N-CSR

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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM N-CSR

CERTIFIED SHAREHOLDER REPORT OF REGISTERED
MANAGEMENT INVESTMENT COMPANIES

Investment Company Act file number			811-22955
Tekla Healthcare Opportunities Fund
(Exact name of registrant as specified in charter)
100 Federal Street, 19th Floor, Boston, MA					02110
(Address of principal executive offices)					(Zip code)
Laura Woodward, Chief Compliance Officer and Vice President of Fund Administration 100 Federal Street, 19th Floor, Boston, MA  02110
(Name and address of agent for service)
Registrant’s telephone number, including area code:				617-772-8500
Date of fiscal year end:	September 30
Date of reporting period:		October 1, 2016 to September 30, 2017

ITEM 1. REPORTS TO STOCKHOLDERS.

TEKLA HEALTHCARE
OPPORTUNITIES FUND

Annual Report

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TEKLA HEALTHCARE
OPPORTUNITIES FUND

Distribution policy: The Fund has implemented a managed distribution policy (the Policy) that provides for monthly distributions at a rate set by the Board of Trustees. Under the current Policy, the Fund intends to make monthly distributions at a rate of $0.1125 per share to shareholders of record. The Policy would result in a return of capital to shareholders, if the amount of the distribution exceeds the Fund's net investment income and realized capital gains. A return of capital may occur, for example, when some or all of the money that you invested in the Fund is paid back to you. A return of capital distribution does not necessarily reflect the Fund's investment performance and should not be confused with "yield" or "income."

The amounts and sources of distributions reported in the Fund's notices pursuant to Section 19(a) of the Investment Company Act of 1940 are only estimates and are not being provided for tax reporting purposes. The actual amounts and sources of the amounts for tax reporting purposes will depend upon the Fund's investment experience during its fiscal year and may be subject to changes based on tax regulations. The Fund will send you a Form 1099-DIV for the calendar year that tells you how to report distributions for federal income tax purposes.

You should not draw any conclusions about the Fund's investment performance from the amount of distributions pursuant to the Policy or from the terms of the Policy. The Policy has been established by the Trustees and may be changed or terminated by them without shareholder approval. The Trustees regularly review the Policy and the frequency and rate of distributions considering the purpose and effect of the Policy, the financial market environment, and the Fund's income, capital gains and capital available to pay distributions. The suspension or termination of the Policy could have the effect of creating a trading discount or widening an existing trading discount. At this time there are no reasonably foreseeable circumstances that might cause the Trustees to terminate the Policy.

Consider these risks before investing: As with any investment company that invests in equity securities, the Fund is subject to market risk—the possibility that the prices of equity securities will decline over short or extended periods of time. As a result, the value of an investment in the Fund's shares will fluctuate with the market generally and market sectors in particular. You could lose money over short or long periods of time. Political and economic news can influence marketwide trends and can cause disruptions in the U.S. or world financial markets. Other factors may be ignored by the market as a whole but may cause movements in the price of one company's stock or the stock of companies in one or more industries. All of these factors may have a greater impact on initial public offerings and emerging company shares. Different types of equity securities tend to shift into and out of favor with investors, depending on market and economic conditions. The performance of funds that invest in equity securities of Healthcare Companies may at times be better or worse than the performance of funds that focus on other types of securities or that have a broader investment style.

TEKLA HEALTHCARE
OPPORTUNITIES FUND

Dear Shareholders,

In the last ten to fifteen year period, the performance of the healthcare sector, and that of the biotechnology sub-sector in particular, has been impressive. Note in the following graph that both the S&P Composite 1500^® Health Care Index* ("S15HLTH") and the NASDAQ Biotechnology Index^®* ("NBI") materially outperformed the broad S&P 500^® Index* ("SPX") in the fifteen year period ending September 30, 2017.

Biotechnology, Healthcare, and S&P 500 Performance
2002 – 2017

We believe that a consistent record of discovery, development and commercialization of new drugs and products that improve quality of life, address medical need and ultimately save lives is the basis for this performance. Nearly everyone has heard of the remarkable genetic engineering and related technologies that are the basis of these new medical products. Moreover, just about everyone we know has a friend or relative who has benefitted from these products and technologies. We think that the combination of accomplishment and positive sentiment has driven healthcare/biotech sector performance.

We also feel that, despite the long history of fundamental progress, angst over drug industry profitability in general, and over drug pricing in particular, has had a negative effect on sector sentiment as of late. These issues were front and center during the recently concluded presidential election cycle and have remained a controversial topic since then as Congress debated the potential repeal and/or replacement of Obamacare. In particular, we think that outrage over drug pricing, justified or (maybe) not, has hurt sentiment for the healthcare/biotech sector.

1

Despite these challenges, recent sector performance has been quite positive. In fact, the broad SPX was up approximately 20% in calendar 2017 while the healthcare and biotech indices we track were up closer to 30%. As the quarter ended, we were quite upbeat.

However, third quarter 2017 healthcare/biotech sector company reports (made in the month or so after the September 30, 2017 end of the Fund's fiscal year) were mediocre overall, particularly for the large bellwether biotech and pharma companies. This has caused a pullback of approximately 10% in the healthcare sector. As of this writing in early November 2017, both the broad SPX and the healthcare and biotech indices are up approximately 20% in calendar 2017. Such a move in the markets in a ten-month period would always be welcome. However, given both the apparent sentiment and a weak quarter, we have taken a step back to review our thoughts on the healthcare/biotech sector.

More detail is provided later in this note, but in summary, we remain optimistic about the sector. Overall, we expect a continuation of the impressive innovation we have seen. In just the last few years, there have been remarkable developments in immuno-oncology, gene therapy and other areas. In addition, the FDA (while remaining formidable) appears to have become incrementally more accommodative. The IPO market continues to produce new public companies. Our aggregate view is that, in combination with the broad creation and funding of a new generation of public companies, this continued innovation will lead to the discovery and development of many new and novel medical products that will propel the healthcare and biotech sectors forward. We expect these newly formed companies to either be acquired by or to replace the current industry leaders forming the next generation of healthcare/biotech growth. Although we may see some volatility as this renewal process sorts itself out, this makes us optimistic about the medium- and
long-term.

As always, we thank you for your consideration of the Tekla Funds. Please call us if you have any questions.

Respectfully yours,

Daniel R. Omstead, Ph.D.
President and Portfolio Manager

2

Perspective on the Biotechnology and Healthcare Sectors

For some time, Tekla has been positive about the long-term prospects for the healthcare/biotech sector. Over any reasonable multi-year timeframe, we are bullish. As we and others have noted, this sector continues to be a large portion of the US GDP. Healthcare spending is expected to reach 20% of the US economy within the next decade. While the sector comprises a smaller portion of the GDP of other countries, spending is considerable and expected to grow meaningfully in many developed countries. Furthermore, it is reported that overall US Medicare health spending is expected to grow at 5.8% for at least the next decade. In particular, prescription drug spending is expected to grow at 6.7% per year in this same timeframe. We think these projections make the sector attractive.

Actual and Projected Net Medicare Spending
2010 – 2027

Long-term sector fundamentals are also attractive when we consider healthcare spending on an individual basis. As seen in the figure below and the citation above, the population of the largest countries is expected to age in the coming years. Since more is spent on healthcare as individuals get older, overall healthcare spending should grow. This suggests that, over the long-term, demand for healthcare products and services should continue to grow, likely at an attractive rate.

Population 65 to 84 and 85 Years and Over in the World's Four Largest Countries: 2012, 2030, and 2050

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In the intermediate term, we see the continued creation of new and differentiated medical products that are safer and/or more efficacious than existing products and that address currently unmet medical needs in the US and non-US population. These products will be the basis for continued growth in the sector.

The creation of new and novel products depends on the advancement of science in key areas, the identification and clinical testing of newly discovered drugs, and the regulatory approval of such drugs. We see evidence of these accomplishments. The following three charts present favorable trends in the publication of new NIH papers, in the number of registered clinical trials and in the approval of new drugs. For additional data and information, visit fda.gov, clintrials.gov and i2.wp.com.

National Institute of Health (NIH)
Funded Papers Per Year

Number of Registered Clinical Trials

4

New Molecular Entity (NME) and New Biologic License
Application (BLA) Approvals by Calendar Year

These data suggest that the pipeline of new drugs should continue to grow over time. As previously reported, an entirely new generation of public companies has been created and funded in the last several years. For example, note that Bloomberg reports that since 2014, there have been 839 IPOs and follow-on financings which raised an aggregate of $49.21 billion.

In combination with existing corporations, this new generation of well-funded companies will sponsor the new and novel products we anticipate. We continue to see encouraging technological and clinical results. As an example, we point to the coming of age of cell, gene and RNAi therapies. These technologies have been in development for many years; each of these somewhat related approaches have accomplished major milestones. For example, we have seen the approval of an antisense product (Biogen's SPINRAZA^TM) which treats an otherwise lethal pediatric condition called Spinal Muscular Atrophy, the approval of two T cell based therapies (Novartis' KYMRIAH^TM and Gilead/Kite's Yescarta) that are remarkably effective in certain hematologic cancers, and clear proof of principle by an RNAi based product (Alnylam's patisiran) in the treatment of a form of amyloidosis, and finally, a positive FDA panel recommendation for Spark Therapeutic's Luxturna to treat a rare genetic form of blindness.

These are just a few examples of the encouraging developments we are seeing. There are certainly many challenges to overcome but, in aggregate, these and other developments are an important part of our underlying optimism toward the healthcare/biotech sector.

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TEKLA HEALTHCARE
OPPORTUNITIES FUND

Fund Essentials

Objective of the Fund

The Fund's investment objective is to seek current income and long-term capital appreciation by investing primarily in securities of healthcare companies. In addition, the Fund seeks to provide regular distribution of income and realized capital gains.

Description of the Fund

Tekla Healthcare Opportunities Fund ("THQ") is a non-diversified closed-end healthcare fund traded on the New York Stock Exchange under the ticker THQ. THQ employs a versatile investment strategy with broad access to opportunities within 11 sub-sectors of healthcare and has the ability to invest across a company's full capital structure.

Investment Philosophy

Tekla Capital Management LLC, the Investment Adviser to the Fund, believes that:

•  Aging demographics and adoption of new medical products and services can provide long-term tailwinds for healthcare companies

•  Late stage biotechnology product pipeline could lead to significant increases in biotechnology sales

•  Investment opportunity spans 11 sub-sectors including biotechnology, healthcare technology, and managed care REITs

•  Robust M&A activity in healthcare may create additional investment opportunities

Fund Overview and Characteristics as of 9/30/17

Market Price1	$	18.57
NAV2	$	20.12
Premium/(Discount)		-7.70	%
Average 30 Day Volume		92,157
Net Assets	$	875,656,100
Managed Assets	$	1,100,656,100
Leverage Outstanding	$	225,000,000
Total Leverage Ratio3		20.44	%
Ticker		THQ
NAV Ticker		XTHQX
Commencement of Operations Date		7/31/14
Fiscal Year to Date Distributions Per Share	$	1.35

¹ The closing price at which the Fund's shares were traded on the exchange.

² Per-share dollar value of the Fund, calculated by dividing the total value of all the securities in its portfolio, plus any other assets and less liabilities, by the number of Fund shares outstanding.

³ As a percentage of managed assets.

Holdings of the Fund(Data is based on net assets)

Asset Allocation as of 9/30/17

Sub-Sector Allocation as of 9/30/17

This data is subject to change on a daily basis.

6

TEKLA HEALTHCARE
OPPORTUNITIES FUND

Largest Holdings by Issuer

(Excludes Short-Term Investments)

As of September 30, 2017

Issuer – Sector	% of Net Assets
Johnson & Johnson– Pharmaceuticals		9.9	%
Gilead Sciences, Inc.– Biotechnology		7.8	%
Merck & Co., Inc.– Pharmaceuticals		7.0	%
Celgene Corporation– Biotechnology		6.8	%
Abbott Laboratories– Health Care Equipment & Supplies		6.2	%
UnitedHealth Group Inc.– Health Care Providers & Services		5.3	%
Amgen Inc.– Biotechnology		4.3	%
Allergan plc– Pharmaceuticals		3.8	%
Medtronic plc– Health Care Equipment & Supplies		3.8	%
Alexion Pharmaceuticals, Inc.– Biotechnology		3.6	%
Vertex Pharmaceuticals Incorporated– Biotechnology		3.3	%
Humana Inc.– Health Care Providers & Services		3.1	%
Eli Lilly & Company– Pharmaceuticals		2.7	%
Pfizer Inc.– Pharmaceuticals		2.6	%
CVS Health Corporation– Health Care Providers & Services		2.6	%
Biogen Inc.– Biotechnology		2.4	%
McKesson Corporation– Health Care Providers & Services		1.8	%
Cigna Corporation– Health Care Providers & Services		1.8	%
Thermo Fisher Scientific Inc.– Life Sciences Tools & Services		1.6	%
Omega Healthcare Investors, Inc.– Real Estate Investment Trusts		1.5	%

Fund Performance

THQ is a closed-end fund which invests predominantly in healthcare companies. Subject to regular consideration, the Trustees of THQ have instituted a policy of making monthly distributions to shareholders.

The Fund seeks to benefit from the earnings growth of the healthcare industry while capturing income. Income is derived from multiple sources including equity dividends, fixed income coupons, real estate investment trust distributions, convertible securities coupons and selective equity covered call writing premiums. In order to accomplish its objectives, THQ often holds a majority of its assets in equities. Allocation of assets to various healthcare sectors can vary significantly as can the percentage of the portfolio which is overwritten.

7

The Fund may invest up to 15 percent of managed assets, measured at the time of investment, in the debt of healthcare companies. It may also invest up to 25 percent of managed assets in healthcare REITs. The Fund may also hold up to 30 percent of managed assets in convertible securities and may invest a portion of its assets in restricted securities. In order to generate additional "current" income THQ often sells (or writes) calls against a material portion of its equity assets. The portion of equity assets overwritten can vary, but usually represents less than 20 percent of managed assets. At times, the overwritten portion of assets is materially less than 20 percent of managed assets. The use of covered calls is intended to produce "current" income, but may limit upside in bullish markets. The Fund may also use leverage to enhance yield. The Fund may incur leverage up to 20 percent of managed assets at the time of borrowing. "Managed assets" means the total assets of the Fund (including any assets attributable to borrowings for investment purposes) minus the sum of the Fund's accrued liabilities (other than liabilities representing borrowings for investment purposes).

The Fund considers investments in companies of all sizes and in all healthcare subsectors, including but not limited to, biotechnology, pharmaceuticals, healthcare equipment, healthcare supplies, life science tools and services, healthcare distributors, managed healthcare, healthcare technology, and healthcare facilities. The Fund emphasizes innovation, investing both in public and pre-public venture companies. The Fund considers its pre-public and other restricted investments to be a differentiating characteristic. Among the various healthcare subsectors, THQ has considered the biotechnology subsector, including both pre-public and public companies, to be a key contributor to the healthcare sector. The Fund holds biotech assets, including both public and pre-public, often representing 25-35% of net assets.

There is no commonly published index which matches the investment strategy of THQ. With respect to the Fund's equity investments, THQ often holds 20-40% of its managed assets, measured at the time of investment, in biotechnology. The S15HLTH consists of more than 160 companies representing most or all of the healthcare subsectors in which THQ typically invests; biotechnology often represents 15-20% of this index. By contrast, the NASDAQ Biotechnology Index^®* ("NBI"), which contains approximately 160 constituents, is much more narrowly constructed. The vast majority of this index is comprised of biotechnology, pharmaceutical and life science tools companies. In recent years, biotechnology has often represented 72-82% of the NBI. Neither the S15HLTH nor NBI indices contain any material amount of pre-public company assets.

8

The S&P 500 Health Care Corporate Bond Index^®* ("SP5HCBIT") measures the performance of U.S. corporate debt issued by constituents in the healthcare sector of the SPX. This index is generally reflective of the debt assets in which THQ invests though the Fund invests in the SPX debt components as well as those of smaller capitalization companies.

The FTSE NAREIT Health Care Property Sector Index^®* ("FNHEA") is comprised of U.S. publicly traded REITs in the healthcare sector. This index is generally reflective of the REITs in which THQ invests.

We present both NAV and stock returns for the Fund in comparison to several commonly published indices. We note that THQ is a dynamically configured multi-asset class healthcare growth and income fund. There is no readily available index comprised of similar characteristics to THQ and to which THQ can directly be compared. Therefore, we provide returns for a number of indices representing the major components of THQ's assets. Having said this, we note that there are no readily available indices representing the covered call strategy employed by THQ or the restricted security components of THQ. The following data for available funds over the six-month, one-year and since inception periods are provided for comparison.

Inception date July 29, 2014.

All performance over one-year has been annualized.

Performance data quoted represents past performance, which is no guarantee of future results, and current performance may be lower or higher than the figures shown. The NAV total return takes into account the Fund's total annual expenses and does not reflect transaction charges. If transaction charges were reflected, NAV total return would be reduced. All distributions are assumed to be reinvested either in accordance with the dividend reinvestment plan (DRIP) for market price returns or NAV for NAV returns. The market price returns reflect the reinvestment at the closing market price on the last business day of the month.

**The trademarks NASDAQ Biotechnology Index^®, S&P Composite 1500 Healthcare Index^®, S&P 500 Index^®, S&P 500 Health Care Corporate Bond Index^® and FTSE NAREIT Health Care Property Sector Index^® referenced in this report are the property of their respective owners. These trademarks are not owned by or associated with the Fund or its service providers, including Tekla Capital Management LLC.

