February 7, 2019

John Tucker
Chief Executive Officer
scPharmaceuticals Inc.
2400 District Avenue
Suite 310
Burlington, Massachusetts 01803

       Re: scPharmaceuticals Inc.
           Registration Staterment on Form S-3
           Filed January 3, 2019
           File No. 333-229120

Dear Mr. Tucker:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Todd Schiffman at 202-551-3491 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of
Healthcare & Insurance