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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Operating activities    
Net loss $ (153,730) $ (246,792)
Adjustments to reconcile net loss to net cash used in operating activities:    
Gain on sale of ATOM Facility (50,237) 0
Stock-based compensation expense 42,475 39,837
Depreciation and amortization expense 4,398 6,857
Amortization of investment premiums 974 1,251
Non-cash operating lease expense 6,103 1,275
Asset retirement obligation accretion expense 70 64
Changes in operating assets and liabilities:    
Accounts receivable 737 1,250
Prepaid expenses and other current assets (3,903) 10,841
Other assets (139) 27
Accounts payable (4,760) 8,710
Accrued compensation (7,545) (1,318)
Accrued research and development expenses 4,417 (5,839)
Other current liabilities 5,595 1,859
Deferred revenue (51,468) (3,182)
Operating lease liabilities (6,781) (1,294)
Other long-term liabilities 244 201
Net cash used in operating activities (213,550) (186,253)
Investing activities    
Purchases of short-term investments (181,164) (224,754)
Proceeds from maturities and sales of short-term investments 242,293 279,450
Purchases of property and equipment (4,156) (8,114)
Net proceeds from sale of ATOM Facility 94,765 0
Net cash provided by investing activities 151,738 46,582
Financing activities    
Proceeds from issuance of common stock through ATM facilities, net 20,516 48,739
Proceeds from employee stock awards 1,452 5,190
Taxes paid related to net share settlement of restricted stock units (623) (1,244)
Principal payments on finance lease obligations (396) (192)
Other financing activities, net (155) (17)
Net cash provided by financing activities 20,794 52,476
Decrease in cash, cash equivalents and restricted cash (41,018) (87,195)
Cash, cash equivalents and restricted cash at beginning of period 107,478 201,798
Cash, cash equivalents and restricted cash at end of period 66,460 114,603
Non-cash investing and financing activities    
Property and equipment purchases included in accounts payable and other accrued liabilities 35 1,858
Proceeds from issuance of common stock through ATM facilities not yet received 0 2,344
Supplemental cash flow disclosure    
Cash paid for interest 256 25
Cash paid for income taxes $ 19 $ 16