9

Portfolio Highlights as of September 30, 2017

Among other investments, THQ's performance benefitted in the past year by the following:

Vertex Pharmaceuticals Inc. (VRTX) is developing small molecules for the treatment of Cystic Fibrosis. The excitement now surrounds upcoming full phase 2 datasets for their triple combinations in heterozygous CF patients, which is expected in early 2018. The company proposes that these triple combination treatments could treat up to 90% of CF patients with a disease-modifying therapy. Sales on existing products continue to be strong as additional countries gain reimbursement outside U.S. We expect this trend to continue into 2018. We also anticipate the company to start sharing more data around their non-CF franchise going into 2018.

Abbott Laboratories (ABT) is a large cap diversified healthcare company with businesses in established pharmaceuticals, adult and pediatric nutrition, and more recently, through acquisitions, cardiac rhythm management and neurostimulation (St. Jude Medical); and molecular diagnostics (Alere). Consistent strength in core businesses, successful integration of St. Jude coinciding with the lifting of overhangs on its cardiac rhythm management and continued growth in neurostimulation, and the completion of the protracted Alere acquisition have all contributed to Abbott's outperformance.

Humana Inc. (HUM) is a managed care company focused on what we believe is an attractive market segment—Medicare Advantage (MA). Aetna's bid to acquire HUM was blocked earlier this year, allowing HUM to refocus on capital deployment. President Trump's apparent healthcare policy views may benefit the stock as he appears to favor MA over FFS Medicare and more broadly favors corporate tax reform.

Among other examples, THQ's performance was negatively impacted by the following:

We have been underweight Abbvie Inc. (ABBV) due fears of biosimilar competition for the blockbuster anti-inflammatory antibody Humira which makes up nearly two-thirds of company sales. Abbvie surged on news that it settled patent litigation with Amgen on Humira, helping fend off this competitive threat. Although we still believe there is a possibility that Humira becomes genericized earlier than consensus anticipates, the company was experienced multiple expansion as it has a deep and undervalued drug pipeline and the settlement seemingly removed a big overhang on the stock.

*The trademarks NASDAQ Biotechnology Index^®, S&P Composite 1500^® Healthcare Index, S&P Composite 1500^®Biotechnology Index, S&P 500^® Index, S&P 500^® Health Care Corporate Bond Index and FTSE NAREIT Health Care Property Sector Index^® referenced in this report are the property of their respective owners. These trademarks are not owned by or associated with the Fund or its service providers, including Tekla Capital Management LLC.

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TEKLA HEALTHCARE
OPPORTUNITIES FUND

SCHEDULE OF INVESTMENTS

SEPTEMBER 30, 2017

SHARES		CONVERTIBLE PREFERRED AND WARRANTS (Restricted) (a) (b) - 0.6% of Net Assets	VALUE
		Biotechnology - 0.6%
	2,538,462	BioClin Therapeutics, Inc. Series A (c)	$	1,650,000
	980,392	BioClin Therapeutics, Inc. Series B (c)		733,333
	2,133,333	GenomeDx Biosciences, Inc. Series C		3,199,999
				5,583,332
		Health Care Equipment & Supplies - 0.0%
	383,470	IlluminOss Medical, Inc. Junior Preferred		0
	407,078	IlluminOss Medical, Inc. Series AA		0
	32,792	IlluminOss Medical, Inc. Warrants (expiration 3/31/27)		0
				0
		TOTAL CONVERTIBLE PREFERRED AND WARRANTS (Cost $6,001,914)		5,583,332
		PREFERRED STOCK - 1.5% of Net Assets
		Real Estate Investment Trust - 1.5%
	200,000	Welltower Inc.		12,686,000
		TOTAL PREFERRED STOCK (Cost $11,919,595)		12,686,000
		MANDATORY CONVERTIBLE PREFERRED STOCKS - 0.9% of Net Assets
		Pharmaceuticals - 0.9%
	5,000	Allergan plc, 5.50% due 03/01/18		3,689,100
	13,000	Teva Pharmaceutical Industries Ltd., 7.00%, due 12/15/18		4,480,320
		TOTAL MANDATORY CONVERTIBLE PREFERRED STOCKS (Cost $18,000,000)		8,169,420

The accompanying notes are an integral part of these financial statements.
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TEKLA HEALTHCARE
OPPORTUNITIES FUND

SCHEDULE OF INVESTMENTS

SEPTEMBER 30, 2017

(continued)

PRINCIPAL AMOUNT		CONVERTIBLE AND NON-CONVERTIBLE NOTES - 15.2% of Net Assets Convertible Notes - 2.2%	VALUE
		Health Care Equipment & Supplies - 0.0%
$	131,169	IlluminOss Medical, Inc. Promissory Note, (Restricted) 8.00%, due 3/31/18	$	65,585
		Pharmaceuticals - 2.2%
	13,000,000	Aegerion Pharmaceuticals, Inc., 2.00% due 8/15/19		10,302,500
	7,000,000	Egalet Corporation, 5.50% due 4/01/20		3,600,625
	6,900,000	Intercept Pharmaceuticals, Inc., 3.25%, due 7/01/23		5,330,250
				19,233,375
		TOTAL CONVERTIBLE NOTES		19,298,960
		Non-Convertible Notes - 13.0%
		Biotechnology - 2.3%
	10,000,000	Amgen Inc., 3.63% due 5/15/22		10,443,461
	10,000,000	Gilead Sciences, Inc., 2.95%, due 3/01/27		9,913,102
				20,356,563
		Health Care Equipment & Supplies - 1.3%
	5,000,000	Medtronic, Inc., 3.50% due 3/15/25		5,214,556
	6,000,000	Zimmer Biomet Holdings, Inc., 4.25%, due 8/15/35		5,893,352
				11,107,908
		Health Care Providers & Services - 7.9%
	12,693,000	Acadia Healthcare Company, Inc., 5.13% due 7/01/22		13,142,332
	10,500,000	Anthem, Inc., 3.50% due 8/15/24		10,801,946
	8,250,000	Express Scripts Holding Company, 6.13% due 11/15/41		9,929,219
	9,700,000	HCA Healthcare, Inc., 6.25% due 2/15/21		10,500,250
	7,500,000	HealthSouth Corporation, 5.75%, due 11/1/24		7,696,875
	5,500,000	Tenet Healthcare Corporation, 4.63%, due 07/15/24 (d)		5,450,280
	10,500,000	UnitedHealth Group Inc., 4.38% due 3/15/42		11,367,060
				68,887,962

The accompanying notes are an integral part of these financial statements.
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TEKLA HEALTHCARE
OPPORTUNITIES FUND

SCHEDULE OF INVESTMENTS

SEPTEMBER 30, 2017

(continued)

PRINCIPAL AMOUNT		Pharmaceuticals - 1.5%	VALUE
$	4,750,000	AstraZeneca PLC, 6.45% due 9/15/37 (g)	$	6,363,190
	780,000	Mallinckrodt International Finance SA, 4.75% due 4/15/23		664,950
	5,020,000	Wyeth LLC, 5.95% due 4/01/37		6,570,419
				13,598,559
		TOTAL NON-CONVERTIBLE NOTES		113,950,992
		TOTAL CONVERTIBLE AND NON-CONVERTIBLE NOTES (Cost $136,882,614)		133,249,952
SHARES		COMMON STOCKS AND WARRANTS - 102.8% of Net Assets
		Biotechnology - 31.7%
	68,092	AbbVie Inc.		6,050,655
	224,090	Alexion Pharmaceuticals, Inc. (b)		31,437,586
	146,000	Amgen Inc. (e)		27,221,700
	67,975	Biogen Inc. (b) (e)		21,284,332
	407,584	Celgene Corporation (b)		59,433,899
	305,100	Eleven Biotherapeutics, Inc. Warrants (expiration 11/24/17) (a) (b)		0
	715,719	Gilead Sciences, Inc.		57,987,553
	73,552	Incyte Corporation (b)		8,586,461
	300,000	Karyopharm Therapeutics Inc. (b)		3,294,000
	185,561	Natera, Inc. (b)		2,391,881
	161,000	Neurocrine Biosciences, Inc. (b) (e)		9,866,080
	101,241	Pieris Pharmaceuticals, Inc. (b)		583,148
	40,496	Pieris Pharmaceuticals, Inc., Series A Warrants (expiration 6/8/21) (a) (b)		115,819
	20,248	Pieris Pharmaceuticals, Inc., Series B Warrants (expiration 6/8/21) (a) (b)		67,831
	48,392	Puma Biotechnology, Inc. (b)		5,794,942
	221,800	Sarepta Therapeutics, Inc. (b) (e)		10,060,848
	32,440	United Therapeutics Corporation (b)		3,801,644
	191,143	Vertex Pharmaceuticals Incorporated (b)		29,061,382
				277,039,761
		Health Care Equipment & Supplies - 14.2%
	1,021,320	Abbott Laboratories		54,497,635
	97,400	Edwards Lifesciences Corporation (b)		10,646,794
	242,558	Entellus Medical, Inc. (b)		4,477,621

The accompanying notes are an integral part of these financial statements.
13

TEKLA HEALTHCARE
OPPORTUNITIES FUND

SCHEDULE OF INVESTMENTS

SEPTEMBER 30, 2017

(continued)

SHARES		Health Care Equipment & Supplies - continued	VALUE
	358,130	Medtronic plc	$	27,851,770
	55,721	Nevro Corp. (b)		5,063,924
	113,277	NuVasive, Inc. (b)		6,282,342
	31,500	Stryker Corporation		4,473,630
	121,981	Wright Medical Group N.V. (b)		3,155,648
	67,800	Zimmer Biomet Holdings, Inc.		7,938,702
				124,388,066
		Health Care Providers & Services - 20.3%
	99,300	Acadia Healthcare Company, Inc. (b)		4,742,568
	134,007	AmerisourceBergen Corporation		11,089,079
	28,953	Anthem, Inc.		5,497,596
	114,200	Centene Corporation (b)		11,051,134
	60,450	Charles River Laboratories International, Inc. (b)		6,529,809
	83,900	Cigna Corporation		15,684,266
	109,035	Community Health Systems, Inc. (b)		837,389
	278,479	CVS Health Corporation (e)		22,645,912
	293,112	Diplomat Pharmacy, Inc. (b)		6,070,350
	84,500	Express Scripts Holding Company (b) (e)		5,350,540
	85,777	HCA Healthcare, Inc. (b) (e)		6,826,991
	112,000	Humana Inc.		27,286,560
	105,100	McKesson Corporation		16,144,411
	164,500	Tenet Healthcare Corporation (b)		2,702,735
	180,778	UnitedHealth Group Inc.		35,405,371
				177,864,711
		Life Sciences Tools & Services - 2.3%
	32,400	Illumina, Inc. (b)		6,454,080
	71,966	Thermo Fisher Scientific Inc.		13,615,967
				20,070,047
		Pharmaceuticals - 26.7%
	145,970	Allergan plc		29,916,552
	275,405	Eli Lilly & Company (e)		23,558,144
	664,232	Johnson & Johnson (e)		86,356,802
	954,681	Merck & Co., Inc.		61,128,224
	197,760	Mylan NV (b)		6,203,731
	646,037	Pfizer Inc.		23,063,521
	216,800	Teva Pharmaceutical Industries Ltd. (f)		3,815,680
				234,042,654
		Real Estate Investment Trusts - 7.6%
	106,212	LTC Properties, Inc.		4,989,840
	709,455	Medical Properties Trust, Inc.		9,315,144

The accompanying notes are an integral part of these financial statements.
14

TEKLA HEALTHCARE
OPPORTUNITIES FUND

SCHEDULE OF INVESTMENTS

SEPTEMBER 30, 2017

(continued)

SHARES		Real Estate Investment Trusts - continued	VALUE
	413,116	Omega Healthcare Investors, Inc.	$	13,182,532
	530,672	Physicians Realty Trust		9,408,815
	456,190	Sabra Health Care REIT, Inc.		10,008,809
	479,604	Senior Housing Properties Trust		9,376,258
	15,000	Ventas Realty, LP / Ventas Capital Corporation		381,900
	152,491	Ventas, Inc.		9,931,739
				66,595,037
		Real Estate Management & Development - 0.0%
	5,323	The RMR Group Inc., Class A		273,336
		TOTAL COMMON STOCKS AND WARRANTS (Cost $845,340,102)		900,273,612
PRINCIPAL AMOUNT		SHORT-TERM INVESTMENT - 6.0% of Net Assets
$	52,585,000	Repurchase Agreement, Fixed Income Clearing Corp., repurchase value $52,585,000, 0.12%, dated 09/29/17, due 10/02/17 (collateralized by U.S. Treasury Notes 1.50%, due 8/15/26, market value $53,637,996)		52,585,000
		TOTAL SHORT-TERM INVESTMENT (Cost $52,585,000)		52,585,000
		TOTAL INVESTMENTS - 127.0% (Cost $1,070,729,225)		1,112,547,316
NUMBER OF CONTRACTS (100 SHARES EACH)/ NOTIONAL AMOUNT		CALL OPTION CONTRACTS WRITTEN - (0.1)% of Net Assets
	292/29,200	Amgen Inc. Oct17 190 Call		(44,968	)
	404/40,400	Biogen Inc. Oct17 325 Call		(109,080	)
	1,182/118,200	CVS Health Corporation Oct17 83 Call		(65,010	)
	743/74,300	Eli Lilly & Company Oct17 87 Call		(30,463	)
	845/84,500	Express Scripts Holding Company Oct17 65 Call		(38,025	)

The accompanying notes are an integral part of these financial statements.
15

TEKLA HEALTHCARE
OPPORTUNITIES FUND

SCHEDULE OF INVESTMENTS

SEPTEMBER 30, 2017

(continued)

NUMBER OF CONTRACTS (100 SHARES EACH)/ NOTIONAL AMOUNT	CALL OPTION CONTRACTS WRITTEN - (continued)	VALUE
318/31,800	HCA Healthcare, Inc. Oct17 78 Call	$	(77,910	)
1,059/105,900	Johnson & Johnson Oct17 131 Call		(138,729	)
1,040/104,000	Neurocrine Biosciences, Inc. Oct17 60 Call		(364,000	)
1,281/128,100	Sarepta Therapeutics, Inc. Oct17 50 Call		(179,340	)
	TOTAL CALL OPTION CONTRACTS WRITTEN (Premiums received $782,363)		(1,047,525	)
	TOTAL INVESTMENTS LESS CALL OPTION CONTRACTS WRITTEN - 126.9% (Cost $1,069,946,862)		1,111,499,791
	OTHER LIABILITIES IN EXCESS OF ASSETS - (26.9)%		(235,843,691	)
	NET ASSETS - 100%	$	875,656,100

(a)  Security fair valued. See Investment Valuation and Fair Value Measurements.

(b)  Non-income producing security.

(c)  Affiliated issuers in which the Fund holds 5% or more of the voting securities (total market value of $2,383,333).

(d)  Security exempt from registration under Rule 144A of the Securities Act of 1933, as amended. These securities may be resold in transactions exempt from registration, normally to qualified institutional buyers.

(e)  A portion of security is pledged as collateral for call options written.

(f)  American Depository Receipt

(g)  Foreign security.

The accompanying notes are an integral part of these financial statements.
16

TEKLA HEALTHCARE
OPPORTUNITIES FUND

STATEMENT OF ASSETS AND LIABILITIES

SEPTEMBER 30, 2017

ASSETS:
Investments, at value (cost $1,068,344,804)	$	1,110,163,983
Investments in affiliated issuers, at value (cost $2,384,421)		2,383,333
Total investments		1,112,547,316
Cash		5,554,156
Dividends and interest receivable		2,490,260
Prepaid expenses		100,471
Total assets		1,120,692,203
LIABILITIES:
Payable for investments purchased		16,521,077
Accrued advisory fee		911,841
Accrued investor support service fees		45,592
Accrued shareholder reporting fees		48,153
Accrued trustee fees		185
Loan payable		225,000,000
Options written, at value (premium received $782,363)		1,047,525
Income distribution payable		164,726
Interest payable		1,099,477
Accrued other		197,527
Total liabilities		245,036,103
Commitments and Contingencies (see Note 1)
NET ASSETS	$	875,656,100
SOURCES OF NET ASSETS:
Shares of beneficial interest, par value $.01 per share, unlimited number of shares authorized, amount paid in on 43,516,091 shares issued and outstanding	$	830,092,602
Accumulated net investment income		3,048,422
Accumulated net realized gain on investments and options		962,148
Net unrealized gain on investments and options		41,552,928
Total net assets (equivalent to $20.12 per share based on 43,516,091 shares outstanding)	$	875,656,100

The accompanying notes are an integral part of these financial statements.
17

TEKLA HEALTHCARE
OPPORTUNITIES FUND

STATEMENT OF OPERATIONS

YEAR ENDED SEPTEMBER 30, 2017

INVESTMENT INCOME:
Dividend income (net of foreign tax of $165,065)	$	17,947,159
Interest and other income		5,822,708
Total investment income		23,769,867
EXPENSES:
Advisory fees		10,416,527
Interest expense		4,324,963
Investor support service fees		520,826
Legal fees		218,299
Administration fees		170,991
Auditing fees		65,500
Shareholder reporting		164,643
Custodian fees		144,310
Trustees' fees and expenses		131,840
Transfer agent fees		27,919
Other (see Note 2)		494,513
Total expenses		16,680,331
Net investment income		7,089,536
REALIZED AND UNREALIZED GAIN (LOSS):
Net realized gain (loss) on:
Investments		28,388,255
Closed or expired option contracts written		7,401,753
Net realized gain		35,790,008
Change in unrealized appreciation (depreciation)
Investments in unaffiliated issuers		58,815,076
Investments in affiliated issuers		(1,088	)
Option contracts written		(853,642	)
Change in unrealized appreciation (depreciation)		57,960,346
Net realized and unrealized gain (loss)		93,750,354
Net increase in net assets resulting from operations	$	100,839,890

The accompanying notes are an integral part of these financial statements.
18

TEKLA HEALTHCARE
OPPORTUNITIES FUND

STATEMENTS OF CHANGES IN NET ASSETS

	Year ended September 30, 2017			Year ended September 30, 2016
NET INCREASE (DECREASE) IN NET ASSETS RESULTING FROM OPERATIONS:
Net investment income	$	7,089,536		$	7,867,507
Net realized gain		35,790,008			31,409,642
Change in net unrealized appreciation		57,960,346			49,304,898
Net increase in net assets resulting from operations		100,839,890			88,582,047
DISTRIBUTIONS TO SHAREHOLDERS FROM:
Net investment income		(13,787,893	)		(72,504,372	)
Net realized capital gain		(44,964,370	)		—
Total distributions		(58,752,263	)		(72,504,372	)
CAPITAL SHARE TRANSACTIONS:
Fund shares repurchased (208,999 and 153,131 shares, respectively) (see Note 1)		(3,505,008	)		(2,709,105	)
Total capital share transactions		(3,505,008	)		(2,709,105	)
Net increase in net assets		38,582,619			13,368,570
NET ASSETS:
Beginning of year		837,073,481			823,704,911
End of year	$	875,656,100		$	837,073,481
Accumulated net investment income/ loss included in net assets at end of year	$	3,048,422	(a)	($	219,228	) (a)

(a) Reflects reclassifications to the Fund's capital accounts to reflect income and gains available for distribution under income tax regulations.

