Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Taxes Disclosure [Line Items]
Provision for income taxes	$ 0	$ 0	$ 0
Increase in the valuation allowance	35,400,000	13,500,000
Accruals for interest or penalties	0	0
Interest or penalties	0	$ 0
Federal
Income Taxes Disclosure [Line Items]
Net operating loss (NOL) carryforwards	$ 147,900,000
Net operating loss available to offset against current taxable income percentage	100.00%
Net operating loss available to offset against future taxable income percentage	80.00%
Federal and state tax credit carryforwards	$ 4,700,000
Tax credit expiration beginning year	2039
Federal | Orphan Drug Tax Credits
Income Taxes Disclosure [Line Items]
Federal and state tax credit carryforwards	$ 700,000
Tax credit expiration beginning year	2041
State
Income Taxes Disclosure [Line Items]
Net operating loss (NOL) carryforwards	$ 147,700,000
Net operating loss carryforwards, expiration beginning year	2039
Federal and state tax credit carryforwards	$ 2,600,000