Income Tax - Reconciliation of the effective income tax rate to statutory rate (Details)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Abstract]
U.S. federal income tax statutory rate	21.00%	21.00%
Change in valuation allowance	(16.80%)	(10.50%)
Non-deductible expenses	0.00%	(0.40%)
Refundable research and development tax credit	(3.60%)	(8.30%)
Effect of foreign operations taxed at various rates	2.10%	0.50%
Stock-based compensation	(2.20%)	(1.60%)
Other	(0.50%)	(0.70%)
Effective tax rate	0.00%	0.00%