The accompanying notes are an integral part of these financial statements.
19

TEKLA HEALTHCARE
OPPORTUNITIES FUND

STATEMENT OF CASH FLOWS

YEAR ENDED SEPTEMBER 30, 2017

CASH FLOWS FROM OPERATING ACTIVITIES:
Purchases of portfolio securities	($	354,821,724	)
Purchases to close option contracts written		(829,816	)
Net maturities of short-term investments		(34,551,000	)
Sales of portfolio securities		441,158,898
Proceeds from option contracts written		9,405,815
Interest income received		5,940,953
Dividend income received		17,756,168
Other operating receipts (expenses paid)		(16,193,898	)
Net cash provided from operating activities		67,865,396
CASH FLOWS FROM FINANCING ACTIVITIES:
Cash distributions paid		(58,806,765	)
Fund shares repurchased		(3,505,008	)
Net cash used for financing activities		(62,311,773	)
NET INCREASE IN CASH		5,553,623
CASH AT BEGINNING OF YEAR		533
CASH AT END OF YEAR	$	5,554,156
RECONCILIATION OF NET INCREASE IN NET ASSETS RESULTING FROM OPERATIONS TO NET CASH PROVIDED FROM OPERATING ACTIVITIES:
Net increase in net assets resulting from operations	$	100,839,890
Purchases of portfolio securities		(354,821,724	)
Purchases to close option contracts written		(829,816	)
Net maturities of short-term investments		(34,551,000	)
Sales of portfolio securities		441,158,898
Proceeds from option contracts written		9,405,815
Accretion of discount		80,311
Net realized (loss) on investments and options		(35,790,008	)
Increase in net unrealized appreciation (depreciation) on investments and options		(57,960,346	)
Increase in dividends and interest receivable		(153,057	)
Increase in accrued expenses		81,666
Increase in prepaid expenses and interest payable		404,767
Net cash provided from operating activities	$	67,865,396

The accompanying notes are an integral part of these financial statements.
20

TEKLA HEALTHCARE
OPPORTUNITIES FUND

FINANCIAL HIGHLIGHTS

	Year ended September 30,									Period July 31, 2014 to September 30,
	2017			2016			2015			2014 (1)
OPERATING PERFORMANCE FOR A SHARE OUTSTANDING THROUGHOUT EACH PERIOD
Net asset value per share, beginning of period	$	19.14		$	18.77		$	19.33		$	19.10	(2)
Net investment income (loss) (3)		0.16			0.18			0.11			(0.01	)
Net realized and unrealized gain		2.16			1.78			0.68			0.39
Total increase (decrease) from investment operations		2.32			1.96			0.79			0.38
Distributions to shareholders from:
Income distributions to shareholders		(1.03	)		(1.65	)		(1.35	)		(0.11	)
Net realized capital gain		(0.32	)		—			—			—
Total distributions		(1.35	)		(1.65	)		(1.35	)		(0.11	)
Capital charges with respect to issuance of shares		—			—			—			(0.04	)
Increase resulting from shares repurchased (3)		0.01			0.06			—			—
Net asset value per share, end of period	$	20.12		$	19.14		$	18.77		$	19.33
Per share market value, end of period	$	18.57		$	17.48		$	16.30		$	18.85
Total investment return at market value		14.85	%		18.25	%		(7.37	%)		(5.42	%)*
Total investment return at net asset value		13.64	%		12.44	%		4.02	%		2.02	%*
RATIOS
Expenses to average net assets		2.03	%		1.88	%		1.60	%		1.28	%**
Expenses, excluding interest expense		1.51	%		1.50	%		1.44	%		1.28	%**
Net investment income (loss) to average net assets		0.86	%		0.96	%		0.50	%		(0.41	%)**
SUPPLEMENTAL DATA
Net assets at end of period (in millions)	$	876		$	837		$	824		$	848
Portfolio turnover rate		36.22	%		48.24	%		92.61	%		19.61	%*

*  Not Annualized.

**  Annualized.

(1)  Commenced operations on July 31, 2014.

(2)  Net asset value beginning of period reflects a deduction of $0.90 per share sales charge from the initial offering price of $20.00 per share.

(3)  Computed using average shares outstanding.

The accompanying notes are an integral part of these financial statements.
21

TEKLA HEALTHCARE
OPPORTUNITIES FUND

NOTES TO FINANCIAL STATEMENTS

SEPTEMBER 30, 2017

(1)  Organization and Significant Accounting Policies

Tekla Healthcare Opportunities Fund (the Fund) is a Massachusetts business trust formed on April 2, 2014 and registered under the Investment Company Act of 1940 as a non-diversified closed-end management investment company. The Fund commenced operations on July 31, 2014. The Fund's investment objective is to seek current income and long-term capital appreciation through investments in U.S. and non-U.S. companies in the healthcare industry (including equity securities, debt securities and pooled investment vehicles). The Fund invests primarily in securities of public and private companies believed by the Fund's Investment Adviser, Tekla Capital Management LLC (the Adviser), to have significant potential for above-average growth. The Fund may invest in private companies and other restricted securities, including private investments in public equity and venture capital investments, if these securities would currently comprise 10% or less of Managed Assets.

The preparation of these financial statements requires the use of certain estimates by management in determining the Fund's assets, liabilities, revenues and expenses. Actual results could differ from these estimates and such differences could be material. The following is a summary of significant accounting policies followed by the Fund, which are in conformity with accounting principles generally accepted in the United States of America (GAAP). The Fund is an investment company and follows accounting and reporting guidance in the Financial Accounting Standards Board Accounting Standards Codification 946. Events or transactions occurring after September 30, 2017, through the date that the financial statements were issued, have been evaluated in the preparation of these financial statements.

Investment Valuation

Shares of publicly traded companies listed on national securities exchanges or trading in the over-the-counter market are typically valued at the last sale price, as of the close of trading, generally 4 p.m., Eastern time. The Board of Trustees of the Fund (the Trustees) has established and approved fair valuation policies and procedures with respect to securities for which quoted prices may not be available or which do not reflect fair value. Convertible bonds, corporate and government bonds are valued using a third-party pricing service. Convertible bonds are valued using this pricing service only on days when there is no sale reported. Puts and calls generally are valued at the close of regular trading on the securities or commodities exchange on which they are primarily traded. Options on securities generally are valued at their last bid price in the case of exchange traded options or, in the case of OTC-traded options, the average of the last bid price as obtained from two or more dealers unless there is only one dealer, in which case that dealer's price is used. Forward foreign currency contracts are valued on the basis of the value of the underlying currencies at the prevailing currency exchange rate. Restricted securities of companies that are publicly traded are typically valued based on the closing market quote on the valuation date adjusted for the impact of the restriction as determined in good faith by the Adviser also using fair valuation policies and procedures approved by the Trustees described below. Non-exchange traded warrants of publicly traded companies are generally valued using the Black-Scholes model, which incorporates both observable and unobservable inputs. Short-term investments with a maturity of 60 days or less are generally valued at amortized cost, which approximates fair value.

22

TEKLA HEALTHCARE
OPPORTUNITIES FUND

NOTES TO FINANCIAL STATEMENTS

SEPTEMBER 30, 2017

(continued)

Convertible preferred shares, warrants or convertible note interests in private companies, and other restricted securities, as well as shares of publicly traded companies for which market quotations are not readily available, such as stocks for which trading has been halted or for which there are no current day sales, or which do not reflect fair value, are typically valued in good faith, based upon the recommendations made by the Adviser pursuant to fair valuation policies and procedures approved by the Trustees.

The Adviser has a Valuation Sub-Committee comprised of senior management which reports to the Valuation Committee of the Board at least quarterly. Each fair value determination is based on a consideration of relevant factors, including both observable and unobservable inputs. Observable and unobservable inputs the Adviser considers may include (i) the existence of any contractual restrictions on the disposition of securities; (ii) information obtained from the company, which may include an analysis of the company's financial statements, the company's products or intended markets or the company's technologies; (iii) the price of the same or similar security negotiated at arm's length in an issuer's completed subsequent round of financing; (iv) the price and extent of public trading in similar securities of the issuer or of comparable companies; or (v) a probability and time value adjusted analysis of contractual terms. Where available and appropriate, multiple valuation methodologies are applied to confirm fair value. Significant unobservable inputs identified by the Adviser are often used in the fair value determination. A significant change in any of these inputs may result in a significant change in the fair value measurement. Due to the uncertainty inherent in the valuation process, such estimates of fair value may differ significantly from the values that would have been used had a ready market for the investments existed, and differences could be material. Additionally, changes in the market environment and other events that may occur over the life of the investments may cause the gains or losses ultimately realized on these investments to be different from the valuations used at the date of these financial statements.

Options on Securities

An option contract is a contract in which the writer (seller) of the option grants the buyer of the option, upon payment of a premium, the right to purchase from (call option) or sell to (put option) the writer a designated instrument at a specified price within a specified period of time. Certain options, including options on indices, will require cash settlement by the Fund if the option is exercised. The Fund enters into option contracts in order to hedge against potential adverse price movements in the value of portfolio assets, as a temporary substitute for selling selected investments, to lock in the purchase price of a security or currency which it expects to purchase in the near future, as a temporary substitute for purchasing selected investments, or to enhance potential gain or to gain or hedge exposure to financial market risk.

The Fund's obligation under an exchange traded written option or investment in an exchange traded purchased option is valued at the last sale price or in the absence of a sale, the mean between the closing bid and asked prices. Gain or loss is recognized when the option contract expires, is exercised or is closed.

If the Fund writes a covered call option, the Fund foregoes, in exchange for the premium, the opportunity to profit during the option period from an increase in the market value of the underlying security above the exercise price. If the Fund writes a put option it accepts the risk

23

TEKLA HEALTHCARE
OPPORTUNITIES FUND

NOTES TO FINANCIAL STATEMENTS

SEPTEMBER 30, 2017

(continued)

of a decline in the market value of the underlying security below the exercise price. Over-the-counter options have the risk of the potential inability of counterparties to meet the terms of their contracts. The Fund's maximum exposure to purchased options is limited to the premium initially paid. In addition, certain risks may arise upon entering into option contracts including the risk that an illiquid secondary market will limit the Fund's ability to close out an option contract prior to the expiration date and that a change in the value of the option contract may not correlate exactly with changes in the value of the securities or currencies hedged.

All options on securities and securities indices written by the Fund are required to be covered. When the Fund writes a call option, this means that during the life of the option the Fund may own or have the contractual right to acquire the securities subject to the option or may maintain with the Fund's custodian in a segregated account appropriate liquid securities in an amount at least equal to the market value of the securities underlying the option. When the Fund writes a put option, this means that the Fund will maintain with the Fund's custodian in a segregated account appropriate liquid securities in an amount at least equal to the exercise price of the option.

The average number of outstanding call options written for the year ended September 30, 2017 were 7,868.

Derivatives not accounted for as hedging instruments under ASC 815	Statement of Assets and Liabilities Location		Statement of Operations Location
Equity Contracts	Liabilities, options written, at value	$1,047,525	Net realized gain on closed or expired option contracts written	$7,401,753
			Change in unrealized appreciation (depreciation) on option contracts written	($853,642)

Investment Transactions and Income

Investment transactions are recorded on a trade date basis. Gains and losses from sales of investments are recorded using the "identified cost" method. Interest income is recorded on the accrual basis, adjusted for amortization of premiums and accretion of discounts. Dividend income is recorded on the ex-dividend date, less any foreign taxes withheld. Upon notification from issuers, some of the dividend income received may be redesignated as a reduction of cost of the related investment if it represents a return of capital.

The aggregate cost of purchases and proceeds from sales of investment securities (other than short-term investments) for the year ended September 30, 2017 totaled $363,621,521 and $441,003,873, respectively.

Repurchase Agreements

In managing short-term investments the Fund may from time to time enter into transactions in repurchase agreements. In a repurchase agreement, the Fund's custodian takes possession of the underlying collateral securities from the counterparty, the market value of which is at least

24

TEKLA HEALTHCARE
OPPORTUNITIES FUND

NOTES TO FINANCIAL STATEMENTS

SEPTEMBER 30, 2017

(continued)

equal to the principal, including accrued interest, of the repurchase transaction at all times. In the event of default or bankruptcy by the other party to the agreement, realization and/or retention of the collateral by the Fund may be delayed. The Fund may enter into repurchase transactions with any broker, dealer, registered clearing agency or bank. Repurchase agreement transactions are not counted for purposes of the limitations imposed on the Fund's investment in debt securities.

Distribution Policy

Pursuant to a Securities and Exchange Commission exemptive order the Fund may make periodic distributions that include capital gains as frequently as 12 times in any one taxable year in respect of its common shares, and the Fund has implemented a managed distribution policy (the Policy) providing for monthly distributions at a rate set by the Board of Trustees. Under the current Policy, the Fund intends to make monthly distributions at a rate of $0.1125 per share to shareholders of record. If taxable income and net long-term realized gains exceed the amount required to be distributed under the Policy, the Fund will at a minimum make distributions necessary to comply with the requirements of the Internal Revenue Code. The Policy has been established by the Trustees and may be changed by them without shareholder approval. The Trustees regularly review the Policy and the frequency and distribution rate considering the purpose and effect of the Policy, the financial market environment, and the Fund's income, capital gains and capital available to pay distributions.

Share Repurchase Program

In March 2017, the Trustees approved the renewal of the share repurchase program to allow the Fund to purchase up to 12% of its outstanding common shares in the open market for a one-year period ending July 14, 2018. Prior to this renewal, in March 2016, the Trustees approved the renewal of the share repurchase program to allow the Fund to repurchase up to 12% of its outstanding shares for a one year period ending July 10, 2017. The share repurchase program is intended to enhance shareholder value and potentially reduce the discount between the market price of the Fund's shares and the Fund's net asset value.

During the year ended Sepember 30, 2017 the Fund repurchased 208,999 shares at a total cost of $3,505,008. The weighted average discount per share between the cost of repurchase and net asset value applicable to such shares at the date of repurchase was 7.28%.

During the year ended September 30, 2016, the Fund repurchased 153,131 shares at a total cost of $2,709,105. The weighted average discount per share between the cost of repurchase and net asset value applicable to such shares at the date of repurchase was 8.76%.

Federal Taxes

It is the Fund's policy to comply with the requirements of the Internal Revenue Code applicable to regulated investment companies and to distribute to its shareholders substantially all of its taxable income and its net realized capital gains, if any. Therefore, no Federal income or excise tax provision is required.

As of September 30, 2017, the Fund had no uncertain tax positions that would require financial statement recognition or disclosure. The Fund's federal tax returns are subject to examination by the Internal Revenue Service for a period of three years.

25

TEKLA HEALTHCARE
OPPORTUNITIES FUND

NOTES TO FINANCIAL STATEMENTS

SEPTEMBER 30, 2017

(continued)

Distributions

The Fund records all distributions to shareholders on the ex-dividend date. Such distributions are determined in conformity with income tax regulations, which may differ from GAAP. These differences include temporary and permanent differences from losses on wash sale transactions, installment sale adjustments and ordinary loss netting to reduce short term capital gains. Reclassifications are made to the Fund's capital accounts to reflect income and gains available for distribution under income tax regulations. At September 30, 2017, the Fund reclassified $54,930,377 from accumulated net realized gain on investment and $54,930,377 to undistributed net investment income to adjust for current period book/tax differences.

The tax basis components of distributable earnings and the tax cost as of September 30, 2017 were as follows:

Cost of investments for tax purposes	$	1,068,984,714
Gross tax unrealized appreciation	$	122,931,600
Gross tax unrealized depreciation	($	80,416,523	)
Net tax unrealized depreciation on investments	$	42,515,077
Undistributed ordinary income	$	3,213,148

The Fund has designated the distributions for its taxable years ended September 30, 2017 and 2016 as follows:

Distributions paid from:	2017		2016
Ordinary income (includes short-term capital gain)	$	13,787,893	$	60,171,751
Long-term capital gain	$	44,964,370	$	12,332,621

Statement of Cash Flows

The cash amount shown in the Statement of Cash Flows is the amount included in the Fund's Statement of Assets and Liabilities and represents cash on hand at September 30, 2017.

