Condensed Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Cash flows from operating activities
Net loss	$ (68,855)	$ (52,394)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	641	391
Stock-based compensation expense	10,306	9,104
Amortization of premiums and discounts on marketable securities, net	(2,960)	(2,231)
Non-cash operating lease costs	828	688
Changes in operating assets and liabilities:
Prepaid and other assets	(2,528)	1,491
Accounts payable and accrued liabilities	2,575	1,158
Accrued compensation	(6,539)	(5,181)
Operating lease liabilities	(887)	(774)
Deferred revenue	(2,961)	(1,219)
Net cash used in operating activities	(70,380)	(48,967)
Cash flows from investing activities
Maturities of marketable securities	109,725	57,490
Purchases of marketable securities	(141,557)	(251,350)
Purchases of property and equipment	(915)	(1,820)
Net cash used in investing activities	(32,747)	(195,680)
Cash flows from financing activities
Proceeds from issuance of common stock in public offerings, net of issuance costs	5,594	22,441
Proceeds from issuance of common stock under employee incentive equity plans	3,655	520
Proceeds from the issuance of common stock in a private placement, net of issuance costs	238,647	0
Proceeds from issuance of pre-funded warrants in a private placement, net of issuance costs	141,549	0
Net cash provided by financing activities	389,445	22,961
Net increase (decrease) in cash, cash equivalents and restricted cash	286,318	(221,686)
Cash, cash equivalents and restricted cash at beginning of period	185,377	340,647
Cash, cash equivalents and restricted cash at end of period	471,695	118,961
Supplemental schedule of noncash investing and financing activities:
Costs incurred, but not paid, in connection with deferred financing costs included in accounts payable and accrued liabilities	$ 413	$ 0