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Accrued Expenses and Other Current Liabilities - Summary of Accrued Expenses and Other Current Liabilities (Detail) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Payables And Accruals [Abstract]    
Development and manufacturing costs $ 6,779 $ 7,046
Payroll and payroll-related costs 3,550 5,020
Facility and other 1,460 3,141
Total accrued expenses and other current liabilities $ 11,789 $ 15,207