Commitments and Contingencies

Under the Fund's organizational documents, its officers and Trustees may be indemnified against certain liabilities and expenses arising out of the performance of their duties to the Fund. Additionally, in the normal course of business, the Fund enters into agreements with service providers that may contain indemnification clauses. The Fund's maximum exposure under these agreements is unknown as this would involve future claims that may be made against the Fund that have not yet occurred. However, based on experience, the Fund expects the risk of loss to be remote.

Loan Payable

The Fund maintains a $225,000,000 line of credit with the Bank of Nova Scotia (the "Line of Credit") which expires on January 3, 2018. As of September 30, 2017, the Fund had drawn down $225,000,000 from the Line of Credit, which was the maximum borrowing outstanding during the period. The Fund is charged interest at the rate of 0.70% above the relevant LIBOR rate adjusted by the Statutory Reserve Rate for borrowing (per annum). The Fund is also charged a commitment fee on the daily unused balance of the line of credit at the rate of 0.25% (per annum). Per the Line of Credit agreement, the Fund paid an upfront fee of 0.10% on the total line of credit balance, which is being amortized through January 4, 2018. The

26

TEKLA HEALTHCARE
OPPORTUNITIES FUND

NOTES TO FINANCIAL STATEMENTS

SEPTEMBER 30, 2017

(continued)

Fund pledges its investment securities as the collateral for the line of credit per the terms of the agreement. The weighted average interest rate and the average outstanding loan payable for the period from October 1, 2016 to September 30, 2017 were 1.8900% and $225,000,000, respectively. The stated carrying amount of the line of credit approximates its fair value based upon the short term nature of the borrowings and the interest rates being based upon the market terms. The borrowings under the line of credit would be considered as Level 2 in the fair value hierarchy (See Note 4) at September 30, 2017.

Investor Support Services

The Fund has retained Destra Capital Investment LLC (Destra) to provide investor support services in connection with the ongoing operation of the Fund. The Fund pays Destra a fee in an annual amount equal to (i) 0.10% of the average aggregate daily value of the Fund's Managed Assets from July 31, 2015 to December 31, 2015 and (ii) 0.05% of the average aggregate daily value of the Fund's Managed Assets from January 1, 2016 through the remaining term of the investor support services agreement.

(2)  Investment Advisory and Other Affiliated Fees

The Fund has entered into an Investment Advisory Agreement (the Advisory Agreement) with the Adviser. Pursuant to the terms of the Advisory Agreement, the Fund pays the Adviser a monthly fee at the rate when annualized of 1.00% of the average daily value of the Fund's Managed Assets. Managed Assets means the total assets of the Fund minus the Fund's liabilities other than the loan payable.

The Fund has entered into a Services Agreement (the Agreement) with the Adviser. Pursuant to the terms of the Agreement, the Fund reimburses the Adviser for certain services related to a portion of the payment of salary and provision of benefits to the Fund's Chief Compliance Officer. During the year ended September 30, 2017, these payments amounted to $92,623 and are included in the Other category of expenses in the Statement of Operations, together with insurance and other expenses incurred to unaffiliated entities. Expenses incurred pursuant to the Agreement as well as certain expenses paid for by the Adviser are allocated to the Fund in an equitable fashion as approved by the Trustees or officers of the Fund who are also officers of the Adviser.

The Fund pays compensation to Independent Trustees in the form of a retainer, attendance fees, and additional compensation to Board and Committee chairpersons. The Fund does not pay compensation directly to Trustees or officers of the Fund who are also officers of the Adviser.

27

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OPPORTUNITIES FUND

NOTES TO FINANCIAL STATEMENTS

SEPTEMBER 30, 2017

(continued)

(3)  Other Transactions with Affiliates

An affiliate company is a company in which the Fund holds 5% or more of the voting securities. Transactions involving such companies during the year ended September 30, 2017 were as follows:

Affiliated Companies	Begining Value as of September 30, 2016			Purchases at Cost		Proceeds from Sales		Net Realized Gain/(Loss) on sale of Affiliated Companies		Change in Unrealized Appreciation/ Depreciation			Ending Value as of September 30, 2017
BioClin Therapeutics, Inc.	$	951,923	*	$	1,432,498	$	—	$	—	($	1,088	)	$	2,383,333
	$	951,923	*	$	1,432,498	$	—	$	—	($	1,088	)	$	2,383,333

* Not an affiliate as of September 30, 2016.

Affiliated Companies	Shares as of September 30, 2017		Dividend Income from Affiliated Companies		Capital Gain Distributions from Affiliated Companies
BioClin Therapeutics, Inc.		3,518,854	$	—	$	—
		3,518,854	$	—	$	—

(4)  Fair Value Measurements

The Fund uses a three-tier hierarchy to prioritize the assumptions, referred to as inputs, used in valuation techniques to measure fair value. The three-tier hierarchy of inputs is summarized in the three broad levels. Level 1 includes quoted prices in active markets for identical investments. Level 2 includes prices determined using other significant observable inputs (including quoted prices for similar investments, interest rates, credit risk, etc.). The independent pricing vendor may value bank loans and debt securities at an evaluated bid price by employing methodologies designed to identify the market value for such securities and such securities are considered Level 2 in the fair value hierarchy. Level 3 includes prices determined using significant unobservable inputs (including the Fund's own assumptions in determining the fair value of investments). These inputs or methodology used for valuing securities are not necessarily an indication of the risk associated with investing in those securities.

For the year ended September 30, 2017, there were no transfers between Levels 1, 2 and 3. The Fund accounts for transfers between levels at the beginning of the period.

The following is a summary of the levels used as of September 30, 2017 to value the Fund's net assets.

Assets at Value	Level 1	Level 2	Level 3		Total
Convertible Preferred and Warrants
Biotechnology			$	5,583,332	$	5,583,332
Health Care Equipment & Supplies				0		0

28

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OPPORTUNITIES FUND

NOTES TO FINANCIAL STATEMENTS

SEPTEMBER 30, 2017

(continued)

Assets at Value	Level 1			Level 2		Level 3		Total
Preferred Stock
Real Estate Investment Trust	$	12,686,000						$	12,686,000
Mandatory Convertible Preferred Stock
Pharmaceuticals		8,169,420							8,169,420
Convertible Notes
Health Care Equipment & Supplies		—				$	65,585		65,585
Pharmaceuticals		—		$	19,233,375		—		19,233,375
Non-Convertible Notes
Biotechnology		—			20,356,563		—		20,356,563
Health Care Equipment & Supplies		—			11,107,908		—		11,107,908
Health Care Providers & Services		—			68,887,962		—		68,887,962
Pharmaceuticals		—			13,598,559		—		13,598,559
Common Stocks and Warrants
Biotechnology		276,856,111			—		183,650		277,039,761
Health Care Equipment & Supplies		124,388,066			—		—		124,388,066
Health Care Providers & Services		177,864,711			—		—		177,864,711
Life Sciences Tools & Services		20,070,047			—		—		20,070,047
Pharmaceuticals		234,042,654			—		—		234,042,654
Real Estate Investment Trusts		66,595,037			—		—		66,595,037
Real Estate Management & Development		273,336			—		—		273,336
Short-Term Investment		—			52,585,000		—		52,585,000
Total	$	920,945,382		$	185,769,367	$	5,832,567	$	1,112,547,316
Other Financial Instruments
Liabilities
Call Options Contracts Written	($	1,047,525	)	$	—	$	—	($	1,047,525	)
Total	($	1,047,525	)	$	—	$	—	($	1,047,525	)

The following is a reconciliation of Level 3 assets for which significant unobservable inputs were used to determine fair value.

Level 3 Assets	Balance as of September 30, 2016		Net realized gain (loss) and change in unrealized appreciation (depreciation)			Cost of purchases and conversions		Proceeds from sales and conversions	Net transfers in (out of) Level 3	Balance as of September 30, 2017
Convertible Preferred and Warrants
Biotechnology	$	4,151,922	($	1,779	)	$	1,433,189			$	5,583,332
Health Care Equipment & Supplies		790,548		(791,556	)		1,008				0
Convertible Notes
Health Care Equipment & Supplies		0		(65,668	)		131,253				65,585

29

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OPPORTUNITIES FUND

NOTES TO FINANCIAL STATEMENTS

SEPTEMBER 30, 2017

(continued)

Level 3 Assets	Balance as of September 30, 2016		Net realized gain (loss) and change in unrealized appreciation (depreciation)			Cost of purchases and conversions		Proceeds from sales and conversions		Net transfers in (out of) Level 3		Balance as of September 30, 2017
Common Stocks and Warrants
Biotechnology	$	37,528	$	145,558		$	564					$	183,650
Total	$	4,979,998	($	713,445	)	$	1,566,014	$	—	$	—	$	5,832,567
Net change in unrealized appreciation (depreciation) from investments still held as of September 30, 2017												(	$713,445	)

The following is a quantitative disclosure about significant unobservable inputs used in the determination of the fair value of Level 3 assets.

	Fair Value at September 30, 2017		Valuation Technique	Unobservable Input	Range (Weighted Average)
Private Companies and Other Restricted Securities		$183,650	Income approach, Black-Scholes	Discount for lack of marketability	20%-50% (20%)
		5,583,332	Probability-weighed expected return model	Discount rate Price to sales multiple	16.94%-60.54% (35.56%) 3.06x-10.90x (6.41x)
		65,585	Market approach, recent transaction	(a)	N/A
		$5,832,567

(a)  The valuation technique used as a basis to approximate fair value of these investments is based upon subsequent financing rounds. There is no quantitative information to provide as these methods of measure are investment specific.

(5)  Private Companies and Other Restricted Securities

The Fund may invest in private companies and other restricted securities if these securities would currently comprise 10% or less of Managed Assets. The value of these securities represented less than 1% of the Fund's Managed Assets at September 30, 2017.

The following table details the acquisition date, cost, carrying value per unit, and value of the Fund's private companies and other restricted securities at September 30, 2017. The Fund on its own does not have the right to demand that such securities be registered.

Security (#)	Acquisition Date	Cost		Carrying Value per Unit		Value
BioClin Therapeutics, Inc.
Series A Cvt. Pfd	1/19/16, 10/24/16	$	1,651,088	$	0.65	$	1,650,000
Series B Cvt. Pfd	3/3/17		733,333		0.75		733,333
GenomeDx Biosciences, Inc.
Series C Cvt. Pfd	2/22/16		3,203,634		1.50		3,199,999

30

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OPPORTUNITIES FUND

NOTES TO FINANCIAL STATEMENTS

SEPTEMBER 30, 2017

(continued)

Security (#)	Acquisition Date	Cost		Carrying Value per Unit		Value
IlluminOss Medical, Inc.
Junior Preferred Cvt. Pfd	1/21/16	$	130,781	$	0.00	$	0
Series AA Cvt. Pfd	1/21/16		283,057		0.00		0
Cvt. Promissory Note	3/28/17		131,212		50.00		65,585
Warrants (expiration 3/31/27)	3/28/17		21		0.00		0
		$	6,133,126			$	5,648,917

  (#)  See Schedule of Investments and corresponding footnotes for more information on each issuer.

31

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Trustees and Shareholders of Tekla Healthcare Opportunities Fund:

We have audited the accompanying statement of assets and liabilities of Tekla Healthcare Opportunities Fund (the "Fund"), including the schedule of investments, as of September 30, 2017, the related statements of operations and cash flows for the year then ended, the statements of changes in net assets for each of the two years in the period then ended and the financial highlights for each of the three years in the period then ended and for the period July 31, 2014 (commencement of operations) to September 30, 2014. These financial statements and financial highlights are the responsibility of the Fund's management. Our responsibility is to express an opinion on these financial statements and financial highlights based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement. The Fund is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. Our audits included consideration of internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Fund's internal control over financial reporting. Accordingly, we express no such opinion. An audit also includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. Our procedures included confirmation of securities owned as of September 30, 2017, by correspondence with the custodian and brokers; where replies were not received from brokers, we performed other auditing procedures. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, such financial statements and financial highlights referred to above present fairly, in all material respects, the financial position of Tekla Healthcare Opportunities Fund as of September 30, 2017, the results of its operations and its cash flows for the year then ended, the changes in its net assets for each of the two years in the period then ended and the financial highlights for each of the three years in the period then ended and for the period July 31, 2014 (commencement of operations) to September 30, 2014, in conformity with accounting principles generally accepted in the United States of America.

DELOITTE & TOUCHE LLP
Boston, Massachusetts
November 20, 2017

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OPPORTUNITIES FUND

TRUSTEES

Name, Address1 and Date of Birth	Position(s) Held with Fund, Term of Office2 and Length of Time Served	Principal Occupation(s) During Past 5 Years and Other Directorship(s) Held	Number of Portfolios in Fund Complex Overseen by Trustee
Independent Trustees:
Michael W. Bonney 8/1958	Trustee (since 2014)	Chief Executive Officer and Chairman of the Board of Trustees, Kaleido Biosciences (since 2017); Partner, Third Rock Ventures (2016); Chief Executive Officer and Director, Cubist Pharmaceuticals, Inc. (2012-2015); President, Chief Executive Officer and Director, Cubist Pharmaceuticals, Inc. (2002-2012); Director, Magenta Therapeutics (since 2016); Director, Global Blood Therapeutics (since 2016); Director, Revolution Medicine (since 2016); Director, Celgene Corporation (since 2015); Director, Whitehead Institute (since 2015); Director, Alnylam Pharmaceuticals, Inc. (since 2014); Director, Gulf of Maine Research Institute (since 2015); Director, NPS Pharmaceuticals, Inc. (2012-2015); Chairman of the Board of Trustees, Bates College (since 2010); Board member of Pharmaceutical Research and Manufacturers of America (PhRMA) (2009-2014) Trustee, Bates College (since 2002).		4
Rakesh K. Jain, Ph.D. 12/1950	Trustee (since 2014)	Director, Steele Lab of Tumor Biology at Massachusetts General Hospital (since 1991); A.W. Cook Professor of Tumor Biology (Radiation Oncology) at Harvard Medical School (since 1991); Ad hoc Consultant/Scientific Advisory Board Member for pharmaceutical/biotech companies (various times since 2002); Ad hoc Consultant, Gershon Lehman Group (since 2004); Director, Co-Founder, XTuit Pharmaceuticals, Inc. (since 2012).		4

33

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OPPORTUNITIES FUND

TRUSTEES

(continued)

Name, Address1 and Date of Birth	Position(s) Held with Fund, Term of Office2 and Length of Time Served	Principal Occupation(s) During Past 5 Years and Other Directorship(s) Held	Number of Portfolios in Fund Complex Overseen by Trustee
Oleg M. Pohotsky, M.B.A., J.D. 3/1947	Trustee (since 2014) Chairman (since 2014)	Consultant and Managing Partner, Right Bank Partners (since 2002); Adviser, Board Advisers, Kaufman & Co. LLC (since 2008); Director, AvangardCo Investment Holdings (since 2011); Director, The New America High Income Fund, Inc. (since 2013).		4
William S. Reardon 6/1946	Trustee (since 2014)	Certified Public Accountant (until 2017); Independent Consultant (since 2002); Director, Idera Pharmaceuticals, Inc (since 2002); Director, Synta Pharmaceuticals, Inc. (2004-2016).		4
Uwe E. Reinhardt, Ph.D. 9/1937 (deceased 11/2017)	Trustee (since 2014)	Professor of Economics, Princeton University (since 1968); Director, Boston Scientific Corporation (2002-2015); Director, Amerigroup, Inc. (2002-2012).		4
Lucinda H. Stebbins, CPA 11/1945	Trustee (since 2014)	Independent Consultant, Deutsche Bank (2004-2015); Director, Bald Peak Land Company, Inc. (2008-2014); Director, Solstice Home Care, Inc. (since 2014).		4

34

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OPPORTUNITIES FUND

TRUSTEES

(continued)

Name, Address1 and Date of Birth	Position(s) Held with Fund, Term of Office2 and Length of Time Served	Principal Occupation(s) During Past 5 Years and Other Directorship(s) Held	Number of Portfolios in Fund Complex Overseen by Trustee
Interested Trustee:
Daniel R. Omstead, Ph.D.3 7/1953	President (since 2014); Trustee (since 2014)	President of the Fund, Tekla Healthcare Investors (HQH) (since 2001), Tekla Life Sciences Investors (HQL) (since 2001) and Tekla Healthcare World Healthcare Fund (THW) (since 2015); President, Chief Executive Officer and Managing Member of Tekla Capital Management LLC (since 2002); Director Celladon Corporation (2012-2014); Director: IlluminOss Medical, Inc. (since 2012); Magellan Diagnostics, Inc.(since 2006); Dynex Corporation (since 2012); Insightra Medical, Inc. (since 2015); Neurovance, Inc. (since 2015); EBI Life Sciences, Inc. (since 2015); Euthymics Biosciences, Inc. (since 2015); Veniti, Inc. (since 2015).		4

¹  The Address for each Trustee is: Tekla Healthcare Opportunities Fund, 100 Federal Street, 19th Floor, Boston, Massachusetts, 02110, 617-772-8500.

²  Each Trustee currently is serving a three year term.

³  Trustee considered to be an "interested person" within the meaning of the Investment Company Act of 1940, as amended (the "1940 Act"), through position or affiliation with the Adviser.

