Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Income Taxes Disclosure [Line Items]
Provision for income taxes	$ 0	$ 0	$ 0
Increase in the valuation allowance	54,800,000	35,400,000
Unrecognized tax benefits that would impact effective tax rate	0
Accruals for interest or penalties	0	$ 0
Federal
Income Taxes Disclosure [Line Items]
Net operating loss (NOL) carryforwards	172,900,000
Federal and state tax credit carryforwards	9,000,000
Federal | Orphan Drug Tax Credits
Income Taxes Disclosure [Line Items]
Federal and state tax credit carryforwards	4,600,000
State
Income Taxes Disclosure [Line Items]
Net operating loss (NOL) carryforwards	293,200,000
Federal and state tax credit carryforwards	$ 4,800,000