The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 207 6,880 SH   SOLE   6,880 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 1,017 30,000 SH   SOLE   30,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,641 28,704 SH   SOLE   28,704 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 312 21,009 SH   SOLE   21,009 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 1,143 9,558 SH   SOLE   9,558 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 2,392 20,000 SH Call SOLE   20,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 1,794 15,000 SH Call SOLE   15,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 5,471 43,064 SH   SOLE   43,064 0 0
AMGEN INC COM 031162100 1,726 9,924 SH   SOLE   9,924 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 4,164 120,000 SH   SOLE   120,000 0 0
AVEXIS INC COM 05366U100 277 2,500 SH   SOLE   2,500 0 0
AXSOME THERAPEUTICS INC COM 05464T104 748 133,500 SH   SOLE   133,500 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 1,526 17,118 SH   SOLE   17,118 0 0
BIOGEN INC COM 09062X103 1,845 5,793 SH   SOLE   5,793 0 0
BIO TECHNE CORP COM 09073M104 257 1,987 SH   SOLE   1,987 0 0
BIOVERATIV INC COM 09075E100 361 6,689 SH   SOLE   6,689 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 5,515 90,000 SH   SOLE   90,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 2,758 45,000 SH Call SOLE   45,000 0 0
CELGENE CORP COM 151020104 1,517 14,540 SH   SOLE   14,540 0 0
CHARLES RIV LABS INTL INC COM 159864107 236 2,154 SH   SOLE   2,154 0 0
CHECKPOINT THERAPEUTICS INC COM 162828107 438 112,760 SH   SOLE   112,760 0 0
CLOVIS ONCOLOGY INC COM 189464100 1,020 15,000 SH   SOLE   15,000 0 0
CONTRAFECT CORP COM 212326102 152 150,000 SH   SOLE   150,000 0 0
FIBROGEN INC COM 31572Q808 210 4,423 SH   SOLE   4,423 0 0
GILEAD SCIENCES INC COM 375558103 716 10,000 SH Call SOLE   10,000 0 0
GILEAD SCIENCES INC COM 375558103 220 3,075 SH   SOLE   3,075 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 2,128 60,000 SH   SOLE   60,000 0 0
GRIFOLS S A SP ADR REP B NVT 398438408 265 11,565 SH   SOLE   11,565 0 0
HERON THERAPEUTICS INC COM 427746102 287 15,874 SH   SOLE   15,874 0 0
IGNYTA INC COM 451731103 4,552 170,500 SH   SOLE   170,500 0 0
ILLUMINA INC COM 452327109 2,123 9,717 SH   SOLE   9,717 0 0
INCYTE CORP COM 45337C102 1,735 18,318 SH   SOLE   18,318 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 221 3,779 SH   SOLE   3,779 0 0
INTREXON CORP COM 46122T102 164 14,221 SH   SOLE   14,221 0 0
IONIS PHARMACEUTICALS INC COM 462222100 1,981 39,388 SH   SOLE   39,388 0 0
IQVIA HLDGS INC COM 46266C105 236 2,415 SH   SOLE   2,415 0 0
ISHARES TR NASDAQ BIOTECH 464287556 4,004 37,500 SH   SOLE   37,500 0 0
JUNO THERAPEUTICS INC COM 48205A109 255 5,588 SH   SOLE   5,588 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 960 100,000 SH   SOLE   100,000 0 0
LILLY ELI & CO COM 532457108 1,267 15,000 SH Call SOLE   15,000 0 0
LOXO ONCOLOGY INC COM 548862101 1,162 13,800 SH   SOLE   13,800 0 0
MEDICINES CO COM 584688105 383 14,000 SH   SOLE   14,000 0 0
MERCK & CO INC COM 58933Y105 4,710 83,700 SH   SOLE   83,700 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 2,227 3,594 SH   SOLE   3,594 0 0
NEKTAR THERAPEUTICS COM 640268108 5,498 92,070 SH   SOLE   92,070 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 326 4,204 SH   SOLE   4,204 0 0
NEW SR INVT GROUP INC COM 648691103 316 41,850 SH   SOLE   41,850 0 0
PACIRA PHARMACEUTICALS INC COM 695127100 1,141 25,000 SH   SOLE   25,000 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 716 40,000 SH   SOLE   40,000 0 0
PFIZER INC COM 717081103 4,068 112,300 SH   SOLE   112,300 0 0
PROGENICS PHARMACEUTICALS IN COM 743187106 130 21,782 SH   SOLE   21,782 0 0
PROSHARES TR PSHS ULT NASB 74347R214 7,317 130,500 SH   SOLE   130,500 0 0
RECRO PHARMA INC COM 75629F109 233 25,231 SH   SOLE   25,231 0 0
REGENERON PHARMACEUTICALS COM 75886F107 1,532 4,076 SH   SOLE   4,076 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 5,517 65,000 SH   SOLE   65,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 11,694 71,000 SH Put SOLE   71,000 0 0
SCYNEXIS INC COM 811292101 155 66,608 SH   SOLE   66,608 0 0
SEATTLE GENETICS INC COM 812578102 1,908 35,668 SH   SOLE   35,668 0 0
TESARO INC COM 881569107 414 5,000 SH   SOLE   5,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 393 8,472 SH   SOLE   8,472 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 303 2,050 SH   SOLE   2,050 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 2,494 16,639 SH   SOLE   16,639 0 0
ALKERMES PLC SHS G01767105 2,395 43,763 SH   SOLE   43,763 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 992 307,692 SH   SOLE   307,692 0 0
QIAGEN NV SHS NEW N72482123 1,746 56,445 SH   SOLE   56,445 0 0