35

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OPPORTUNITIES FUND

OFFICERS

Name, Address1 and Date of Birth	Position(s) Held with Fund, Term of Office2 and Length of Time Served	Principal Occupation(s) During Past 5 Years
Daniel R. Omstead, Ph.D. 7/1953	President (since 2014); Trustee (since 2014)	President of the Fund, HQH (since 2001), HQL (since 2001) and THW (since 2015); President, Chief Executive Officer and Managing Member of Tekla Capital Management LLC (since 2002); Director: IlluminOss Medical, Inc. (since 2012); Magellan Diagnostics, Inc. (since 2006); Dynex Corporation (since 2012); Insightra Medical, Inc. (since 2015); Neurovance, Inc. (since 2015); EBI Life Sciences, Inc. (since 2015); Euthymics Biosciences, Inc. (since 2015); Veniti, Inc. (since 2015).
Laura Woodward, CPA 11/1968	Chief Compliance Officer, Secretary and Treasurer (since 2014)	Chief Compliance Officer, Secretary and Treasurer, the Fund, HQH (since 2009), HQL (since 2009) and THW (since 2015); Chief Compliance Officer and Vice President of Fund Administration, Tekla Capital Management LLC (since 2009); Senior Manager, PricewaterhouseCoopers LLP (1990-2009).

¹  The Address for each officer is: Tekla Healthcare Opportunities Fund; 100 Federal Street, 19th Floor, Boston, Massachusetts, 02110, 617-772-8500.

²  Each officer serves in such capacity for an indefinite period of time at the pleasure of the Trustees.

The Fund's Statement of Additional Information includes additional information about the Fund's Trustees and is available without charge, upon request by calling (617) 772-8500 or writing to Tekla Capital Management LLC at 100 Federal Street, 19th Floor, Boston, MA 02110.

36

TEKLA HEALTHCARE
OPPORTUNITIES FUND

ANNUAL MEETING REPORT: An Annual Meeting of Shareholders was held on June 15, 2017. Shareholders voted to elect Trustees of the Fund to hold office for a term of three years or until their respective successors shall have been duly elected and qualified. The following votes were cast with respect to each of the nominees:

	For		Withheld
Michael W. Bonney		38,771,758		898,397
Uwe E. Reinhardt, Ph. D.		38,734,659		935,496

Michael W. Bonney and Uwe E. Reinhardt, Ph. D. were elected to serve until the 2020 Annual Meeting.

Trustees serving until the 2018 Annual Meeting are Oleg M. Pohotsky, MBA, J.D. and William S. Reardon.

Trustees serving until the 2019 Annual Meeting are Rakesh K. Jain, Ph.D., Daniel R. Omstead, Ph.D. and Lucinda H. Stebbins, CPA.

Shareholders ratified the appointment of Deloitte & Touche LLP as the independent registered public accountants of the Fund for the fiscal year ending September 30, 2017 by the following votes:

For		Against		Abstain
	39,212,141		192,117		265,897

FOR MORE INFORMATION: A description of the Fund's proxy voting policies and procedures and information on how the Fund voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available (i) without charge, upon request by calling 1-800-451-2597; (ii) by writing to Tekla Capital Management LLC at 100 Federal Street, 19th Floor, Boston, MA 02110; (iii) on the Fund's website at www.teklacap.com; and (iv) on the SEC's website at http://www.sec.gov.

The Fund's complete Schedule of Investments for the first and third quarters of its fiscal year will be filed quarterly with the SEC on Form N-Q. This Schedule of Investments will also be available on the Fund's website at www.teklacap.com, or the SEC's website at http://www.sec.gov. The Fund's Form N-Q may be reviewed and copied at the SEC's Public Reference Room in Washington, DC or by calling 1-800-SEC-0330.

You can find information regarding the Fund at the Fund's website, www.teklacap.com. The Fund regularly posts information to its website, including information regarding daily share pricing and distributions and press releases, and maintains links to the Fund's SEC filings. The Fund currently publishes and distributes quarterly fact cards, including performance, portfolio holdings and sector information for each fiscal quarter. These fact cards will be available on the Fund's website and by request from the Fund's marketing and investor support services agent, Destra Capital Investments, at 1-877-855-3434.

37

TEKLA HEALTHCARE
OPPORTUNITIES FUND

FEDERAL TAX INFORMATION (unaudited): Certain information for the Fund is required to be provided to shareholders based on the Fund's income and distributions for the taxable year ended December 31, 2017. In February 2018, shareholders will receive Form 1099-DIV, which will include their share of qualified dividends and capital gains and return of capital distributed during the calendar year 2017. Shareholders are advised to check with their tax advisors for information on the treatment of these amounts on their individual tax returns.

For corporate shareholders, 60.59% of ordinary income dividends paid by the Fund qualified for the dividends received deduction during the period July 31, 2017 to September 30, 2017.

Under Section 854(b)(2) of the Code, the Fund designated $12,686,404 as qualified dividends for the year ended September 30, 2017.

DISTRIBUTION POLICY: The Fund has a fixed distribution policy as described in the Notes to Financial Statements. For more information contact your financial adviser.

SHARE REPURCHASE PROGRAM: In March 2017, the Trustees approved the renewal of the share repurchase program to allow the Fund to purchase up to 12% of its outstanding common shares in the open market for a one-year period ending July 14, 2018.

PORTFOLIO MANAGEMENT: Daniel R. Omstead, Ph.D., Jason C. Akus, M.D./M.B.A., Timothy Gasperoni, M.B.A, Ph.D., Christian M. Richard, M.B.A, M.S., Henry Skinner, Ph.D., Christopher Abbott, Robert Benson, CFA, CAIA, Amanda Birdsey-Benson, Ph.D. and Alan Kwan, M.B.A, Ph.D. are members of a team that analyzes investments on behalf of the Fund. Dr. Omstead exercises ultimate decision making authority with respect to investments.

DIVIDEND REINVESTMENT AND
STOCK PURCHASE PLAN

Reinvestment of Distributions. Under the Dividend Reinvestment and Stock Purchase Plan, dividends and/or distributions to a Shareholder will automatically be reinvested in additional Shares of the Fund. Each registered Shareholder may elect to have dividends and distributions distributed in cash (i.e., "opt-out") rather than participate in the Dividend Reinvestment and Stock Purchase Plan. For any registered Shareholder that does not so elect, dividends and/or distributions on such Shareholder's Shares will be reinvested by Computershare Trust Company, N.A. (the "Plan Agent"), as agent for Shareholders in additional Shares, as set forth below. Participation in the Dividend Reinvestment and Stock Purchase Plan is completely voluntary, and may be terminated or resumed at any time without penalty by internet, telephone or notice if received and processed by the Plan Agent prior to the dividend record date; otherwise such termination or resumption will be effective with respect to any subsequently declared dividend or other distribution. Participants who hold their Shares through a broker or other nominee and who wish to elect to receive any dividends and distributions in cash must contact their broker or nominee.

The Plan Agent's fees for the handling of the reinvestment of dividends and distributions will be paid by the Fund. Each participant will pay a per Share fee (currently $0.05 per Share) incurred in connection with open market purchases. If a participant elects to have the Plan Agent sell all or a part of his or her Shares and remit the proceeds to the participant, the Plan

38

TEKLA HEALTHCARE
OPPORTUNITIES FUND

DIVIDEND REINVESTMENT AND
STOCK PURCHASE PLAN

(continued)

Agent is authorized to deduct a $15 sales fee per trade and a per Share fee of $0.12 from such proceeds. All per Share fees include any applicable brokerage commissions the Plan Agent is required to pay. The automatic reinvestment of Dividends will not relieve Participants of any federal, state or local income tax that may be payable (or required to be withheld) on such dividend.

The Plan Agent will acquire shares for participants' accounts by purchasing either newly issued shares from the Fund or outstanding shares in the open market, depending upon the circumstances. If on the payment date of a dividend or distribution the NAV per share is equal to or less than the closing market price (plus estimated per share fees in connection with the purchase of shares), the Plan Agent will invest the dividend or distribution in newly issued shares. The number of newly issued shares to be credited to each participant's account will be determined by dividing the amount of the participant's cash dividend or distribution by the greater of the NAV per share on the payment date or 95% of the closing market price per share on the payment date. If on the payment date the NAV per share is greater than the closing market price per share (plus per share fees), the Plan Agent will invest the dividend or distribution in shares acquired in open-market purchases. The per share price for open-market purchases will be the weighted average price of the shares on the payment date.

Stock Purchase Plan. All registered shareholders can voluntarily purchase additional shares in the Fund at any time through the Plan Agent. The minimum investment under this option is $50. Participants can make an investment online or by sending a check to the Plan Agent. Each investment will entail a transaction fee of $5.00 plus $0.05 per share purchased. Shareholders can also authorize the Plan Agent to make automatic withdrawals from a bank account.

Each automatic transaction will entail a fee of $2.50 plus $0.05 per share purchased. There is a $25 charge for each returned check or rejected electronic funds transfer.

Amendment or Termination of Plan. The Fund reserves the right to amend or terminate the Plan upon notice in writing to each participant at least 30 days prior to any record date for the payment of any dividend or distribution by the Fund.

Plan Agent. You can contact the Plan Agent at www.computershare.com/investor, at P.O. Box 30170, College Station, TX 77842-3170 or at 1-800-426-5523.

39

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OPPORTUNITIES FUND

New York Stock Exchange Symbol: THQ
NAV Symbol: XTHQX

100 Federal Street, 19th Floor
Boston, Massachusetts 02110
(617) 772-8500
www.teklacap.com

Officers

Daniel R. Omstead, Ph.D., President
Laura Woodward, CPA, Chief Compliance Officer,
Secretary and Treasurer

Trustees

Michael W. Bonney
Rakesh K. Jain, Ph.D.
Daniel R. Omstead, Ph.D.
Oleg M. Pohotsky, M.B.A., J.D.
William S. Reardon
Uwe E. Reinhardt, Ph.D.
Lucinda H. Stebbins, CPA

Investment Adviser

Tekla Capital Management LLC

Administrator & Custodian

State Street Bank and Trust Company

Transfer Agent

Computershare, Inc.

Legal Counsel

Dechert LLP

Shareholders with questions regarding share transfers may call

1-800-426-5523

Daily net asset value may be obtained from
our website (www.teklacap.com) or by calling

617-772-8500

Item 2.  CODE OF ETHICS.

(a)As of the end of the period covered by this report, the Registrant has adopted a code of ethics that applies to the Registrant’s principal executive officer, principal financial officer, principal accounting officer or controller, or persons performing similar functions, regardless of whether these individuals are employed by the Registrant or a third party.

(b)No disclosures are required by this Item.

(c)During the period covered by this report, the Registrant did not make any substantive amendment to the code of ethics.

(d)During the period covered by this report, the Registrant did not grant any waiver, including any implicit waiver, from any provision of the code of ethics.

(e)Not applicable.

(f)A copy of the Registrant’s code is filed as Exhibit 1 to this Form N-CSR.  Copies of the Code will also be made available, free of charge, upon request, by writing or calling Tekla Capital Management LLC at 100 Federal Street, 19th Floor, Boston, MA  02110, (617) 772-8500.

ITEM 3. AUDIT COMMITTEE FINANCIAL EXPERT.

The Registrant’s Board of Trustees has determined that the Registrant has at least one audit committee financial expert serving on its audit committee.  The audit committee financial expert is Oleg M. Pohotsky.  He is “independent” for the purposes of Item 3.

ITEM 4. PRINCIPAL ACCOUNTANT FEES AND SERVICES.

(a)Audit Fees.  The aggregate fees billed in each of the last two fiscal years for professional services rendered by the principal accountant for the audit of the Registrant’s annual financial statements or services that are normally provided by the accountant in connection with statutory and regulatory filings or engagements for those fiscal years were $37,080 for the fiscal year ended September 30, 2017 and $36,000 for the fiscal year ended September 30, 2016.

(b)Audit Related Fees.  The Registrant was not billed any fees in each of the last two fiscal years ended September 30 for assurance and related services by the principal accountant that are reasonably related to the performance of the audit of the Registrant’s financial statements and not otherwise included above.

(c)Tax Fees.  The aggregate fees billed in each of the last two fiscal years for professional services rendered by the principal accountant for tax compliance, tax advice, and tax planning were $5,500 for the fiscal year ended September 30, 2017 and $4,650 for the fiscal year ended September 30, 2016.  The nature of the services comprising the fees disclosed under this category was tax compliance.

(d)All Other Fees.  The aggregate fees billed in each of the last two fiscal years ended September 30 for products and services provided by the principal accountant, other than the services reported in paragraphs (a) through (c) of this Item were $0 for the fiscal year ended September 30, 2017 and $0 for the fiscal year ended September 30, 2016. The nature of the services comprising the fees disclosed under this category was services related to the initial public offering of the Registrant.

(e)(1)  Pre-approval Policies and Procedures.

Pursuant to the Registrant’s Audit Committee Charter (“Charter”), the Audit Committee is responsible for approving in advance the firm to be employed as the Registrant’s independent auditor.  In addition, the Charter provides

that the Audit Committee is responsible for approving any and all proposals by the Registrant, its investment adviser or their affiliated persons or any entity controlling, controlled by, or under common control with the adviser that provides services to the Registrant to employ the independent auditor to render permissible non-audit services related directly to the operations and financial reporting of the Registrant.  In determining whether to pre-approve non-audit services, the Audit Committee considers whether such services are consistent with the independent auditor’s independence.  The Charter further permits the Audit Committee to delegate to one or more of its members authority to pre-approve permissible non-audit services to the registrant, provided that any pre-approval determination of a delegate is for services with an estimated budget of less than $15,000.

(2)None of the services described in each of paragraphs (b) through (d) of this Item were approved by the Audit Committee pursuant to paragraph (c)(7)(i)(C) of Rule 2-01 of Regulation S-X.  All services described in paragraphs (b) through (d) of the NCSR were approved in advance by the Audit Committee of each Fund.

(f)Not applicable.

(g)None.

(h)Not applicable.

ITEM 5.  AUDIT COMMITTEE OF LISTED REGISTRANTS.

The Registrant has a separately-designated standing Audit Committee established in accordance with Section 3(a)(58)(A) of the Exchange Act (15 U.S.C. 78c(a)(58)(A)).  The members of the Audit Committee are Oleg M. Pohotsky, Uwe E. Reinhardt (deceased 11/17), Lucinda H. Stebbins and William S. Reardon.

ITEM 6.  INVESTMENTS.

The Registrant’s Schedule of Investments is included as part of the Report to Shareholders filed under Item 1 of this form.

ITEM 7.  DISCLOSURE OF PROXY VOTING POLICIES AND PROCEDURES FOR CLOSED-END MANAGEMENT INVESTMENT COMPANIES.

The Registrant has adopted the following proxy voting policies and procedures.

PROXY VOTING POLICIES AND PROCEDURES

Policy

The following are the policies and procedures adopted and implemented by Tekla Capital Management LLC (“TCM”) for voting proxies with respect to portfolio securities held by Tekla Healthcare Investors,Tekla Life Sciences Investors, Tekla Healthcare Opportunities Fund and Tekla World Healthcare Fund (each a “Fund” and collectively the “Funds”). The policies and procedures are reasonably designed to ensure that proxies are voted in the best interest of the Funds and the Funds’ shareholders, in accordance with TCM’s fiduciary duties and Rule 206(4)-6 under the Investment Advisers Act of 1940 (the “Investment Advisers Act”). TCM considers the “best interests” of the Funds and their shareholders to mean their best long-term economic interests.

TCM shall vote proxies for the exclusive benefit, and in the best economic interest, of the Funds and their shareholders. Such exercise of voting rights shall be subject to the same standard of care as is generally applicable to TCM’s performance of its duties, as set forth in the advisory agreements with the Funds. The policies and procedures contained herein are designed to be guidelines, however each vote is ultimately cast on a case-by-case basis, taking into consideration the relevant facts and circumstances at the time of the vote. Any material conflicts that may arise will be resolved in the best interests of the Funds and their shareholders.

A proxy committee has been designated and is responsible for administering and overseeing the proxy voting process. The committee consists of the President of TCM, TCM’s Chief Compliance Officer (“CCO”), and the analyst responsible for oversight of the company that is the subject of the proxy.  The committee considers proxy questions and determines the vote on behalf of the Funds.

Procedures

Logistics

TCM’s CCO shall be responsible for maintaining the proxy log, monitoring corporate actions and confirming the timely voting of proxies. The proxy log shall contain the following information, in accordance with Form N-PX:

·the name of the issuer;

·the exchange ticker symbol, if available;

·the CUSIP number, if available;

·the shareholder meeting date;

·a brief identification of the matter voted on;

·whether the matter was proposed by the issuer or a security holder;

·whether TCM cast its vote on the matter;

·how TCM cast its vote on the matter (for, against, abstain; for or withhold regarding the election of directors); and

·whether TCM cast its vote for or against management;

TCM’s CCO shall also record whether any conflicts of interest have been identified and, if so, what action was taken to resolve the conflict with respect to each vote cast and each abstention.

Substantive Voting Decisions

TCM’s substantive voting decisions turn on the particular facts and circumstances of each proxy vote. The following is a list of common proxy vote issues and TCM’s standard considerations when determining how to vote such proxies.

Routine Matters/Corporate Administrative Items. After an initial review, TCM generally votes with management on routine matters related to the operation of the issuer that are not expected to have a significant economic impact on the issuer and/or its shareholders.

Potential for Major Economic Impact. TCM may review and analyze on a case-by-case basis, non-routine proposals that are more likely to affect the structure and operation of the issuer and to have a greater impact on the value of the investment.

Corporate Governance. TCM may review and consider corporate governance issues related to proxy matters and generally supports proposals that foster good corporate governance practices.

Special Interest Issues. TCM may consider: (i) the long-term benefit to shareholders of promoting corporate accountability and responsibility on social issues; (ii) management’s responsibility with respect to special interest issues; (iii) any economic costs and restrictions on management; and (iv) the responsibility of TCM to vote proxies for the greatest long-term shareholder value.

Limitations on Director Tenure and Retirement. TCM may consider: (i) a reasonable retirement age for directors, e.g. 70 or 72; (ii) the introduction of new perspectives on the board; and (iii) the arbitrary nature of such limitations and the possibility of detracting from the board’s stability and continuity.

