Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Income Taxes Disclosure [Line Items]
Provision for income taxes	$ 0	$ 0	$ 0
Increase in the valuation allowance	61,300,000	54,800,000
Unrecognized tax benefits that would impact effective tax rate	0
Accruals for interest or penalties	0	$ 0
Federal
Income Taxes Disclosure [Line Items]
Net operating loss (NOL) carryforwards	226,900,000
Federal and state tax credit carryforwards	11,700,000
Federal | Orphan Drug Tax Credits
Income Taxes Disclosure [Line Items]
Federal and state tax credit carryforwards	22,800,000
State
Income Taxes Disclosure [Line Items]
Net operating loss (NOL) carryforwards	355,000,000
Federal and state tax credit carryforwards	$ 8,800,000