The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Argos Therapeutics Inc. Common 040221103 64,887 13,242,279 SH   DFND 1 0 13,242,279 0
Argos Therapeutics Inc. Common 040221103 27,390 5,120,604 SH Call DFND 1 0 5,120,604 0
Proteon Therapeutics Inc. Common 74371L109 2,214 1,165,344 SH   DFND 1 0 1,165,344 0
Protagonist Therapeutic, Inc. Common 74366E102 21,628 983,570 SH   DFND 1 0 983,570 0