Exhibit 99.1

Ascendis Pharma A/S Reports Second Quarter 2022 Financial Results

– U.S. regulatory submission for TransCon PTH, designed to be the first parathyroid hormone replacement therapy, on track for Q3 2022; EU submission planned for Q4 2022

– SKYTROFA revenue continued to double quarter-to-quarter, reaching €4.4 million in the second quarter

– With anticipated growth in U.S. revenues and approximately €1 billion of cash, cash equivalents, and marketable securities on hand, Ascendis is positioned to fulfill Vision 3x3 and become cash flow positive

– Conference call today at 4:30 pm ET

COPENHAGEN, Denmark, August 10, 2022 (GLOBE NEWSWIRE) – Ascendis Pharma A/S (Nasdaq: ASND) today announced financial results for the second quarter ended June 30, 2022, and provided a business update.

“Our anticipated launch of TransCon PTH in the U.S. next year, combined with our progress towards making SKYTROFA the leading product in a growing growth hormone market, moves us closer to fulfilling our Vision 3x3 and becoming a sustainable, profitable, leading biopharma company,” said Jan Mikkelsen, Ascendis Pharma’s President and Chief Executive Officer.

Company Highlights & Progress

• TransCon hGH:

• SKYTROFA revenue continued to double quarter-to-quarter, reaching €4.4 million in the second quarter.

U.S. SKYTROFA Launch Metrics	Q4-2021			Q1-2022			Q2-2022
SKYTROFA revenue (millions)	€	0.9		€	1.9		€	4.4
Cumulative number of new patient SKYTROFA prescriptions		369			976			1,707
Total number of prescribers to date		139			349			505
Percent of prescribers to date who have written prescriptions for more than one patient		42	%		46	%		53	%
% of U.S. lives covered*		34	%		45	%		57	%

* Per MMIT - data accessed on July 15, 2022

• In June 2022, submitted a trial protocol to the FDA to evaluate TransCon hGH in Turner Syndrome.

• The foresiGHt Trial in adult GHD on track to complete enrollment by the end of 2022.

• Enrollment in the riGHt Trial, a Phase 3 trial in Japan for pediatric GHD, is expected to complete by the end of 2022.

• Commercial launch of TransCon hGH planned for Europe in mid-2023.

• TransCon PTH:

• Following pre-NDA meeting with the FDA, on track to submit regulatory filing in the U.S. during the third quarter of 2022, with expected U.S. launch in mid-2023.

• EU MAA submission planned during the fourth quarter of 2022.

• After more than two years of treatment in the open-label extension portion of the Phase 2 PaTH Forward Trial, 57 out of 59 original subjects continue in the open label extension portion of the trial as of June 30, 2022.

• In the Phase 3 PaTHway Trial, 79 out of 79 patients completed one-year follow-up; 78 out of 79 patients continue in the open-label extension portion of the trial as of June 30, 2022.

• TransCon CNP:

• Top-line data from the ACcomplisH Trial, a Phase 2 randomized, double-blind, placebo-controlled clinical trial in North America, Europe, and Oceania in children ages 2-10 years with achondroplasia expected in the fourth quarter of 2022.

• Planned fourth-quarter regulatory submissions for a new global randomized, double-blind, placebo-controlled Phase 2b trial of TransCon CNP in children down to 2 years of age with achondroplasia.

• TransCon TLR7/8 Agonist:

• Enrollment continues in transcendIT-101, a Phase 1/2 trial of TransCon TLR7/8 Agonist with or without a checkpoint inhibitor in patients with advanced or metastatic solid tumors who have failed prior lines of therapy.

• transcendIT-101 monotherapy and combo-therapy dose escalation top-line data are expected during the third quarter of 2022.

• TransCon IL-2 ß/g:

• The Phase 1/2 IL-ßeliege Trial evaluating TransCon IL-2 ß/g monotherapy in patients with locally advanced or metastatic solid tumors continues to enroll patients. The Phase 1/2 IL-ßeliege Trial top-line data are expected in the fourth quarter of 2022.

• During the second quarter of 2022, dosed first patient in combination checkpoint inhibitor and TransCon IL-2 ß/g dose-escalation arm of the IL-ßeliege Trial.

• TransCon TLR7/8 Agonist and TransCon IL-2 ß/g Combination Therapy:

• Plan to submit an IND or similar for Phase 2 cohort expansion for TransCon TLR7/8 Agonist and TransCon IL-2 ß/g during the fourth quarter of 2022.

• Board of Directors to nominate Bill Fairey, and Siham Imani, both leaders in pharmaceutical commercialization, as new independent board members. The Board of Directors will call into an Extraordinary General Meeting to take place first half of September 2022.

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• Ended the second quarter of 2022 with cash, cash equivalents, and marketable securities totaling €995 million.

