Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Revenues
Total revenues	$ 391,005	$ 302,328	$ 257,654
Cost and expenses
Research and development	100,035	51,357	51,355
Selling, general and administrative	303,627	206,176	154,872
Gain from disposal of business		(14,388)
Total cost and expenses	607,282	418,615	372,282
Loss from operations	(216,277)	(116,287)	(114,628)
Interest expense	(15,082)	(10,693)	(10,476)
Interest and other (expense) income, net	7,562	4,152	(2,729)
Loss on debt extinguishment	(5,848)
Loss before income taxes	(229,645)	(122,828)	(127,833)
Income tax expense	(98)	(1,999)	(321)
Net loss	(229,743)	(124,827)	(128,154)
Unrealized gain on available-for-sale securities, net of tax	3,340	1,471	214
Comprehensive loss	$ (226,403)	$ (123,356)	$ (127,940)
Net loss per share (Note 14):
Basic and diluted (in dollars per share)	$ (2.84)	$ (1.79)	$ (2.22)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic and diluted (in shares)	81,011	69,555	57,848
Product
Revenues
Total revenues	$ 367,211	$ 269,881	$ 240,366
Cost and expenses
Cost of revenues	185,865	162,604	158,081
Licensing and other
Revenues
Total revenues	23,794	32,447	17,288
Cost and expenses
Cost of revenues	$ 17,755	$ 12,866	$ 7,974