclosure of disaggregation of revenue from contracts with customers [line items]
Deferred income	€ 58,181	€ 64,739	€ 2,047	$ 2,429

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Cash and Cash Equivalents (Details) - EUR (€) € in Thousands	Jun. 30, 2024	Mar. 31, 2024	Dec. 31, 2023	Jun. 30, 2023	Mar. 31, 2023	Dec. 31, 2022
Cash and Cash Equivalents.
Cash and cash equivalents	€ 78,970	€ 85,713	€ 118,925	€ 128,562	€ 138,986	€ 94,775

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Financial Asset - Current (Details) € in Thousands	Jun. 30, 2024 EUR (€)
Financial Asset - Current
Term deposit and interest accrued	€ 17,183
Financial asset - current	€ 17,183

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Prepayments and Other Receivables (Details) - EUR (€) € in Thousands	Jun. 30, 2024	Dec. 31, 2023
Prepayments and Other Receivables.
Prepayments	€ 1,067	€ 793
Other receivables	4,049	745
Total Prepayments and Other Receivables	€ 5,116	€ 1,538

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Property, Plant and Equipment (Details) - EUR (€) € in Thousands	Jun. 30, 2024	Dec. 31, 2023
Building And Leasehold Improvements
Property, Plant and Equipment
Right-of-use assets	€ 13,741	€ 14,524

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Other Current Liabilities (Details) - EUR (€) € in Thousands	Jun. 30, 2024	Dec. 31, 2023
Current contract liabilities [abstract]
Other current liabilities	€ 5,675	€ 8,509

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Borrowings (Details) - EUR (€) € in Thousands	1 Months Ended		3 Months Ended	6 Months Ended	12 Months Ended	24 Months Ended
	Dec. 31, 2023	Sep. 30, 2022	Jun. 30, 2023	Jun. 30, 2023	Dec. 31, 2023	Dec. 31, 2019	Jun. 30, 2024	Dec. 10, 2018
Disclosure of detailed information about borrowings [line items]
Total borrowings	€ 4,292				€ 4,292		€ 4,437
Current portion							(4,437)
Non Current portion	4,292				4,292
Result on derecognition of financial liabilities			€ 101	€ 509
Pontifax and Kreos warrants
Disclosure of detailed information about borrowings [line items]
Warrants, economic lifetime		5 years
Innovation credit
Disclosure of detailed information about borrowings [line items]
Accrued interest	1,393				1,393		1,538
Total borrowings	2,899				2,899		2,899
Current portion							€ (2,899)
Notional amount								€ 3,907
Total conditional waiver of debt	€ 4,437
Repayment of borrowings					€ 1,008
Convertible loans Amylon Therapeutics B.V. [Member]
Disclosure of detailed information about borrowings [line items]
Interest rate (as percent)						8.00%
Convertible loans Amylon Therapeutics B.V. [Member] | Minimum
Disclosure of detailed information about borrowings [line items]
Period upon which unconverted loans become payable on demand						24 months
Convertible loans Amylon Therapeutics B.V. [Member] | Maximum
Disclosure of detailed information about borrowings [line items]
Debt instrument convertible term						36 months
Period upon which unconverted loans become payable on demand						36 months

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Lease Liabilities (Details) - Office and laboratory facilities at Zernikedreef, Leiden - m²		1 Months Ended	6 Months Ended
	Jul. 01, 2020	Dec. 31, 2020	Jun. 30, 2024
Disclosure of quantitative information about right-of-use assets [line items]
Area under lease			4,818
Lease term	10 years	11 years
Lease extension term		1 year
Lease, current extension period under option			5 years

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Deferred income (Details) € in Thousands, $ in Thousands	Jun. 30, 2024 EUR (€)	Dec. 31, 2023 EUR (€)	Sep. 30, 2021 EUR (€)	Sep. 30, 2021 USD ($)
Disclosure of disaggregation of revenue from contracts with customers [line items]
Deferred income, current portion	€ 23,827	€ 20,569
Deferred income, non-current portion	34,840	44,170
Total deferred income	58,667	64,739
Eli Lilly
Disclosure of disaggregation of revenue from contracts with customers [line items]
Deferred income, current portion	23,341	20,569
Deferred income, non-current portion	34,840	44,170
Total deferred income	58,181	€ 64,739	€ 2,047	$ 2,429
Rett Syndrome Research Trust
Disclosure of disaggregation of revenue from contracts with customers [line items]
Deferred income, current portion	€ 486

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Shareholders Equity - Share capital (Details) - EUR (€)	Jun. 30, 2024	Dec. 31, 2023
Shareholders Equity
Authorized share capital	€ 13,600,000
Par value per share	€ 0.04
Ordinary
Shareholders Equity
Number of shares issued	84,247,306
Number of shares authorised	170,000,000
Shares were issued and fully paid in cash	81,680,195
Treasury shares	2,567,111	2,893,792
Preferred
Shareholders Equity
Number of shares authorised	170,000,000

