The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Universal Health Services Inc B CL B 913903100 5,943 52,433 SH   SOLE   0 0 52,433
Symantec Corp COM 871503108 263 9,359 SH   SOLE   0 0 9,359
IBM Corp COM 459200101 271 1,766 SH   SOLE   0 0 1,766
Qualcomm Inc COM 747525103 344 5,368 SH   SOLE   0 0 5,368
Pfizer Inc COM 717081103 377 10,422 SH   SOLE   0 0 10,422
Microsoft Corp COM 594918104 410 4,793 SH   SOLE   0 0 4,793
Adverum Biotechnologies Inc COM 00773U108 445 127,006 SH   SOLE   0 0 127,006
Wells Fargo & Co COM 949746101 463 7,635 SH   SOLE   0 0 7,635
Exxon Mobil Corp COM 30231G102 476 5,696 SH   SOLE   0 0 5,696
JPMorgan Chase & Co COM 46625H100 483 4,518 SH   SOLE   0 0 4,518
Regulus Therapeutic Inc COM 75915K101 513 492,878 SH   SOLE   0 0 492,878
Halliburton Co (Hg Co) COM 406216101 545 11,144 SH   SOLE   0 0 11,144
Ra Pharmaceuticals Inc Reg COM 74933V108 922 108,451 SH   SOLE   0 0 108,451
Tetraphase Pharmaceuticals Inc COM 88165N105 1,014 160,908 SH   SOLE   0 0 160,908
Nevro Corp COM 64157F103 1,046 15,145 SH   SOLE   0 0 15,145
Keryx Biopharmaceuticals Inc COM 492515101 1,405 302,157 SH   SOLE   0 0 302,157
NewLink Genetics Corp COM 651511107 1,468 181,047 SH   SOLE   0 0 181,047
Chimerix Inc COM 16934W106 1,583 342,000 SH   SOLE   0 0 342,000
Achillion Pharmaceuticals Inc COM 00448Q201 1,923 667,800 SH   SOLE   0 0 667,800
Intercept Pharmaceuticals Inc COM 45845P108 2,249 38,500 SH   SOLE   0 0 38,500
ViewRay Inc Reg COM 92672L107 2,615 282,385 SH   SOLE   0 0 282,385
Dermira Inc Reg COM 24983L104 2,642 95,000 SH   SOLE   0 0 95,000
Epizyme Inc COM 29428V104 2,731 217,591 SH   SOLE   0 0 217,591
Omnicell Inc COM 68213N109 2,835 58,445 SH   SOLE   0 0 58,445
Coherus BioSciences Inc COM 19249H103 3,080 350,000 SH   SOLE   0 0 350,000
Spark Therapeutics Inc COM 84652J103 3,610 70,200 SH   SOLE   0 0 70,200
Dexcom Inc COM 252131107 4,053 70,625 SH   SOLE   0 0 70,625
Sangamo Therapeutics Inc Reg COM 800677106 4,195 255,793 SH   SOLE   0 0 255,793
Ultragenyx Pharmaceutical Inc COM 90400D108 4,406 95,000 SH   SOLE   0 0 95,000
Centene Corp COM 15135B101 4,540 45,000 SH   SOLE   0 0 45,000
Walgreens Boots Alliance Inc COM 931427108 4,771 65,700 SH   SOLE   0 0 65,700
Biogen Inc COM 09062X103 4,874 15,300 SH   SOLE   0 0 15,300
Puma Biotechnology Inc COM 74587V107 4,943 50,000 SH   SOLE   0 0 50,000
Juno Therapeutics Inc COM 48205A109 5,002 109,430 SH   SOLE   0 0 109,430
Endologix Inc COM 29266S106 5,115 956,002 SH   SOLE   0 0 956,002
HCA Healthcare Inc COM 40412C101 5,173 58,886 SH   SOLE   0 0 58,886
Agios Pharmaceuticals Inc COM 00847X104 5,717 100,000 SH   SOLE   0 0 100,000
Macrogenics Inc COM 556099109 5,863 308,604 SH   SOLE   0 0 308,604
Array BioPharma Inc COM 04269X105 6,439 503,059 SH   SOLE   0 0 503,059
Revance Therapeutics Inc COM 761330109 6,527 182,580 SH   SOLE   0 0 182,580
Flexion Therapeutics Inc COM 33938J106 6,553 261,686 SH   SOLE   0 0 261,686
Xencor Inc COM 98401F105 6,960 317,500 SH   SOLE   0 0 317,500
Abbott Laboratories COM 002824100 6,963 122,000 SH   SOLE   0 0 122,000
Anthem Inc COM 036752103 6,975 31,000 SH   SOLE   0 0 31,000
Alnylam Pharmaceuticals Inc COM 02043Q107 7,492 58,967 SH   SOLE   0 0 58,967
MyoKardia Inc Reg COM 62857M105 7,505 178,272 SH   SOLE   0 0 178,272
Iovance Biotherapeutics Inc Reg COM 462260100 7,553 944,185 SH   SOLE   0 0 944,185
Aerie Pharmaceuticals Inc COM 00771V108 7,578 126,829 SH   SOLE   0 0 126,829
