Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Taxes [Line Items]
Change in capitalized expenses	$ 43,700
Tax credit carryforward, change in amount	17,800
Increase in valuation allowance tax	46,400
Net operating loss carryforwards, federal	1,000,000
Research and development tax credit carryforwards	$ 106,900
Research and development tax credit carryforwards, expiration year	2035
Tax credit carryforwards	$ 19,427	$ 1,580
Accrued interest and penalties	0	0
Unrecognized tax benefits	$ 150,965	$ 144,067	$ 110,601	$ 86,000
Domestic
Income Taxes [Line Items]
Capitalized expenses, amortization period	5 years
Net operating loss carryforwards subject to expiration	$ 22,600
Net tax operating losses, expiration	begin to expire in 2036
Research and development tax credit carryforwards	$ 24,000
Research and development tax credit carryforwards, expiration year	2032
Operating loss carryforwards	$ 42,700
State
Income Taxes [Line Items]
Net tax operating losses, expiration	begin to expire in 2030
Net operating loss carryforwards not subject to expiration	$ 38,000
Net operating loss carryforwards, state	$ 1,300,000
Foreign
Income Taxes [Line Items]
Capitalized expenses, amortization period	15 years
Tax credit carryforwards	$ 2,000
Tax credit carryforwards, expiration year	2025