Directors’ Minimum Stock Ownership. TCM may consider: (i) the benefits of additional vested interest; (ii) the ability of a director to serve a company well regardless of the extent of his or her share ownership; and (iii) the impact of limiting the number of persons qualified to be directors.

D&O Indemnification and Liability Protection. TCM may consider: (i) indemnifying directors for acts conducted in the normal course of business; (ii) limiting liability for monetary damages for violating the duty of care; (iii) expanding coverage beyond legal expenses to acts that represent more serious violations of fiduciary obligation than carelessness (e.g. negligence); and (iv) providing expanded coverage in cases when a director’s legal defense was unsuccessful if the director was found to have acted in good faith and in a manner that he or she reasonably believed was in the best interests of the issuer.

Director Nominations in Contested Elections. TCM may consider: (i) long-term financial performance of the issuer relative to its industry; (ii) management’s track record; (iii) background to proxy contest; (iv) qualifications of both slates of nominees; (v) evaluations of what each side is offering shareholders as well as the likelihood that the proposed objectives and goals can be met; and (vi) stock ownership positions.

Cumulative Voting. TCM may consider: (i) the ability of significant stockholders to elect a director of their choosing; (ii) the ability of minority shareholders to concentrate their support in favor of a director or directors of their choosing; and (iii) the potential to limit the ability of directors to work for all shareholders.

Classified Boards.  TCM may consider: (i) providing continuity; (ii) promoting long-term planning; and (iii) guarding against unwanted takeovers.

Poison Pills. TCM may consider: (i) TCM’s position on supporting proposals to require a shareholder vote on other shareholder rights plans; (ii) ratifying or redeeming a poison pill in the interest of protecting the value of the issuer; and (iii) other alternatives to prevent a takeover at a price demonstrably below the true value of the issuer.

Fair Price Provisions. TCM may consider: (i) the vote required to approve the proposed acquisition; (ii) the vote required to repeal the fair price provision; (iii) the mechanism for determining fair price; and (iv) whether these provisions are bundled with other anti-takeover measures (e.g., supermajority voting requirements) that may entrench management and discourage attractive tender offers.

Equal Access. TCM may consider: (i) the opportunity for significant shareholders of the issuer to evaluate and propose voting recommendations on proxy proposals and director nominees, and to nominate candidates to the board; and (ii) the added complexity and burden.

Charitable Contributions. TCM may consider: (i) the potential benefits to shareholders; (ii) the potential to detract the issuer’s resources from more direct uses of increasing shareholder value; and (iii) the responsibility of shareholders to make individual contributions.

Stock Authorizations: TCM may consider: (i) the need for the increase; (ii) the percentage increase with respect to the existing authorization; (iii) voting rights of the stock; and (iv) overall capitalization structures.

Preferred Stock. TCM may consider: (i) whether the new class of preferred stock has unspecified voting, conversion, dividend distribution, and other rights; (ii) whether the issuer expressly states that the stock will not be used as a takeover defense or carry superior voting rights; (iii) whether the issuer specifies the voting, dividend, conversion, and other rights of such stock and the terms of the preferred stock appear reasonable; and (iv) whether the stated purpose is to raise capital or make acquisitions in the normal course of business.

Director Compensation. TCM may consider: (i) whether director shares are at the same market risk as those of the shareholders; and (ii) how option programs for outside directors compare with the standards of internal programs.

Golden and Tin Parachutes. TCM may consider: (i) whether they will be submitted for shareholder approval; and (ii) the employees covered by the plan and the quality of management.

Compensation. TCM may consider: (i) Whether the company has an independent compensation committee; (ii) whether the compensation committee engaged independent consultants; (iii) whether the compensation committee has lapsed or waived equity vesting restrictions; and (iv) whether the company has adopted or extended a Golden Parachute without shareholder approval. TCM will generally support annual advisory votes on executive compensation.

Limitations

TCM may abstain from voting a proxy if it concludes that the effect on shareholders’ economic interests or the value of the portfolio holding is indeterminable or insignificant. TCM may abstain from voting a proxy if it concludes that the cost of voting is disproportionate to the economic impact the vote would have on the portfolio holdings. With respect to certain privately held companies, TCM may not have the opportunity to vote or may have a limitation on its ability to vote. For example, in certain cases a company may be permitted by its charter or other governing documents to take action without a shareholder meeting and with written consent of fewer than all shareholders.

Conflicts of Interest

The Proxy Committee identifies any potential conflicts of interest.  Each potential conflict must be addressed in a manner which will be in the best interest of the Funds and their shareholders. If any potential conflict is identified the Proxy Committee consults with the Funds’ counsel.  Where conflicts of interest arise between clients and TCM, TCM may convene an ad-hoc committee to debate the conflict and to give a ruling on a preferred course of action. If the ad-hoc committee determines that TCM has a conflict of interest in any instance, TCM’s CCO shall disclose the conflict to the Board and seek voting instructions.

TCM may cause the proxies to be voted in accordance with the recommendations of an independent third party service provider that TCM may use to assist in voting proxies.

Disclosure

The following disclosure shall be provided in connection with these policies and procedures:

·TCM shall provide a description or a copy of these policies and procedures to the Boards of Trustees of the Funds annually and upon request.

·TCM shall make available to the Funds its proxy voting records, for inclusion on the Funds’ Form N-PX.

·TCM shall include its proxy voting policies and procedures in its annual filing on Form N-CSR.

·TCM shall cause the Funds’ shareholder reports to include a statement that a copy of these policies and procedures is available upon request (i) by calling a toll-free number; (ii) on the Funds’ website, (if the Funds choose); and (iii) on the SEC’s website.

·TCM shall cause the Funds’ annual and semi-annual reports to include a statement that information is available regarding how the Funds voted proxies during the most recent twelve-month period (i) without charge, upon request, either by calling a toll-free number or on or through the Funds’ website, or both; and (ii) on the SEC’s website.

Recordkeeping

TCM shall maintain records of proxies voted in accordance with Section 204-2 of the Advisers Act, including proxy statements, a record of each vote cast, and a copy of any document created by the Adviser that was material to making a decision of how to vote the proxy, or that memorializes the basis for the Adviser’s decision on how to vote the proxy. TCM shall also maintain a copy of its policies and procedures and each written request from a client for proxy voting records and the Adviser’s written response to any client request, either written or oral, for such records. Proxy statements that are filed on EDGAR shall be considered maintained by TCM. All such records shall be maintained for a period of five years in an easily accessible place, the first two years in the offices of TCM.

ITEM 8.  PORTFOLIO MANAGERS OF CLOSED-END MANAGEMENT INVESTMENT COMPANIES.

(a)(1)As of December 5, 2017, Daniel R. Omstead, Ph.D., Jason C. Akus, M.D./M.B.A., Timothy Gasperoni, Ph.D, M.B.A., Christian M. Richard, M.S, M.B.A,  Henry Skinner, Ph.D., Amanda Birdsey-Benson, Ph.D., Alan Kwan, Ph.D, M.B.A., Christopher Abbott and Robert Benson, CFA®, CAIA are members of a team that analyzes investments on behalf of the Registrant.  Dr. Omstead exercises ultimate decision making authority with respect to investments.  Dr. Omstead also performs other duties including management of the investment adviser and makes investments on behalf of Tekla Healthcare Investors (“HQH”), Tekla Life Science Investors (“HQL”), and Tekla World Healthcare Fund (“THW”).  The date each team member joined the portfolio management team and each team member’s business experience for at least the last five years is included below.

Daniel R. Omstead, Ph.D. is President and Chief Executive Officer of the investment adviser and has been employed by the investment adviser of the Registrant since 2000. He is also President of the Registrant, HQH, HQL and THW.

Jason C. Akus, M.D./M.B.A. is Senior Vice President, Research of the investment adviser and is responsible for investment research and due diligence in the biotechnology, medical device, and diagnostic areas. Dr. Akus joined the investment adviser of the Registrant in 2001.

Timothy Gasperoni, Ph.D., M.B.A. is Senior Vice President, Research of TCM. He was previously a Senior Analyst and Founding Member of Sabby Capital and was a Partner and Senior Analyst at Crosswind Investments, LLC.  He joined TCM in 2015.

Christian M. Richard, M.S., M.B.A. is Senior Vice President, Research of TCM. He was previously a Partner/Head of Research for Merlin Biomed Private Equity, Merlin. He joined TCM in 2015.

Henry Skinner, Ph.D. is Senior Vice President, Venture of TCM. He was previously Vice President and Deputy Head and Managing Director of the Novartis Venture Fund. He joined TCM in October 2017.

Amanda Birdsey-Benson, Ph.D. is Senior Analyst of TCM. She was previously an analyst for R.A. Capital Management.  She joined TCM in 2014.

Alan Kwan, Ph.D., M.B.A. is Senior Analyst of TCM. He was previously a Principal Investigator at GlaxoSmithKline, plc. He joined TCM in 2014.

Christopher Abbott, is Senior Analyst of TCM.  Previously, Mr. Abbott spent 8 years at Leerink Partners where he was a Vice President on the Equity Research team covering the Healthcare IT and Healthcare Supply Chain group. He joined TCM in 2016.

Robert Benson, CFA®, CAIA, is Senior Analyst, Research. Previously, Mr. Benson spent 12 years at State Street Global Advisors (SSgA) where he performed quantitative research for asset allocation, equities, and alternatives teams. He joined TCM in 2016.

(a)(2)The following table lists the number and types of other accounts and assets under management in those accounts advised by the Registrant’s portfolio management team as of the end of the Registrant’s fiscal year.

	REGISTERED
	INVESTMENT
PORTFOLIO	COMPANY	ASSETS		POOLED	ASSETS	OTHER	ASSETS
MANAGER	ACCOUNTS	MANAGED		ACCOUNTS	MANAGED	ACCOUNTS	MANAGED
Daniel R. Omstead	3	$	2,124 million	0	0	0	0
Jason C. Akus	3	$	2,124 million	0	0	0	0
Christian Richard	3	$	2,124 million	0	0	0	0
Timothy Gasperoni	3	$	2,124 million	0	0	0	0
Henry Skinner	3	$	2,124 million	0	0	0	0
Amanda Birdsey-Benson	3	$	2,124 million	0	0	0	0
Alan Kwan	3	$	2,124 million	0	0	0	0
Christopher Abbott	3	$	2,124 million	0	0	0	0
Robert Benson	3	$	2,124 million	0	0	0	0

None of the funds or other accounts is subject to a performance-based advisory fee.

Each member of the portfolio management team may perform investment management services for other accounts similar to those provided to the Registrant and the investment action for each account may differ. The portfolio management team may discover an investment opportunity that may be suitable for more than one account. However, the investment opportunity may be limited so that all accounts may not be able to fully participate or an investment opportunity or investment allocation may be allocated to just one account or may be allocated between accounts at different levels based on an investment decision made by the investment team.  The investment team may subsequently make investment decisions that result in investment levels that make the accounts more differentiated or, conversely, more closely or completely aligned.  Such investment decisions may occur within a day or two.  In addition, the investment adviser may receive different compensation from each account. In that case, the portfolio management team may have an incentive to direct investments to an account that could result in higher fees for the investment adviser. The registrant has adopted procedures designed to allocate investments fairly across multiple accounts.

Additionally, a portfolio manager may be perceived to have a conflict of interest if he has other executive management responsibilities.  In addition to managing the Registrant, HQH, HQL and THW, Dr. Omstead is the President of the investment adviser of the Registrant.  Dr. Omstead periodically discusses the amount of time he allocates to each of his responsibilities with the Registrant’s Board of Trustees.

The portfolio management team’s management of personal accounts may also present certain conflicts of interest.  The Registrant has adopted a code of ethics designed to address these potential conflicts.

(a)(3)As of September 30, 2017, portfolio manager compensation is comprised of a base salary and discretionary compensation as described below.

Base Salary Compensation.  The team members receive a base salary compensation linked to individual experience and responsibilities. The amount of base salary is reviewed annually.

Discretionary Compensation.  Discretionary Compensation is in the form of a cash bonus, paid annually, which may be up to 60% of the team member’s base salary. Several factors affect discretionary compensation, which can vary by team member and circumstances. The discretionary compensation component is determined based on factors including investment performance of accounts managed by the team predominantly relative to the S&P 500 Index and a blended consideration of appropriate healthcare indices and related performance metrics during the Fund’s fiscal year, performance of specific investments proposed by the individual, financial performance of the investment adviser and a qualitative assessment of the individual overall contribution to the investment team and to the investment adviser. Discretionary compensation is evaluated annually after the completion of the Registrant’s fiscal year.

(a)(4)As of September 30, 2017, the dollar range of Registrant’s shares beneficially owned by the portfolio managers are as follows as of the end of the Registrant’s fiscal year:

PORTFOLIO MANAGER	DOLLAR RANGE OF SHARES BENEFICIALLY OWNED
Daniel R. Omstead	$10,001-$50,000
Jason C. Akus	none
Christian Richard	none
Timothy Gasperoni	none
Henry Skinner	none
Amanda Birdsey-Benson	none
Alan Kwan	none
Christopher Abbott	none
Robert Benson	none

(b) N/A.

ITEM 9.  PURCHASES OF EQUITY SECURITIES BY CLOSED-END MANAGEMENT INVESTMENT COMPANY AND AFFILIATED PURCHASERS.

Period	(a) Total No. of Shares Purchased (1)	(b) Average Price Paid per Share		(c) Total No. of Shares Purchased as Part of Publicly Announced Plans or Programs	(d) Maximum No. of Shares that May Yet Be Purchased Under the Plans or Programs
Month #1 (Oct. 1, 2016 - Oct. 31, 2016)	159,752	$	17.13	159,752	4,952,503
Month #2 (Nov. 1, 2016 – Nov. 30, 2016)	49,247	$	15.51	49,247	4,903,256
Month #3 (Dec. 1, 2016 – Dec. 31, 2016)					4,903,256
Month #4 (Jan. 1, 2017 – Jan. 31, 2017)					4,903,256
Month #5 (Feb. 1, 2017 – Feb. 28, 2017)					4,903,256
Month #6 (Mar. 1, 2017 – Mar. 31, 2017)					4,903,256
Month #7 (Apri. 1, 2017 – Apri. 30, 2017)					4,903,256
Month #8 (May 1, 2017 – May 31, 2017)					4,903,256
Month #9 (June 1, 2017 – June 30, 2017)					4,903,256
Month #10 (Jul. 1, 2017 – Jul. 31, 2017)					5,221,931
Month #11 (Aug. 1, 2017 – Aug. 31, 2017)					5,221,931
Month #12 (Sep. 1, 2017 – Sep. 30, 2017)					5,221,931
Total	208,999	$	16.75	208,999

(1)On March 19, 2015, the share repurchase program was announced, which has been subsequently reviewed and approved by the Board of Trustees.  On March 24, 2016, the Trustees approved the renewal of the repurchase program, allowing the Registrant to repurchase up to 12% of its outstanding shares in the open market for a one year period ending July 10, 2017. On March 23, 2017, the Trustees approved the renewal of the share repurchase program allowing the Registrant to repurchase up to 12% of its outstanding shares in the open market for a one year period ending July 14, 2018.

ITEM 10. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS.

There have been no material changes, to the procedures by which the shareholders may recommend nominees to the Registrant’s Board of Trustees, where those changes were implemented after the Registrant last provided disclosure in response to

the requirements of Item 407(c)(2)(iv) of Regulation S-K (17 CFR229.407)(as required by Item 22(b)(15) of Schedule 14A (17 CFR240.14a-101)), or this Item.

ITEM 11. CONTROLS AND PROCEDURES.

(a)In the opinion of the principal executive officer and principal financial officer, based on their evaluation which took place within 90 days of this filing, the Registrant’s disclosure controls and procedures are adequately designed and are operating effectively to ensure (i) that material information relating to the Registrant, including its consolidated subsidiaries, is made known to them by others within those entities, particularly during the period in which this report is being prepared; and (ii) that information required to be disclosed by the registrant on Form N-CSR is recorded, processed, summarized and reported within the time period specified in the Securities and Exchange Commission’s rules and forms.

(b)There were no changes in the Registrant’s internal control over financial reporting that occurred during the Registrant’s most recent fiscal half-year that have materially affected or that are reasonably likely to materially affect the Registrant’s internal control over financial reporting.

ITEM 12. EXHIBITS.

(a)(1)  The Code of Ethics that is the subject of the disclosure required by Item 2 is attached hereto (Exhibit 1).

(a)(2)  Separate certifications of the Principal Executive and Financial Officers as required by Rule 30a-2(a) under the 1940 Act and Section 302 of the Sarbanes-Oxley Act of 2002 are attached hereto (Exhibit 2 and 3).

(a)(3)  Notice to Fund’s shareholders in accordance with Investment Company Act Section 19(a) and Rule 19a-1(Exhibit 4).

(b)Certifications pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 are attached hereto (Exhibit 5).

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

(Registrant)		TEKLA HEALTHCARE OPPORTUNITIES FUND
By (Signature and Title)*			/s/ Daniel R. Omstead
			Daniel R. Omstead, President
Date:	12/5/17

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

By (Signature and Title)*		/s/ Laura Woodward
		Laura Woodward, Treasurer
Date:	12/5/17

* Print the name and title of each signing officer under his or her signature.

EX-99.CODEETH

Exhibit 99.CODEETH

Exhibit 1

Sarbanes-Oxley Code of Ethics

Introduction

The Board of Trustees of Tekla Life Sciences Investors, Tekla Healthcare Investors, Tekla Healthcare Opportunities Fund and Tekla World Healthcare Fund (each a “Fund”) has established this Code of Ethics (“Code”) in accordance with the Sarbanes-Oxley Act of 2002 and the rules promulgated thereunder. This Code does not supersede or otherwise affect the separate code of ethics that the Fund and its investment adviser have adopted pursuant to Rule 17j-1 under the Investment Company Act of 1940, as amended (“1940 Act”).