Loxo Oncology Inc COM 548862101 7,600 90,280 SH   SOLE   0 0 90,280
Immunomedics Inc COM 452907108 7,762 480,330 SH   SOLE   0 0 480,330
Bristol Myers Squibb Co COM 110122108 7,954 129,802 SH   SOLE   0 0 129,802
FibroGen Inc COM 31572Q808 8,037 169,547 SH   SOLE   0 0 169,547
Edwards Lifesciences Corp COM 28176E108 8,269 73,364 SH   SOLE   0 0 73,364
Boston Scientific Corp COM 101137107 8,626 347,968 SH   SOLE   0 0 347,968
Neurocrine Biosciences Inc COM 64125C109 9,153 117,969 SH   SOLE   0 0 117,969
Cigna Corp COM 125509109 9,220 45,400 SH   SOLE   0 0 45,400
Acadia Pharmaceuticals Inc COM 004225108 10,204 338,882 SH   SOLE   0 0 338,882
Portola Pharmaceuticals Inc COM 737010108 10,279 211,153 SH   SOLE   0 0 211,153
Regeneron Pharmaceuticals Inc COM 75886F107 11,713 31,154 SH   SOLE   0 0 31,154
Eli Lilly & Co COM 532457108 12,066 142,859 SH   SOLE   0 0 142,859
BioMarin Pharmaceutical Inc COM 09061G101 12,470 139,849 SH   SOLE   0 0 139,849
Humana Inc COM 444859102 14,388 58,000 SH   SOLE   0 0 58,000
AbbVie Inc COM 00287Y109 15,154 156,700 SH   SOLE   0 0 156,700
Incyte Corp Ltd COM 45337C102 15,504 163,703 SH   SOLE   0 0 163,703
Glaukos Corp COM 377322102 15,605 608,400 SH   SOLE   0 0 608,400
Intra-Cellular Therapies Inc COM 46116X101 15,705 1,084,581 SH   SOLE   0 0 1,084,581
AmerisourceBergen Corp COM 03073E105 16,001 174,261 SH   SOLE   0 0 174,261
Abiomed Inc COM 003654100 16,209 86,490 SH   SOLE   0 0 86,490
Express Scripts Hg Co COM 30219G108 16,531 221,483 SH   SOLE   0 0 221,483
United Health Group Inc COM 91324P102 16,645 75,500 SH   SOLE   0 0 75,500
Celgene Corp COM 151020104 16,845 161,412 SH   SOLE   0 0 161,412
Sage Therapeutics Inc COM 78667J108 17,283 104,930 SH   SOLE   0 0 104,930
Alexion Pharmaceuticals Inc COM 015351109 18,161 151,863 SH   SOLE   0 0 151,863
Gilead Sciences Inc COM 375558103 20,471 285,751 SH   SOLE   0 0 285,751
Nektar Therapeutics COM 640268108 21,111 353,503 SH   SOLE   0 0 353,503
Vertex Pharmaceuticals Inc COM 92532F100 22,809 152,204 SH   SOLE   0 0 152,204
Exelixis Inc COM 30161Q104 22,989 756,214 SH   SOLE   0 0 756,214
Adamas Pharmaceuticals Inc COM 00548A106 23,483 692,913 SH   SOLE   0 0 692,913
Esperion Therapeutics Inc COM 29664W105 25,455 386,626 SH   SOLE   0 0 386,626
Zogenix Inc Reg COM NEW 98978L204 2,075 51,808 SH   SOLE   0 0 51,808
Dynavax Technologies Corp COM NEW 268158201 4,541 242,812 SH   SOLE   0 0 242,812
Rigel Pharmaceuticals Inc COM NEW 766559603 7,499 1,932,831 SH   SOLE   0 0 1,932,831
Arena Pharmaceuticals Inc Reg COM NEW 040047607 13,100 385,642 SH   SOLE   0 0 385,642
Sunesis Pharmaceuticals Inc Reg COM PAR 867328700 1,661 450,100 SH   SOLE   0 0 450,100
Ford Motor Co COM PAR $0.01 345370860 355 28,404 SH   SOLE   0 0 28,404
Staar Surgical Co COM PAR $0.01 852312305 1,182 76,256 SH   SOLE   0 0 76,256
Janus Henderson Group Plc Reg ORD SHS G4474Y214 456 11,906 SH   SOLE   0 0 11,906
NovoCure Ltd Reg ORD SHS G6674U108 9,445 467,569 SH   SOLE   0 0 467,569
Alkermes Plc SHS G01767105 3,218 58,800 SH   SOLE   0 0 58,800
Livanova Plc SHS G5509L101 4,236 53,000 SH   SOLE   0 0 53,000
Allergan Plc SHS G0177J108 9,660 59,052 SH   SOLE   0 0 59,052
Medtronic Plc SHS G5960L103 13,261 164,225 SH   SOLE   0 0 164,225
Horizon Pharma Plc SHS G4617B105 28,542 1,954,912 SH   SOLE   0 0 1,954,912
Jazz Pharmaceuticals Plc SHS USD G50871105 17,967 133,436 SH   SOLE   0 0 133,436
Anheuser-Busch InBev SA ADR spons repr 1 Share SPONSORED ADR 03524A108 313 2,806 SH   SOLE   0 0 2,806