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Insider Trading Arrangements

3 Months Ended

6 Months Ended

Jun. 30, 2023

From time to time, our officers (as defined in Rule 16a–1(f)) and directors may enter into Rule 10b5-1 or non-Rule 10b5-1 trading arrangements (as each such term is defined in Item 408 of Regulation S-K). During the

three months ended June 30, 2023, our officers and directors took the following actions with respect to 10b5-1 trading arrangements:

Action

Date

Trading Arrangement

Total Shares to be Sold

Expiration Date

Rule 10b5-1

Non-Rule 10b5-1

Sarah Boyce (President, Chief Executive Officer and Director)

Adopt

6/9/2023

636,000

12/31/2024

Michael MacLean (Chief Financial and Chief Business Officer)

Adopt

5/23/2023

254,245

6/30/2024

Arthur Levin, Ph.D. (Distinguished Scientist and Strategic Leader; Director) (1)

Adopt

5/26/2023

258,323 (2)

12/31/2024

____________________

(1)Consists of shares directly owned by Dr. Levin and shares controlled by Dr. Levin through a revocable trust.

(2)Subject to increase based on a future award of our common stock covered by this 10b5-1 plan, the number of such securities is not able to be determined as of the date hereof.

Non-Rule 10b5-1 Arrangement Adopted

false

Rule 10b5-1 Arrangement Terminated

false

Non-Rule 10b5-1 Arrangement Terminated

false

Sarah Boyce [Member]

Trading Arrangements, by Individual

Name

Sarah Boyce

Title

(President, Chief Executive Officer and Director)