This Code is designed to deter wrongdoing and promote: (i) honest and ethical conduct, including the ethical handling of actual or apparent conflicts of interest between personal and professional relationships; (ii) full, fair, accurate, timely, and understandable disclosure in reports and documents that the Fund files with, or submits to, the Securities and Exchange Commission (“SEC”) and in other public communications made by the Fund; (iii) compliance with applicable governmental laws, rules, and regulations; (iv) the prompt internal reporting of violations of the Code to an appropriate person or persons; and (v) accountability for adherence to the Code. The Code applies to the Funds’ President, Treasurer, Secretary and Assistant Treasurer (collectively, “Covered Officers,” each of whom is set forth in Exhibit A).

A.Principles of Honest and Ethical Conduct

1. General Objectives

The Fund expects all Covered Officers to adhere to the highest possible standards of honest and ethical conduct. All Covered Officers are expected to handle actual or apparent conflicts of interest between personal and professional relationships in a manner that is above reproach, and to place the interests of the Fund above their own personal interests.

2. Conflicts of Interest

All Covered Officers should be scrupulous in avoiding a conflict of interest with regard to the Fund’s interests. A conflict of interest occurs when an individual’s private interest interferes in any way with the interests of the Fund. This includes any specific situation or transaction that the Trustees of the Fund who are not interested persons as defined in the 1940 Act, would consider to create the appearance of a conflict of interest. A conflict situation can arise when a Covered Officer takes actions or has interests that may make it difficult to perform his or her work for the Fund objectively and effectively.  Conflicts of interest also arise when a Covered Officer, or a member of his or her family, receives improper benefits as a result of his or her position with the Fund, whether such benefits are received from the Fund or a third party.  Any conflict of interest that arises in a specific situation or transaction must be disclosed by the Covered Officer and resolved before taking any action.

Conflicts of interest may not always be evident, and Covered Officers should consult with the Funds’ Chief Compliance Officer or the Funds’ legal counsel if they are uncertain about any situation.

Examples of possible conflicts of interest include:

i)Outside Employment or Activities.  Covered Officers may not engage in any outside employment or activity that interferes with their performance or responsibilities to the

Fund or is otherwise in conflict with or prejudicial to the Fund.  A Covered Officer must disclose to the Funds’ Chief Compliance Officer any outside employment or activity that may constitute a conflict of interest and obtain the Funds’ Chief Compliance Officer’s approval before engaging in any such employment or activity.

ii)Gifts.Covered Officers may not accept gifts or other items of more than small value, consistent with industry standards from any person or entity that does business with or on behalf of the Fund.

iii)Other Situations.  Because other conflicts of interest may arise, it would be impractical to attempt to list all possible situations in this Code. If a proposed transaction or situation raises questions or doubts, a Covered Officer should consult with the Funds’ Chief Compliance Officer before engaging in the transaction or activity.

1.Corporate Opportunities

Covered Officers may not exploit for their own personal gain, or for the personal gain or their family members or relatives, opportunities that are discovered through the use of Fund property, information, or position, unless the opportunity is first disclosed fully in writing to the Board of Trustees and the Board of Trustees declines to pursue such opportunity.

B.Full, Fair, Accurate, Timely, and Understandable Disclosure in Fund Disclosure and Reporting Documents

As registered investment companies, it is of critical importance that the Funds’ public communications, reports, and filings contain full, fair, accurate, timely, and understandable disclosure. Accordingly, Covered Officers are expected to consider it central to their roles as officers of the Funds to promote full, fair, accurate, timely, and understandable disclosure in the Funds’ public communications and reports, and in the documents that the Funds file with, or submits to, the Securities and Exchange Commission (the “SEC”).

Depending on his or her position with the Funds, a Covered Officer may be called upon to provide necessary information to make the Funds’ public reports, communications, and SEC filings and submissions complete, fair, and understandable. The Funds expect Covered Officers to take this responsibility very seriously and to provide prompt and accurate answers to inquiries related to the Funds’ public disclosure requirements. Covered Officers may be asked to certify the accuracy of all responses and information provided for inclusion in the Funds’ public reports, communications, and SEC filings and submissions.

C.Compliance with Applicable Governmental Rules and Regulations

As registered investment companies, the Funds are subject to regulation by the SEC and must comply with Federal securities laws and regulations, as well as other applicable laws.  The Funds insist on strict compliance with the spirit and the letter of these laws and regulations. Each Covered Officer shall cooperate with Fund counsel, the Funds’ independent accountants, and the Funds’ other service providers with the goal of maintaining the Funds’ material compliance with applicable governmental rules and regulations.

The Funds expect their Covered Officers to comply with all laws, rules, and regulations applicable to the Funds’ operations and business. Covered Officers should seek guidance whenever they are in doubt as to the applicability of any law, rule, or regulation, or regarding any

contemplated course of action. Covered Officers should also make use of the various guidelines which the Funds and their service providers have prepared on specific laws and regulations.  If in doubt on a course of action, a good guideline is “always ask first, act later” — if you are unsure of what to do in any situation, seek guidance before you act.

Covered Officers are encouraged to attend courses and seminars for the purpose of keeping themselves apprised of developments relating to those governmental statutes, rules, and regulations applicable to the Funds.

Upon obtaining knowledge of any material violation of any applicable law, rule, or regulation by the Funds or a person acting with or on behalf of the Fund, a Covered Officer shall report such violation to the Funds’ Chief Compliance Officer, Fund counsel, or both. (See Section VI of the Code for a discussion of reporting Code violations.) Each Covered Officer shall cooperate or take such steps as may be necessary or appropriate to remedy any such material violation.

D.Confidentiality

Covered Officers must maintain the confidentiality of information entrusted to them by the Funds, except when disclosure is authorized by Fund counsel or required by laws or regulations. Whenever possible, Covered Officers should consult with Fund counsel if they believe they have a legal obligation to disclose confidential information. Confidential information includes all non-public information that might be of use to competitors, or harmful to the Funds or their shareholders, if disclosed. The obligation to preserve confidential information continues even after employment as a Covered Officer ends.

E.Prompt Internal Reporting of Violations of the Code; Evaluation of Possible Violations; Determination of Sanctions

1.Reporting to the Funds’ Chief Compliance Officer

A Covered Officer shall promptly report knowledge of, or information concerning, any material violation of this Code to the Funds’ Chief Compliance Officer. Any such report shall preferably be in writing, and shall describe in reasonable detail the conduct that such Covered Officer believes to have violated this Code. The Funds’ Chief Compliance Officer shall also have the authority to draft a report of a suspected material violation of the Code, if no written report is made by a Covered Officer.

2.Evaluation of Reports

The Funds’ Chief Compliance Officer shall then consult with Fund counsel to the extent necessary to determine whether the reported conduct actually violates the Code. If it is determined that there has been a violation of the Code, the Funds’ Chief Compliance Officer will determine (in consultation with Fund counsel) whether the violation has had or may have, in the reasonable judgment of the Funds’ Chief Compliance Officer, a material adverse impact upon the Fund.

iNo Material Adverse Impact on the Funds.  If the Funds’ Chief Compliance Officer determines that the violation has not caused a material adverse impact upon the Fund, the Funds’ Chief Compliance Officer shall determine what sanctions, if any, may be appropriate for the violation. (See G of this Code for a discussion of possible sanctions.)

iiMaterial Adverse Impact on the Funds.  If the Funds’ Chief Compliance Officer determines that the violation has caused a material adverse impact upon the Fund, the Funds’ Chief Compliance Officer shall promptly notify the Board of such violation. The Board shall be entitled to consult with independent legal counsel to determine whether the violation actually has had a material adverse impact upon the Fund; to formulate sanctions, if any, appropriate for the violation; or for any other purpose that the Board, in its business judgment, determines to be necessary or advisable. (See G of this Code for a discussion of possible sanctions.)

3.Periodic Reports by the Funds’ Chief Compliance Officer to Board of Trustees.

The Funds’ Chief Compliance Officer shall report to the Board at each regularly scheduled Board meeting all violations of this Code (whether or not they caused a material adverse impact upon the Fund) and all sanctions imposed.

F.Waivers of Provisions of the Code

1.Waivers.

A Covered Officer may request a waiver of a provision of this Code if there is a reasonable likelihood that a contemplated action would be a material departure from a provision of the Code. Waivers will not be granted except under extraordinary or special circumstances.

The process of requesting a waiver shall consist of the following steps:

i.The Covered Officer shall set forth a request for waiver in writing and submit such request to the Funds’ Chief Compliance Officer. The request shall describe the conduct, activity, or transaction for which the Covered Officer seeks a waiver, and shall briefly explain the reason for engaging in the conduct, activity, or transaction.

ii.The determination with respect to the waiver shall be made in a timely fashion by the Funds’ Chief Compliance Officer, in consultation with Fund counsel, and submitted to the Board for ratification.

iii.The decision with respect to the waiver request shall be documented and kept in the Fund’s records for the appropriate period mandated by applicable law or regulation.

2.Disclosure of Waivers.

To the extent required by applicable law, waivers (including “implicit waivers”) shall be publicly disclosed on a timely basis. An “implicit waiver” is defined as the Fund’s failure to take action within a reasonable period of time regarding a material departure from a provision of the Code that has been made known to an “executive officer” of the Fund. For this purpose, an “executive officer” is a Fund’s President or Chief Executive Officer, Vice President (who is in charge of a principal policymaking function), or any other person who performs similar policymaking functions for the Fund. For the purpose of determining whether an “implicit waiver” has occurred, if a material departure from a provision of the Code is known only by the Covered Officer who has caused the material departure, the material departure will not be considered to have been made known to an executive officer of the Fund.

G.Accountability for Adherence to the Code

The matters covered in this Code are of the utmost importance to the Fund and its shareholders, and are essential to the Fund’s ability to conduct its business in accordance with its stated values. Covered Officers are expected to adhere to these rules in carrying out their duties for the Fund.

The Fund will, if appropriate, take action against any Covered Officer whose actions are found to violate this Code. Sanctions for violations of the Code may include, among other things, a requirement that the violator undergo training related to the violation, a letter of sanction, the imposition of a monetary penalty, and/or suspension or termination of the employment of the violator. Where the Fund has suffered a loss because of violations of this Code or applicable laws, regulations, or rules, it may pursue its remedies against the individuals or entities responsible.

H.Recordkeeping

1.General.

The Fund requires accurate recording and reporting of information in order to make responsible business decisions. All of the Fund’s books, records, accounts and financial statements must be maintained in reasonable detail, must appropriately reflect the Fund’s transactions and must conform both to applicable legal requirements and to the Fund’s system of internal controls.

2.Code of Ethics Records.

A copy of this Code, any amendments hereto, and any reports or other records created in relation to waivers of or amendments to provisions of this Code shall be kept as records of the Fund for six years from the end of the fiscal year in which such document was created. Such records shall be furnished to the SEC or its staff upon request.

I.Amendments to the Code

The Covered Officers and the Funds’ Chief Compliance Officer are encouraged to recommend improvements to this Code to the Board, and the Board may amend the Code in its discretion. In connection with any amendment to the Code, the Funds’ Chief Compliance Officer shall prepare a brief description of the amendment, in order that this description may be disclosed in accordance with applicable law and regulations.

Exhibit A: Covered Officers

Daniel R. Omstead, President

Laura Woodward, Treasurer and Secretary

EX-99.CERT

Exhibit 99.CERT

EXHIBIT 2: CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER

I, Daniel R. Omstead, certify that:

1.I have reviewed this report on Form N-CSR of TEKLA HEALTHCARE OPPORTUNITIES FUND;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations, changes in net assets, and cash flows (if the financial statements are required to include a statement of cash flows) of the registrant as of, and for, the periods presented in this report;

4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940) and internal control over financial reporting (as defined in Rule 30a-3(d) under the Investment Company Act of 1940) for the registrant and have:

(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of a date within 90 days prior to the filing date of this report based on such evaluation; and

(d)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the second fiscal quarter of the period covered by this report that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.The registrant’s other certifying officer(s) and I have disclosed to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize, and report financial information; and

(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date:	12/5/17	/s/ Daniel R. Omstead
		Name: Daniel R. Omstead
		Title: President

EXHIBIT 3: CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER

I, Laura Woodward, certify that:

1.I have reviewed this report on Form N-CSR of TEKLA HEALTHCARE OPPORTUNITIES FUND;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations, changes in net assets, and cash flows (if the financial statements are required to include a statement of cash flows) of the registrant as of, and for, the periods presented in this report;

4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940) and internal control over financial reporting (as defined in Rule 30a-3(d) under the Investment Company Act of 1940) for the registrant and have:

(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of a date within 90 days prior to the filing date of this report based on such evaluation; and

(d)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the second fiscal quarter of the period covered by this report that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.The registrant’s other certifying officer(s) and I have disclosed to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize, and report financial information; and

(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date:	12/5/17	/s/ Laura Woodward
		Name: Laura Woodward
		Title: Treasurer

EX-99.SECTION 19(A)

Exhibit 99.Section 19(a)

EXHIBIT 4: SECTION 19(a) NOTICE TO FUND’S SHAREHOLDERS

TEKLA HEALTHCARE OPPORTUNITIES FUND

Notification of Sources of Distribution

Distribution Paid Date: May 31, 2017

Distribution Amount Per Common Share: $0.1125

The following table sets forth the estimated amounts of the current distribution, paid May 31, 2017, and the cumulative distributions paid this fiscal year-to-date from the following sources: net investment income, net realized short-term capital gains, net realized long-term capital gains, return of capital or other capital source. All amounts are expressed per common share.

			Percentage				Percentage Breakdown
			Breakdown		Total Cumulative		of the Total Cumulative
	Current		of Current		Distributions for the		Distributions for the
	Distribution		Distribution		Fiscal Year to Date(1)		Fiscal Year to Date(1)
Net Investment Income	$	0.0076	7	%	$	0.0941	10	%
Net Realized ST Cap Gains	$	0.0164	14	%	$	0.0243	3	%
Net Realized LT Cap Gains	$	0.0885	79	%	$	0.7816	87	%
Return of Capital or Other Capital Source	$	0.0000	0	%	$	0.0000	0	%
TOTAL (per common share):	$	0.1125	100	%	$	0.9000	100	%

The table below includes information relating to the Fund’s performance based on its NAV for certain periods.

Average annual total return at NAV for the period from inception through April 30, 2017(2)	8.15	%
Annualized current distribution rate expressed as a percentage of NAV as of April 30, 2017	7.11	%
Cumulative total return at NAV for the fiscal year, through April 30, 2017(3)	3.96	%
Cumulative fiscal year-to-date distribution rate expressed as a percentage of NAV as of April 30, 2017(1)	4.74	%

You should not draw any conclusions about the Fund’s investment performance from the amount of this distribution or from the terms of the Fund’s managed distribution plan.

The composition of this and subsequent distribution may vary from month to month because it may be materially impacted by future realized gains and losses on securities. The aggregate of the net unrealized depreciation of portfolio securities and net realized gains on sale of securities is -$1,112,001, of which $24,907,665 represents net unrealized depreciation of portfolio securities.

The amounts and sources of distributions reported in this 19(a) Notice are only estimates and not being provided for tax reporting purposes. The actual amounts and sources of the amounts for tax reporting purposes will depend upon the Fund’s investment experience during the remainder of its fiscal year and may be subject to changes based on tax regulations. The Fund will send you a Form 1099-DIV for the calendar year that will tell you how to report these distributions for federal income tax purposes.

(1)The Fund’s current fiscal year began on October 1, 2016.

(2)Inception date was July 29, 2014, which is the date of the initial public offering.

(3)Cumulative total return at NAV is the percentage change in the Fund’s NAV and includes all distributions and assumes the reinvestment of those distributions for the period of September 30, 2016 through April 30, 2017.

Tekla Healthcare Opportunities Fund
CUSIP: 879105104
www.teklacap.com

Tekla Capital Management LLC
100 Federal Street, 19th Floor
Boston, Massachusetts 02110

617-772-8500
Fax: 617-772-8577

TEKLA HEALTHCARE OPPORTUNITIES FUND

Notification of Sources of Distribution

Distribution Paid Date: June 30, 2017

Distribution Amount Per Common Share: $0.1125

The following table sets forth the estimated amounts of the current distribution, paid June 30, 2017, and the cumulative distributions paid this fiscal year-to-date from the following sources: net investment income, net realized short-term capital gains,  net realized long-term capital gains, return of capital or other capital source. All amounts are expressed per common share.

			Percentage				Percentage Breakdown
			Breakdown		Total Cumulative		of the Total Cumulative
	Current		of Current		Distributions for the		Distributions for the
	Distribution		Distribution		Fiscal Year to Date(1)		Fiscal Year to Date(1)
Net Investment Income	$	0.0301	27	%	$	0.1242	12	%
Net Realized ST Cap Gains	$	0.0638	57	%	$	0.0881	9	%
Net Realized LT Cap Gains	$	0.0186	16	%	$	0.8002	79	%
Return of Capital or Other Capital Source	$	0.0000	0	%	$	0.0000	0	%
TOTAL (per common share):	$	0.1125	100	%	$	1.0125	100	%

The table below includes information relating to the Fund’s performance based on its NAV for certain periods.

Average annual total return at NAV for the period from inception through May 31, 2017(2)	7.74	%
Annualized current distribution rate expressed as a percentage of NAV as of May 31, 2017	7.19	%
Cumulative total return at NAV for the fiscal year, through May 31, 2017(3)	3.54	%
Cumulative fiscal year-to-date distribution rate expressed as a percentage of NAV as of May 31, 2017(1)	5.39	%

You should not draw any conclusions about the Fund’s investment performance from the amount of this distribution or from the terms of the Fund’s managed distribution plan.