Second Quarter 2022 Financial Results

Total revenue for the second quarter was €6.2 million compared to €1.0 million in the same quarter of 2021. Revenue included U.S. revenue from SKYTROFA, as well as license, clinical supply and services provided to third parties, primarily VISEN Pharmaceuticals. The increase in revenue compared to the same period the prior year was primarily attributable to the €4.4 million commercial revenue from SKYTROFA (lonapegsomatropin-tcgd) in the second quarter following U.S. commercial launch in October 2021.

Research and development (R&D) costs for the second quarter were €90.4 million compared to €83.3 million during the same period in 2021, reflecting primarily higher employee costs resulting from an increase in the number of R&D related personnel.

Selling, general, and administrative (SG&A) expenses for the second quarter were €56.6 million compared to €35.3 million during the same period in 2021. Higher SG&A expenses were primarily due to an increase in commercial and administrative personnel following the launch of SKYTROFA.

Our share of net loss of associate was €1.2 million in the second quarter, compared to a net loss of €4.8 million during the same period in 2021.

Net finance income was €61.7 million in the second quarter compared to a net finance expense of €12.0 million in the same period in 2021.

For the second quarter of 2022, Ascendis Pharma reported a net loss of €81.3 million, or €1.46 per share (basic and diluted) compared to a net loss of €134.4 million, or €2.50 per share (basic and diluted) for the same period in 2021.

As of June 30, 2022, Ascendis Pharma had cash, cash equivalents, and marketable securities totaling €994.9 million compared to €789.6 million as of December 31, 2021. As of June 30, 2022, Ascendis Pharma had 56,965,058 ordinary shares outstanding.

Conference Call and Webcast Information

Ascendis Pharma will host a conference call and webcast today at 4:30 pm Eastern Time (ET) to discuss its second quarter 2022 financial results.

Those who would like to listen to the live webcast can access it through the following link. To access the live teleconference, register online here. Participants are encouraged to register at least 15 minutes prior to the call.

A replay of the webcast will be available on the Investors & News section of the Ascendis Pharma website at https://investors.ascendispharma.com shortly after conclusion of the event for 30 days.

About Ascendis Pharma A/S

Ascendis Pharma is applying its innovative platform technology to build a leading, fully integrated, global biopharmaceutical company focused on making a meaningful difference in patients’ lives. Guided by its core values of patients, science and passion, the company uses its TransCon technologies to create new and potentially best-in-class therapies. Ascendis is headquartered in Copenhagen, Denmark, and has additional facilities in Heidelberg and Berlin, Germany; Palo Alto and Redwood City, California; and Princeton, New Jersey. Please visit www.ascendispharma.com to learn more.

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Forward-Looking Statements

This press release contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, included in this press release regarding Ascendis’ future operations, plans and objectives of management are forward-looking statements. Examples of such statements include, but are not limited to, statements relating to (i) the timing of top-line results from the ACcomplisH Trial, the transcendIT-101 Trial and the Phase 1/2 IL-ßeliege Trial, (ii) the timing of completion of patient enrollment in the foresiGHt Trial and the riGHt Trial, (iii) Ascendis’ expectations regarding the strength of 2022, the growth of U.S. revenues and its ability to fulfill Vision 3x3 and become cash flow positive, (iv) whether Ascendis is able to become a sustainable, profitable, leading biopharma company, (v) the expected launch of TransCon PTH in the U.S. in 2023, (vi) the expected launch of TransCon hGH in Europe in 2023, (vii) Ascendis’ expectations regarding the timing of its regulatory submissions, applications, protocols, clinical trials and the results thereof, (viii) Ascendis’ expectations regarding the potential for TransCon PTH to become the first parathyroid replacement therapy, (ix) Ascendis’ ability to make SKYTROFA the leading product in the growth hormone market, (x) Ascendis’ ability to apply its platform technology to build a leading, fully integrated biopharma company, (xi) Ascendis’ use of its TransCon technologies to create new and potentially best-in-class therapies and (xii) Ascendis’ intent to nominate Bill Fairey and Siham Imani to its Board of Directors and the timing of the Extraordinary General Meeting. Ascendis may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions, expectations and projections disclosed in the forward-looking statements. Various important factors could cause actual results or events to differ materially from the forward-looking statements that Ascendis makes, including the following: dependence on third party manufacturers and distributors to supply TransCon hGH and the SKYTROFA^® Auto-Injector for commercial sales in the U.S. and other study drug for clinical studies; unforeseen safety or efficacy results in its oncology programs, TransCon hGH, TransCon PTH and TransCon CNP or other development programs; unforeseen expenses related to commercialization of TransCon hGH in the U.S., the co-pay program and the further development of TransCon hGH; expenses related to the development and potential commercialization of its oncology programs, TransCon hGH, TransCon PTH and TransCon CNP or other development programs; unforeseen selling, general and administrative expenses, other research and development expenses and Ascendis’ business generally; delays in the development of its oncology programs, TransCon hGH, TransCon PTH and TransCon CNP or other development programs related to manufacturing, regulatory requirements, speed of patient recruitment or other unforeseen delays; dependence on third party manufacturers to supply study drug for planned clinical studies; Ascendis’ ability to obtain additional funding, if needed, to support its business activities and the effects on its business from the worldwide COVID-19 pandemic and the ongoing conflict in the region surrounding Ukraine and Russia. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Ascendis’ business in general, see Ascendis’ Annual Report on Form 20-F filed with the U.S. Securities and Exchange Commission (SEC) on March 2, 2022 and Ascendis’ other future reports filed with, or submitted to, the SEC. Forward-looking statements do not reflect the potential impact of any future licensing, collaborations, acquisitions, mergers, dispositions, joint ventures, or investments that Ascendis may enter into or make. Ascendis does not assume any obligation to update any forward- looking statements, except as required by law.