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Shareholders Equity - Share options (Details) - EUR (€) € in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Operating costs
Shareholders Equity
Equity-settled share based payments	€ 1,364	€ 1,860
General and administrative costs
Shareholders Equity
Equity-settled share based payments	1,089	1,644
Research and development costs
Shareholders Equity
Equity-settled share based payments	€ 275	€ 216

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Revenue (Details) € in Thousands	1 Months Ended								6 Months Ended
	Feb. 28, 2023 EUR (€)	Feb. 28, 2023 USD ($)	Dec. 31, 2022 EUR (€) shares	Dec. 31, 2022 USD ($) shares	Oct. 31, 2021 EUR (€)	Oct. 31, 2021 USD ($)	Sep. 30, 2021 EUR (€) shares	Sep. 30, 2021 USD ($) shares	Jun. 30, 2024 EUR (€)	Jun. 30, 2024 USD ($)	Jun. 30, 2024 USD ($)	Dec. 31, 2023 EUR (€)	Sep. 30, 2021 USD ($)
Disclosure of disaggregation of revenue from contracts with customers [line items]
Deferred income | €									€ 58,667			€ 64,739
Eli Lilly and Company
Disclosure of disaggregation of revenue from contracts with customers [line items]
Issuance of ordinary shares (in shares) | shares			9,381,586	9,381,586			3,989,976	3,989,976
Proceeds from issuing shares			€ 14,122	$ 15,000,000			€ 25,270	$ 30,000,000
Deferred income							€ 2,047		€ 58,181			€ 64,739	$ 2,429,000
Up-front payment received	€ 56,412	$ 60,000,000			€ 16,849	$ 20,000,000
Number of performance obligations in collaboration agreement							1	1	1	1
Discount on share issue			€ 451	$ 480,000
Consideration payable upon exercise of option to further expand partnership | $											$ 50,000,000
Value of milestone achieved during the period									€ 4,196	$ 4,500,000
Other current receivables									€ 3,275		$ 3,500,000

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Other Income (Details) - EUR (€) € in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Other Income
Grant income			€ 366	€ 76
Other income				4
Total other income	€ 156	€ 38	€ 366	€ 80

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Other Income - Narrative (Details) - EUR (€) € in Thousands	1 Months Ended
	Jan. 31, 2024	Dec. 31, 2023
Rett Syndrome Research Trust
Other Income [Line Items]
Maximum grant receivable for initial phase of project	€ 1,015
Innovation credit
Other Income [Line Items]
Total conditional waiver of debt		€ 4,437

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Research and Development Costs (Details) - EUR (€) € in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Research and Development Costs
Research and development costs	€ 7,048	€ 5,909	€ 16,331	€ 11,969

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General and Administrative Costs (Details) - EUR (€) € in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
General and Administrative Costs
General and administrative costs	€ 3,013	€ 4,145	€ 6,465	€ 8,171

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Investment in Financial Assets (Details) - EUR (€) € in Thousands	Jun. 30, 2024	Dec. 31, 2023	Oct. 31, 2023
Phoenicis Therapeutics Inc.
Disclosure of financial assets [line items]
Proportion of ownership interest	3.90%
Financial assets at fair value through other comprehensive income	€ 0	€ 0
Yarrow Biotechnology, Inc
Disclosure of financial assets [line items]
Proportion of ownership interest	5.10%
Financial assets at fair value through other comprehensive income	€ 0	€ 0	€ 0

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Results Related to Derecognition of Financial Liabilities (Details) - EUR (€) € in Thousands	3 Months Ended	6 Months Ended		24 Months Ended
	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023	Dec. 31, 2019
Disclosure of detailed information about borrowings [line items]
Gain on waivers of Amylon convertible loans			€ 509
Total results related to derecognition of financial liabilities	€ 101		509
Amylon Therapeutics B.V
Disclosure of detailed information about borrowings [line items]
Proportion of ownership interest in subsidiary				80.00%
Convertible loans Amylon Therapeutics B.V.
Disclosure of detailed information about borrowings [line items]
Gain on waivers of Amylon convertible loans		€ 0	€ 509
Borrowings, interest rate				8.00%
Convertible loans Amylon Therapeutics B.V. | Minimum
Disclosure of detailed information about borrowings [line items]
Period upon which unconverted loans become payable on demand				24 months
Convertible loans Amylon Therapeutics B.V. | Maximum
Disclosure of detailed information about borrowings [line items]
Debt Instrument Conversion Term				36 months
Period upon which unconverted loans become payable on demand				36 months

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Income Taxes (Details) - EUR (€) € in Thousands	Jun. 30, 2024	Dec. 31, 2023
Income Taxes
Current tax liabilities	€ 0	€ 0
Provision for tax	€ 0	€ 0