The composition of this and subsequent distribution may vary from month to month because it may be materially impacted by future realized gains and losses on securities. The aggregate of the net unrealized appreciation of portfolio securities and net realized gains on sale of securities is $69,950,534, of which $44,758,727 represents net unrealized appreciation of portfolio securities.

The amounts and sources of distributions reported in this 19(a) Notice are only estimates and not being provided for tax reporting purposes. The actual amounts and sources of the amounts for tax reporting purposes will depend upon the Fund’s investment experience during the remainder of its fiscal year and may be subject to changes based on tax regulations. The Fund will send you a Form 1099-DIV for the calendar year that will tell you how to report these distributions for federal income tax purposes.

(1)The Fund’s current fiscal year began on October 1, 2016.

(2)Inception date was July 29, 2014, which is the date of the initial public offering.

(3)Cumulative total return at NAV is the percentage change in the Fund’s NAV and includes all distributions and assumes the reinvestment of those distributions for the period of September 30, 2016 through May 31, 2017.

Tekla Healthcare Opportunities Fund
CUSIP: 879105104
www.teklacap.com

Tekla Capital Management LLC
100 Federal Street, 19th Floor
Boston, Massachusetts 02110

617-772-8500
Fax: 617-772-8577

TEKLA HEALTHCARE OPPORTUNITIES FUND

Notification of Sources of Distribution

Distribution Paid Date: July 31, 2017

Distribution Amount Per Common Share: $0.1125

The following table sets forth the estimated amounts of the current distribution, paid July 31, 2017, and the cumulative distributions paid this fiscal year-to-date from the following sources: net investment income, net realized short-term capital gains,  net realized long-term capital gains, return of capital or other capital source. All amounts are expressed per common share.

			Percentage				Percentage Breakdown
			Breakdown		Total Cumulative		of the Total Cumulative
	Current		of Current		Distributions for the		Distributions for the
	Distribution		Distribution		Fiscal Year to Date(1)		Fiscal Year to Date(1)
Net Investment Income	$	0.0225	20	%	$	0.1467	13	%
Net Realized ST Cap Gains	$	0.0303	27	%	$	0.1184	11	%
Net Realized LT Cap Gains	$	0.0597	53	%	$	0.8599	76	%
Return of Capital or Other Capital Source	$	0.0000	0	%	$	0.0000	0	%
TOTAL (per common share):	$	0.1125	100	%	$	1.1250	100	%

The table below includes information relating to the Fund’s performance based on its NAV for certain periods.

Average annual total return at NAV for the period from inception through June 30, 2017(2)	9.86	%
Annualized current distribution rate expressed as a percentage of NAV as of June 30, 2017	6.79	%
Cumulative total return at NAV for the fiscal year, through June 30, 2017(3)	10.27	%
Cumulative fiscal year-to-date distribution rate expressed as a percentage of NAV as of June 30, 2017(1)	5.66	%

You should not draw any conclusions about the Fund’s investment performance from the amount of this distribution or from the terms of the Fund’s managed distribution plan.

The composition of this and subsequent distribution may vary from month to month because it may be materially impacted by future realized gains and losses on securities. The aggregate of the net unrealized appreciation of portfolio securities and net realized gains on sale of securities is $77,150,951, of which $51,118,411 represents net unrealized appreciation of portfolio securities.

The amounts and sources of distributions reported in this 19(a) Notice are only estimates and not being provided for tax reporting purposes. The actual amounts and sources of the amounts for tax reporting purposes will depend upon the Fund’s investment experience during the remainder of its fiscal year and may be subject to changes based on tax regulations. The Fund will send you a Form 1099-DIV for the calendar year that will tell you how to report these distributions for federal income tax purposes.

(1)The Fund’s current fiscal year began on October 1, 2016.

(2)Inception date was July 29, 2014, which is the date of the initial public offering.

(3)Cumulative total return at NAV is the percentage change in the Fund’s NAV and includes all distributions and assumes the reinvestment of those distributions for the period of September 30, 2016 through June 30, 2017.

Tekla Healthcare Opportunities Fund
CUSIP: 879105104
www.teklacap.com

Tekla Capital Management LLC
100 Federal Street, 19th Floor
Boston, Massachusetts 02110

617-772-8500
Fax: 617-772-8577

TEKLA HEALTHCARE OPPORTUNITIES FUND

Notification of Sources of Distribution

Distribution Paid Date: August 31, 2017

Distribution Amount Per Common Share: $0.1125

The following table sets forth the estimated amounts of the current distribution, paid August 31, 2017, and the cumulative distributions paid this fiscal year-to-date from the following sources: net investment income, net realized short-term capital gains,  net realized long-term capital gains, return of capital or other capital source. The Fund estimates that it has distributed more than its income and net realized capital gains; therefore, a portion of your distribution may be a return of capital.  A return of capital may occur, for example, when some or all the money that you invested in the Fund is paid back to you.  A return of capital distribution does not necessarily reflect the Fund’s investment performance and should not be confused with ‘yield’ or ‘income’. All amounts are expressed per common share.

			Percentage				Percentage Breakdown
			Breakdown		Total Cumulative		of the Total Cumulative
	Current		of Current		Distributions for the		Distributions for the
	Distribution		Distribution		Fiscal Year to Date(1)		Fiscal YeartoDate(1)
Net Investment Income	$	0.0197	17	%	$	0.1664	14	%
Net Realized ST Cap Gains	$	0.0356	32	%	$	0.1540	12	%
Net Realized LT Cap Gains	$	0.0530	47	%	$	0.9129	74	%
Return of Capital or Other Capital Source	$	0.0042	4	%	$	0.0042	0	%
TOTAL (per common share):	$	0.1125	100	%	$	1.2375	100	%

The table below includes information relating to the Fund’s performance based on its NAV for certain periods.

Average annual total return at NAV for the period from inception through July 31, 2017(2)	10.23	%
Annualized current distribution rate expressed as a percentage of NAV as of July 31, 2017	6.71	%
Cumulative total return at NAV for the fiscal year, through July 31, 2017(3)	12.28	%
Cumulative fiscal year-to-date distribution rate expressed as a percentage of NAV as of July 31, 2017(1)	6.15	%

You should not draw any conclusions about the Fund’s investment performance from the amount of this distribution or from the terms of the Fund’s managed distribution plan.

The composition of this and subsequent distribution may vary from month to month because it may be materially impacted by future realized gains and losses on securities. The aggregate of the net unrealized appreciation of portfolio securities and net realized gains on sale of securities is $41,839,754, of which $15,208,911 represents net unrealized appreciation of portfolio securities.

The amounts and sources of distributions reported in this 19(a) Notice are only estimates and not being provided for tax reporting purposes. The actual amounts and sources of the amounts for tax reporting purposes will depend upon the Fund’s investment experience during the remainder of its fiscal year and may be subject to changes based on tax regulations. The Fund will send you a Form 1099-DIV for the calendar year that will tell you how to report these distributions for federal income tax purposes.

(1)The Fund’s current fiscal year began on October 1, 2016.

(2)Inception date was July 29, 2014, which is the date of the initial public offering.

(3)Cumulative total return at NAV is the percentage change in the Fund’s NAV and includes all distributions and assumes the reinvestment of those distributions for the period of September 30, 2016 through July 31, 2017.

Tekla Healthcare Opportunities Fund
CUSIP: 879105104
www.teklacap.com

Tekla Capital Management LLC
100 Federal Street, 19th Floor
Boston, Massachusetts 02110

617-772-8500
Fax: 617-772-8577

TEKLA HEALTHCARE OPPORTUNITIES FUND

Notification of Sources of Distribution

Distribution Paid Date: September 29, 2017

Distribution Amount Per Common Share: $0.1125

The following table sets forth the estimated amounts of the current distribution, paid September 29, 2017, and the cumulative distributions paid this fiscal year-to-date from the following sources: net investment income, net realized short-term capital gains,  net realized long-term capital gains, return of capital or other capital source. The Fund estimates that it has distributed more than its income and net realized capital gains; therefore, a portion of your distribution may be a return of capital.  A return of capital may occur, for example, when some or all the money that you invested in the Fund is paid back to you.  A return of capital distribution does not necessarily reflect the Fund’s investment performance and should not be confused with ‘yield’ or ‘income’. All amounts are expressed per common share.

			Percentage				Percentage Breakdown
			Breakdown		Total Cumulative		of the Total Cumulative
	Current		of Current		Distributions for the		Distributions for the
	Distribution		Distribution		Fiscal Year to Date(1)		Fiscal YeartoDate(1)
Net Investment Income	$	0.0206	18	%	$	0.1870	14	%
Net Realized ST Cap Gains	$	0.0321	29	%	$	0.1861	14	%
Net Realized LT Cap Gains	$	0.0598	53	%	$	0.9727	72	%
Return of Capital or Other Capital Source	$	0.0000	0	%	$	0.0042	0	%
TOTAL (per common share):	$	0.1125	100	%	$	1.3500	100	%

The table below includes information relating to the Fund’s performance based on its NAV for certain periods.

Average annual total return at NAV for the period from inception through August 31, 2017(2)	10.33	%
Annualized current distribution rate expressed as a percentage of NAV as of August 31, 2017	6.68	%
Cumulative total return at NAV for the fiscal year, through August 31, 2017(3)	13.52	%
Cumulative fiscal year-to-date distribution rate expressed as a percentage of NAV as of August 31, 2017(1)	6.68	%

You should not draw any conclusions about the Fund’s investment performance from the amount of this distribution or from the terms of the Fund’s managed distribution plan.

The composition of this and subsequent distribution may vary from month to month because it may be materially impacted by future realized gains and losses on securities. The aggregate of the net unrealized appreciation of portfolio securities and net realized gains on sale of securities is $74,160,279, of which $38,486,870 represents net unrealized appreciation of portfolio securities.

The amounts and sources of distributions reported in this 19(a) Notice are only estimates and not being provided for tax reporting purposes. The actual amounts and sources of the amounts for tax reporting purposes will depend upon the Fund’s investment experience during the remainder of its fiscal year and may be subject to changes based on tax regulations. The Fund will send you a Form 1099-DIV for the calendar year that will tell you how to report these distributions for federal income tax purposes.

(1)The Fund’s current fiscal year began on October 1, 2016.

(2)Inception date was July 29, 2014, which is the date of the initial public offering.

(3)Cumulative total return at NAV is the percentage change in the Fund’s NAV and includes all distributions and assumes the reinvestment of those distributions for the period of September 30, 2016 through August 31, 2017.

Tekla Healthcare Opportunities Fund
CUSIP: 879105104
www.teklacap.com

Tekla Capital Management LLC
100 Federal Street, 19th Floor
Boston, Massachusetts 02110

617-772-8500
Fax: 617-772-8577

TEKLA HEALTHCARE OPPORTUNITIES FUND

Notification of Sources of Distribution

Distribution Paid Date: October 31, 2017

Distribution Amount Per Common Share: $0.1125

The following table sets forth the estimated amounts of the current distribution, paid October 31, 2017, and the cumulative distributions paid this fiscal year-to-date from the following sources: net investment income, net realized short-term capital gains, net realized  long-term capital gains, return of capital or other capital source. All amounts are expressed per common share.

			Percentage				Percentage Breakdown
			Breakdown		Total Cumulative		of the Total Cumulative
	Current		of Current		Distributions for the		Distributions for the
	Distribution		Distribution		Fiscal Year to Date(1)		Fiscal Year to Date(1)
Net Investment Income	$	0.1125	100	%	$	0.1125	100	%
Net Realized ST Cap Gains	$	0.0000	0	%	$	0.0000	0	%
Net Realized LT Cap Gains	$	0.0000	0	%	$	0.0000	0	%
Return of Capital or Other Capital Source	$	0.0000	0	%	$	0.0000	0	%
TOTAL (per common share):	$	0.1125	100	%	$	0.1125	100	%

The table below includes information relating to the Fund’s performance based on its NAV for certain periods.

Average annual total return at NAV for the period from inception through September 30, 2017(2)	10.08	%
Annualized current distribution rate expressed as a percentage of NAV as of September 30, 2017	6.71	%
Cumulative total return at NAV for the fiscal year, through September 30, 2017(3)	13.64	%
Cumulative fiscal year-to-date distribution rate expressed as a percentage of NAV as of September 30, 2017(1)	0.56	%

You should not draw any conclusions about the Fund’s investment performance from the amount of this distribution or from the terms of the Fund’s managed distribution plan.

The composition of this and subsequent distribution may vary from month to month because it may be materially impacted by future realized gains and losses on securities. The aggregate of the net unrealized appreciation of portfolio securities and net realized gains on sale of securities is $34,165,454, of which $30,046,256 represents net unrealized appreciation of portfolio securities.

The amounts and sources of distributions reported in this 19(a) Notice are only estimates and not being provided for tax reporting purposes. The actual amounts and sources of the amounts for tax reporting purposes will depend upon the Fund’s investment experience during the remainder of its fiscal year and may be subject to changes based on tax regulations. The Fund will send you a Form 1099-DIV for the calendar year that will tell you how to report these distributions for federal income tax purposes.

(1)The Fund’s current fiscal year began on October 1, 2017.

(2)Inception date was July 29, 2014, which is the date of the initial public offering.

(3)Cumulative total return at NAV is the percentage change in the Fund’s NAV and includes all distributions and assumes the reinvestment of those distributions for the period of September 30, 2016 through September 30, 2017.

Tekla Healthcare Opportunities Fund
CUSIP: 879105104
www.teklacap.com

Tekla Capital Management LLC
100 Federal Street, 19th Floor
Boston, Massachusetts 02110

617-772-8500
Fax: 617-772-8577

TEKLA HEALTHCARE OPPORTUNITIES FUND

Notification of Sources of Distribution

Distribution Paid Date: November 30, 2017

Distribution Amount Per Common Share: $0.1125

The following table sets forth the estimated amounts of the current distribution, paid November 30, 2017, and the cumulative distributions paid this fiscal year-to-date from the following sources: net investment income, net realized short-term capital gains, net realized long-term capital gains, return of capital or other capital source. All amounts are expressed per common share.

			Percentage				Percentage Breakdown
			Breakdown		Total Cumulative		of the Total Cumulative
	Current		of Current		Distributions for the		Distributions for the
	Distribution		Distribution		Fiscal Year to Date(1)		Fiscal Year to Date(1)
Net Investment Income	$	0.0411	37	%	$	0.1536	68	%
Net Realized ST Cap Gains	$	0.0714	63	%	$	0.0714	32	%
Net Realized LT Cap Gains	$	0.0000	0	%	$	0.0000	0	%
Return of Capital or Other Capital Source	$	0.0000	0	%	$	0.0000	0	%
TOTAL (per common share):	$	0.1125	100	%	$	0.2250	100	%

The table below includes information relating to the Fund’s performance based on its NAV for certain periods.

Average annual total return at NAV for the period from inception through October 31, 2017(2)	8.17	%
Annualized current distribution rate expressed as a percentage of NAV as of October 31, 2017	7.09	%
Cumulative total return at NAV for the fiscal year, through October 31, 2017(3)	-4.76	%
Cumulative fiscal year-to-date distribution rate expressed as a percentage of NAV as of October 31, 2017(1)	1.18	%

You should not draw any conclusions about the Fund’s investment performance from the amount of this distribution or from the terms of the Fund’s managed distribution plan.

The composition of this and subsequent distribution may vary from month to month because it may be materially impacted by future realized gains and losses on securities. The aggregate of the net unrealized depreciation of portfolio securities and net realized gains on sale of securities is -$2,368,250, of which $9,502,271 represents net unrealized depreciation of portfolio securities.

The amounts and sources of distributions reported in this 19(a) Notice are only estimates and not being provided for tax reporting purposes. The actual amounts and sources of the amounts for tax reporting purposes will depend upon the Fund’s investment experience during the remainder of its fiscal year and may be subject to changes based on tax regulations. The Fund will send you a Form 1099-DIV for the calendar year that will tell you how to report these distributions for federal income tax purposes.

(1)The Fund’s current fiscal year began on October 1, 2017.

(2)Inception date was July 29, 2014, which is the date of the initial public offering.

(3)Cumulative total return at NAV is the percentage change in the Fund’s NAV and includes all distributions and assumes the reinvestment of those distributions for the period of September 30, 2017 through October 31, 2017.

Tekla Healthcare Opportunities Fund
CUSIP: 879105104
www.teklacap.com

Tekla Capital Management LLC
100 Federal Street, 19th Floor
Boston, Massachusetts 02110

617-772-8500
Fax: 617-772-8577

EX-99.906CERT

Exhibit 99.906CERT

EHIBIT 5: CERTIFICATION PUSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, each of the undersigned officers of TEKLA HEALTHCARE OPPORTUNITIES FUND, do hereby certify, to such officer’s knowledge, that the report on Form N-CSR of TEKLA HEALTHCARE OPPORTUNITIES FUND for the period ended September 30, 2017 fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as applicable, and information contained in the Form N-CSR fairly presents, in all material respects, the financial condition and results of operations of TEKLA HEALTHCARE OPPORTUNITIES FUND for the stated period.

Dated:	12/5/17
	/s/ Daniel R. Omstead		/s/ Laura Woodward
	Name:	Daniel R. Omstead	Name:	Laura Woodward
	Title:	President	Title:	Treasurer

A signed original of this written statement required by Section 906 has been provided to TEKLA HEALTHCARE OPPORTUNITIES FUND and will be retained by TEKLA HEALTHCARE OPPORTUNITIES FUND and furnished to the SEC or its staff upon request. This statement accompanies this report on Form N-CSR pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.