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Ascendis, Ascendis Pharma, the Ascendis Pharma logo, the company logo, TransCon, and SKYTROFA are trademarks owned by the Ascendis Pharma Group. ^© August 2022 Ascendis Pharma A/S.

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FINANCIAL TABLES FOLLOW

Ascendis Pharma A/S

Consolidated Statements of Profit or Loss and Comprehensive Income / (loss)

(In EUR’000s, except share and per share data)

	Three Months ended June 30,						Six Months ended June 30,
	2022			2021			2022			2021
Revenue		6,160			1,022			12,988			1,767
Cost of sales		1,086			—			5,332			—
Gross profit / (loss)		5,074			1,022			7,656			1,767
Research and development costs		90,383			83,306			173,576			171,455
Selling, general and administrative expenses		56,584			35,345			104,002			72,591
Operating profit / (loss)		(141,893	)		(117,629	)		(269,922	)		(242,279	)
Share of profit / (loss) of associate		(1,166	)		(4,817	)		(6,039	)		23,289
Finance income		71,127			145			84,171			23,268
Finance expenses		9,434			12,141			14,833			1,703
Profit / (loss) before tax		(81,366	)		(134,442	)		(206,623	)		(197,425	)
Tax on profit / (loss) for the period		47			68			(195	)		259
Net profit / (loss) for the period		(81,319	)		(134,374	)		(206,818	)		(197,166	)
Attributable to owners of the Company		(81,319	)		(134,374	)		(206,818	)		(197,166	)
Basic and diluted earnings / (loss) per share	€	(1.46	)	€	(2.50	)	€	(3.68	)	€	(3.66	)
Number of shares used for calculation (basic and diluted)		55,805,486			53,848,166			56,260,248			53,804,300
Net profit / (loss) for the period		(81,319	)		(134,374	)		(206,818	)		(197,166	)
Other comprehensive income / (loss)
Items that may be reclassified subsequently to profit or loss:
Exchange differences on translating foreign operations		(757	)		77			(332	)		1,765
Other comprehensive income / (loss) for the period, net of tax		(757	)		77			(332	)		1,765
Total comprehensive income / (loss) for the period, net of tax		(82,076	)		(134,297	)		(207,150	)		(195,401	)
Attributable to owners of the Company		(82,076	)		(134,297	)		(207,150	)		(195,401	)

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Ascendis Pharma A/S

Consolidated Statements of Financial Position

(In EUR’000s)

	June 30,		December 31,
	2022		2021
Assets
Non-current assets
Intangible assets		5,050		5,272
Property, plant and equipment		133,224		126,049
Investment in associate		34,905		38,345
Other receivables		1,836		1,808
Marketable securities		39,721		107,561
		214,736		279,035
Current assets
Inventories		101,322		75,405
Trade receivables		4,369		2,200
Income tax receivable		1,128		893
Other receivables		15,055		20,093
Prepayments		35,067		25,231
Marketable securities		282,767		235,797
Cash and cash equivalents		672,387		446,267
		1,112,095		805,886
Total assets		1,326,831		1,084,921
Equity and liabilities
Equity
Share capital		7,649		7,646
Distributable equity		600,193		875,989
Total equity		607,842		883,635
Non-current liabilities
Borrowings		498,130		97,966
Derivative liabilities		102,031		—
Contract liabilities		3,700		2,964
		603,861		100,930
Current liabilities
Borrowings		14,079		6,995
Contract liabilities		—		2,601
Trade payables and accrued expenses		74,984		59,417
Other liabilities		20,957		29,952
Income taxes payable		90		198
Provisions		5,018		1,193
		115,128		100,356
Total liabilities		718,989		201,286
Total equity and liabilities		1,326,831		1,084,921

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Investor Contacts:	Media Contact:
Tim Lee	Melinda Baker
Ascendis Pharma	Ascendis Pharma
+1 (650) 374-6343	+1 (650) 709-8875
tle@ascendispharma.com	media@ascendispharma.com

Patti Bank

ICR Westwicke

+1 (415) 513-1284

patti.bank@westwicke.com

ir@ascendispharma.com

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