CONSOLIDATED STATEMENTS OF CASH FLOWS $ in Thousands	12 Months Ended
Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Cash flows from operating activities:
Net loss	$ (108,180)	$ (180,966)	$ (102,680)
Adjustments to reconcile consolidated net loss to net cash used in operating activities:
Depreciation and amortization	2,706	2,761	1,371
Upfront license and milestone expense	0	10,000	0
Share-based compensation	32,300	31,243	17,454
Write-down of inventory	3,646	245	0
Other, net	(3,184)	658	9,477
Net changes in operating assets and liabilities:
Accounts receivable, net	1,927	(15,415)	(650)
Inventories, net	(9,072)	(5,644)	(13,927)
Prepaid expenses and other current assets	(2,404)	(5,335)	2,559
Non-current assets	(839)	247	0
Right of use assets	476	106	(5,489)
Accounts payable and accrued liabilities	699	4,076	13,620
Deferred revenue	3,048	0	0
Lease liabilities	(652)	332	8,407
Net cash used in operating activities	(79,529)	(157,692)	(69,858)
Cash flows from investing activities:
Proceeds from investments	464,316	354,427	52,108
Purchase of investments	(523,993)	(438,958)	(202,951)
Upfront lease payment	(663)	(11,838)	0
Upfront license payment	0	(6,000)	0
Purchase of long-lived assets and intangibles	(292)	(303)	(5,668)
Additions to internal use-software implementation costs	0	(1,198)	(1,675)
Capitalized patent costs	0	0	0
Net cash used in investing activities	(60,632)	(103,870)	(158,186)
Cash flows from financing activities:
Proceeds from issuance of common shares pursuant to Public Offering, net of issuance costs	0	196,740	187,732
Proceeds from exercise of stock options and employee share purchase plan	2,433	24,007	6,642
Proceeds from exercise of warrants	0	365	1
Net cash provided by financing activities	2,433	221,112	194,375
Net (decrease) increase in cash and cash equivalents during the year	(137,728)	(40,450)	(33,669)
Cash and cash equivalents, beginning of the year	231,900	272,350	306,019
Cash, cash equivalents and restricted cash, end of the year	94,172	231,900	272,350
Supplemental cash flow information:
Cash received for interest	2,344	749	1,884
Cash paid for taxes	(1,979)	(257)	(261)
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets
Cash, cash equivalents	94,088	231,643	272,350
Restricted cash	84	257	0
Total cash, cash equivalents and restricted cash	$ 94,172	$ 231,900	$ 272,350

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